Insulinpromoter in human pancreatic β cells contacts diabetes susceptibility loci and regulates genes affecting insulin metabolism

The type 2 diabetes-associated HMG20A gene is mandatory for islet beta cell functional maturity

(2018) Jose M. Mellado-Gil et al.   Cell Death & Disease

Small chromosomal regions position themselves autonomously according to their chromatin class

(2017) Harmen J.G. van de Werken et al.   GENOME RESEARCH

Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease

(2017) Wei Zhao et al.   NATURE GENETICS

Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression

(2017) Ayako Fukunaka et al.   PLoS Genetics

Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion

(2017) Fatou K. Ndiaye et al.   Molecular Metabolism

The Pancreatic Islet Regulome Browser

(2017) Loris Mularoni et al.   Frontiers in Genetics

FoxO1 Plays an Important Role in Regulating β-Cell Compensation for Insulin Resistance in Male Mice

(2016) Ting Zhang et al.   ENDOCRINOLOGY

Still a geneticist's nightmare

(2016) Stephen S. Rich   NATURE

Organization and function of the 3D genome

(2016) Boyan Bonev et al.   NATURE REVIEWS GENETICS

Transcriptional gene silencing in humans

(2016) Marc S. Weinberg et al.   NUCLEIC ACIDS RESEARCH

Three single nucleotide polymorphisms associated with type 2 diabetes mellitus in a Chinese population

(2016) Meijun Chen et al.   Experimental and Therapeutic Medicine

Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes

(2016) Minako Imamura et al.   Nature Communications

4C-ker: A Method to Reproducibly Identify Genome-Wide Interactions Captured by 4C-Seq Experiments

(2016) Ramya Raviram et al.   PLoS Computational Biology

Overexpression of Pref-1 in pancreatic islet β-cells in mice causes hyperinsulinemia with increased islet mass and insulin secretion

(2015) Yuhui Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CTCF-Mediated Human 3D Genome Architecture Reveals Chromatin Topology for Transcription

(2015) Zhonghui Tang et al.   CELL

Rare and Common Genetic Events in Type 2 Diabetes: What Should Biologists Know?

(2015) Amélie Bonnefond et al.   Cell Metabolism

Genes Affecting β-Cell Function in Type 1 Diabetes

(2015) Tina Fløyel et al.   Current Diabetes Reports

Functional relevance for type 1 diabetes mellitus-associated genetic variants by using integrative analyses

(2015) Ying-Hua Qiu et al.   HUMAN IMMUNOLOGY

Recent advances in understanding the genetic architecture of type 2 diabetes

(2015) Karen L. Mohlke et al.   HUMAN MOLECULAR GENETICS

The VGF-derived peptide TLQP-62 modulates insulin secretion and glucose homeostasis

(2015) P. Petrocchi-Passeri et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Therapeutic uses of somatostatin and its analogues: Current view and potential applications

(2015) Uma Rai et al.   PHARMACOLOGY & THERAPEUTICS

Imaging RNA Polymerase II transcription sites in living cells

(2014) Martin S Buckley et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants

(2014) Lorenzo Pasquali et al.   NATURE GENETICS

Modeling epigenome folding: formation and dynamics of topologically associated chromatin domains

(2014) Daniel Jost et al.   NUCLEIC ACIDS RESEARCH

Mapping of long-rangeINSpromoter interactions reveals a role for calcium-activated chloride channel ANO1 in insulin secretion

(2014) Zhixiong Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

(2013) Warren A. Whyte et al.   CELL

Chromosomal Contact Permits Transcription between Coregulated Genes

(2013) Stephanie Fanucchi et al.   CELL

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells

(2012) Balrik Kailey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Diabetes and breast cancer risk: a meta-analysis

(2012) P Boyle et al.   BRITISH JOURNAL OF CANCER

Extensive Promoter-Centered Chromatin Interactions Provide a Topological Basis for Transcription Regulation

(2012) Guoliang Li et al.   CELL

TNFα signals through specialized factories where responsive coding and miRNA genes are transcribed

(2012) Argyris Papantonis et al.   EMBO JOURNAL

Determining long-range chromatin interactions for selected genomic sites using 4C-seq technology: From fixation to computation

(2012) Erik Splinter et al.   METHODS

Differential analysis of gene regulation at transcript resolution with RNA-seq

(2012) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Robust 4C-seq data analysis to screen for regulatory DNA interactions

(2012) Harmen J G van de Werken et al.   NATURE METHODS

The Past 200 Years in Diabetes

(2012) Kenneth S. Polonsky   NEW ENGLAND JOURNAL OF MEDICINE

A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion

(2011) Philippe Ravassard et al.   JOURNAL OF CLINICAL INVESTIGATION

Genome architectures revealed by tethered chromosome conformation capture and population-based modeling

(2011) Reza Kalhor et al.   NATURE BIOTECHNOLOGY

Mapping of INS promoter interactions reveals its role in long-range regulation of SYT8 transcription

(2011) Zhixiong Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Musashi expression in β-cells coordinates insulin expression, apoptosis and proliferation in response to endoplasmic reticulum stress in diabetes

(2011) M Szabat et al.   Cell Death & Disease

A signal–noise model for significance analysis of ChIP-seq with negative control

(2010) Han Xu et al.   BIOINFORMATICS

Histone H3K27ac separates active from poised enhancers and predicts developmental state

(2010) M. P. Creyghton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circos: An information aesthetic for comparative genomics

(2009) M. Krzywinski et al.   GENOME RESEARCH

Histone modifications at human enhancers reflect global cell-type-specific gene expression

(2009) Nathaniel D. Heintzman et al.   NATURE

Parental origin of sequence variants associated with complex diseases

(2009) Augustine Kong et al.   NATURE

Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells

(2009) Stefan Schoenfelder et al.   NATURE GENETICS

Cohesins Functionally Associate with CTCF on Mammalian Chromosome Arms

(2008) Vania Parelho et al.   CELL

Cohesins localize with CTCF at the KSHV latency control region and at cellular c-myc and H19/Igf2 insulators

(2008) William Stedman et al.   EMBO JOURNAL

Cohesin mediates transcriptional insulation by CCCTC-binding factor

(2008) Kerstin S. Wendt et al.   NATURE

CTCF physically links cohesin to chromatin

(2008) E. D. Rubio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA