Article
Food Science & Technology
Hina Shanakhat, Susan P. McCormick, Mark Busman, Joseph O. Rich, Matthew G. Bakker
Summary: This study characterized the transformation products of deoxynivalenol using a combination of fungal laccase and a chemical mediator. The results showed that alcohol groups on deoxynivalenol were oxidized to ketones, and the chemical mediator formed a covalent bond with the molecule. Understanding these chemical modifications is crucial for effective remediation of contaminated grain.
Article
Food Science & Technology
Yongli Ye, Kaimin Wei, Jian Ji, Xiao Ning, Jia-Sheng Wang, Xiulan Sun
Summary: In this study, the toxic effects and mechanisms of individual and combined DON, 3-acetylDON, and 15-acetylDON were analyzed using the Caco-2 cell line. DON showed the highest inhibitory rate on cell viability, followed by 15-acetylDON and 3-acetylDON. Combinations of these mycotoxins exhibited varying effects on Caco-2 cells, including antagonistic, additive, and synergistic effects. Furthermore, the trichothecenes disrupted amino acid metabolism and protein synthesis.
Article
Food Science & Technology
Jianming Yue, Dawei Guo, Xiuge Gao, Jiacai Wang, Eugenie Nepovimova, Wenda Wu, Kamil Kuca
Summary: The research shows that DON can induce anorexia in mice by increasing levels of intestinal hormones, and injection of exogenous intestinal hormones can also trigger anorectic responses. Furthermore, inhibiting intestinal hormone receptors can attenuate both intestinal hormone and DON-induced anorexic responses.
Article
Physiology
Anita R. Patel, Henriette Frikke-Schmidt, Paul V. Sabatini, Alan C. Rupp, Darleen A. Sandoval, Martin G. Myers, Randy J. Seeley
Summary: Deoxynivalenol (DON), a mycotoxin contaminating grain, induces nausea, emesis, and anorexia. The study found that GLP-1 is not necessary for DON-induced effects on food intake and visceral illness. Additionally, the study showed that the calcium-sensing receptor (CaSR) on GFRAL neurons may play a role in DON signaling, but neither GLP-1 signaling nor GFRAL signaling and neurons are required for DON-induced visceral illness or anorexia.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2023)
Article
Microbiology
Maria Lorena Castrillo, Gustavo Angel Bich, Natalia Soledad Amerio, Marcela Paola Barengo, Pedro Dario Zapata, Mario Carlos Nazareno Saparrat, Laura Lidia Villalba
Summary: The mitochondrial genome of the mycoparasitic fungus Trichoderma koningiopsis was determined and found to be a circular molecule of 27,560 bp with a GC content of 27.80%. It contains 14 conserved protein-coding genes, 26 transfer RNA genes, and two introns. This study provides valuable insights for further research in taxonomy, phylogenetics, conservation genetics, and evolutionary biology of this important genus.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Microbiology
Haijiang Chen, Lijuan Mao, Nan Zhao, Chenyang Xia, Jian Liu, Christian P. Kubicek, Wenneng Wu, Su Xu, Chulong Zhang
Summary: Trichodermin is a sesquiterpenoid antibiotic isolated from Trichoderma species with inhibitory activity against pathogenic fungi and potential as an anticancer agent. The biosynthetic pathway of trichodermin has been identified in Trichoderma taxi, revealing the essential role of the TRI3 gene in catalyzing trichodermol esterification to trichodermin.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Xiong Yi, Yancui Guo, Raja Asad Ali Khan, Zhenyu Fan
Summary: It is estimated that 10% of global food production losses are due to plant pathogens, with plant parasitic nematodes posing a continuous threat to food security worldwide. Root knot nematodes (RKN), specifically Meloidogyne spp., are economically important nematodes infecting almost all agricultural crops. Various management practices have been developed for RKN, including biocontrol methods with Pochonia chlamydosporia being the most studied antagonist fungus against M. incognita. Advances in omics approaches have enabled scientists to study P. chlamydosporia and its antagonistic activity against RKN, leading to new findings and insights for effective RKN management.
