The natural anti-tumor compound Celastrol targets a Myb-C/EBPβ-p300 transcriptional module implicated in myeloid gene expression

Helenalin Acetate, a Natural Sesquiterpene Lactone with Anti-inflammatory and Anti-cancer Activity, Disrupts the Cooperation of CCAAT Box/Enhancer-binding Protein β (C/EBPβ) and Co-activator p300

(2016) Anke Jakobs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C/EBPβ regulates homeostatic and oncogenic gastric cell proliferation

(2016) Goncalo Regalo et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Small-Molecule Disruption of the Myb/p300 Cooperation Targets Acute Myeloid Leukemia Cells

(2016) Sagar Uttarkar et al.   MOLECULAR CANCER THERAPEUTICS

Targeting acute myeloid leukemia with a small molecule inhibitor of the Myb/p300 interaction

(2015) Sagar Uttarkar et al.   BLOOD

Naphthol AS-E Phosphate Inhibits the Activity of the Transcription Factor Myb by Blocking the Interaction with the KIX Domain of the Coactivator p300

(2015) S. Uttarkar et al.   MOLECULAR CANCER THERAPEUTICS

BET Bromodomain Inhibition Suppresses the Function of Hematopoietic Transcription Factors in Acute Myeloid Leukemia

(2015) Jae-Seok Roe et al.   MOLECULAR CELL

CCAAT/enhancer binding protein β induces motility and invasion of glioblastoma cells through transcriptional regulation of the calcium binding protein S100A4

(2015) Diana Aguilar-Morante et al.   Oncotarget

An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element

(2014) M. R. Mansour et al.   SCIENCE

Structural insights into interactions of C/EBP transcriptional activators with the Taz2 domain of p300

(2014) Prasenjit Bhaumik et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

(2013) Jakob Lovén et al.   CELL

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

(2013) Warren A. Whyte et al.   CELL

Super-Enhancers in the Control of Cell Identity and Disease

(2013) Denes Hnisz et al.   CELL

Interaction and Cooperation of the CCAAT-box Enhancer-binding Protein β (C/EBPβ) with the Homeodomain-interacting Protein Kinase 2 (Hipk2)

(2013) Simone Steinmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas

(2013)   NATURE GENETICS

An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance

(2011) J. Zuber et al.   GENES & DEVELOPMENT

Inhibition of Myb-dependent gene expression by the sesquiterpene lactone mexicanin-I

(2011) T Bujnicki et al.   LEUKEMIA

Celastrol: Molecular targets of Thunder God Vine

(2010) Antero Salminen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Crosstalk between C/EBPβ phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code

(2010) Elisabeth Kowenz-Leutz et al.   EMBO JOURNAL

C/EBP  regulates transcription factors critical for proliferation and survival of multiple myeloma cells

(2009) R. Pal et al.   BLOOD

Hierarchical Maintenance of MLL Myeloid Leukemia Stem Cells Employs a Transcriptional Program Shared with Embryonic Rather Than Adult Stem Cells

(2009) Tim C.P. Somervaille et al.   Cell Stem Cell

The transcriptional network for mesenchymal transformation of brain tumours

(2009) Maria Stella Carro et al.   NATURE

v-Myc inhibits C/EBPβ activity by preventing C/EBPβ-induced phosphorylation of the co-activator p300

(2009) S Steinmann et al.   ONCOGENE

Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck

(2009) M. Persson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C/EBPβ regulates metastatic gene expression and confers TNF-α resistance to prostate cancer cells

(2009) Myoung H. Kim et al.   PROSTATE

G9a-mediated Lysine Methylation Alters the Function of CCAAT/Enhancer-binding Protein-β

(2008) Ole Pless et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C/EBP  Induces Chromatin Opening at a Cell-Type-Specific Enhancer

(2008) A. Plachetka et al.   MOLECULAR AND CELLULAR BIOLOGY

Acetylation and deacetylation regulate CCAAT/enhancer binding protein β at K39 in mediating gene transcription

(2008) Teresa I. Ceseña et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY