Article
Critical Care Medicine
Tim M. J. Ewoldt, Alan Abdulla, Wim J. R. Rietdijk, Anouk E. Muller, Brenda C. M. de Winter, Nicole G. M. Hunfeld, Ilse M. Purmer, Peter van Vliet, Evert-Jan Wils, Jasper Haringman, Annelies Draisma, Tom A. Rijpstra, Attila Karakus, Diederik Gommers, Henrik Endeman, Birgit C. P. Koch
Summary: This study failed to demonstrate the beneficial effect of model-informed precision dosing (MIPD) of beta-lactam antibiotics and ciprofloxacin on ICU length of stay in critically ill patients, highlighting the need to identify other approaches to dose optimization.
INTENSIVE CARE MEDICINE
(2022)
Article
Critical Care Medicine
Audrey De Jong, Anne Bignon, Francois Stephan, Thomas Godet, Jean-Michel Constantin, Karim Asehnoune, Aude Sylvestre, Juliette Sautillet, Raiko Blondonnet, Martine Ferrandiere, Philippe Seguin, Sigismond Lasocki, Amelie Rolle, Pierre-Marie Fayolle, Laurent Muller, Emmanuel Pardo, Nicolas Terzi, Severin Ramin, Boris Jung, Paer-Selim Abback, Philippe Guerci, Benjamine Sarton, Hadrien Roze, Claire Dupuis, Joel Cousson, Marion Faucher, Virginie Lemiale, Bernard Cholley, Gerald Chanques, Fouad Belafia, Helena Huguet, Emmanuel Futier, Elie Azoulay, Nicolas Molinari, Samir Jaber
Summary: This study compared non-invasive ventilation (NIV) and oxygen therapy (high-flow nasal oxygen [HFNO] or standard oxygen) following extubation in critically ill patients with obesity, and found that NIV was effective in reducing treatment failure within 3 days. The results are relevant to clinical practice and support the use of NIV after extubation in critically ill patients with obesity.
LANCET RESPIRATORY MEDICINE
(2023)
Article
Nutrition & Dietetics
Zeinab Javid, Mahdi Shadnoush, Majid Khadem-Rezaiyan, Niyaz Mohammad Zadeh Honarvar, Alireza Sedaghat, Seyed Mohammadreza Hashemian, Seyed Hossein Ardehali, Mohsen Nematy, Omid Pournik, Mohammad Taghi Beigmohammadi, Mohammad Safarian, Omid Moradi Moghaddam, Masoum Khoshfetrat, Farid Zand, Afshin Mohammad Alizadeh, Mahboube Kosari Monfared, Fatemeh Mazaheri Eftekhar, Maryam Mohamadi Narab, Arefe Sadat Taheri, Khatereh Babakhani, Behnam Foroutan, Tannaz Jamialahmadi, Bahareh Jabbarzadeh Gangeh, Mehrnoush Meshkani, Fahime Kimiaee, Abdolreza Norouzy
Summary: The study revealed insufficient nutritional support for ICU patients in Iran, with most patients not receiving adequate intake of energy and protein. There is a need for improvement in nutritional care to meet the patients' requirements and improve their nutritional status.
CLINICAL NUTRITION
(2021)
Review
Microbiology
Pedro Povoa, Patricia Moniz, Joao Goncalves Pereira, Luis Coelho
Summary: Choosing and managing antimicrobial dosing in critically ill patients is a significant challenge. The unstable pharmacokinetic status and rapidly changing clinical condition of these patients require consideration of multiple factors to maximize treatment effectiveness.
Article
Critical Care Medicine
Christian Stoppe, Jayshil J. Patel, Alex Zarbock, Zheng-Yii Lee, Todd W. Rice, Bruno Mafrici, Rebecca Wehner, Man Hung Manuel Chan, Peter Chi Keung Lai, Kristen MacEachern, Pavlos Myrianthefs, Evdoxia Tsigou, Luis Ortiz-Reyes, Xuran Jiang, Andrew G. Day, M. Shahnaz Hasan, Patrick Meybohm, Lu Ke, Daren K. Heyland
Summary: In critically ill patients with acute kidney injury (AKI), high-dose protein may lead to worse outcomes. The recommendation of higher protein dose in AKI patients needs to be re-evaluated to avoid potential harmful effects, especially in patients who did not receive kidney replacement therapy (KRT).