BIOLOGICAL CONTROL
(2021)
Article
Agriculture, Multidisciplinary
Yi Zhang, Wen-Ying Zhuang
Summary: In this study, the functions of three MAPK genes in Trichoderma brevicrassum strain TC967 were investigated. The Hog1-MAPK was essential for conidiation and tolerance to saline/osmotic stress, while Fus3- and Slt2-MAPK deletion mutants showed increased effectiveness in inhibiting the growth of the plant pathogen Rhizoctonia solani. These findings suggest that MAPKs play a major role in regulating biocontrol-related gene expressions in TC967.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Michal Piegza, Kamil Szura, Wojciech Laba
Summary: The direct impact of Trichoderma fungi on other organisms is a complex process influenced by the strain and environment. Certain strains of Trichoderma producing extracellular biosurfactants have shown anti-fungal properties, which could be beneficial for plant protection against pathogenic molds.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Entomology
Hamza Bouanaka, Ines Bellil, Wahiba Harrat, Saoussene Boussaha, Abdelkader Benbelkacem, Douadi Khelifi
Summary: Trichoderma afroharzianum, identified as T14 in this study, showed promising biocontrol potential against fusarium crown rot and fusarium head blight. The biological control approach using T14 led to significant reduction in disease severity and increased yields in durum wheat cultivars tested. The characterization of T14 using molecular tools confirmed its effectiveness as a biocontrol agent.
EGYPTIAN JOURNAL OF BIOLOGICAL PEST CONTROL
(2021)
Review
Microbiology
Yujie Qin, Xiaoyu Liu, Guoxiong Peng, Yuxian Xia, Yueqing Cao
Summary: Fungal diseases are widely present in insects and can help control insect populations. Mosquitoes, which transmit various infectious diseases, pose a great threat to human health. Entomopathogenic fungi (EPF) have emerged as a promising alternative to chemical mosquitocides becasue they can infect mosquitoes through direct contact. Recent advancements have been made in understanding the infection pathways and mechanisms of EPF against mosquitoes, and various strategies, including genetic technologies, have been employed. This review provides a comprehensive summary of these advancements and discusses the potential of EPF as a future tool for mosquito control.
Review
Biotechnology & Applied Microbiology
Yolanda Martinez, Javier Ribera, Francis W. M. R. Schwarze, Kevin De France
Summary: Trichoderma spp. are fungi that promote plant growth, modulate plant functions, and protect against pathogens. Their use as a biological control method can reduce chemical pesticide and fertilizer usage. This review discusses biotechnological innovations in preparing Trichoderma formulations, covering various carrier substances and processing techniques that enhance shelf life and efficacy. Promising microencapsulation techniques are also discussed for the development of next-generation biological control formulations.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Food Science & Technology
Ye Tian, Dachuan Zhang, Pengli Cai, Huikang Lin, Hao Ying, Qian-Nan Hu, Aibo Wu
Summary: The review article summarized recent research on microbial and enzymatic methods for eliminating Fusarium mycotoxin DON, highlighting the potential of biological approaches for DON detoxification. The proposed conceptual framework combining computational tools with multi-omics approaches for discovering DON detoxification enzymes provides a new foundation for future mycotoxin detoxification research.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Plant Sciences
Fei Dong, Yunpeng Li, Xinyuan Chen, Jirong Wu, Shufang Wang, Xiao Zhang, Guizhen Ma, Yin-Won Lee, Mduduzi P. Mokoena, Ademola O. Olaniran, Jian Hong Xu, Jian Rong Shi
Summary: The study investigated the occurrence of FGSC in gramineous weeds near wheat fields in China, identifying Fusarium graminearum and Fusarium asiaticum as the dominant species. Different trichothecene genotypes and mycotoxins had varying effects on Fusarium head blight severity in wheat, highlighting the importance of weed management for reducing FHB inoculum.
