Article
Obstetrics & Gynecology
Christopher P. Allen, David J. McLernon, Sohinee Bhattahcharya, Abha Maheshwari
Summary: This study analyzed the association between donor sperm and perinatal outcomes of live births conceived via IVF. The results showed that singleton live births conceived with donor sperm had a lower risk of very preterm and preterm birth, while the risk of low and high birthweight was also affected. For liveborn twins conceived with donor sperm, there was a lower risk of very low and low birthweight, and a suggestion of a reduced risk of very preterm and preterm birth. The study concludes that there is no greater chance of adverse outcomes for IVF live births conceived with donor sperm compared to partner sperm.
FERTILITY AND STERILITY
(2022)
Article
Obstetrics & Gynecology
R. Matorras, S. Perez-Fernandez, A. Hubel, M. Ferrando, F. Quintana, A. Vendrell, M. Hernandez
Summary: In lesbian couples, shared motherhood IVF (SMI) and artificial insemination with donor sperm (AID) have similar outcomes in singleton pregnancies, except for a non-significant increase in the rate of preeclampsia/hypertension (PE/HT) in SMI. However, twin pregnancies in SMI have a much higher frequency of PE/HT compared to AID twins.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Colleen M. Miller, Stephanie Duong, Amy L. Weaver, Yulian Zhao, Chandra C. Shenoy
Summary: The study compared outcomes of frozen donor oocyte IVF cycles with intracytoplasmic sperm injection (ICSI) of good quality fresh versus frozen ejaculated sperm. While there were no significant differences in clinical pregnancy rate, fertilization rate, and blastocyst development rate between using frozen and fresh sperm, there was a trend towards improved live birth rate with fresh sperm. Further research with larger sample sizes is needed to explore this finding.
REPRODUCTIVE SCIENCES
(2022)
Article
Obstetrics & Gynecology
P. Bortoletto, S. Willson, P. A. Romanski, O. K. Davis, Z. Rosenwaks
Summary: Women aged 40 and older who use donor sperm for IVF have higher odds of live birth compared to those using their partner's sperm, after adjusting for relevant confounders.
HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Yong Zhu, Feng Zhang, Hua Chen, Xiaoxi Sun, Feng Jiang
Summary: This retrospective study aimed to uncover the effects of using frozen sperm and embryos on the outcomes of in vitro fertilization treatments. The results showed that using frozen embryos and frozen sperm increased the clinical pregnancy rate, live birth rate, and low birth weight rate. The study also found accumulative effects of frozen gametes. These findings are important for both clinical and basic research.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Obstetrics & Gynecology
Russell Frank, Naama Steiner, Maryam Al Shatti, Jacob Ruiter-Ligeti, Michael H. Dahan
Summary: In women aged 38-43 undergoing IUI treatment, using donor sperm compared with partner sperm did not increase the pregnancy rate.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Obstetrics & Gynecology
Audrey M. Marsidi, Lauren M. Kipling, Jennifer F. Kawwass, Akanksha Mehta
Summary: The study found that paternal age has an impact on the likelihood of pregnancy and live birth among couples undergoing assisted reproductive technology, especially in women aged 35 and older. Compared to paternal age under 45, paternal age over 46 is associated with lower success rates in IVF cycles.
FERTILITY AND STERILITY
(2021)
Article
Genetics & Heredity
Daniela Diego, Alexandra Medline, Lisa M. Shandley, Jennifer F. Kawwass, Heather S. Hipp
Summary: This retrospective study analyzed the fertility treatment use and outcomes of patients who used donor sperm at a reproductive center between 2014 and 2020. The results showed high live birth rates among patients using donor sperm, but also highlighted the risks of pregnancy complications. Older patients and those with higher body mass index were more likely to experience pregnancy and neonatal complications.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Review
Obstetrics & Gynecology
Christopher P. Allen, Nicola Marconi, David J. McLernon, Sohinee Bhattacharya, Abha Maheshwari
Summary: The study found that pregnancies conceived using donor sperm may have a higher risk of obstetric complications such as hypertensive disorders of pregnancy and small for gestational age, compared to pregnancies conceived with partner sperm. However, further high-quality population-based studies are needed to confirm these findings due to the limited evidence and variations in study quality and bias.
HUMAN REPRODUCTION UPDATE
(2021)
Article
Obstetrics & Gynecology
M. Pontesilli, M. H. Hof, A. C. J. Ravelli, A. J. van Altena, A. T. Soufan, B. W. Mol, E. H. Kostelijk, E. Slappendel, D. Consten, A. E. P. Cantineau, L. A. J. van der Westerlaken, W. van Inzen, J. C. M. Dumoulin, L. Ramos, E. B. Baart, F. J. M. Broekmans, P. M. Rijnders, M. H. J. M. Curfs, S. Mastenbroek, S. Repping, T. J. Roseboom, R. C. Painter
Summary: Both parental characteristics and ART treatment characteristics affect perinatal outcomes in singleton pregnancies, including birth weight, preterm birth rate, congenital abnormalities, and perinatal mortality.
