Article
Allergy
Brandy M. Byrwa-Hill, Tricia L. Morphew, Albert A. Presto, James P. Fabisiak, Sally E. Wenzel
Summary: Living in an environmentally just tract increases the likelihood of severe and uncontrolled asthma, which is influenced by age at onset, disease duration, and traffic-related air pollution.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Rheumatology
Satoshi Takanashi, Jun Kikuchi, Takanori Sasaki, Mitsuhiro Akiyama, Hidekata Yasuoka, Keiko Yoshimoto, Noriyasu Seki, Kunio Sugahara, Kenji Chiba, Yuko Kaneko, Tsutomu Takeuchi
Summary: This study identified that patients with IgG4-related disease and lymphadenopathy exhibit high disease activity, eosinophilia, and a higher likelihood of disease relapse. Eotaxin-3 was identified as a potential serum biomarker for this phenotype.
Article
Respiratory System
Yenealem Solomon, Birhanemaskal Malkamu, Ayenew Berhan, Tahir Eyayu, Andargachew Almaw, Biruk Legese, Berhanu Woldu
Summary: This study aimed to determine the association between the severity of asthma and high blood eosinophil count. The overall prevalence of eosinophilia among asthmatic patients was 19.6%. Female gender and admission to the emergency department were negatively associated with eosinophilia, while asthmatic patients with intestinal parasitic infection had significantly higher eosinophil counts.
BMC PULMONARY MEDICINE
(2023)
Article
Multidisciplinary Sciences
Vincent Wellemans, Hassan Ait Benhassou, Eloise Fuselier, Fabienne Bellesort, Sandra Dury, Francois Lebargy, Valerian Dormoy, Caroline Fichel, Richard Le Naour, Abdelilah S. Gounni, Bouchaib Lamkhioued
Summary: RSV infection may enhance virus replication by interacting with CCR3 and increasing airway responsiveness; lack of CCR3 is beneficial for resistance against RSV infection and reduction of airway inflammation.
Article
Critical Care Medicine
Xingnan Li, Stefano Guerra, Julie G. Ledford, Monica Kraft, Huashi Li, Annette T. Hastie, Mario Castro, Loren C. Denlinger, Serpil C. Erzurum, John Fahy, Benjamin Gaston, Elliot Israel, Nizar N. Jarjour, Bruce D. Levy, David T. Mauger, Wendy C. Moore, Joe Zein, Naftali Kaminski, Sally E. Wenzel, Prescott G. Woodruff, Deborah A. Meyers, Eugene R. Bleecker
Summary: This study investigated the association between CC16 mRNA expression levels in nonciliated bronchial epithelial cells (BECs) and asthma severity. The results showed that low CC16 mRNA expression levels were significantly associated with asthma susceptibility, severity, exacerbations, and T2 inflammation biomarkers. Additionally, CC16 mRNA expression levels were correlated with the expression levels of Th2, Th1, and inflammation genes. A combination of CC16 and IL-6 could identify different asthma endotypes.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Allergy
Lingling Yi, Shuchen Zhang, Yuchen Feng, Wenliang Wu, Chenli Chang, Dian Chen, Shengchong Chen, Jianping Zhao, Guohua Zhen
Summary: Galectin-13 expression is significantly increased in asthma patients and is correlated with eosinophilic airway inflammation and Th2 signature genes. Inhaled corticosteroid treatment can reduce plasma galectin-13 levels, and galectin-13 may contribute to allergic airway eosinophilic inflammation by upregulating the expression of certain cytokines. Plasma galectin-13 levels may serve as a useful predictor for responses to ICS treatment.
CLINICAL AND EXPERIMENTAL ALLERGY
(2021)
Article
Dermatology
J. C. Ho, H. J. Wen, C. W. Sun, S. F. Tsai, P. H. Su, C. L. Chang, H. L. Sun, S. L. Wang, C. H. Lee
Summary: This study showed that maternal nickel exposure is associated with changes in serum analyte levels in their children, as well as a potential impact on the development of childhood atopic dermatitis. The findings suggest a possible link between maternal nickel exposure and immune abnormalities in children at an early developmental stage.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Allergy
Lin Sun, Bo Peng, Jun Zhou, Ping Wang, Yuqing Mo, Guofang Xu, Yi Tao, Hejie Song, Wei Tang, Meiling Jin
Summary: The study compared the difference in serum cytokine profiles between allergic asthma patients with different disease severity and identified YKL-40, eotaxin-1, and MCP-1 as potential biomarkers for reflecting disease severity.
