Repurposing drugs for use against Zika virus infection

N -(2-(arylmethylimino)ethyl)-7-chloroquinolin-4-amine derivatives, synthesized by thermal and ultrasonic means, are endowed with anti-Zika virus activity

(2017) Giselle Barbosa-Lima et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

QSAR models for predicting the toxicity of piperidine derivatives against Aedes aegypti

(2017) J. P. Doucet et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Quantitative structure–activity relationship study of amide mosquito repellents

(2017) P. Wang et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Pediatric Drug Nitazoxanide: A Potential Choice for Control of Zika

(2017) Rui-Yuan Cao et al.   Open Forum Infectious Diseases

A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection

(2016) Nicholas J. Barrows et al.   Cell Host & Microbe

Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth

(2016) Hengli Tang et al.   Cell Stem Cell

In-silico screening for anti-Zika virus phytochemicals

(2016) Kendall G. Byler et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

An Approach for Zika Virus Inhibition Using Homology Structure of the Envelope Protein

(2016) Sandun Fernando et al.   MOLECULAR BIOTECHNOLOGY

A second look: Efforts to repurpose old drugs against Zika cast a wide net

(2016) Ellie Kincaid   NATURE MEDICINE

Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

(2016) Miao Xu et al.   NATURE MEDICINE

Zika Virus and Birth Defects — Reviewing the Evidence for Causality

(2016) Sonja A. Rasmussen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Zika Virus in the Americas — Yet Another Arbovirus Threat

(2016) Anthony S. Fauci et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification of novelPfDHODH inhibitors as antimalarial agents via pharmacophore-based virtual screening followed by molecular docking andin vivoantimalarial activity

(2016) V. K. Vyas et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

QSAR study on the antimalarial activity ofPlasmodium falciparumdihydroorotate dehydrogenase (PfDHODH) inhibitors

(2016) X. Hou et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Chloroquine, an Endocytosis Blocking Agent, Inhibits Zika Virus Infection in Different Cell Models

(2016) Rodrigo Delvecchio et al.   Viruses-Basel

OpenZika: An IBM World Community Grid Project to Accelerate Zika Virus Drug Discovery

(2016) Sean Ekins et al.   PLoS Neglected Tropical Diseases

The global spread of Zika virus: is public and media concern justified in regions currently unaffected?

(2016) Narayan Gyawali et al.   Infectious Diseases of Poverty

Suramin inhibits chikungunya virus replication through multiple mechanisms

(2015) Irina C. Albulescu et al.   ANTIVIRAL RESEARCH

Computational and Practical Aspects of Drug Repositioning

(2015) Tudor I. Oprea et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

First report of autochthonous transmission of Zika virus in Brazil

(2015) Camila Zanluca et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Prioritization of active antimalarials using structural interaction profile ofPlasmodium falciparumenoyl-acyl carrier protein reductase (PfENR)-triclosan derivatives

(2015) S.P. Kumar et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Structure–activity relationship (SAR) modelling of mosquito larvicides

(2015) J. Devillers et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Nitazoxanide: A first-in-class broad-spectrum antiviral agent

(2014) Jean-François Rossignol   ANTIVIRAL RESEARCH

Suramin inhibits helicase activity of NS3 protein of dengue virus in a fluorescence-based high throughput assay format

(2014) Chandrakala Basavannacharya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

In silicomodels for predicting vector control chemicals targetingAedes aegypti

(2014) J. Devillers et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

The drug and vaccine landscape for neglected diseases (2000–11): a systematic assessment

(2013) Belen Pedrique et al.   Lancet Global Health

Predictive methods in drug repurposing: gold mine or just a bigger haystack?

(2012) David Cavalla   DRUG DISCOVERY TODAY

Structure-guided fragment-based in silico drug design of dengue protease inhibitors

(2011) Tim Knehans et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Zika Virus Outbreak on Yap Island, Federated States of Micronesia

(2009) Mark R. Duffy et al.   NEW ENGLAND JOURNAL OF MEDICINE