Targeting tryptophan hydroxylase 2 in affective disorder

TPH25′- and 3′-regulatory polymorphisms are differentially associated with HPA axis function and self-injurious behavior in rhesus monkeys

(2010) G.-L. Chen et al.   GENES BRAIN AND BEHAVIOR

Receptor-genes cross-talk: effect of chronic 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino) tetralin treatment on the expression of key genes in brain serotonin system and on behavior

(2010) N.K. Popova et al.   NEUROSCIENCE

Tryptophan hydroxylase 2 genotype determines brain serotonin synthesis but not tissue content in C57Bl/6 and BALB/c congenic mice

(2010) William B. Siesser et al.   NEUROSCIENCE LETTERS

Tryptophan Hydroxylase as Novel Target for the Treatment of Depressive Disorders

(2010) Susann Matthes et al.   PHARMACOLOGY

Alternative Splicing and Extensive RNA Editing of Human TPH2 Transcripts

(2010) Maik Grohmann et al.   PLoS One

A Tryptophan Hydroxylase 2 Gene Polymorphism is Associated with Panic Disorder

(2009) Yong-Ku Kim et al.   BEHAVIOR GENETICS

Functional properties of missense variants of human tryptophan hydroxylase 2

(2009) Jeffrey A. McKinney et al.   HUMAN MUTATION

Common genetic variations in human brain-specific tryptophan hydroxylase-2 and response to antidepressant treatment

(2009) Mladen Vassilev Tzvetkov et al.   Pharmacogenetics and Genomics

Growth retardation and altered autonomic control in mice lacking brain serotonin

(2009) N. Alenina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tryptophan hydroxylase 2 gene is associated with major depression and antidepressant treatment response

(2009) Shih-Jen Tsai et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on neural correlates of affective processing

(2008) Turhan Canli et al.   BIOLOGICAL PSYCHOLOGY

Stress Upregulates TPH1 but not TPH2 mRNA in the Rat Dorsal Raphe Nucleus: Identification of Two TPH2 mRNA Splice Variants

(2008) Nashat Abumaria et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice

(2008) Lise Gutknecht et al.   JOURNAL OF NEURAL TRANSMISSION

C1473G polymorphism in mousetph2gene is linked to tryptophan hydroxylase-2 activity in the brain, intermale aggression, and depressive-like behavior in the forced swim test

(2008) Daria V. Osipova et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A loss-of-function mutation in tryptophan hydroxylase 2 segregating with attention-deficit/hyperactivity disorder

(2008) J McKinney et al.   MOLECULAR PSYCHIATRY

Genetic architecture of the human tryptophan hydroxylase 2 Gene: existence of neural isoforms and relevance for major depression

(2008) F Haghighi et al.   MOLECULAR PSYCHIATRY

Elevated expression of tryptophan hydroxylase-2 mRNA at the neuronal level in the dorsal and median raphe nuclei of depressed suicides

(2008) H Bach-Mizrachi et al.   MOLECULAR PSYCHIATRY

Dietary Amino Acids and Brain Serotonin Function; Implications for Stress-Related Affective Changes

(2008) C. Rob Markus   NEUROMOLECULAR MEDICINE

Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response

(2008) Eric J. Peters et al.   Pharmacogenetics and Genomics

Genetic Disruption of Both Tryptophan Hydroxylase Genes Dramatically Reduces Serotonin and Affects Behavior in Models Sensitive to Antidepressants

(2008) Katerina V. Savelieva et al.   PLoS One

Role of GSK3  in behavioral abnormalities induced by serotonin deficiency

(2008) J.-M. Beaulieu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Investigation of the tryptophan hydroxylase 2 gene in bipolar I disorder in the Romanian population

(2008) Maria Grigoroiu-Serbanescu et al.   PSYCHIATRIC GENETICS

The mTPH2 C1473G single nucleotide polymorphism is not responsible for behavioural differences between mouse strains

(2007) Katja Tenner et al.   NEUROSCIENCE LETTERS