Article
Nutrition & Dietetics
Matthieu Karakus, Olivier Pantet, Melanie Charriere, Doris Favre, Olivier Gaide, Mette M. Berger
Summary: Drug-induced toxidermia is a potentially life-threatening adverse skin reaction that requires ICU admission. Treatment recommendations are based on extrapolation from major burns, but there is limited prospective data. This study aimed to observe the application of these recommendations in patients treated in a burn ICU.
CLINICAL NUTRITION
(2023)
Article
Medicine, General & Internal
Gregoire Muller, Toufik Kamel, Damien Contou, Stephan Ehrmann, Maelle Martin, Jean-Pierre Quenot, Jean-Claude Lacherade, Florence Boissier, Alexandra Monnier, Sylvie Vimeux, Solene Brunet Houdard, Elsa Tavernier, Thierry Boulain
Summary: The EVERDAC study aims to compare the outcomes of shock patients who receive less invasive intervention without arterial catheter placement with those who receive routine care. The study, involving 1010 patients, will provide valuable insights into the necessity of arterial catheter insertion in shock patients.
Article
Infectious Diseases
Lisa F. Amann, Rawan Alraish, Astrid Broeker, Magnus Kaffarnik, Sebastian G. Wicha
Summary: This study investigated tigecycline exposure in critically ill patients from a population pharmacokinetic perspective and found that liver impairment significantly reduced tigecycline clearance. The study suggests dose adjustments based on liver function scores.
Article
Critical Care Medicine
William D. Schweickert, Julianne Jablonski, Brian Bayes, Marzana Chowdhury, Casey Whitman, Jenny Tian, Bryan Blette, Teresa Tran, Scott D. Halpern
Summary: This study evaluated a low-cost, multifaceted mobilization intervention and found that it did not improve overall mobility but improved patients' odds of standing and was safe.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Infectious Diseases
Erwin Dreesen, Matthias Gijsen, Omar Elkayal, Pieter Annaert, Yves Debaveye, Joost Wauters, Mats O. Karlsson, Isabel Spriet
Summary: The study aimed to determine an optimized ceftriaxone dosage regimen based on the probability of developing augmented renal clearance (ARC) in critically ill patients with community-acquired pneumonia (CAP). It was found that critically ill patients with CAP who have a high probability of developing ARC may benefit from twice-daily 2 g ceftriaxone dosing for achieving adequate exposure on the next day.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Medicine, General & Internal
Bijoy K. Menon, Brian H. Buck, Nishita Singh, Yan Deschaintre, Mohammed A. Almekhlafi, Shelagh B. Coutts, Sibi Thirunavukkarasu, Houman Khosravani, Ramana Appireddy, Francois Moreau, Gord Gubitz, Aleksander Tkach, Luciana Catanese, Dar Dowlatshahi, George Medvedev, Jennifer Mandzia, Aleksandra Pikula, Jai Shankar, Heather Williams, Thalia S. Field, Alejandro Manosalva, Muzaffar Siddiqui, Atif Zafar, Oje Imoukhuede, Gary Hunter, Andrew M. Demchuk, Sachin Mishra, Laura C. Gioia, Shirin Jalini, Caroline Cayer, Stephen Phillips, Elsadig Elamin, Ashkan Shoamanesh, Suresh Subramaniam, Mahesh Kate, Gregory Jacquin, Marie-Christine Camden, Faysal Benali, Ibrahim Alhabli, Fouzi Bala, MacKenzie Horn, Grant Stotts, Michael D. Hill, David J. Gladstone, Alexandre Poppe, Arshia Sehgal, Qiao Zhang, Brendan Cord Lethebe, Craig Doram, Ayoola Ademola, Michel Shamy, Carol Kenney, Tolulope T. Sajobi, Richard H. Swartz
Summary: This study aimed to compare the efficacy of tenecteplase and alteplase in treating acute ischemic stroke. The results showed that tenecteplase, given as a single bolus, is a reasonable alternative to alteplase for thrombolysis in patients who meet the standard criteria.
