Platelet toll-like receptors are crucial sensors of infectious danger moieties

The NF-κB inhibitor celastrol attenuates acute hepatic dysfunction induced by cecal ligation and puncture in rats

(2017) Ghada S. El‐Tanbouly et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Platelet toll-like receptors in thromboinflammation

(2017) Mirta Schattner   Frontiers in Bioscience-Landmark

Lipopolysaccharide as trigger of platelet aggregation via eicosanoid over-production

(2017) Simona Bartimoccia et al.   THROMBOSIS AND HAEMOSTASIS

Blood platelets and sepsis pathophysiology: A new therapeutic prospect in critical ill patients?

(2017) Antoine Dewitte et al.   Annals of Intensive Care

NF-κB Links TLR2 and PAR1 to Soluble Immunomodulator Factor Secretion in Human Platelets

(2017) Pauline Damien et al.   Frontiers in Immunology

Human platelet interaction with E. coli O111 promotes tissue-factor-dependent procoagulant activity, involving Toll like receptor 4

(2017) Valeria Matus et al.   PLoS One

Heat shock protein 70 regulates platelet integrin activation, granule secretion and aggregation

(2016) Rachel A. Rigg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Short fungal fractions of β-1,3 glucans affect platelet activation

(2016) Hélène Vancraeyneste et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

In vitro activation of coagulation by human neutrophil DNA and histone proteins but not neutrophil extracellular traps

(2016) Denis F. Noubouossie et al.   BLOOD

Arterial thrombosis in the context of HCV-associated vascular disease can be prevented by protein C

(2016) Philipp Blüm et al.   Cellular & Molecular Immunology

Evidence of NI-0101 pharmacological activity, an anti-TLR4 antibody, in a randomized phase I dose escalation study in healthy volunteers receiving LPS

(2016) E Monnet et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Platelets Toll-like receptor-4 in Crohns disease

(2016) Werner Schmid et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

How can non-nucleated platelets be so smart?

(2016) F. Cognasse et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Intact Toll-like receptor 9 signaling in neutrophils modulates normal thrombogenesis in mice

(2016) Osama M. El-Sayed et al.   JOURNAL OF VASCULAR SURGERY

Platelet activation at the onset of human endotoxemia is undetectablein vivo

(2016) Waltraud Cornelia Schrottmaier et al.   PLATELETS

Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3

(2016) Callum N. Watson et al.   PLATELETS

Toll-Like Receptor Signalling Is Not Involved in Platelet Response to Streptococcus pneumoniae In Vitro or In Vivo

(2016) Sacha F. de Stoppelaar et al.   PLoS One

Toll-like receptor 9 expression and activation in acute coronary syndrome patients on dual anti-platelet therapy

(2016) Kathryn E Hally et al.   THROMBOSIS RESEARCH

Enhanced Platelet Toll-like Receptor 2 and 4 Expression in Acute Coronary Syndrome and Stable Angina Pectoris

(2015) Kadri Murat Gurses et al.   AMERICAN JOURNAL OF CARDIOLOGY

Platelet P2Y12Inhibitors Reduce Systemic Inflammation and Its Prothrombotic Effects in an Experimental Human ModelSignificance

(2015) Mark R. Thomas et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Sex Differences in Platelet Toll-Like Receptors and Their Association With Cardiovascular Risk FactorsSignificance

(2015) Milka Koupenova et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Platelet secretion: From haemostasis to wound healing and beyond

(2015) Ewelina M. Golebiewska et al.   BLOOD REVIEWS

LPS stimulation of purified human platelets is partly dependent on plasma soluble CD14 to secrete their main secreted product, soluble-CD40-Ligand

(2015) Pauline Damien et al.   BMC IMMUNOLOGY

Human platelets and their capacity of binding viruses: meaning and challenges?

(2015) Adrien Chabert et al.   BMC IMMUNOLOGY

HMGB1: a novel protein that induced platelets active and aggregation via Toll-like receptor-4, NF-κB and cGMP dependent mechanisms

(2015) Xinyu Yang et al.   Diagnostic Pathology

Roll, adhere, spread and contract: Structural mechanics of platelet function

(2015) Simona Sorrentino et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

IL-1α induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs

(2015) Satoshi Nishimura et al.   JOURNAL OF CELL BIOLOGY

Nouvelle Cuisine: Platelets Served with Inflammation

(2015) Rick Kapur et al.   JOURNAL OF IMMUNOLOGY

Expression and functionality of Toll-like receptor 3 in the megakaryocytic lineage

(2015) L. P. D'Atri et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

New explanations for old observations: marginal band coiling during platelet activation

(2015) K. Sadoul   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Platelets and Infections – Complex Interactions with Bacteria

(2015) Hind Hamzeh-Cognasse et al.   Frontiers in Immunology

Breaking the Mold: Transcription Factors in the Anucleate Platelet and Platelet-Derived Microparticles