HUMAN REPRODUCTION
(2021)
Article
Endocrinology & Metabolism
Yi-Chen He, Kai-Zhen Su, Jie Cai, Qing-Xia Meng, Yan-Ting Wu, He-Feng Huang
Summary: This study explored the association between anti-Mullerian hormone (AMH) levels and perinatal outcomes in women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). The study found that abnormal AMH levels increased the risk of intrahepatic cholestasis of pregnancy (ICP) regardless of the number of live births, while high AMH levels increased the risks of gestational diabetes mellitus (GDM) and pregnancy-induced hypertension (PIH) in multiple deliveries. However, there was no association between AMH levels and adverse neonatal outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Mauro Cozzolino, Irene Hervas, Rocio Rivera-Egea, Antonio Pellicer, Nicolas Garrido
Summary: The study found that using donor spermatozoa after the first failed oocyte donation cycle can improve IVF outcomes. The cumulative live birth rate (CLBR) curves for using autologous or donor spermatozoa can be used to determine the cumulative chances of live birth and provide guidance on when to replace spermatozoa.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Medicine, General & Internal
Laura Catalini, Jens Fedder, Bente Mertz Norgard, Line Riis Jolving
Summary: This nationwide cohort study examined the outcomes of assisted reproductive technology treatments in women using donor or partner sperm in Denmark from 2007 to 2017. The study found that the use of donor sperm was associated with higher odds of live birth after IUI treatments in women with male partners (aOR 1.48), single women (aOR 1.20), and women with female partners (aOR 1.46). However, there was no significant difference in live birth rates between women using donor and partner sperm after IVF treatments. The study highlights the importance of healthcare professionals attending to the individual needs and fertility issues of women seeking fertility treatments.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Pedro Brandao, Brent Monseur, Pedro Melo, Manuel Goncalves-Henriques, Nathan Ceschin, Sergio Reis-Soares, Ricardo Sousa-Santos, Jose Bellver
Summary: This study investigated the population and outcomes of the ROPA method in 18 fertility clinics in Spain from 2011 to 2020. The results showed that the outcomes of the ROPA method are reassuring, with about one-half of the treatment cycles resulting in live births and one-quarter of the cycles having surplus embryos after achieving a live birth. Overall, the neonatal outcomes of the ROPA method are also reassuring.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Obstetrics & Gynecology
Robert West, Arri Coomarasamy, Lorraine Frew, Rachel Hutton, Jackson Kirkman-Brown, Martin Lawlor, Sheena Lewis, Riitta Partanen, Alex Payne-Dwyer, Claudia Roman-Montanana, Forough Torabi, Sofia Tsagdi, David Miller
Summary: What effects did treatment using hyaluronic acid (HA) binding/selection prior to ICSI have on clinical outcomes in the Hyaluronic Acid Binding sperm Selection (HABSelect) clinical trial? Older women randomized to the trial's experimental arm (selection of sperm bound to immobilized (solid-state) HA) had the same live birth rates as younger women, most likely a result of better avoidance of sperm with damaged DNA. Recent randomized controlled trials (RCTs) investigating the efficacy of HA-based sperm selection prior to ICSI, including HABSelect, have consistently reported reductions in the numbers of miscarriages among couples randomized to the intervention, suggesting a pathological sperm-mediated factor mitigated by prior HA-binding/selection. The mechanism of that protection is unknown.
HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
M. Mignini Renzini, M. Dal Canto, M. C. Guglielmo, D. Garcia, E. De Ponti, A. La Marca, R. Vassena, J. Buratini
Summary: Sperm donation increases live birth rates in AMA patients undergoing ICSI cycles, with a significant difference observed in live birth and miscarriage rates compared to homologous cycles. This suggests that sperm donation may be a valuable strategy to improve ICSI outcomes in AMA patients.
HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Jose Buratini, Thaisy Tino Dellaqua, Mariabeatrice Dal Canto, Antonio La Marca, Domenico Carone, Mario Mignini Renzini, Robert Webb
Summary: Fertility loss during female ageing is associated with changes in FSH and AMH concentrations, leading to compromised oocyte quality. Understanding the regulation of FSH and AMH and their effects on oocyte quality is crucial for addressing age-related subfertility.