Article
Agronomy
Nur Syafikah Abdullah, Febri Doni, Muhamad Shakirin Mispan, Mohd Zuwairi Saiman, Yusmin Mohd Yusuf, Mushafau Adebayo Oke, Nurul Shamsinah Mohd Suhaimi
Summary: The increased agricultural activities driven by rising food demand have led to environmental problems, and solutions like utilizing beneficial microbes as soil inoculants, especially Trichoderma, have shown promise in enhancing crop production and resistance towards biotic and abiotic stresses. A better understanding of the mechanisms involved in the use of Trichoderma is crucial for deriving maximum benefits.
Article
Computer Science, Artificial Intelligence
Zhiqiang Pu, Huimu Wang, Zhen Liu, Jianqiang Yi, Shiguang Wu
Summary: In this article, a novel method called AERL is proposed to address complex interaction and communication issues in multi agent cooperation. The method utilizes attention mechanism and parameter sharing to achieve effective and robust performance, as demonstrated in simulation experiments in three representative scenarios.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2023)
Article
Public, Environmental & Occupational Health
Zheng Xu, Ru Liu, Liping Guo, Ziyi Gao, Zicheng Gao, Xiaowei Liu, Jieyun Li, Bin Li, Kehu Yang
Summary: This scientometric investigation provides a comprehensive analysis of the development and emerging research trends in bibliotherapy. The study identifies the leading countries and institutions in the field and highlights the hot topics of research, such as depression and anxiety. The findings of this study serve as a valuable reference for researchers in the field of bibliotherapy.
PSYCHOLOGY HEALTH & MEDICINE
(2023)
Article
Environmental Sciences
Yu Qin, Meixuan Li, Jiani Han, Gecheng Cui, Weiping Du, Kehu Yang
Summary: This study explored the research hotspots and trends of Kinesio Taping in the past decade through bibliometric analysis. The results revealed that pain relief, sports injury prevention and treatment, and proprioception enhancement for improved postural control were important research areas in the field of Kinesio Taping.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Medicine, Research & Experimental
Junjie Cao, Renzhi Pei, Ying Lu, Zhongzheng Zheng, Zhiyang Yuan, Daiyang Li, Pisheng Zhang, Xuhui Liu, Dong Chen, Xiaohong Du, Lieguang Chen, Shuangyue Li, Peipei Ye, Tiantian Wang
Summary: The study found that the modified antithymocyte globulin-post-transplant cyclophosphamide combination can decrease the risk of acute and chronic graft-versus-host disease and improve graft-versus-host disease and relapse-free survival in high-risk acute myeloid leukemia and myelodysplastic syndrome patients after allogeneic hematopoietic stem cell transplantation.
CURRENT RESEARCH IN TRANSLATIONAL MEDICINE
(2023)
Article
Plant Sciences
Hongling Zhang, Guiqiong Li, Min Jiang, Changling Zhao, Pengyu Zhao, Chen Wang, Guosong Wen, Feng Zhou, Wenhua Dongchen, Shaozhong Xu, Ting Mu, Fanlai Meng, Xinglei Xiao, Di Yang, Zhengjie Liu, Ya Zhou, Qin Xiong
Summary: The expression of flavonoid synthesis-related genes in Panax notoginseng stems shows multi-peak curves, and the distribution of total flavonoid and anthocyanin content in the stems is asymmetric, mainly concentrated in the upper parts. The correlations between gene expression and flavonoid accumulation are highly diverse.
ACTA PHYSIOLOGIAE PLANTARUM
(2023)
Review
Oncology
Qian Wang, Ruifeng Liu, Qiuning Zhang, Hongtao Luo, Xun Wu, Tianqi Du, Yanliang Chen, Mingyu Tan, