Pathophysiology of severe asthma: We’ve only just started

Tezepelumab in Adults with Uncontrolled Asthma

(2017) Jonathan Corren et al.   NEW ENGLAND JOURNAL OF MEDICINE

Myofibroblasts are increased in the lung parenchyma in asthma

(2017) Stacey R. Boser et al.   PLoS One

Innate lymphoid cells in asthma: Will they take your breath away?

(2016) Hye Young Kim et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Increased numbers of activated group 2 innate lymphoid cells in the airways of patients with severe asthma and persistent airway eosinophilia

(2016) Steven G. Smith et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Type 2 innate lymphoid cells in induced sputum from children with severe asthma

(2016) Prasad Nagakumar et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting β2 agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial

(2016) Sally Wenzel et al.   LANCET

Airway remodelling in COPD: It's not asthma!

(2016) Robyn L. Jones et al.   RESPIROLOGY

Infant lung function predicts asthma persistence and remission in young adults

(2016) Louisa Owens et al.   RESPIROLOGY

High IFN-γ and low SLPI mark severe asthma in mice and humans

(2015) Mahesh Raundhal et al.   JOURNAL OF CLINICAL INVESTIGATION

The immunology of asthma

(2015) Bart N Lambrecht et al.   NATURE IMMUNOLOGY

Greater parallel heterogeneity of airway narrowing and airway closure in asthma measured by high-resolution CT

(2015) J R Dame Carroll et al.   THORAX

Lung function trajectories from birth through puberty reflect asthma phenotypes with allergic comorbidity

(2014) Karin C. Lødrup Carlsen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data

(2014) Wei Wu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

An airway epithelial iNOS–DUOX2–thyroid peroxidase metabolome drives Th1/Th2 nitrative stress in human severe asthma

(2014) N Voraphani et al.   Mucosal Immunology

Potentially Pathogenic Airway Bacteria and Neutrophilic Inflammation in Treatment Resistant Severe Asthma

(2014) Benjamin J. Green et al.   PLoS One

Distribution of airway smooth muscle remodelling in asthma: Relation to airway inflammation

(2014) John G. Elliot et al.   RESPIROLOGY

The association between childhood asthma and adult chronic obstructive pulmonary disease

(2014) Andrew Tai et al.   THORAX

Bronchoalveolar lavage in infants with recurrent lower respiratory symptoms

(2014) Kristiina Malmström et al.   Clinical and Translational Allergy

Exploring the Effects of Omalizumab in Allergic Asthma

(2013) Nicola A. Hanania et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Obesity-Associated Severe Asthma Represents a Distinct Clinical Phenotype

(2013) David Gibeon et al.   CHEST

Peripheral lung function in patients with stable and unstable asthma

(2013) Bruce R. Thompson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Prostaglandin D2 pathway upregulation: Relation to asthma severity, control, and TH2 inflammation

(2013) Merritt L. Fajt et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Respiratory system reactance is an independent determinant of asthma control

(2013) Vanessa J. Kelly et al.   JOURNAL OF APPLIED PHYSIOLOGY

T Cell-Derived IL-17 Mediates Epithelial Changes in the Airway and Drives Pulmonary Neutrophilia

(2013) L. K. Fogli et al.   JOURNAL OF IMMUNOLOGY

Interleukin-17–producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity

(2013) Hye Young Kim et al.   NATURE MEDICINE

Lipoxin A4 Regulates Natural Killer Cell and Type 2 Innate Lymphoid Cell Activation in Asthma

(2013) C. Barnig et al.   Science Translational Medicine

Airway Smooth Muscle Hypertrophy and Hyperplasia in Asthma

(2012) Alan L. James et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Ventilation heterogeneity predicts asthma control in adults following inhaled corticosteroid dose titration

(2012) Claude S. Farah et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Airway closure on imaging relates to airway hyperresponsiveness and peripheral airway disease in asthma

(2012) Catherine E. Farrow et al.   JOURNAL OF APPLIED PHYSIOLOGY

Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial

(2012) Ian D Pavord et al.   LANCET

Elastin in asthma

(2012) Caroline J. Reddel et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Epithelial eotaxin-2 and eotaxin-3 expression: relation to asthma severity, luminal eosinophilia and age at onset

(2012) John M Coleman et al.   THORAX

Predictors of Airway Hyperresponsiveness Differ Between Old and Young Patients With Asthma

(2011) Kate M. Hardaker et al.   CHEST

Patterns of airway disease and the clinical diagnosis of asthma in the Busselton population

(2011) A. W. Musk et al.   EUROPEAN RESPIRATORY JOURNAL

Obesity and asthma: An association modified by age of asthma onset

(2011) Fernando Holguin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The effect of airway remodelling on airway hyper-responsiveness in asthma

(2011) Jessica A. Kermode et al.   RESPIRATORY MEDICINE

A ‘Good’ muscle in a ‘Bad’ environment: The importance of airway smooth muscle force adaptation to airway hyperresponsiveness

(2011) Ynuk Bossé et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Mast Cell Phenotype, Location, and Activation in Severe Asthma

(2010) Silvana Balzar et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Use of cluster analysis to define COPD phenotypes

(2010) M. Weatherall et al.   EUROPEAN RESPIRATORY JOURNAL

Persistent bronchiolar remodeling following brief ventilation of the very immature ovine lung

(2009) Megan O'Reilly et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Reduction of Tumstatin in Asthmatic Airways Contributes to Angiogenesis, Inflammation, and Hyperresponsiveness

(2009) Janette K. Burgess et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma

(2009) Pranabashis Haldar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cluster Analysis and Clinical Asthma Phenotypes

(2008) Pranab Haldar et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Airway Lipoxin A4Generation and Lipoxin A4Receptor Expression Are Decreased in Severe Asthma

(2008) Anna Planagumà et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Extracellular matrix components and regulators in the airway smooth muscle in asthma

(2008) B. B. Araujo et al.   EUROPEAN RESPIRATORY JOURNAL

Nitrative stress in refractory asthma

(2008) Hisatoshi Sugiura et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The difference in ventilation heterogeneity between asthmatic and healthy subjects quantified using hyperpolarized 3He MRI

(2008) Yang-Sheng Tzeng et al.   JOURNAL OF APPLIED PHYSIOLOGY

The course of persistent airflow limitation in subjects with and without asthma

(2008) Stefano Guerra et al.   RESPIRATORY MEDICINE

Differences in Airway Cytokine Profile in Severe Asthma Compared to Moderate Asthma

(2007) Joanne Shannon et al.   CHEST