Review
Geriatrics & Gerontology
Wenting Guo, Changhong Ren, Bowei Zhang, Wenbo Zhao, Yu Gao, Wantong Yu, Xunming Ji
Summary: Hypertension is the leading preventable risk factor for all-cause morbidity and mortality worldwide, and increasing the blood pressure control rate is a challenge. Limb remote ischemic conditioning may potentially reduce hypertension through various mechanisms, but existing studies have reported controversial findings.
Article
Biochemistry & Molecular Biology
Sijie Li, Yong Yang, Ning Li, Haiyan Li, Jiali Xu, Wenbo Zhao, Xiaojie Wang, Linqing Ma, Chen Gao, Yuchuan Ding, Xunming Ji, Changhong Ren
Summary: Neurogenesis plays a crucial role in the prognosis of stroke patients. This study demonstrated that limb remote ischemic conditioning (LRIC) could promote neurogenesis in cerebral ischemic mice, and the miR-449b/Notch1 pathway was involved in LRIC-induced neuroprotection.
Article
Geriatrics & Gerontology
Yu Gao, Changhong Ren, Xiaohua Li, Wantong Yu, Sijie Li, Haiyan Li, Yan Wang, Dong Li, Ming Ren, Xunming Ji
Summary: Vascular remodeling is an initial step in the development of hypertension, and limb remote ischemic conditioning (LRIC) has shown promising effects on ameliorating blood pressure and vascular remodeling through inflammation regulation in animal models and patients with prehypertension and early-stage hypertension. The study suggests that long-term LRIC treatment may be a potential preventive approach for individuals with elevated blood pressure or prehypertension.
Article
Endocrinology & Metabolism
Il-doo Kim, Hyunwoo Ju, Joseph Minkler, Ahmed Madkoor, Keun Woo Park, Sunghee Cho
Summary: Remote limb conditioning (RLC) improves stroke outcomes by changing the inflammatory state of circulating monocytes. However, in obese patients, RLC fails to induce this change and loses its therapeutic effect.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Neurosciences
Yu Cui, Jing Zhang, Hui-Sheng Chen
Summary: This study aimed to evaluate the relationship between patient age and functional outcomes. The analysis of different age groups showed that the effect of remote ischemic conditioning (RIC) on functional recovery decreased with increasing age. This is the first report to demonstrate the age-related impact of RIC on functional outcomes in patients with acute moderate ischemic stroke.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Immunology
Dong Han, Jue Wang, Lulu Wen, Miao Sun, Hang Liu, Yan Gao
Summary: The results of the study showed that remote limb ischemic postconditioning significantly reduced infarct size and improved neurological defects in mice after middle cerebral artery occlusion/reperfusion, promoted the transmigration of Ly6C(hi) monocytes to the brain post-ischemia reperfusion. Additionally, the remote limb ischemic postconditioning affected the transition of M1 to M2 microglia/macrophage by suppressing NF-kappa B and promoting PPAR gamma activation.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Article
Geriatrics & Gerontology
Changhong Ren, Yuanyuan Liu, Christopher Stone, Ning Li, Sijie Li, Haiyan Li, Zichao Cheng, Jiangnan Hu, Weiguang Li, Kunlin Jin, Xunming Ji, Yuchuan Ding
Summary: Cognitive impairment in rats with chronic cerebral hypoperfusion can be ameliorated by limb remote ischemic conditioning (LRIC) through regulating glucose transport via the AMPK/GLUT signaling pathway. The expression of GLUT1 and GLUT3 in the cortex strongly correlates with learning and memory, suggesting that AMPK-mediated glucose transport plays a key role in LRIC-induced cognitive improvement. These findings indicate that targeting glucose transport may provide a clinically applicable intervention for improving cognitive impairment in conditions such as chronic cerebral hypoperfusion.
Review
Oncology
Xian Wang, Xunming Ji
Summary: Sleep disturbances are common in stroke patients, and sleep quality plays a critical role in the onset and outcome of stroke. Research suggests that remote ischemic conditioning can improve post-stroke sleep quality, possibly through mechanisms related to sleep regulation.