Review
Pharmacology & Pharmacy
Sonya Tang Girdwood, Kathryn Pavia, Kelli Paice, H. Rhodes Hambrick, Jennifer Kaplan, Alexander A. A. Vinks
Summary: This review highlights the pharmacokinetics and pharmacodynamics of beta-lactam antibiotics in critically ill children, and identifies the knowledge gaps that hinder the acceptance and implementation of precision dosing in this population. These gaps include a lack of consensus on the most appropriate subpopulations for precision dosing, and uncertainty regarding the impact of precision dosing on outcomes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Danhong Liang, Zhi Liang, Guoliang Deng, Anfen Cen, Dandan Luo, Chen Zhang, Suiqin Ni
Summary: The use of Polymyxin B is increasing due to the global spread of multidrug-resistant gram-negative bacteria. However, unsatisfactory therapeutic effects have been observed in critically ill patients. This study aims to determine the pharmacokinetic characteristics of polymyxin B, identify influencing factors, and optimize dosing regimens for clinical effectiveness.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Guilhem Dreydemy, Alexis Coussy, Alexandre Lannou, Laurent Petit, Matthieu Biais, Cedric Carrie
Summary: This pilot study aimed to investigate the association between augmented renal clearance (ARC), urinary nitrogen loss, and muscle wasting in critically ill trauma patients. The findings suggest that patients with ARC have lower nitrogen balance and increased muscle loss in the first 10 days after ICU admission. The benefits of increased protein intake (>1.5 g/kg/day) in these patients are still a matter of controversy and require further randomized trials for confirmation.
Article
Medicine, General & Internal
Anthony J. King, Jemma Hudson, Gordon Fernie, Ashleigh Kernohan, Augusto Azuara-Blanco, Jennifer Burr, Tara Homer, Hosein Shabaninejad, John M. Sparrow, David Garway-Heath, Keith Barton, John Norrie, Alison McDonald, Luke Vale, Graeme MacLennan
Summary: This study compared primary trabeculectomy and primary medical treatment for patients with advanced glaucoma, and found that primary trabeculectomy had similar quality of life and safety outcomes, but achieved a greater reduction in intraocular pressure compared to medical treatment.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Critical Care Medicine
Inessa Beck, Christian Tapking, Valentin Haug, Steffen Nolte, Arne Boecker, Christian Stoppe, Ulrich Kneser, Christoph Hirche, Gabriel Hundeshagen
Summary: This study found that impaired smell and taste are common after facial burns, especially in cases with inhalation injury or large burn size. Most patients recovered their sense of smell after one year, but some still had olfactory dysfunction. Taste remained comparable between burn patients and healthy controls.
Article
Critical Care Medicine
Jayshil J. Patel, Rodney Willoughby, Jennifer Peterson, Thomas Carver, James Zelten, Adrienne Markiewicz, Kaitlin Spiegelhoff, Lauren A. Hipp, Bethany Canales, Aniko Szabo, Daren K. Heyland, Christian Stoppe, Jacek Zielonka, Julie K. Freed
Summary: This study examined the feasibility of using high-dose IV hydroxocobalamin compared to placebo in patients with septic shock. The results showed that the high-dose IV hydroxocobalamin group had a greater reduction in vasopressor dose after randomization and infusion, and there were no serious adverse events. This is the first proof of concept for the feasibility of delivering high-dose IV hydroxocobalamin in septic shock.
Review
Nutrition & Dietetics
Ellen Dresen, Zheng-Yii Lee, Aileen Hill, Quirin Notz, Jayshil J. Patel, Christian Stoppe
Summary: In 1747, Scottish surgeon James Lind conducted the first randomized controlled trial, studying the effect of vitamin C on scurvy. Subsequently, the use of vitamin C in critical illness gained attention, as it was found to have the potential to improve inflammatory response and clinical outcomes.
NUTRITION IN CLINICAL PRACTICE
(2023)
Article
Medicine, General & Internal
Aileen Hill, Christina Starchl, Ellen Dresen, Christian Stoppe, Karin Amrein
Summary: Micronutrient supplementation for critically ill patients has become a focus of attention in recent years. However, there is still uncertainty in clinical practice regarding the optimal strategy for supplementation, including the choice of substance, dosage, and timing for specific patient groups. This narrative review aims to summarize the current evidence and recommendations for vitamin C and vitamin D supplementation. It discusses the physiological roles of these vitamins, presents findings from recent clinical trials, and provides practical tips for use in the intensive care unit.
