Ethyl pyruvate ameliorates hepatic injury following blunt chest trauma and hemorrhagic shock by reducing local inflammation, NF-kappaB activation and HMGB1 release

Ethyl pyruvate alleviates early brain injury following subarachnoid hemorrhage in rats

(2016) Rong Fang et al.   ACTA NEUROCHIRURGICA

Prognostic value of HMGB1 and oxidative stress markers in multiple trauma patients: A single-centre prospective study

(2016) Francesca Polito et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Ethyl pyruvate is a novel anti-inflammatory agent to treat multiple inflammatory organ injuries

(2016) Runkuan Yang et al.   Journal of Inflammation-London

Complement therapeutic strategies in trauma, hemorrhagic shock and systemic inflammation – closing Pandora’s box?

(2016) Markus Huber-Lang et al.   SEMINARS IN IMMUNOLOGY

Ethyl pyruvate attenuated coxsackievirus B3-induced acute viral myocarditis by suppression of HMGB1/RAGE/NF-ΚB pathway

(2016) Ying Yu et al.   SpringerPlus

Long-Term Effects of Induced Hypothermia on Local and Systemic Inflammation - Results from a Porcine Long-Term Trauma Model

(2016) K. Horst et al.   PLoS One

Ethanol, ethyl and sodium pyruvate decrease the inflammatory responses of human lung epithelial cells via Akt and NF-κB in vitro but have a low impact on hepatocellular cells

(2015) B. RELJA et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Inflammatory response to trauma

(2014) Albert Pierce et al.   Current Opinion in Anesthesiology

Induction of acute lung inflammation in mice with hemorrhagic shock and resuscitation: role of HMGB1

(2014) Raymond LC Kao et al.   Journal of Inflammation-London

Ethyl Pyruvate Pretreatment Attenuates Concanavalin A-Induced Autoimmune Hepatitis in Mice

(2014) Miao Shen et al.   PLoS One

Role of Ethyl Pyruvate in Systemic Inflammatory Response and Lung Injury in an Experimental Model of Ruptured Abdominal Aortic Aneurysm

(2014) Zerrin Pulathan et al.   Biomed Research International

Pathophysiologie des Polytraumas

(2013) S. Wutzler et al.   CHIRURG

Ethyl Pyruvate Ameliorates Hepatic Ischemia-Reperfusion Injury by Inhibiting Intrinsic Pathway of Apoptosis and Autophagy

(2013) Miao Shen et al.   MEDIATORS OF INFLAMMATION

Resuscitation after hemorrhagic shock: the effect on the liver—a review of experimental data

(2012) Iosifina I. Karmaniolou et al.   Journal of Anesthesia

Acute Ethanol Gavage Attenuates Hemorrhage/Resuscitation-Induced Hepatic Oxidative Stress in Rats

(2012) B. Relja et al.   Oxidative Medicine and Cellular Longevity

Care of the injured worldwide: trauma still the neglected disease of modern society

(2012) Joseph V Sakran et al.   Scandinavian Journal of Trauma Resuscitation & Emergency Medicine

Acute alcohol intoxication reduces mortality, inflammatory responses and hepatic injury after haemorrhage and resuscitationin vivo

(2011) B Relja et al.   BRITISH JOURNAL OF PHARMACOLOGY

Plant polyphenols attenuate hepatic injury after hemorrhage/resuscitation by inhibition of apoptosis, oxidative stress, and inflammation via NF-kappaB in rats

(2011) Borna Relja et al.   EUROPEAN JOURNAL OF NUTRITION

The biochemical basis for the anti-inflammatory and cytoprotective actions of ethyl pyruvate and related compounds

(2010) Kenneth K. Kao et al.   BIOCHEMICAL PHARMACOLOGY

ETHYL PYRUVATE PREVENTS INFLAMMATORY RESPONSES AND ORGAN DAMAGE DURING RESUSCITATION IN PORCINE HEMORRHAGE

(2010) WeiHong Dong et al.   SHOCK

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Ethyl pyruvate

(2009) Mitchell P Fink   Current Opinion in Anesthesiology

Role of lung contusions on posttraumatic inflammatory response and organ dysfunction in traumatized patients

(2009) Marcus Maier et al.   European Journal of Trauma and Emergency Surgery

Base excess determined within one hour of admission predicts mortality in patients with severe pelvic fractures and severe hemorrhagic shock

(2009) Rahel Abt et al.   European Journal of Trauma and Emergency Surgery

INHIBITION OF C-JUN N-TERMINAL KINASE AFTER HEMORRHAGE BUT BEFORE RESUSCITATION MITIGATES HEPATIC DAMAGE AND INFLAMMATORY RESPONSE IN MALE RATS

(2009) Borna Relja et al.   SHOCK

A Phase II Multicenter Double-Blind Placebo-Controlled Study of Ethyl Pyruvate in High-Risk Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass

(2008) Elliott Bennett-Guerrero et al.   JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA

Ethyl Pyruvate Ameliorates Liver Injury Secondary to Severe Acute Pancreatitis

(2008) Runkuan Yang et al.   JOURNAL OF SURGICAL RESEARCH

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

PULMONARY CONTUSION INDUCES ALVEOLAR TYPE 2 EPITHELIAL CELL APOPTOSIS

(2008) Daniel H. Seitz et al.   SHOCK