Article
Oncology
Emma Bluemke, Ambre Bertrand, Kwun-Ye Chu, Nigar Syed, Andrew G. Murchison, Rosie Cooke, Tessa Greenhalgh, Brian Burns, Martin Craig, Nia Taylor, Ketan Shah, Fergus Gleeson, Daniel Bulte
Summary: This study aimed to assess the role of T1 mapping and oxygen-enhanced MRI in patients undergoing radical dose radiotherapy for HPV positive oropharyngeal cancer. Through the analysis of T1 mapping in 12 patients, it was found that the tumor R1 increased in some patients while decreasing in others, consistent with previously reported tumor OE-MRI responses. The study also discussed some practical challenges faced when integrating this technique into a clinical trial. Overall, further clinical OE-MRI studies are needed to evaluate hypoxia and radiotherapy response, and improve the robustness of the technique for widespread clinical use.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Article
Oncology
Jon-Vidar Gaustad, Einar K. Rofstad
Summary: K (trans) maps are strongly correlated with hypoxic fraction and can predict disease-free and overall survival in cervical carcinoma patients, while v (e) maps do not provide relevant information on hypoxia status or patient outcome.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biology
Zeyuan Chen, Zikuan Chen
Summary: In MRI, tissue magnetization in the main field B0 is a necessary step for signal formation but can lead to dipole effects. By using QSM and CIMRI techniques, it is possible to computationally reconstruct the source chi of MRI signals and depict brain function activity with fQSM. This allows for the removal of artifacts and distortions introduced by MRI, providing a more accurate intrinsic structural and functional depiction of the brain.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Neurosciences
Chia-Ming Shih, Hsin-Chih Lo, Meng-Chi Hsieh, Jyh-Horng Chen
Summary: Functional quantitative susceptibility mapping (fQSM) was introduced in this study to complement BOLD-fMRI in quantitatively assessing local susceptibility and venous oxygen saturation (SvO(2)). Results showed that the susceptibility change of fQSM was four times larger than the BOLD signal change, with more restricted activation responses in the visual pathway compared to BOLD. This study demonstrated the feasibility, sensitivity, and specificity of fQSM, providing quantitative clues and localized information in small animal brains.
Article
Chemistry, Multidisciplinary
Jianpeng Sheng, Jiangchao Wu, Xianghong Yin, Zhu Sun, Xun Wang, Junlei Zhang, Jianghui Tang, Yongtao Ji, Jinyuan Song, Xiaobao Wei, Lin Wang, Yaxing Zhao, Hui Zhang, Taohong Li, Qi Zhang, Xueli Bai, Li Chen, Dong Chen, Tingbo Liang
Summary: Hypoxia is a major obstacle in the treatment of hepatocellular carcinoma (HCC). Current treatments can worsen tumor hypoxia. Utilizing nanoparticle-stabilized oxygen microcapsules in combination with Lenvatinib, it is possible to alleviate tumor hypoxia and enhance the therapeutic effect.
CHINESE CHEMICAL LETTERS
(2023)
Review
Cell Biology
T. van Vliet, F. Casciaro, M. Demaria
Summary: Oxygen is crucial for tissue function, disruptions in oxygen pathways lead to health issues and aging. Oxygen-modulating therapies and natural oxygen oscillations may impact lifespan and healthy aging.