MEDIZINISCHE KLINIK-INTENSIVMEDIZIN UND NOTFALLMEDIZIN
(2023)
Article
Surgery
Christian Stoppe, Bernard McDonald, Patrick Meybohm, Kenneth B. Christopher, Stephen Fremes, Richard Whitlock, Siamak Mohammadi, Dimitri Kalavrouziotis, Gunnar Elke, Rolf Rossaint, Philipp Helmer, Kai Zacharowski, Ulf Guenther, Matteo Parotto, Bernd Niemann, Andreas Boening, C. David Mazer, Philip M. Jones, Marion Ferner, Yoan Lamarche, Francois Lamontagne, Oliver J. Liakopoulos, Matthew Cameron, Matthias Mueller, Alexander Zarbock, Maria Wittmann, Andreas Goetzenich, Erich Kilger, Lutz Schomburg, Andrew G. Day, Daren K. Heyland
Summary: High-dose intravenous sodium selenite treatment did not reduce morbidity or mortality in high-risk cardiac surgery patients.
Article
Anesthesiology
Sascha Ott, Quirin Notz, Johannes Menger, Christian Stoppe
Summary: The use of Impella device family has become well-established and is now widely used in different clinical areas. It plays a key role in the treatment of cardiogenic shock and as a preventive option during high-risk procedures. This article provides an overview for anesthesiologists and intensivists, focusing on technical basics, indications, contraindications, as well as intra- and post-operative management for patients on Impella support.
ANASTHESIOLOGIE INTENSIVMEDIZIN NOTFALLMEDIZIN SCHMERZTHERAPIE
(2023)
Review
Nutrition & Dietetics
Zheng-Yii Lee, Charles Chin Han Lew, Alfonso Ortiz-Reyes, Jayshil J. Patel, Yu Jun Wong, Carolyn Tze Ing Loh, Robert G. Martindale, Daren K. Heyland
Summary: Several systematic reviews have shown that probiotics administration is safe and reduces the rates of ventilator-associated pneumonia and diarrhea in critically ill patients. However, a recent large multicenter trial found that probiotics were not efficacious and increased adverse events. Therefore, an updated meta-analysis is needed to confirm the safety and efficacy of probiotic use in critically ill patients.
CLINICAL NUTRITION
(2023)
Review
Critical Care Medicine
Zheng-Yii Lee, Luis Ortiz-Reyes, Charles Chin Han Lew, M. Shahnaz Hasan, Lu Ke, Jayshil J. Patel, Christian Stoppe, Daren K. Heyland
Summary: This study found that intravenous Vitamin C (IVVC) monotherapy may reduce the risk of mortality in critically ill patients, especially those with a high risk of dying. However, further research is needed to determine the optimal timing, dosage, treatment duration, and patient population that will benefit most from IVVC monotherapy.
ANNALS OF INTENSIVE CARE
(2023)
Letter
Critical Care Medicine
Zheng-Yii Lee, Charles Chin Han Lew, Mette M. Berger, Aileen Hill, Christian Stoppe
LANCET RESPIRATORY MEDICINE
(2023)
Review
Nutrition & Dietetics
Ghaith Mohsen, Annika Stroemer, Andreas Mayr, Andrea Kunsorg, Christian Stoppe, Maria Wittmann, Markus Velten
Summary: Initial evidence suggests that preoperative administration of omega-3 fatty acids can reduce postoperative inflammatory reaction. However, the effects of immunonutrition with omega-3 fatty acids on inflammatory response in abdominal surgery patients are still unclear. This study found no significant difference in inflammatory markers or postoperative length of hospital stay between the preoperative omega-3 fatty acids group and the control group.
Review
Nutrition & Dietetics
Courtney Wedemire, Hamed Samavat, Melanie Newkirk, Anna Parker
Summary: High-dose vitamin B12 has the potential to be a treatment for refractory vasodilatory shock. Limited studies suggest that vitamin B12 infusion may decrease vasopressor requirements, but not all patients respond to this treatment. However, these findings are limited by patient selection and differences in timing of assessments.
NUTRITION IN CLINICAL PRACTICE
(2023)