JOURNAL OF ASTHMA AND ALLERGY
(2022)
Article
Respiratory System
Wenliang Wu, Jiali Gao, Dian Chen, Gongqi Chen, Yuchen Feng, Chenli Chang, Shengchong Chen, Lingling Yi, Guohua Zhen
Summary: The expression of miR-30a-3p in bronchial brushings is significantly decreased in asthma patients and is negatively correlated with airway eosinophilia. miR-30a-3p may suppress airway eosinophilia in asthma by targeting the RUNX2/HMGB1 axis.
RESPIRATORY RESEARCH
(2022)
Article
Respiratory System
Annette Evans, Daniel Farewell, Joanne Demmler, Amrita Bandyopadhyay, Colin Victor Eric Powell, Shantini Paranjothy
Summary: The study suggests that children with inpatient asthma admissions are at higher risk of not attaining expected educational levels at age 6-7, while lower respiratory tract infection GP contacts are an independent predictor of poor educational outcomes. School absence may mediate the relationship between inpatient asthma admissions and educational attainment.
Article
Medicine, General & Internal
Yoshitomo Kushima, Yasuo Shimizu, Hiromi Hoshi, Ryo Arai, Naoya Ikeda, Yusuke Nakamura, Meitetsu Masawa, Hiroaki Okutomi, Nana Yazawa, Kazuyuki Chibana, Akihiro Takemasa, Seiji Niho
Summary: The purpose of this study is to investigate the changes in peripheral blood eosinophil counts and the onset of eosinophilic granulomatosis with polyangiitis (EGPA) in asthma patients treated with dupilumab. Results showed that the development of EGPA was more frequent in patients with continuously rising eosinophil counts compared to those with peaked and declined counts. Additionally, patients with eosinophil counts greater than 1500 cells/μL at 3 or 6 months after administration of dupilumab had a significantly higher risk of developing EGPA.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Environmental Sciences
Zhebin Yu, Gerard H. Koppelman, Jolanda M. A. Boer, Gerard Hoek, Jules Kerckhoffs, Judith M. Vonk, Roel Vermeulen, Ulrike Gehring
Summary: The study found that long-term exposure to ultrafine particles (UFP) is associated with an increased risk of asthma development, but this association becomes non-significant after adjusting for other pollutants.
ENVIRONMENTAL RESEARCH
(2022)
Article
Physiology
Zeneng Wang, Weiling Xu, Suzy A. A. Comhair, Xiaoming Fu, Zhili Shao, Rebecca Bearden, Joe G. Zein, Eugene R. Bleecker, Mario Castro, Loren C. Denlinger, John V. Fahy, Elliot Israel, Bruce D. Levy, Nizar N. Jarjour, Wendy C. Moore, Sally E. Wenzel, David T. Mauger, Benjamin Gaston, Stanley L. Hazen, Serpil C. Erzurum
Summary: Total conjugated bromotyrosine in urine can be used to differentiate asthma severity and predict asthma exacerbations. The levels of urinary total conjugated bromotyrosine are associated with asthma severity and the number of asthma exacerbations.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Article
Respiratory System
M. de Vries, K. O. Nwozor, K. Muizer, M. Wisman, W. Timens, M. van den Berge, A. Faiz, T-L Hackett, I. H. Heijink, C. A. Brandsma
Summary: A study found a significant association between genes involved in epithelial barrier function and age, indicating a role for epithelial barrier dysfunction in age-related airway disease.