AGEING RESEARCH REVIEWS
(2021)
Review
Endocrinology & Metabolism
Nirmal Verma, Florin Despa
Summary: Chronic kidney disease (CKD) is on the rise globally, especially in individuals with diabetic states. CKD progression is influenced by renal hypoxia and the accumulation of amyloid-forming amylin in the kidney, which is secreted by the pancreas. This accumulation is associated with hypertension, mitochondrial dysfunction, increased production of reactive oxygen species (ROS), and activation of hypoxia signaling in the kidney. This review discusses the potential associations between renal amylin amyloid accumulation, hypertension, and mechanisms of hypoxia-induced kidney dysfunction, including activation of hypoxia-inducible factors (HIFs) and mitochondrial dysfunction.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kai Luo, Anding Yu, Qinglin Fu, Liang Pan, Weiqiang Dou, Jinggang Zhang, Jie Chen
Summary: This study explores the feasibility of using quantitative susceptibility mapping (QSM) technique to evaluate the dynamic changes in the outer medulla during early stage of renal ischemia-reperfusion injury (IRI) in rabbits. The results indicate that QSM can be used as a noninvasive method to assess the dynamic changes in the outer medulla during early stage of renal IRI in rabbits.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Meicheng Chen, Xiaoqi Zhou, Huasong Cai, Di Li, Chenyu Song, Huayu You, Ruixia Ma, Zhi Dong, Zhenpeng Peng, Shi-Ting Feng
Summary: This review aims to evaluate the feasibility of MRI methods in assessing tumor hypoxia in hepatocellular carcinoma (HCC). Various methods, such as oxygen electrodes, protein markers, optical imaging, and positron emission tomography, are limited in clinical applicability due to invasiveness, tissue depth, and radiation exposure. MRI methods, including blood oxygenation level-dependent, dynamic contrast-enhanced MRI, diffusion-weighted imaging, MRI spectroscopy, chemical exchange saturation transfer MRI, and multinuclear MRI, are promising noninvasive alternatives that can evaluate the hypoxic microenvironment by observing biochemical processes in vivo. However, further validation and improvement of current quantitative MRI methods are necessary for clinical translation.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Pharmacology & Pharmacy
Xin Gu, Hongxue Meng, Jia Wang, Ruitao Wang, Muyang Cao, Siyu Liu, Hui Chen, Yangyang Xu
Summary: In renal cell carcinoma, the expression of galectin-3 and HIF-1α is significantly elevated, and hypoxia can further promote their expression. HIF-1α plays a critical role in the regulation of galectin-3 in RCC.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Anatomy & Morphology
Zikuan Chen, Xiulan Zhai, Zeyuan Chen
Summary: We hypothesized that brain normal aging consists of a balanced whole-brain functional connectivity, where some connections decline while others increase or retain, resulting in a summation balance. We validated this hypothesis by using brain intrinsic magnetic susceptibility source reconstructed from fMRI phase data. Our results showed that the chi FC aging upholds a FC balance in life span and is closer to the brain FC aging truth compared to the MRI-borne mFC and pFC agings.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Chemistry, Multidisciplinary
Zhenbang Cao, Liang Zhang, Jianxin Liu, Dong Wang, Kang Liang, Yu Chen, Zi Gu
Summary: A dual enzyme-mimicking radical generator has been developed to enhance the efficacy of photodynamic therapy by in situ generation of oxygen and radical oxygen species. The metal organic framework-based radical generator nanoparticles exhibit catalase-like and peroxidase-like activities specifically at the tumor microenvironment, leading to increased reactive oxygen species levels and improved anti-cancer effects.