FRONTIERS OF MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Beata Bodi, Patrick M. Pilz, Lilla Martha, Miriam Lang, Ouafa Hamza, Miklos Fagyas, Petra L. Szabo, Dietmar Abraham, Attila Toth, Bruno K. Podesser, Attila Kiss, Zoltan Papp
Summary: The study found that post-ischemic left ventricular remodeling involves alterations in ACE and ACE2 activities, as well as changes in cardiomyocyte myofilament protein phosphorylation. Repeated remote ischemic conditioning (rRIC) effectively mitigates these alterations and improves left ventricular performance after myocardial infarction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Siying Song, Linlin Guo, Di Wu, Jingfei Shi, Yunxia Duan, Xiaoduo He, Yunhuan Liu, Yuchuan Ding, Xunming Ji, Ran Meng
Summary: The study showed that remote ischemic conditioning (RIC) induces significant changes in the plasma proteome of rhesus monkey models of strokes, involving proteins related to lipid metabolism, coagulation, immunoinflammatory responses, and endovascular hemostasis. These changes started as early as two weeks following the RIC intervention and continued for more than three weeks, indicating multiple protective effects induced by RIC.
Article
Biology
Claudia Penna, Matteo Sorge, Francesca Tullio, Stefano Comita, Saveria Femmino, Mara Brancaccio, Pasquale Pagliaro
Summary: Remote ischemic conditioning is a simple cardioprotective practice that involves brief intermittent ischemia applied to a limb. Keeping the limb warm during intermittent ischemia can enhance the efficacy of remote ischemic conditioning. Using a thermal blanket around the ischemic limb could be a simple and safe approach to test in humans.
Review
Clinical Neurology
Harry Keevil, Bethan E. Phillips, Timothy J. England
Summary: Remote ischemic conditioning (RIC) is a technique that aims to protect distant organs from ischemia by applying short periods of ischemia to another organ or tissue. It was initially developed for cardioprotection but has gained attention as a potential neuroprotective intervention. The mechanism behind RIC's neuroprotective effects is not fully understood, but preclinical studies suggest it could protect the brain from ischemia-reperfusion injury. Recent randomized control trials have shown promise in improving functional outcomes after acute ischemic stroke and preventing recurrent stroke. Further research is needed to explore the potential benefits of RIC in reducing vasospasm and improving cognitive outcomes in cerebrovascular diseases.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Review
Clinical Neurology
Luigi F. Saccaro, Alberto Aimo, Michele Emdin, Fernando Pico
Summary: Acute myocardial infarction and ischemic stroke are leading causes of morbidity and mortality worldwide. Although reperfusion therapies have greatly improved outcomes, some patients still face death or severe disability. Ischemic conditioning, including remote ischemic conditioning, may be a strategy to prevent ischemic necrosis progression and reduce ischemia-reperfusion injury, but its efficacy for ischemic stroke patients remains to be proven.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Csaba Korei, Balazs Szabo, Adam Varga, Barbara Barath, Adam Deak, Erzsebet Vanyolos, Zoltan Hargitai, Ilona Kovacs, Norbert Nemeth, Katalin Peto
Summary: In this study, the effects of local ischemic pre-conditioning and post-conditioning on limb ischemia-reperfusion were examined in rats. The results showed that limb I/R caused micro-rheological impairment with hematological and metabolic changes. Ischemic pre- and post-conditioning had additive effects in various aspects, with post-conditioning showing better micro-rheological effects. However, based on the parameters studied, it is inconclusive which protocol is superior.
Review
Neurosciences
Wantong Yu, Changhong Ren, Xunming Ji
Summary: Ischemic stroke is a major disabling health-care problem and neural repair is crucial for rehabilitation. Remote ischemic conditioning (RIC) is a strategy that triggers endogenous protection and has been reported to have neuroprotective effects in acute stroke. This review proposes that RIC is a potential therapeutic strategy for stroke rehabilitation based on existing evidence and highlights the need for further research to clarify the mechanisms and effects of RIC on neural repair.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Critical Care Medicine
Inessa Beck, Christian Tapking, Valentin Haug, Steffen Nolte, Arne Boecker, Christian Stoppe, Ulrich Kneser, Christoph Hirche, Gabriel Hundeshagen
Summary: This study found that impaired smell and taste are common after facial burns, especially in cases with inhalation injury or large burn size. Most patients recovered their sense of smell after one year, but some still had olfactory dysfunction. Taste remained comparable between burn patients and healthy controls.
