Article
Biochemistry & Molecular Biology
Ok-Joo Sul, Guoen Li, Ji-Eun Kim, Eun-Sook Kim, Hye-Seon Choi
Summary: This study identified that the oxysterol 7-ketocholesterol (7-KC) plays a role in cholesterol-induced bone loss by enhancing autophagy in osteoclasts (OCs). The findings suggest that 7-KC acts as a cholesterol metabolite and is at least partially responsible for cholesterol-induced bone loss.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Nutrition & Dietetics
Rajiv Rana, Jayakumar Manoharan, Anubhuti Gupta, Dheerendra Gupta, Ahmed Elwakiel, Hamzah Khawaja, Sameen Fatima, Silke Zimmermann, Kunal Singh, Saira Ambreen, Ihsan Gadi, Ronald Biemann, Shihai Jiang, Khurrum Shahzad, Shrey Kohli, Berend Isermann
Summary: Diabetic kidney disease (DKD) is a growing pandemic associated with obesity and diabetes mellitus. DKD is now the leading cause of end-stage renal disease and is linked to increased risk of cardiovascular morbidity and mortality. This study demonstrates that the cytoprotective coagulation protease activated protein C (aPC) reduces mitochondrial ROS generation in tubular cells and mitigates renal sterile inflammation in DKD, supporting the potential therapeutic use of aPC in DKD treatment.
Article
Biochemistry & Molecular Biology
Adrian L. Gajewski, Mateusz Gawrysiak, Agnieszka Krupa, Tomasz Rechcinski, Maciej Chalubinski, Weronika Gonciarz, Magdalena Chmiela
Summary: The gastric pathogen Helicobacter pylori has been found to influence the development of coronary heart disease (CHD) by inducing reactive oxygen species (ROS) and transforming cholesterol into 7-ketocholesterol (7-kCh). This study examined the effects of H. pylori components, in the presence of 7-kCh and acetylsalicylic acid (ASA), on gastric epithelial cells and vascular endothelial cells. The results showed that ASA and 7-kCh, especially in conjunction with H. pylori components, increased ROS levels, apoptosis, cell disintegration, activation of STAT3, and elevation of IL-8. AGS cells were unable to undergo wound healing. The findings suggest that the ROS response to H. pylori components may be enhanced by 7-kCh and ASA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Bingbing Zhu, Ji Fang, Zhengcai Ju, Ying Chen, Li Wang, Hao Wang, Lina Xing, Aili Cao
Summary: The study demonstrates that Zuogui Wan can improve diabetic nephropathy by inhibiting oxidative stress and podocyte apoptosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Urology & Nephrology
Seunghyeok Choi, Seon Pyo Hong, Jung Hyun Bae, Sang Heon Suh, Hosung Bae, Kyung Pyo Kang, Hyuek Jong Lee, Gou Young Koh
Summary: This study reveals that high blood glucose in diabetes mellitus activates YAP/TAZ through the canonical Hippo pathway, leading to excessive proliferation of MCs, extracellular matrix deposition, endothelial cell impairment, glomerular sclerosis, albuminuria, and reduced glomerular filtration rate, which are the hallmarks of DN. Mechanistically, YAP/TAZ bind and stabilize N-Myc protein, enhancing its transcriptional activity and eventually causing MC impairments and DN pathogenesis.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hai-Jian Sun, Si-Ping Xiong, Xu Cao, Lei Cao, Meng-Yuan Zhu, Zhi-Yuan Wu, Jin-Song Bian
Summary: Sodium tetrasulfide (Na2S4) treatment can ameliorate diabetic kidney disease by inhibiting inflammation cytokines and reducing oxidative stress, renal fibrosis, and cell apoptosis. Na2S4 acts through sulfhydrating SIRT1 to deactivate p65 NF-kappa B and STAT3 phosphorylation/acetylation, ultimately reducing oxidative stress, inflammation response, and EMT progression in renal tubular epithelial cells.