Article
Neurosciences
Sagar Buch, Yongsheng Chen, Pavan Jella, Yulin Ge, E. Mark Haacke
Summary: This study introduces the use of Ferumoxytol to map the hippocampal micro-vasculature and evaluate the quantitative change in tissue fractional vascular density in each subfield. The results show differences in micro-vascular density among different parts of the hippocampus, and a significant correlation between micro-vascular density in the CA1 region and age, indicating a loss of hippocampal vascularity in the normal aging process. The study suggests that vascular degeneration may precede tissue atrophy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sarah H. Needleman, Mina Kim, Jamie R. Mcclelland, Josephine H. Naish, Marta Tibiletti, James P. B. O'Connor, Geoff J. M. Parker
Summary: This study aims to address the challenges of dynamic lung oxygen-enhanced MRI (OE-MRI) at 3 T, including confounding signals and poor signal-to-noise ratio. The study utilizes independent component analysis (ICA) to automatically extract the oxygen-induced signal change and improve the accuracy and sensitivity of lung OE-MRI. The results demonstrate that the developed pipeline shows sensitivity to the signal enhancements of lung tissue and oxygenated blood.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rui Wang, Zhiyong Lin, Xuedong Yang, Kai Zhao, Suxia Wang, Xueqing Sui, Tao Su, Xiaoying Wang
Summary: Multiparametric functional MRI was used to detect renal hypoxia in the early stage of diabetic kidney disease in a rabbit model. The main finding was increased oxygen consumption, which was not influenced by changes in renal blood flow.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Oncology
Elizabeth R. Tucker, Irene Jimenez, Lindi Chen, Angela Bellini, Chiara Gorrini, Elizabeth Calton, Qiong Gao, Harvey Che, Evon Poon, Yann Jamin, Barbara Martins Da Costa, Karen Barker, Sumana Shrestha, J. Ciaran Hutchinson, Simran Dhariwal, Angharad Goodman, Elaine Del Nery, Pierre Gestraud, Jaydutt Bhalshankar, Yasmine Iddir, Elnaz Saberi-Ansari, Alexandra Saint-Charles, Birgit Geoerger, Maria Eugenia Marques Da Costa, Cecile Pierre-Eugene, Isabelle Janoueix-Lerosey, Didier Decaudin, Fariba Nemati, Angel M. Carcaboso, Didier Surdez, Olivier Delattre, Sally L. George, Louis Chesler, Deborah A. Tweddle, Gudrun Schleiermacher
Summary: ALK-activating mutations are present in approximately 10% of neuroblastomas and ALK amplifications in a further 1%-2% of cases. Lorlatinib, a third-generation ALK inhibitor, is being considered as a treatment for children with ALK-aberrant neuroblastoma. Resistance to single-agent treatment has been reported, and combination therapies with chemotherapy or MDM2 inhibitor are being explored to improve treatment efficacy.
CLINICAL CANCER RESEARCH
(2023)
Review
Engineering, Electrical & Electronic
Lucy Taylor, Xiaorong Ding, David Clifton, Huiqi Lu
Summary: Worldwide, an estimated 461,000 people die from asthma attacks each year. This article aims to provide a comprehensive review of the current state-of-the-art wearable sensors and devices that use vital signs for asthma patient monitoring and management. These technologies can directly measure breathing rate and airflow sound or indirectly estimate them using algorithms based on electrocardiogram (ECG), photoplethysmogram (PPG), and chest movements. Other vital signs used in asthma patient monitoring include blood oxygen saturation, temperature, blood pressure, verbal sound, and pain responses.
IEEE SENSORS JOURNAL
(2023)
Review
Oncology
Erich P. Huang, James P. B. O'Connor, Lisa M. McShane, Maryellen L. Giger, Philippe Lambin, Paul E. Kinahan, Eliot L. Siegel, Lalitha K. Shankar
Summary: Integration of computer-extracted tumour characteristics into medical imaging computer-aided diagnosis (CAD) algorithms has been a long-standing practice. However, the translation of radiomics, an extension of CAD involving quantitative characterization of healthy or pathological structures and processes captured by medical imaging, into clinically useful tools has been limited. This may be due to factors such as varying imaging and radiomic feature extraction protocols, potential pitfalls in radiomic data analysis, and a lack of evidence demonstrating the clinical benefit of radiomic-based tools. The authors provide 16 criteria to guide the clinical translation of radiomics, with the aim of accelerating the use of this technology to improve patient outcomes.
NATURE REVIEWS CLINICAL ONCOLOGY
(2023)
Review
Oncology
James M. Price, Asmithaa Prabhakaran, Catharine M. L. West
Summary: Advances in radiotherapy enable individualized treatment, but optimization is often based on the assumption that all tumors respond similarly to radiation. However, radiation affects multiple cellular pathways, so it is important to study genomic classifiers to guide personalized treatment decisions.
NATURE REVIEWS CLINICAL ONCOLOGY
(2023)
Article
Genetics & Heredity
Burcu F. Darst, Jiayi Shen, Ravi K. Madduri, Alexis A. Rodriguez, Yukai Xiao, Xin Sheng, Edward J. Saunders, Tokhir Dadaev, Mark N. Brook, Thomas J. Hoffmann, Kenneth Muir, Peggy Wan, Loic Le Marchand, Lynne Wilkens, Ying Wang, Johanna Schleutker, Robert J. MacInnis, Cezary Cybulski, David E. Neal, Borge G. Nordestgaard, Sune F. Nielsen, Jyotsna Batra, Judith A. Clements, Henrik Gronberg, Nora Pashayan, Ruth C. Travis, Jong Y. Park, Demetrius Albanes, Stephanie Weinstein, Lorelei A. Mucci, David J. Hunter, Kathryn L. Penney, Catherine M. Tangen, Robert J. Hamilton, Marie-Elise Parent, Janet L. Stanford, Stella Koutros, Alicja Wolk, Karina D. Sorensen, William J. Blot, Edward D. Yeboah, James E. Mensah, Yong-Jie Lu, Daniel J. Schaid, Stephen N. Thibodeau, Catharine M. West, Christiane Maier, Adam S. Kibel, Geraldine Cancel-Tassin, Florence Menegaux, Esther M. John, Eli Marie Grindedal, Kay-Tee Khaw, Sue A. Ingles, Ana Vega, Barry S. Rosenstein, Manuel R. Teixeira, Manoli Kogevinas, Lisa Cannon-Albright, Chad Huff, Luc Multigner, Radka Kaneva, Robin J. Leach, Hermann Brenner, Ann W. Hsing, Rick A. Kittles, Adam B. Murphy, Christopher J. Logothetis, Susan L. Neuhausen, William B. Isaacs, Barbara Nemesure, Anselm J. Hennis, John Carpten, Hardev Pandha, Kim De Ruyck, Jianfeng Xu, Azad Razack, Soo-Hwang Teo, Lisa F. Newcomb, Jay H. Fowke, Christine Neslund-Dudas, Benjamin A. Rybicki, Marija Gamulin, Nawaid Usmani, Frank Claessens, Manuela Gago-Dominguez, Jose Esteban Castelao, Paul A. Townsend, Dana C. Crawford, Gyorgy Petrovics, Graham Casey, Monique J. Roobol, Jennifer F. Hu, Sonja I. Berndt, Stephen K. van den Eeden, Douglas F. Easton, Stephen J. Chanock, Michael B. Cook, Fredrik Wiklund, John S. Witte, Rosalind A. Eeles, Zsofia Kote-Jarai, Stephen Watya, John M. Gaziano, Amy C. Justice, David V. Conti, Christopher A. Haiman
Summary: In this study, the predictive ability of several genome-wide polygenic risk score (GW-PRS) approaches was compared to a recently developed PRS of established prostate cancer-risk variants. The findings suggest that the PRS269 developed from multi-ancestry GWASs and fine-mapping has better predictive ability for prostate cancer risk compared to current GW-PRS approaches.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Engineering, Mechanical
Wen-Chao Sui, Yong-Chen Pei, Bao-Hua Wang, Si-Jia Liu, Ji-Tuo Wu, Huiqi Lu
Summary: Superelastic shape memory alloy wire has been found to have the property of energy storage and release, which can be quantitatively measured using electrical resistance. This finding has significant potential and advantages in the field of mechanical energy storage and ejection release.
MECHANICAL SYSTEMS AND SIGNAL PROCESSING
(2023)
Article
Oncology
Emma L. Reeves, Jin Li, Konstantinos Zormpas-Petridis, Jessica K. R. Boult, James Sullivan, Craig Cummings, Barbara Blouw, David Kang, Ralph Sinkus, Jeffrey C. Bamber, Yann Jamin, Simon P. Robinson
Summary: Hyaluronan is a key component in breast cancer and its accumulation is associated with poor prognosis. PEGPH20 can degrade HA and enhance drug delivery. Multiparametric MRI was used to evaluate the response of breast tumor models to PEGPH20.
