Preclinical evaluation of avermectins as novel therapeutic agents for alcohol use disorders
Published 2018 View Full Article
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Title
Preclinical evaluation of avermectins as novel therapeutic agents for alcohol use disorders
Authors
Keywords
Ivermectin, P2X4 receptors, Alcohol addiction, Drug discovery
Journal
PSYCHOPHARMACOLOGY
Volume 235, Issue 6, Pages 1697-1709
Publisher
Springer Nature
Online
2018-03-03
DOI
10.1007/s00213-018-4869-9
References
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- 2010 National and State Costs of Excessive Alcohol Consumption
- (2015) Jeffrey J. Sacks et al. AMERICAN JOURNAL OF PREVENTIVE MEDICINE
- The P2X7/P2X4 interaction shapes the purinergic response in murine macrophages
- (2015) Gabriela Pérez-Flores et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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- (2014) Megan M. Yardley et al. NEUROREPORT
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- (2014) Mandy Stahre et al. Preventing Chronic Disease
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- (2013) Maya Popova et al. Purinergic Signalling
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- (2012) W Nörenberg et al. BRITISH JOURNAL OF PHARMACOLOGY
- Pharmacological insights into the role of P2X4 receptors in behavioural regulation: lessons from ivermectin
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- Neuromodulation by Extracellular ATP and P2X Receptors in the CNS
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- Ivermectin reduces alcohol intake and preference in mice
- (2012) Megan M. Yardley et al. NEUROPHARMACOLOGY
- Gene expression in the ventral tegmental area of 5 pairs of rat lines selectively bred for high or low ethanol consumption
- (2012) William J. McBride et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Relative Neurotoxicity of Ivermectin and Moxidectin in Mdr1ab (−/−) Mice and Effects on Mammalian GABA(A) Channel Activity
- (2012) Cécile Ménez et al. PLoS Neglected Tropical Diseases
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- (2012) J. M. Korth-Bradley et al. Clinical Pharmacology in Drug Development
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