Article
Biochemistry & Molecular Biology
Anberitha T. Matthews, Hitesh Soni, Katherine E. Robinson-Freeman, Theresa A. John, Randal K. Buddington, Adebowale Adebiyi
Summary: Doxorubicin (DOX), a chemotherapeutic agent, can induce fetal nephrotoxicity by inhibiting proliferation and inducing death of fetal pig glomerular mesangial cells (GMCs). DOX treatment reduces TRPC6 protein expression, leading to mitochondrial ROS generation and cell death in GMCs. The DOX-induced fetal pig GMC apoptosis is independent of TRPC6 upregulation but requires mtROS production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Engineering, Biomedical
Yuan Xiong, Xiangyu Chu, Tao Yu, Samuel Knoedler, Andreas Schroeter, Li Lu, Kangkang Zha, Ze Lin, Dongsheng Jiang, Yuval Rinkevich, Adriana C. Panayi, Bobin Mi, Guohui Liu, Yanli Zhao
Summary: Diabetic wounds present challenges due to drug resistance, biofilm formation, impaired angiogenesis, and oxidative damage. Reactive oxygen species (ROS) play a crucial role in their pathogenesis. ROS-scavenging nanosystems have shown promise for treating diabetic wounds by reducing inflammation and promoting angiogenesis. However, their therapeutic applicability and efficacy need further investigation.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Medicine, Research & Experimental
Yaoyu Liu, Xiaojie Li, Minglan Zhao, Yifan Wu, Yuan Xu, Xiuming Li, Lizhe Fu, Liqiao Han, Wei Zhou, Qinghong Hu, Junqi Chen, Jiuyao Zhou, Xusheng Liu, Hua Lin, Junbiao Wu
Summary: Dysfunction of mesangial cells and infiltration of macrophages are significant pathological features in glomerular lesions. Recent studies highlight the importance of the crosstalk between kidney resident cells and inflammatory cells in the development of DN.
Article
Biochemistry & Molecular Biology
Matthew Reily-Bell, Andrew Bahn, Rajesh Katare
Summary: Research shows that ROS is one of the main causes of diabetic heart disease, and miRNAs play a crucial role in treating the disease. However, since miRNAs have multiple targets and exhibit different functions in different environments, a thorough understanding of their mechanisms is needed for successful application.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Engineering, Biomedical
Chen Shi, Ying Zhang, Guanfu Wu, Zhangyu Zhu, Haiping Zheng, Ximeng Sun, Yongyuan Heng, Shaowei Pan, Haonan Xiu, Jing Zhang, Zhaowei Yin, Ziyi Yu, Bin Liang
Summary: This study developed a reactive oxygen species (ROS)-responsive multifunctional injectable hydrogel for diabetic wound healing. The hydrogel effectively loaded and released curcumin liposomes and silver nanoparticles (AgNPs), promoting wound healing through ROS scavenging, bactericidal activity, anti-inflammatory effects, and angiogenesis. The hydrogel demonstrated favorable biocompatibility, degradability, and injectivity.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Manuela Harloff, Sally Prueschenk, Roland Seifert, Jens Schlossmann
Summary: The study demonstrated the beneficial effects of sGC activator cinaciguat in treating diabetic nephropathy in a mouse model. Activation of sGC may be a potential therapy option for patients with Type 1 diabetes.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Transplantation
Kelly L. Hudkins, Xianwu Li, Alexander L. Holland, Shreya Swaminathan, Charles E. Alpers
Summary: This study showed that empagliflozin treatment in a mouse model of diabetic nephropathy (DN) improved proteinuria and reversed pathologic alterations, including an increase in podocyte number and density, improvement in podocyte foot process effacement and parietal epithelial cell activation. The study also found that SGLT2 inhibition reduced renal oxidative stress. These findings provide insights into the potential long-term benefits of empagliflozin in humans with DN.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Biochemistry & Molecular Biology
