Human aging and disease: Lessons from age-related macular degeneration

Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain

(2018) Michy P. Kelly   CELLULAR SIGNALLING

Deletion of the Thyroid Hormone–Activating Type 2 Deiodinase Rescues Cone Photoreceptor Degeneration but Not Deafness in Mice Lacking Type 3 Deiodinase

(2017) Lily Ng et al.   ENDOCRINOLOGY

Involvement of a gut–retina axis in protection against dietary glycemia-induced age-related macular degeneration

(2017) Sheldon Rowan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo

(2017) G. Sebastian Hönes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On phagocytes and macular degeneration

(2017) Xavier Guillonneau et al.   PROGRESS IN RETINAL AND EYE RESEARCH

A conserved NAD + binding pocket that regulates protein-protein interactions during aging

(2017) Jun Li et al.   SCIENCE

Aging and neurodegeneration are associated with increased mutations in single human neurons

(2017) Michael A. Lodato et al.   SCIENCE

Systems Pharmacology Links GPCRs with Retinal Degenerative Disorders

(2016) Yu Chen et al.   Annual Review of Pharmacology and Toxicology

The Mitochondrial Basis of Aging

(2016) Nuo Sun et al.   MOLECULAR CELL

Synergistically acting agonists and antagonists of G protein–coupled receptors prevent photoreceptor cell degeneration

(2016) Yu Chen et al.   Science Signaling

Synergistically acting agonists and antagonists of G protein–coupled receptors prevent photoreceptor cell degeneration

(2016) Yu Chen et al.   Science Signaling

Retinoids and Retinal Diseases

(2016) Philip D. Kiser et al.   Annual Review of Vision Science

Growth hormone and aging: A challenging controversy

(2016) Andrzej Bartke   Clinical Interventions in Aging

Dementia of the eye: the role of amyloid beta in retinal degeneration

(2015) J A Ratnayaka et al.   EYE

Signal transduction in podocytes—spotlight on receptor tyrosine kinases

(2014) Jochen Reiser et al.   Nature Reviews Nephrology

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Complex diseases require complex therapies

(2013) Ravi Iyengar   EMBO REPORTS

Systems pharmacology identifies drug targets for Stargardt disease–associated retinal degeneration

(2013) Yu Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

(2013) L. E. Hebert et al.   NEUROLOGY

Seven-Year Outcomes in Ranibizumab-Treated Patients in ANCHOR, MARINA, and HORIZON

(2013) Soraya Rofagha et al.   OPHTHALMOLOGY

Update on current and future novel therapies for dry age-related macular degeneration

(2013) Ella Leung et al.   Expert Review of Clinical Pharmacology

Whole transcriptome sequencing of the aging rat brain reveals dynamic RNA changes in the dark matter of the genome

(2012) Shona H. Wood et al.   AGE

Pten Positively Regulates Brown Adipose Function, Energy Expenditure, and Longevity

(2012) Ana Ortega-Molina et al.   Cell Metabolism

Inflammatory priming predisposes mice to age-related retinal degeneration

(2012) Debarshi Mustafi et al.   JOURNAL OF CLINICAL INVESTIGATION

Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch’s membrane/choriocapillaris complex

(2012) Imran Bhutto et al.   MOLECULAR ASPECTS OF MEDICINE

Mechanisms of Age-Related Macular Degeneration

(2012) Jayakrishna Ambati et al.   NEURON

Mitochondrial Stress Signals Revise an Old Aging Theory

(2011) Dong Kyun Woo et al.   CELL

Mechanism of All-trans-retinal Toxicity with Implications for Stargardt Disease and Age-related Macular Degeneration

(2011) Yu Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aging: ROS or TOR

(2010) Mikhail V Blagosklonny   CELL CYCLE

Heart Disease and Stroke Statistics—2011 Update

(2010) Véronique L. Roger et al.   CIRCULATION

Biological and Chemical Approaches to Diseases of Proteostasis Deficiency

(2009) Evan T. Powers et al.   Annual Review of Biochemistry

Retinopathy in Mice Induced by Disrupted All-trans-retinal Clearance

(2008) Akiko Maeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanical Properties of Bovine Rhodopsin and Bacteriorhodopsin:  Possible Roles in Folding and Function†

(2008) K. Tanuj Sapra et al.   LANGMUIR

Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA

(2008) Lars G Fritsche et al.   NATURE GENETICS

Structural diversity of G protein-coupled receptors and significance for drug discovery

(2008) Malin C. Lagerström et al.   NATURE REVIEWS DRUG DISCOVERY