RESPIRATORY RESEARCH
(2022)
Article
Sport Sciences
Rikhard Maki-Heikkila, Jussi Karjalainen, Jari Parkkari, Heini Huhtala, Maarit Valtonen, Lauri Lehtimaki
Summary: This comparative study found that the prevalence of asthma is approximately 2.5 times higher in cross-country skiers compared to the control group, with a later onset of asthma. Most skiers with asthma have well-controlled symptoms and are on regular maintenance treatment.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2021)
Article
Allergy
Jonathan Corren, Mario Castro, Thomas O'Riordan, Nicola A. Hanania, Ian D. Pavord, Santiago Quirce, Bradley E. Chipps, Sally E. Wenzel, Karthinathan Thangavelu, Megan S. Rice, Sivan Harel, Alexandre Jagerschmidt, Asif H. Khan, Siddhesh Kamat, Jaman Maroni, Paul Rowe, Yufang Lu, Nikhil Amin, Gianluca Pirozzi, Marcella Ruddy, Neil M. H. Graham, Ariel Teper
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2020)
Article
Allergy
Kristie R. Ross, Ritika Gupta, Mark D. DeBoer, Joe Zein, Brenda R. Phillips, David T. Mauger, Chun Li, Ross E. Myers, Wanda Phipatanakul, Anne M. Fitzpatrick, Ngoc P. Ly, Leonard B. Bacharier, Daniel J. Jackson, Juan C. Celedon, Allyson Larkin, Elliot Israel, Bruce Levy, John Fahy, Mario Castro, Eugene R. Bleecker, Deborah Meyers, Wendy C. Moore, Sally E. Wenzel, Nizar N. Jarjour, Serpil C. Erzurum, W. Gerald Teague, Benjamin Gaston
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Article
Allergy
Anne M. Fitzpatrick, Stanley J. Szefler, David T. Mauger, Brenda R. Phillips, Loren C. Denlinger, Wendy C. Moore, Ronald L. Sorkness, Sally E. Wenzel, Peter J. Gergen, Eugene R. Bleecker, Mario Castro, Serpil C. Erzurum, John Fahy, Benjamin M. Gaston, Elliot Israel, Bruce D. Levy, Deborah A. Meyers, W. Gerald Teague, Leonard B. Bacharier, Ngoc P. Ly, Wanda Phipatanakul, Kristie R. Ross, Joe Zein, Nizar N. Jarjour
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Review
Critical Care Medicine
Sally E. Wenzel
Summary: Evaluation and management of severe asthma remains a core focus in pulmonary practice. Advances in clinical phenotyping and molecular tools have greatly enhanced our understanding and treatment of severe asthma. Challenges still exist, but conceptual understanding of the disease has evolved significantly in a relatively short period of time.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Immunology
Matthew K. Hensley, William G. Bain, Jana Jacobs, Sham Nambulli, Urvi Parikh, Anthony Cillo, Brittany Staines, Amy Heaps, Michele D. Sobolewski, Linda J. Rennick, Bernard J. C. Macatangay, Cynthia Klamar-Blain, Georgios D. Kitsios, Barbara Methe, Ashwin Somasundaram, Tullia C. Bruno, Carly Cardello, Feng Shan, Creg Workman, Prabir Ray, Anuradha Ray, Janet Lee, Rahil Sethi, William E. Schwarzmann, Mark S. Ladinsky, Pamela J. Bjorkman, Dario A. Vignali, W. Paul Duprex, Mounzer E. Agha, John W. Mellors, Kevin D. McCormick, Alison Morris, Ghady Haidar
Summary: This study reports a case of a recipient of chimeric antigen receptor-modified T-cell therapy who developed severe COVID-19 with prolonged viral replication and evolution, along with minimal immune response, suggesting the possibility of prolonged transmission from immunosuppressed patients.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Physiology
Kaveh Moghbeli, Eleanor Valenzi, Rachel Naramore, John Charles Sembrat, Kong Chen, Mauricio M. Rojas, Sally E. Wenzel, Robert Lafyatis, Brian Modena, Nathaniel M. Weathington
Summary: The study analyzed BAL samples from Severe Asthma patients and found suppression of the BALcAMP gene module, influenced by various factors. The results showed that the BALcAMP gene network expression was suppressed in multiple cell populations, particularly significantly in macrophages.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Allergy
Marc Gauthier, Sagar Laxman Kale, Timothy B. Oriss, Kathryn Scholl, Sudipta Das, Huijuan Yuan, Sanmei Hu, Jie Chen, Matthew Camiolo, Prabir Ray, Sally Wenzel, Anuradha Ray
