Characterization of the molecular crosstalk within the essential Grc3/Las1 pre-rRNA processing complex

Preribosomes escaping from the nucleus are caught during translation by cytoplasmic quality control

(2017) Anshuk Sarkar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Grc3 programs the essential endoribonuclease Las1 for specific RNA cleavage

(2017) Monica C. Pillon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstitution of the complete pathway of ITS2 processing at the pre-ribosome

(2017) Lisa Fromm et al.   Nature Communications

Preribosomes escaping from the nucleus are caught during translation by cytoplasmic quality control

(2017) Anshuk Sarkar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Characterization of the tRNA ligases of pathogenic fungiAspergillus fumigatusandCoccidioides immitis

(2016) Barbara S. Remus et al.   RNA

miR-34 activity is modulated through 5′-end phosphorylation in response to DNA damage

(2016) David W. Salzman et al.   Nature Communications

Coordinated Ribosomal ITS2 RNA Processing by the Las1 Complex Integrating Endonuclease, Polynucleotide Kinase, and Exonuclease Activities

(2015) Lisa Gasse et al.   MOLECULAR CELL

Global analysis of RNA cleavage by 5′-hydroxyl RNA sequencing

(2015) Sally E. Peach et al.   NUCLEIC ACIDS RESEARCH

Reconstitution and structure of a bacterial Pnkp1–Rnl–Hen1 RNA repair complex

(2015) Pei Wang et al.   Nature Communications

Human CLP1 Mutations Alter tRNA Biogenesis, Affecting Both Peripheral and Central Nervous System Function

(2014) Ender Karaca et al.   CELL

CLP1 Founder Mutation Links tRNA Splicing and Maturation to Cerebellar Development and Neurodegeneration

(2014) Ashleigh E. Schaffer et al.   CELL

RNA Specificity and Regulation of Catalysis in the Eukaryotic Polynucleotide Kinase Clp1

(2014) Aytac Dikfidan et al.   MOLECULAR CELL

Dimeric Structure of Pseudokinase RNase L Bound to 2-5A Reveals a Basis for Interferon-Induced Antiviral Activity

(2014) Hao Huang et al.   MOLECULAR CELL

CLP1 as a novel player in linking tRNA splicing to neurodegenerative disorders

(2014) Stefan Weitzer et al.   Wiley Interdisciplinary Reviews-RNA

Structural and Biochemical Analysis of the Phosphate Donor Specificity of the Polynucleotide Kinase Component of the Bacterial Pnkp•Hen1 RNA Repair System

(2013) Ushati Das et al.   BIOCHEMISTRY

CLP1 links tRNA metabolism to progressive motor-neuron loss

(2013) Toshikatsu Hanada et al.   NATURE

Has1 regulates consecutive maturation and processing steps for assembly of 60S ribosomal subunits

(2013) Jill A. Dembowski et al.   NUCLEIC ACIDS RESEARCH

Structures of bacterial polynucleotide kinase in a Michaelis complex with GTP*Mg2+ and 5'-OH oligonucleotide and a product complex with GDP*Mg2+ and 5'-PO4 oligonucleotide reveal a mechanism of general acid-base catalysis and the determinants of phosphoacceptor recognition

(2013) U. Das et al.   NUCLEIC ACIDS RESEARCH

Las1 interacts with Grc3 polynucleotide kinase and is required for ribosome synthesis in Saccharomyces cerevisiae

(2012) Christopher D. Castle et al.   NUCLEIC ACIDS RESEARCH

Structure and mechanism of the polynucleotide kinase component of the bacterial Pnkp-Hen1 RNA repair system

(2012) L. K. Wang et al.   RNA

The Evolutionarily Conserved Protein LAS1 Is Required for Pre-rRNA Processing at Both Ends of ITS2

(2011) S. Schillewaert et al.   MOLECULAR AND CELLULAR BIOLOGY

LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis

(2011) Christopher D. Castle et al.   MOLECULAR BIOLOGY OF THE CELL

Coupled 5′ Nucleotide Recognition and Processivity in Xrn1-Mediated mRNA Decay

(2011) Martin Jinek et al.   MOLECULAR CELL

An essential role for Clp1 in assembly of polyadenylation complex CF IA and Pol II transcription termination

(2011) Raphaël Haddad et al.   NUCLEIC ACIDS RESEARCH

The P-Loop Domain of Yeast Clp1 Mediates Interactions Between CF IA and CPF Factors in Pre-mRNA 3′ End Formation

(2011) Sandra Holbein et al.   PLoS One

Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair

(2011) Michael Weinfeld et al.   TRENDS IN BIOCHEMICAL SCIENCES

Nol9 is a novel polynucleotide 5′-kinase involved in ribosomal RNA processing

(2010) Katrin Heindl et al.   EMBO JOURNAL

Role of the RNA/DNA kinase Grc3 in transcription termination by RNA polymerase I

(2010) Priscilla Braglia et al.   EMBO REPORTS

Mechanism of DNA substrate recognition by the mammalian DNA repair enzyme, Polynucleotide Kinase

(2009) N. K. Bernstein et al.   NUCLEIC ACIDS RESEARCH

Characterization of a thermostable archaeal polynucleotide kinase homologous to human Clp1

(2009) R. Jain et al.   RNA

A vector system for genomic FLAG epitope-tagging inSchizosaccharomyces pombe

(2008) Chiaki Noguchi et al.   Biotechnology Journal