Review
Cell & Tissue Engineering
Vanessa Muth, Joseph M. G. V. Gassner, Simon Moosburner, Georg Lurje, Julian Michelotto, Felix Strobl, Kristina Knaub, Cornelius Engelmann, Frank Tacke, Markus Selzner, Johann Pratschke, Igor M. M. Sauer, Nathanael Raschzok
Summary: Ex vivo machine perfusion is an important aspect of liver transplantation research. This review provides an overview of rodent and porcine animal models of ex vivo liver machine perfusion for transplantation. It discusses different temperature systems used in the perfusion and the improved outcomes achieved with ex vivo machine perfusion compared to cold storage alone. Animal models of ex vivo liver machine perfusion are essential for the further development of this technology.
TISSUE ENGINEERING PART B-REVIEWS
(2023)
Article
Critical Care Medicine
Jayshil J. Patel, Rodney Willoughby, Jennifer Peterson, Thomas Carver, James Zelten, Adrienne Markiewicz, Kaitlin Spiegelhoff, Lauren A. Hipp, Bethany Canales, Aniko Szabo, Daren K. Heyland, Christian Stoppe, Jacek Zielonka, Julie K. Freed
Summary: This study examined the feasibility of using high-dose IV hydroxocobalamin compared to placebo in patients with septic shock. The results showed that the high-dose IV hydroxocobalamin group had a greater reduction in vasopressor dose after randomization and infusion, and there were no serious adverse events. This is the first proof of concept for the feasibility of delivering high-dose IV hydroxocobalamin in septic shock.
Review
Nutrition & Dietetics
Ellen Dresen, Zheng-Yii Lee, Aileen Hill, Quirin Notz, Jayshil J. Patel, Christian Stoppe
Summary: In 1747, Scottish surgeon James Lind conducted the first randomized controlled trial, studying the effect of vitamin C on scurvy. Subsequently, the use of vitamin C in critical illness gained attention, as it was found to have the potential to improve inflammatory response and clinical outcomes.
NUTRITION IN CLINICAL PRACTICE
(2023)
Review
Nutrition & Dietetics
Ellen Dresen, Omy Naidoo, Aileen Hill, Gunnar Elke, Matthias Lindner, Joop Jonckheer, Elisabeth De Waele, Patrick Meybohm, Ranna Modir, Jayshil J. Patel, Kenneth B. Christopher, Christian Stoppe
Summary: Patients receiving ECMO may experience disease-associated metabolic, endocrinologic, and immunologic alterations, which along with the technical components of ECMO, can increase their risk for malnutrition. However, specific recommendations for medical nutrition therapy (MNT) in ECMO patients are limited and lack guidance. This article aims to provide evidence-based guidance for MNT in adult patients receiving ECMO to develop institutional protocols for clinical practice.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2023)
Review
Nutrition & Dietetics
Ellen Dresen, Jose M. Pimiento, Jayshil J. Patel, Daren K. Heyland, Todd W. Rice, Christian Stoppe
Summary: Inflammation and oxidative stress play crucial roles in critical illness, and supplementation with antioxidants and anti-inflammatory nutrients may improve clinical outcomes. However, current evidence on the effectiveness of antioxidant supplementation in critically ill patients is still unclear and further research is needed.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2023)
Article
Medicine, General & Internal
Daren K. Heyland, Jayshil Patel, Charlene Compher, Todd W. Rice, Danielle E. Bear, Zheng-Yii Lee, Victoria C. Gonzalez, Kevin O'Reilly, Racquel Regala, Courtney Wedemire, Miguel Ibarra-Estrada, Christian Stoppe, Luis Ortiz-Reyes, Xuran Jiang, Andrew G. Day
Summary: This study aimed to test the effect of high-dose protein on clinical outcomes in critically ill patients. The results showed that providing high-dose protein did not improve time-to-discharge-alive from hospital in mechanically ventilated patients, and it might have worsened outcomes for patients with acute kidney injury and high organ failure scores.
Article
Medicine, General & Internal
Aileen Hill, Christina Starchl, Ellen Dresen, Christian Stoppe, Karin Amrein
Summary: Micronutrient supplementation for critically ill patients has become a focus of attention in recent years. However, there is still uncertainty in clinical practice regarding the optimal strategy for supplementation, including the choice of substance, dosage, and timing for specific patient groups. This narrative review aims to summarize the current evidence and recommendations for vitamin C and vitamin D supplementation. It discusses the physiological roles of these vitamins, presents findings from recent clinical trials, and provides practical tips for use in the intensive care unit.