Summary: This study investigated the role of chemotactic receptors CXCR3 and CCR5 in establishing type 1 inflammation in severe asthma. The results showed a strong correlation between CXCR3, CCR5, and IFN-γ expression. Inhibiting the CCR5 pathway with maraviroc reduced airway hyperreactivity. Targeting this pathway may be a novel approach for improving lung function in individuals with type 1-high asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Matthew J. Camiolo, Xiuxia Zhou, Qi Wei, Humberto E. Trejo Bittar, Naftali Kaminski, Anuradha Ray, Sally E. Wenzel
Summary: Asthma is a common disease with highly variable natural history and patient morbidity. Previous studies have linked gene expression changes in severe asthma to specific clinical and physiological characteristics. Using bronchial epithelial cell gene expression data, a transcriptional signature was identified for participants with exacerbation-prone asthma and impaired lung function. This approach identified a set of 31 genes that classified patients accurately and highlighted IL-18 signaling in severe asthma pathogenesis.
Article
Critical Care Medicine
Alexander J. Schuyler, Sally E. Wenzel
Summary: This study aims to explore the impact of historical redlining on contemporary racial inequities in environmental quality and lung health. The findings suggest that individuals living in neighborhoods subjected to historical redlining, especially Black individuals, face higher levels of asthma-related outcomes and environmental burdens, indicating the long-term effects of systemic racism.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Cell Biology
Anuradha Ray, Jishnu Das, Sally E. Wenzel
Summary: There is an unprecedented opportunity to accurately diagnose and manage asthma by using machine learning to integrate high-dimensional molecular data with clinical characteristics. Asthma is a complex and heterogeneous disease that cannot be solely explained by an abnormal T2 immune response. Integrating multi-omics asthma datasets and clinical data is necessary to understand asthma heterogeneity.
CELL REPORTS MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Anuradha Ray, Sagar L. Kale, Richard P. Ramonell
Summary: Despite advancements in pulmonary immunology, there is still much work to be done in understanding coordinated immune responses in the lung. The SARS-CoV-2 pandemic has shown the inadequacy of current models of host-pathogen interactions and emphasized the importance of unraveling complex biological questions for immunologists. The 64th Annual Thomas L. Petty Aspen Lung Conference focused on bridging the gap between innate and adaptive immunity in the lung, discussing disease pathogenesis, immune responses, autoimmune lung diseases, immunologic cancer treatments, and new paradigms for lung disease prevention and treatment.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Allergy
Brandy M. Byrwa-Hill, Tricia L. Morphew, Albert A. Presto, James P. Fabisiak, Sally E. Wenzel
Summary: Living in an environmentally just tract increases the likelihood of severe and uncontrolled asthma, which is influenced by age at onset, disease duration, and traffic-related air pollution.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Physiology
Hannah H. Covert, Firoz Abdoel Wahid, Sally E. Wenzel, Maureen Y. Lichtveld
Summary: Anthropogenic climate change has a negative impact on human health, particularly respiratory health. This article examines the effects of climate change on respiratory health risks, including heat, wildfires, pollen, extreme weather events, and viruses. The intersection of exposure and vulnerability, influenced by social determinants of health, determines the risk of adverse health outcomes. The authors call for a transdisciplinary approach to accelerate research, practice, and policy development for respiratory health in the context of climate change.
PHYSIOLOGICAL REVIEWS
(2023)
Article
Biochemical Research Methods
Matthew J. Camiolo, Sally E. Wenzel, Anuradha Ray
Summary: Bulk expression data from heterogeneous cell populations can be challenging for investigators, but ICLite, a tool for bulk RNA sequencing on mixed populations, helps construct correlated gene modules and identify their relationship to specific lineages.