Nitrosylation of GAPDH augments pathological tau acetylation upon exposure to amyloid-β

Reducing expression of synapse-restricting protein Ephexin5 ameliorates Alzheimer’s-like impairment in mice

(2017) Gabrielle L. Sell et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of PERK Elicits Memory Impairment through Inactivation of CREB and Downregulation of PSD95 After Traumatic Brain Injury

(2017) Tanusree Sen et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's Disease and the Amyloid-β Peptide

(2017) M. Paul Murphy et al.   JOURNAL OF ALZHEIMERS DISEASE

Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradation

(2016) M M Harraz et al.   MOLECULAR PSYCHIATRY

Isoflurane-induced inactivation of CREB through histone deacetylase 4 is responsible for cognitive impairment in developing brain

(2016) Tanusree Sen et al.   NEUROBIOLOGY OF DISEASE

Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss

(2016) Tara E. Tracy et al.   NEURON

Treatment with an activator of hypoxia-inducible factor 1, DMOG provides neuroprotection after traumatic brain injury

(2016) Tanusree Sen et al.   NEUROPHARMACOLOGY

Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aβ42-Induced Tau Toxicity

(2016) Kanae Ando et al.   PLoS Genetics

Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo

(2016) Marianna Karina Gorsky et al.   Scientific Reports

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

(2015) Sang-Won Min et al.   NATURE MEDICINE

Tau stabilizes microtubules by binding at the interface between tubulin heterodimers

(2015) Harindranath Kadavath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling

(2015) Marc Zuckermann et al.   Nature Communications

Curcumin Improves Amyloid β-Peptide (1-42) Induced Spatial Memory Deficits through BDNF-ERK Signaling Pathway

(2015) Lu Zhang et al.   PLoS One

Tau aggregation and its interplay with amyloid-β

(2014) Rebecca M. Nisbet et al.   ACTA NEUROPATHOLOGICA

Axonally Synthesized ATF4 Transmits a Neurodegenerative Signal across Brain Regions

(2014) Jimena Baleriola et al.   CELL

HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes

(2014) Monika Noack et al.   GLIA

Inhibition of HDAC6 Modifies Tau Inclusion Body Formation and Impairs Autophagic Clearance

(2014) Janina Leyk et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease

(2014) Shichun Tu et al.   Molecular Neurodegeneration

Targeting the proper amyloid-beta neuronal toxins: a path forward for Alzheimer’s disease immunotherapeutics

(2014) William F Goure et al.   Alzheimers Research & Therapy

Acetylation: a new key to unlock tau’s role in neurodegeneration

(2014) Casey Cook et al.   Alzheimers Research & Therapy

Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death

(2013) Ying Y. Jean et al.   BIOCHEMICAL JOURNAL

Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance

(2013) Casey Cook et al.   HUMAN MOLECULAR GENETICS

Behavioral Effects of Cocaine Mediated by Nitric Oxide-GAPDH Transcriptional Signaling

(2013) Risheng Xu et al.   NEURON

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Neurotoxicity of Amyloid  -Protein: Synaptic and Network Dysfunction

(2013) L. Mucke et al.   Cold Spring Harbor Perspectives in Medicine

Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies

(2012) David J. Irwin et al.   BRAIN

Hydrogen Sulfide-Linked Sulfhydration of NF-κB Mediates Its Antiapoptotic Actions

(2012) Nilkantha Sen et al.   MOLECULAR CELL

Neurotrophin-mediated degradation of histone methyltransferase by S-nitrosylation cascade regulates neuronal differentiation

(2011) N. Sen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by  -amyloid peptide

(2011) J. Qu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The acetylation of tau inhibits its function and promotes pathological tau aggregation

(2011) Todd J. Cohen et al.   Nature Communications

S-Nitrosylation of Drp1 links excessive mitochondrial fission to neuronal injury in neurodegeneration

(2010) Tomohiro Nakamura et al.   MITOCHONDRION

Redox Reactions Induced by Nitrosative Stress Mediate Protein Misfolding and Mitochondrial Dysfunction in Neurodegenerative Diseases

(2010) Zezong Gu et al.   MOLECULAR NEUROBIOLOGY

GAPDH mediates nitrosylation of nuclear proteins

(2010) Michael D. Kornberg et al.   NATURE CELL BIOLOGY

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

Synthetic amyloid-  oligomers impair long-term memory independently of cellular prion protein

(2010) C. Balducci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein modifications involved in neurotransmitter and gasotransmitter signaling

(2010) Nilkantha Sen et al.   TRENDS IN NEUROSCIENCES

Cell death: protein misfolding and neurodegenerative diseases

(2009) Tomohiro Nakamura et al.   APOPTOSIS

GOSPEL: A Neuroprotective Protein that Binds to GAPDH upon S-Nitrosylation

(2009) Nilkantha Sen et al.   NEURON

 -Amyloid1-42 Induces Neuronal Death through the p75 Neurotrophin Receptor

(2008) A. Sotthibundhu et al.   JOURNAL OF NEUROSCIENCE

Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis

(2008) Nilkantha Sen et al.   NATURE CELL BIOLOGY

Emerging Roles of S-Nitrosylation in Protein Misfolding and Neurodegenerative Diseases

(2007) Tomohiro Nakamura et al.   ANTIOXIDANTS & REDOX SIGNALING