MEDIZINISCHE KLINIK-INTENSIVMEDIZIN UND NOTFALLMEDIZIN
(2023)
Article
Surgery
Christian Stoppe, Bernard McDonald, Patrick Meybohm, Kenneth B. Christopher, Stephen Fremes, Richard Whitlock, Siamak Mohammadi, Dimitri Kalavrouziotis, Gunnar Elke, Rolf Rossaint, Philipp Helmer, Kai Zacharowski, Ulf Guenther, Matteo Parotto, Bernd Niemann, Andreas Boening, C. David Mazer, Philip M. Jones, Marion Ferner, Yoan Lamarche, Francois Lamontagne, Oliver J. Liakopoulos, Matthew Cameron, Matthias Mueller, Alexander Zarbock, Maria Wittmann, Andreas Goetzenich, Erich Kilger, Lutz Schomburg, Andrew G. Day, Daren K. Heyland
Summary: High-dose intravenous sodium selenite treatment did not reduce morbidity or mortality in high-risk cardiac surgery patients.
Article
Surgery
Nora Nevermann, Linda Feldbruegge, Sebastian Knitter, Felix Krenzien, Nathanael Raschzok, Georg Lurje, Wenzel Schoening, Johann Pratschke, Moritz Schmelzle
Summary: Extrahepatic transection of the right hepatic artery and right portal vein before parenchymal dissection is a standard procedure in minimal invasive right hepatectomy. This study reports a simplified approach where the hilar dissection is omitted and the dissection line is defined with ultrasound. The results show that ultrasound-guided hepatectomy is at least comparable to the standard technique in terms of intraoperative and postoperative outcomes.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Critical Care Medicine
Zheng-Yii Lee, Luis Ortiz-Reyes, Charles Chin Han Lew, M. Shahnaz Hasan, Lu Ke, Jayshil J. Patel, Christian Stoppe, Daren K. Heyland
Summary: This study found that intravenous Vitamin C (IVVC) monotherapy may reduce the risk of mortality in critically ill patients, especially those with a high risk of dying. However, further research is needed to determine the optimal timing, dosage, treatment duration, and patient population that will benefit most from IVVC monotherapy.
ANNALS OF INTENSIVE CARE
(2023)
Letter
Critical Care Medicine
Zheng-Yii Lee, Charles Chin Han Lew, Mette M. Berger, Aileen Hill, Christian Stoppe
LANCET RESPIRATORY MEDICINE
(2023)
Article
Oncology
Frederike Butz, Agata Dukaczewska, Henning Jann, Eva Maria Dobrindt, Lisa Reinhard, Georg Lurje, Johann Pratschke, Peter E. Goretzki, Wenzel Schoening, Martina T. Mogl
Summary: The choice of surgical and therapeutic approach is crucial in the treatment of neuroendocrine liver metastases. Debulking surgery and minimally invasive liver surgery (MILS) are effective options. Studies show that tumor debulking and MILS have comparable survival outcomes to curative intended liver surgery and open liver surgery (OLS) respectively. MILS provides the advantage of a shorter hospital stay while maintaining good oncological outcomes.
Review
Pharmacology & Pharmacy
Leonard Boerger, Karl H. Hillebrandt, Zoltan Czigany, Georg Lurje, Joseph M. G. V. Gassner, Madhukar S. Patel, Johann Pratschke, Igor M. Sauer, Nathanael Raschzok, Simon Moosburner
Summary: Liver transplantation is the only curative treatment for end-stage liver disease, and utilizing grafts from elderly donors could potentially expand the donor pool. However, these allografts are associated with higher rates of non-function and dysfunction. Ex vivo machine perfusion shows potential in mitigating these risks, but more research is needed to fully understand its effectiveness and impact on hospital stay.
ADVANCED THERAPEUTICS
(2023)
Review
Nutrition & Dietetics
Ghaith Mohsen, Annika Stroemer, Andreas Mayr, Andrea Kunsorg, Christian Stoppe, Maria Wittmann, Markus Velten
Summary: Initial evidence suggests that preoperative administration of omega-3 fatty acids can reduce postoperative inflammatory reaction. However, the effects of immunonutrition with omega-3 fatty acids on inflammatory response in abdominal surgery patients are still unclear. This study found no significant difference in inflammatory markers or postoperative length of hospital stay between the preoperative omega-3 fatty acids group and the control group.
