Rsd balances (p)ppGpp level by stimulating the hydrolase activity of SpoT during carbon source downshift inEscherichia coli

The histidine phosphocarrier protein, HPr, binds to the highly thermostable regulator of sigma D protein, Rsd, and its isolated helical fragments

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The general PTS component HPr determines the preference for glucose over mannitol

(2017) Mangyu Choe et al.   Scientific Reports

Glucose induces delocalization of a flagellar biosynthesis protein from the flagellated pole

(2016) Soyoung Park et al.   MOLECULAR MICROBIOLOGY

Ribosome-dependent activation of stringent control

(2016) Alan Brown et al.   NATURE

ppGpp negatively impacts ribosome assembly affecting growth and antimicrobial tolerance in Gram-positive bacteria

(2016) Rebecca M. Corrigan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphotransferase-dependent accumulation of (p)ppGpp in response to glutamine deprivation in Caulobacter crescentus

(2016) Séverin Ronneau et al.   Nature Communications

Ribosome•RelA structures reveal the mechanism of stringent response activation

(2016) Anna B Loveland et al.   eLife

Reduction of translating ribosomes enables Escherichia coli to maintain elongation rates during slow growth

(2016) Xiongfeng Dai et al.   Nature Microbiology

Obg and Membrane Depolarization Are Part of a Microbial Bet-Hedging Strategy that Leads to Antibiotic Tolerance

(2015) Natalie Verstraeten et al.   MOLECULAR CELL

Histidine phosphocarrier protein regulates pyruvate kinase A activity in response to glucose inVibrio vulnificus

(2015) Hey-Min Kim et al.   MOLECULAR MICROBIOLOGY

The quantitative and condition-dependent Escherichia coli proteome

(2015) Alexander Schmidt et al.   NATURE BIOTECHNOLOGY

Recent functional insights into the role of (p)ppGpp in bacterial physiology

(2015) Vasili Hauryliuk et al.   NATURE REVIEWS MICROBIOLOGY

Structural basis for the sequestration of the anti-σ70factor Rsd from σ70by the histidine-containing phosphocarrier protein HPr

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The Bacterial Phosphoenolpyruvate:Carbohydrate Phosphotransferase System: Regulation by Protein Phosphorylation and Phosphorylation-Dependent Protein-Protein Interactions

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Phosphotransferase protein EIIANtr interacts with SpoT, a key enzyme of the stringent response, in Ralstonia eutropha H16

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RppH-dependent pyrophosphohydrolysis of mRNAs is regulated by direct interaction with DapF in Escherichia coli

(2014) Chang-Ro Lee et al.   NUCLEIC ACIDS RESEARCH

Differential regulation by ppGpp versus pppGpp in Escherichia coli

(2013) Undine Mechold et al.   NUCLEIC ACIDS RESEARCH

HPr antagonizes the anti- 70 activity of Rsd in Escherichia coli

(2013) Y.-H. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Positive allosteric feedback regulation of the stringent response enzyme RelA by its product

(2012) Viktoriya Shyp et al.   EMBO REPORTS

Direct Regulation of GTP Homeostasis by (p)ppGpp: A Critical Component of Viability and Stress Resistance

(2012) Allison Kriel et al.   MOLECULAR CELL

ppGpp: magic beyond RNA polymerase

(2012) Zachary D. Dalebroux et al.   NATURE REVIEWS MICROBIOLOGY

The RelA/SpoT Homolog (RSH) Superfamily: Distribution and Functional Evolution of ppGpp Synthetases and Hydrolases across the Tree of Life

(2011) Gemma C. Atkinson et al.   PLoS One

A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses

(2010) Dawei Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A global view of Escherichia coli Rsd protein and its interactions

(2009) Sarah E. Piper et al.   Molecular BioSystems

The ObgE/CgtA GTPase influences the stringent response to amino acid starvation inEscherichia coli

(2009) Nicole S. Persky et al.   MOLECULAR MICROBIOLOGY

(p)ppGpp: Still Magical?

(2008) Katarzyna Potrykus et al.   Annual Review of Microbiology

Advances in bacterial promoter recognition and its control by factors that do not bind DNA

(2008) Shanil P. Haugen et al.   NATURE REVIEWS MICROBIOLOGY