Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity

ATM directs DNA damage responses and proteostasis via genetically separable pathways

(2018) Ji-Hoon Lee et al.   Science Signaling

ATM directs DNA damage responses and proteostasis via genetically separable pathways

(2018) Ji-Hoon Lee et al.   Science Signaling

Oxidative modifications of glyceraldehyde 3-phosphate dehydrogenase regulate metabolic reprogramming of stored red blood cells

(2016) J. A. Reisz et al.   BLOOD

ATM kinase: Much more than a DNA damage responsive protein

(2016) Ayushi Guleria et al.   DNA REPAIR

Citrate metabolism in red blood cells stored in additive solution-3

(2016) Angelo D'Alessandro et al.   TRANSFUSION

Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density

(2016) Yong Pan et al.   Aging-US

Mechanisms of ATM Activation

(2015) Tanya T. Paull   Annual Review of Biochemistry

Mitochondrial ROS Signaling in Organismal Homeostasis

(2015) Gerald S. Shadel et al.   CELL

ROS-dependent signal transduction

(2015) Colleen R Reczek et al.   CURRENT OPINION IN CELL BIOLOGY

ATM functions at the peroxisome to induce pexophagy in response to ROS

(2015) Jiangwei Zhang et al.   NATURE CELL BIOLOGY

Hepatitis B virus stimulates G6PD expression through HBx-mediated Nrf2 activation

(2015) B Liu et al.   Cell Death & Disease

The zinc finger proteins ZNF644 and WIZ regulate the G9a/GLP complex for gene repression

(2015) Chunjing Bian et al.   eLife

Cloning-free CRISPR

(2015) Mandana Arbab et al.   Stem Cell Reports

Transcriptional and epigenetic basis for restoration of G6PD enzymatic activity in human G6PD-deficient cells

(2014) K. Makarona et al.   BLOOD

Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling

(2014) Mirko C Sobotta et al.   Nature Chemical Biology

DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin

(2014) M. K. Ayrapetov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The pentose phosphate pathway and cancer

(2014) Krushna C. Patra et al.   TRENDS IN BIOCHEMICAL SCIENCES

Epigenetic Silencing Mediates Mitochondria Stress-Induced Longevity

(2013) Elizabeth A. Schroeder et al.   Cell Metabolism

Preparation and use of MitoPY1 for imaging hydrogen peroxide in mitochondria of live cells

(2013) Bryan C Dickinson et al.   Nature Protocols

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Glutathione synthesis

(2012) Shelly C. Lu   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Peroxiredoxin 1 functions as a signal peroxidase to receive, transduce, and transmit peroxide signals in mammalian cells

(2012) Reagan M. Jarvis et al.   FREE RADICAL BIOLOGY AND MEDICINE

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

Reducing Mitochondrial ROS Improves Disease-related Pathology in a Mouse Model of Ataxia-telangiectasia

(2012) Anthony D D'Souza et al.   MOLECULAR THERAPY

Perinuclear Mitochondrial Clustering Creates an Oxidant-Rich Nuclear Domain Required for Hypoxia-Induced Transcription

(2012) A.-B. Al-Mehdi et al.   Science Signaling

Modulating Mitochondrial Intracellular Location as a Redox Signal

(2012) M. P. Murphy   Science Signaling

Thioredoxin-Interacting Protein Mediates TRX1 Translocation to the Plasma Membrane in Response to Tumor Necrosis Factor-α

(2011) Cameron World et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mitochondrial dysfunction in ataxia-telangiectasia

(2011) Y. A. Valentin-Vega et al.   BLOOD

ATM activation in the presence of oxidative stress 

(2011) Zhi Guo et al.   CELL CYCLE

The ATM protein kinase and cellular redox signaling: beyond the DNA damage response

(2011) Scott Ditch et al.   TRENDS IN BIOCHEMICAL SCIENCES

ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair

(2010) Claudia Cosentino et al.   EMBO JOURNAL

The sites and topology of mitochondrial superoxide production

(2010) Martin D. Brand   EXPERIMENTAL GERONTOLOGY

Peroxiredoxin II Restrains DNA Damage-induced Death in Cancer Cells by Positively Regulating JNK-dependent DNA Repair

(2010) Kyung Wha Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapid Activation of Glutamate Cysteine Ligase following Oxidative Stress

(2010) Cecile M. Krejsa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Association of Peroxiredoxin 1 with Genomic DNA and COX-2 Upstream Promoter Elements in Estrogen Receptor Negative Breast Cancer Cells

(2010) Xuemei Wang et al.   MOLECULAR BIOLOGY OF THE CELL

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

(2010) A. Alexander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

Oxidative Stress Is Linked to ERK1/2-p16 Signaling-mediated Growth Defect in ATM-deficient Astrocytes

(2009) Jeesun Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular Shuttling and Mitochondrial Function of Thioredoxin-interacting Protein

(2009) Geetu Saxena et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of ATM Impairs Proliferation of Neural Stem Cells Through Oxidative Stress-Mediated p38 MAPK Signaling

(2009) Jeesun Kim et al.   STEM CELLS

Expression and Maintenance of Mitochondrial DNA

(2008) Gerald S. Shadel   AMERICAN JOURNAL OF PATHOLOGY

Redox compartmentalization in eukaryotic cells

(2008) Young-Mi Go et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Foxo3 Is Essential for the Regulation of Ataxia Telangiectasia Mutated and Oxidative Stress-mediated Homeostasis of Hematopoietic Stem Cells

(2008) Safak Yalcin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Etoposide Induces ATM-Dependent Mitochondrial Biogenesis through AMPK Activation

(2008) Xuan Fu et al.   PLoS One