HUMAN REPRODUCTION UPDATE
(2022)
Letter
Obstetrics & Gynecology
Livio Casarini, Alberto Vaiarelli, Danilo Cimadomo, Daniele Santi, Manuela Simoni, Juan Antonio Garcia-Velasco, Carlo Alviggi, Antonio La Marca, Laura Rienzi, Filippo Maria Ubaldi
HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
Emma Bertucci, Filomena G. Sileo, Marialaura Diamanti, Carlo Alboni, Fabio Facchinetti, Antonio La Marca
Summary: This study aimed to investigate the changes of adenomyosis during pregnancy and their correlation with maternal and fetal outcomes. The results showed that signs of adenomyosis were visible but progressively disappeared during pregnancy, and adenomyosis was associated with an increased risk of early miscarriage.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Genetics & Heredity
Sara Pini, Floriana Maria Napoli, Enrico Tagliafico, Antonio La Marca, Emma Bertucci, Valentina Salsi, Rossella Tupler
Summary: Facioscapulohumeral muscular dystrophy (FSHD) is associated with the deletion of D4Z4 repeat array at 4q35. The study investigated recombination at 4q35 using polymorphic markers and found a recombination frequency of 14% between D4Z4 and D4S1523. It also revealed de novo variants and germline mosaicism. Caution should be taken when interpreting preimplantation genetic testing for monogenic disorders (PGT-M) results, and prenatal DNA analysis is recommended to confirm the size of the D4Z4 alleles carried by the fetus.
Article
Obstetrics & Gynecology
Antonio La Marca, Maria Longo
Summary: New evidence suggests that LH plays a growing role in promoting ovarian follicular growth and maturation, even at the early stages. Hypogonadotropic hypogonadism, characterized by low serum LH and FSH levels, may lead to decreased anti-Mullerian hormone levels and antral follicle count. However, the administration of exogenous LH can increase functional ovarian reserve and improve fertility in patients with hypothalamic amenorrhea.
HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
Antonio La Marca, Martina Capuzzo, Maria Longo, Maria Giovanna Imbrogno, Giorgio Alfredo Spedicato, Francesco Fiorentino, Francesca Spinella, Pierfrancesco Greco, Maria Giulia Minasi, Ermanno Greco
Summary: Ovarian reserve and female age are the most important predictors of having at least one euploid blastocyst and the total number of euploid blastocysts.
HUMAN REPRODUCTION
(2022)
Article
Immunology
Simone Giulini, Valentina Grisendi, Giovanna Sighinolfi, Pierluigi Di Vinci, Daniela Tagliasacchi, Laura Botticelli, Antonio La Marca, Fabio Facchinetti
Summary: The aim of this study was to evaluate the effect of prednisone treatment on IVF outcome in patients with RIF and chronic endometritis. The results showed that the clinical pregnancy rate was 25.9% and the live birth rate was 22.2% after therapy. Additionally, the percentage of CD56 cells on endometrial biopsy was associated with live birth rate.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Marilena Taggi, Francesca Liuzzi, Laura Botticelli, Serena De Carlini, Maria Longo, Valeria Donno, Luca Fabbiani, Antonio La Marca
Summary: The expression and localization of Vasorin (Vasn) in the human female reproductive system were investigated. Vasn mRNA was detected in patient-derived endometrial, myometrial, and granulosa cells (GCs) primary cultures without significant differences, while Vasn protein levels were significantly higher in GCs compared to proliferative endometrial stromal cells (ESCs) and myometrial cells. Immunostaining analyses revealed Vasn expression in ovarian follicles at different stages of development, with higher levels in mature follicles and on the surface of cumulus oophorus cells. In uterine tissues, Vasn was expressed more in the proliferative stroma endometrium and less in the secretory endometrium, with no protein immunoreactivity in healthy myometrial tissue.
GYNECOLOGICAL ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Francesca Liuzzi, Marilena Taggi, Serena De Carlini, Antonio La Marca
Summary: This study provides evidence for the expression and functionality of AMHRII in HOb cells, suggesting that AMH may have stimulatory effects on osteoblasts and could be a potential candidate for treating osteoporosis.
GYNECOLOGICAL ENDOCRINOLOGY
(2023)
Editorial Material
Endocrinology & Metabolism
Antonio La Marca, Serena De Carlini, Francesca Liuzzi
GYNECOLOGICAL ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
A. La Marca, V Donno, M. Longo, P. Greco, F. Cucinelli, M. T. Varricchio, I Listorti, E. Greco
Summary: This study investigates whether anti-Mullerian hormone (AMH) can predict the number of retrieved oocytes during double stimulation (DuoStim). The results show that serum AMH values can be used as a clinical tool to predict ovarian response in IVF cycles following DuoStim. This is beneficial for patients with poor ovarian response and those undergoing medical fertility preservation.