(2015) Katie L. Lannan et al.   Frontiers in Immunology

Platelets in Inflammation and Atherogenesis

(2015) Henry M. Nording et al.   Frontiers in Immunology

Human Cytomegalovirus–Platelet Interaction Triggers Toll-Like Receptor 2–Dependent Proinflammatory and Proangiogenic Responses

(2014) Alice Assinger et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Platelet-TLR7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis

(2014) M. Koupenova et al.   BLOOD

Human platelets express Toll-like receptor 3 and respond to poly I:C

(2014) Antonio-Santos Anabel et al.   HUMAN IMMUNOLOGY

IRAK4 as a Molecular Target in the Amelioration of Innate Immunity–Related Endotoxic Shock and Acute Liver Injury by Chlorogenic Acid

(2014) Sun Hong Park et al.   JOURNAL OF IMMUNOLOGY

Double Blockade of CD14 and Complement C5 Abolishes the Cytokine Storm and Improves Morbidity and Survival in Polymicrobial Sepsis in Mice

(2014) M. Huber-Lang et al.   JOURNAL OF IMMUNOLOGY

Inflammatory role and prognostic value of platelet chemokines in acute coronary syndrome

(2014) Johanna Brandt et al.   THROMBOSIS AND HAEMOSTASIS

The role of platelets in sepsis

(2014) Cornelis van ’t Veer et al.   THROMBOSIS AND HAEMOSTASIS

Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis

(2013) Steven M. Opal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Lipopolysaccharide Stimulates Platelets through an IL-1  Autocrine Loop

(2013) G. T. Brown et al.   JOURNAL OF IMMUNOLOGY

Highly Active Antiretroviral Therapy Alters Inflammation Linked to Platelet Cytokines in HIV-1-Infected Patients

(2013) P. Damien et al.   JOURNAL OF INFECTIOUS DISEASES

Functional responses and molecular mechanisms involved in histone-mediated platelet activation

(2013) Marìa Albertina Romaniuk et al.   THROMBOSIS AND HAEMOSTASIS

Use of antiplatelet agents in sepsis: A glimpse into the future

(2013) Karolina Akinosoglou et al.   THROMBOSIS RESEARCH

Engagement of Platelet Toll-Like Receptor 9 by Novel Endogenous Ligands Promotes Platelet Hyperreactivity and Thrombosis

(2012) Soumya Panigrahi et al.   CIRCULATION RESEARCH

Human platelets can discriminate between various bacterial LPS isoforms via TLR4 signaling and differential cytokine secretion

(2012) Julien Berthet et al.   CLINICAL IMMUNOLOGY

T granules in human platelets function in TLR9 organization and signaling

(2012) Jonathan N. Thon et al.   JOURNAL OF CELL BIOLOGY

Platelet-Derived Toll-Like Receptor 4 (Tlr-4) Is Sufficient to Promote Microvascular Thrombosis in Endotoxemia

(2012) Ryan J. Stark et al.   PLoS One

Periodontopathogens induce expression of CD40L on human platelets via TLR2 and TLR4

(2012) Alice Assinger et al.   THROMBOSIS RESEARCH

Quantitative immunofluorescence mapping reveals little functional coclustering of proteins within platelet  -granules

(2011) J. Kamykowski et al.   BLOOD

Release of angiogenesis regulatory proteins from platelet alpha granules: modulation of physiologic and pathologic angiogenesis

(2011) E. M. Battinelli et al.   BLOOD

How platelets safeguard vascular integrity

(2011) B. HO-TIN-NOÉ et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Efficient phagocytosis of periodontopathogens by neutrophils requires plasma factors, platelets and TLR2

(2011) A. ASSINGER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Toll-Like Receptor 9 Signaling Is Critical for Early Experimental Deep Vein Thrombosis Resolution

(2010) Peter K. Henke et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Deciphering the human platelet sheddome

(2010) K. P. Fong et al.   BLOOD

The platelet interior revisited: electron tomography reveals tubular  -granule subtypes

(2010) H. van Nispen tot Pannerden et al.   BLOOD

A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis*

(2010) Todd W. Rice et al.   CRITICAL CARE MEDICINE

Invasive Streptococcus pneumoniae trigger platelet activation via Toll-like receptor 2

(2010) C. KEANE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Signal-Dependent Protein Synthesis by Activated Platelets

(2008) Guy A. Zimmerman et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Toll-like receptor 4 ligand can differentially modulate the release of cytokines by human platelets

(2008) Fabrice Cognasse et al.   BRITISH JOURNAL OF HAEMATOLOGY

Stimulation of Toll-Like Receptor 2 in Human Platelets Induces a Thromboinflammatory Response Through Activation of Phosphoinositide 3-Kinase

(2008) Price Blair et al.   CIRCULATION RESEARCH

TLR4-induced IFN-γ production increases TLR2 sensitivity and drives Gram-negative sepsis in mice

(2008) Stephan Spiller et al.   JOURNAL OF EXPERIMENTAL MEDICINE