MOLECULAR ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Nicola Melillo, Daniel Scotcher, J. Gerry Kenna, Claudia Green, Catherine D. G. Hines, Iina Laitinen, Paul D. Hockings, Kayode Ogungbenro, Ebony R. Gunwhy, Steven Sourbron, John C. Waterton, Gunnar Schuetz, Aleksandra Galetin
Summary: This study used a physiologically-based pharmacokinetic (PBPK) modeling to predict changes in the metabolism of Gadoxetate caused by different drugs. The results showed that Ciclosporin and Rifampicin significantly decreased the concentration of Gadoxetate in the liver. The effects of other drugs were marginal.
Article
Automation & Control Systems
Yong-Chen Pei, Bao-Hua Wang, Ji-Tuo Wu, Chenyang Wang, Jing-Han Guan, Huiqi Lu
Summary: This article proposes a multiple self-sensing gripper (MssGripper) driven by shape memory alloy (SMA) and empowered by machine learning algorithms. The gripper can accurately predict displacement, force, and stiffness without external sensors. The establishment of self-sensing models using machine learning enhances prediction accuracy and expands the novel idea of gripper sensing.
IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS
(2023)
Article
Chemistry, Analytical
Jinghe Zhao, Lulu Wang, Bo Jiang, Yongchen Pei, Huiqi Lu
Summary: In this paper, a theoretical model of the cutting force of an ultrasonic-assisted inner diameter saw was established based on indentation fracture mechanics. The correctness of the model was verified through experiments. The results showed that the proposed model improved the slice surface quality and provided guidance for the selection of process parameters.
Article
Chemistry, Analytical
Huiqi Y. Lu, Ping Lu, Jane E. Hirst, Lucy Mackillop, David A. Clifton
Summary: This study developed glucose prediction models using LSTM recurrent neural network models and suggested an optimized blood glucose monitoring frequency for women with gestational diabetes. The results showed that the proposed model achieved accurate predictions and reduced the overall number of blood tests.
Article
Chemistry, Analytical
Ping Lu, Andrew P. Creagh, Huiqi Y. Lu, Ho Bich Hai, Carlos VITAL Consortium, Louise Thwaites, David A. Clifton
Summary: In this study, a novel Vision Transformer called 2D-WinSpatt-Net is proposed to classify the severity of tetanus using wearable ECG sensors. It outperforms traditional methods in terms of performance and accuracy.
Article
Oncology
Alan Jackson, Ryan Pathak, Nandita M. deSouza, Yan Liu, Bart K. M. Jacobs, Saskia Litiere, Maria Urbanowicz-Nijaki, Catherine Julie, Arturo Chiti, Jens Theysohn, Juan R. Ayuso, Sigrid Stroobants, John C. Waterton
Summary: We hypothesised that the change in apparent diffusion coefficient (ADC) on magnetic resonance imaging (MRI) after 14 days of treatment could serve as a proxy for tumour regression grade (TRG) on pathology. However, our results showed no significant correlation between ADC and TRG or other measures of tumour response. This suggests that ADC is not a reliable biomarker for metastatic colorectal cancer.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sarah H. Needleman, Mina Kim, Jamie R. Mcclelland, Josephine H. Naish, Marta Tibiletti, James P. B. O'Connor, Geoff J. M. Parker
Summary: This study aims to address the challenges of dynamic lung oxygen-enhanced MRI (OE-MRI) at 3 T, including confounding signals and poor signal-to-noise ratio. The study utilizes independent component analysis (ICA) to automatically extract the oxygen-induced signal change and improve the accuracy and sensitivity of lung OE-MRI. The results demonstrate that the developed pipeline shows sensitivity to the signal enhancements of lung tissue and oxygenated blood.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Engineering, Mechanical
Qing-Yuan Xin, Yong-Chen Pei, Meng-Yan Luo, Zhi-Qiong Wang, Ling He, Jian-Yao Liu, Bin Wang, Huiqi Lu
Summary: This paper proposes a novel and generalized measurement method to accurately and efficiently evaluate the eccentricity parameters of rotary parts. The method overcomes the limitations of existing methods and exhibits great potential in various applications.
MECHANICAL SYSTEMS AND SIGNAL PROCESSING
(2023)