Shuangwen Li, Lisi Zheng, Jun Zhang, Xuejun Liu, Zhongming Wu
Summary: Our research demonstrated the involvement of ferroptosis in the development of DN, and up-regulating Nrf2 with fenofibrate treatment inhibited diabetes-related ferroptosis, delaying the progression of DN. This study provided a new perspective on the development mechanism of DN and offered a new approach to delay the progression of DN.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Thales M. H. Dourado, Victor O. Assis, Wanessa M. C. Awata, Marcela M. B. de Mello, Evelin C. Carnio, Michele M. Castro, Carlos R. Tirapelli
Summary: The effects of ethanol consumption on blood pressure involve vasoconstriction and activation of RAAS. This study found that MR pathway plays a role in ethanol-induced hypertension and vascular hypercontractility. Ethanol increased COX2 expression, ROS levels, and TXB2 production in blood vessels, which were prevented by MR blockade. The mechanism involves MR-triggered ROS generation, up-regulation of COX2, and overproduction of TXA2. MR blockade reversed the hyperreactivity induced by ethanol.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Peripheral Vascular Disease
Takashi Yamaguchi, Kohji Shirai, Daiji Nagayama, Shoko Nakamura, Rena Oka, Sho Tanaka, Yasuhiro Watanabe, Haruki Imamura, Yuta Sato, Hidetoshi Kawana, Masahiro Ohira, Atsuhito Saiki, Naomi Shimizu, Ichiro Tatsuno
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2019)
Article
Multidisciplinary Sciences
Shou Tanaka, Noriko Ishihara, Sawako Suzuki, Yasuhiro Watanabe, Daiji Nagayama, Takashi Yamaguchi, Masahiro Ohira, Atsuhito Saiki, Tomoaki Tanaka, Ichiro Tatsuno
SCIENTIFIC REPORTS
(2019)
Article
Surgery
Masahiro Ohira, Yasuhiro Watanabe, Takashi Yamaguchi, Atsuhito Saiki, Takashi Oshiro, Ichiro Tatsuno
SURGERY FOR OBESITY AND RELATED DISEASES
(2020)
Article
Endocrinology & Metabolism
Masahiro Ohira, Kazuki Abe, Takashi Yamaguchi, Hiroki Onda, Shuhei Yamaoka, Shoko Nakamura, Shou Tanaka, Yasuhiro Watanabe, Taiki Nabekura, Takashi Oshiro, Daiji Nagayama, Atsuhito Saiki, Ichiro Tatsuno
Summary: This study aimed to evaluate the relationship between the improvement in type 2 diabetes and hormones in patients with obesity and type 2 diabetes who underwent bariatric surgery (BS). The results showed that preoperative plasma aldosterone levels were related to complete remission (CR) of type 2 diabetes after BS, and measuring plasma aldosterone levels preoperatively is useful for predicting the CR of type 2 diabetes after BS.
Article
Endocrinology & Metabolism
Masahiro Ohira, Yasuhiro Watanabe, Takashi Yamaguchi, Hiroki Onda, Shuhei Yamaoka, Kazuki Abe, Shoko Nakamura, Sho Tanaka, Naoyuki Kawagoe, Taiki Nabekura, Takashi Oshiro, Daiji Nagayama, Ichiro Tatsuno, Atsuhito Saiki
Summary: Following laparoscopic sleeve gastrectomy (LSG), obese patients experienced significant increases in high-density lipoprotein cholesterol (HDL-C) levels and pre-heparin lipoprotein lipase (LPL) levels, while body mass index (BMI) and serum triglyceride (TG) levels decreased significantly. Simple linear regression analysis revealed a significant correlation between changes in HDL-C levels and total weight loss percentage, change in TG levels, abdominal fat areas, and pre-heparin LPL levels. Multiple regression analysis further indicated that the increase in HDL-C levels after LSG was associated with reductions in TG levels and elevations in pre-heparin LPL levels.
Article
Endocrinology & Metabolism
Masahiro Ohira, Yasuhiro Watanabe, Takashi Yamaguchi, Hiroki Onda, Shuhei Yamaoka, Kazuki Abe, Shoko Nakamura, Shou Tanaka, Naoyuki Kawagoe, Taiki Nabekura, Atsuhito Saiki, Takashi Oshiro, Daiji Nagayama, Ichiro Tatsuno
Summary: The preoperative measurement of IGF-1 can help predict successful weight loss, decrease body fat mass, and maintain skeletal muscle mass after LSG.