HUMAN REPRODUCTION
(2023)
Review
Public, Environmental & Occupational Health
Chiara Selmi, Antonio La Marca
Summary: LNG-IUS 52 mg is the first-line treatment for non-organic causes of abnormal uterine bleeding, but oral hormonal therapies are practical alternatives when LNG-IUS 52 mg is contraindicated or declined by the patient. Further studies are necessary to compare the efficacy of different oral hormonal therapies for treating abnormal uterine bleeding and to approve them with this specific indication.
EUROPEAN JOURNAL OF CONTRACEPTION AND REPRODUCTIVE HEALTH CARE
(2023)
Review
Obstetrics & Gynecology
Antonio La Marca, Maria Longo, Giovanna Sighinol, Valentina Grisendi, Maria Giovanna Imbrogno, Simone Giulini
Summary: Evidence suggests that LH plays a role in enhancing the transition from early follicle to antral follicle stage. Low levels of LH receptors have been found in smaller follicles, even during the traditionally considered gonadotropin-independent phase, indicating a potential role for LH in accelerating the progression of non-growing and primary follicles. Reduced functional ovarian reserve has been associated with conditions such as hypogonadotropic hypogonadism and pituitary suppression, which are characterized by decreased LH serum concentration. This effect seems to be reversible, as the functional ovarian reserve returns to baseline levels after pregnancy or discontinuation of certain medications. Gonadotropins may also influence the number of antral follicles, independently of the primordial follicle reserve. Further research is needed to fully understand the precise role of gonadotropins in early folliculogenesis and their potential use in modifying the functional ovarian reserve.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Review
Obstetrics & Gynecology
Luigi Carbone, Alessandro Conforti, Antonio La Marca, Federica Cariati, Roberta Vallone, Antonio Raffone, Cira Buonfantino, Michela Palese, Marika Mascia, Raffaella Di Girolamo, Martina Capuzzo, Sandro C. Esteves, Carlo Alviggi
Summary: Infections can have varying impacts on reproductive organs, potentially causing infertility or reducing the effectiveness of assisted reproduction technology. This review examines the evidence for pathogens that play a role in reproductive medicine. Viral hepatitis and HIV can reduce sperm quality, while syphilis increases the risk of erectile dysfunction and thicker endometrial lining. Chlamydia is the main cause of pelvic inflammatory disease, and certain species of Mycoplasma and Ureaplasma can be correlated with infertility and poor IVF outcomes. Bacterial vaginosis is associated with early pregnancy loss. HPV infection in males may lead to infertility. Herpesviruses pose a greater risk to fetuses rather than fertility itself. Zika virus affects early embryo development, and waiting to conceive is advised in suspected or confirmed cases. The impact of SARS-CoV-2 is still not fully understood. Rubella and toxoplasmosis can cause congenital defects, hence mandatory screening and Rubella vaccination is recommended. Further studies are needed to better understand the role of infectious agents in improving fertility and its treatments.
MINERVA OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Alice Newman-Sanders, Jackson C. Kirkman-Brown, Meurig T. Gallagher
Summary: This study revealed a significant lack of awareness among young adults in the UK regarding the potential impacts of gym lifestyles and supplementation on male infertility. Men were found to have a concerning lack of concern for their own fertility, with differences in awareness levels between men and women. It was also observed that men were more likely to consider making changes to their behavior if it had a long-term impact on their fertility compared to short-term effects.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Shachar Reuvenny, Michal Youngster, Almog Luz, Rohi Hourvitz, Ettie Maman, Micha Baum, Ariel Hourvitz
Summary: Using a machine-learning model to determine the optimal trigger days can improve the outcomes of antagonist protocol cycles in freeze-all or fresh transfer cycles, for all age groups. Implementing these models can more accurately predict the number of retrieved oocytes, optimizing physicians' decisions, balancing workloads, and creating more standardized yet patient-specific protocols.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Chao Chen, Qi Wen, Feng Deng, Rong Li, Ying Wang, Xiumei Zhen, Jing Hang
Summary: This study investigates the proteomic and phosphoproteomic differences in the endometrium of women with recurrent pregnancy loss (RPL) compared to healthy control women during different phases of the menstrual cycle. The results identify differentially expressed proteins and phosphorylated proteins, and highlight the insulin/cyclic nucleotide signalling pathway and AMPK/mTOR signalling pathway as major contributors to the abnormality of RPL endometrium. The findings provide insights into potential proteins associated with the pathogenesis of RPL and contribute to the identification of potential targets for RPL treatment.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Jaime Guerrero, Juan Carlos Castillo, Jorge Ten, Jose Antonio Ortiz, Belen Lledo, Domingo Orozco, Francisco Quereda, Andrea Bernabeu, Rafael Bernabeu
Summary: The study found no significant differences in clinical outcomes between using oocytes obtained from random-start protocols and those from conventional ovarian stimulation in oocyte donation treatments. Luteal-phase stimulation required longer stimulation and higher FSH consumption.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