Article
Endocrinology & Metabolism
Yasuhiro Watanabe, Takashi Yamaguchi, Shuhei Yamaoka, Kazuki Abe, Hiroki Onda, Shoko Nakamura, Sho Tanaka, Takashi Oshiro, Masahiro Ohira, Daiji Nagayama, Naomi Shimizu, Ichiro Tatsuno, Atsuhito Saiki
Summary: This study compared the impact of weight loss achieved through conventional medical therapy or laparoscopic sleeve gastrectomy (LSG) on albuminuria in Japanese subjects with severe obesity. The results showed that the LSG group had greater weight loss, lower glycosylated hemoglobin levels, and more significant improvement in albuminuria compared to the medical therapy group.
Article
Endocrinology & Metabolism
Masahiro Ohira, Yasuhiro Watanabe, Takashi Yamaguchi, Atsuhito Saiki, Shoko Nakamura, Shou Tanaka, Naomi Shimizu, Taiki Nabekura, Takashi Oshiro, Ichiro Tatsuno
Summary: This study aimed to evaluate the pathophysiology of type 2 diabetes in obese patients who underwent bariatric surgery (BS) using pre- and postoperative parameters and HOMA2, showing that BS significantly improved body weight and glucose metabolism. Preoperative insulin secretion and HOMA2-%B were found to be associated with complete remission (CR) of type 2 diabetes after BS.
DIABETOLOGY INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Masahiro Ohira, Sawako Suzuki, Tomohiko Yoshida, Hisashi Koide, Tomoaki Tanaka, Ichiro Tatsuno
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2020)
Article
Endocrinology & Metabolism
Atsuhito Saiki, Rieko Kanai, Shoko Nakamura, Sho Tanaka, Rena Oka, Yasuhiro Watanabe, Takashi Yamaguchi, Masahiro Ohira, Takashi Oshiro, Karin Hayashi, Ichiro Tatsuno
Article
Endocrinology & Metabolism
Masahiro Ohira, Takashi Yamaguchi, Atsuhito Saiki, Shoko Nakamura, Shou Tanaka, Rena Oka, Yasuhiro Watanabe, Yuta Sato, Takashi Oshiro, Takeyoshi Murano, Ichiro Tatsuno
Article
Endocrinology & Metabolism
Rena Oka, Masahiro Ohira, Sawako Suzuki, Tomohiko Yoshida, Hisashi Koide, Tomoaki Tanaka, Ichiro Tatsuno
Article
Peripheral Vascular Disease
Daiji Nagayama, Haruki Imamura, Yuta Sato, Takashi Yamaguchi, Noriko Ban, Hidetoshi Kawana, Masahiro Ohira, Atsuhito Saiki, Kohji Shirai, Ichiro Tatsuno
VASCULAR HEALTH AND RISK MANAGEMENT
(2017)
Article
Genetics & Heredity
Haruki Imamura, Daiji Nagayama, Noriko Ishihara, Syo Tanaka, Rena Watanabe, Yasuhiro Watanabe, Yuta Sato, Takashi Yamaguchi, Noriko Ban, Hidetoshi Kawana, Masahiro Ohira, Kei Endo, Atsuhito Saiki, Kohji Shirai, Ichiro Tatsuno
MOLECULAR GENETICS AND METABOLISM REPORTS
(2017)
Article
Biochemistry & Molecular Biology
Doha M. Beltagy, Nagat F. Nawar, Tarek M. Mohamed, Ehab Tousson, Mai M. El-Keey
Summary: This study aimed to evaluate the protective role of nanocurcumin as an antioxidant and anti-inflammatory agent, and its synergistic effects with Donepezil in the treatment of Alzheimer's disease in rats. The results showed that treatment with nanocurcumin improved memory, locomotion, and neuronal differentiation by activating the PI3K/AKT/GSK-3 beta pathway.
PROSTAGLANDINS & OTHER LIPID MEDIATORS
(2024)
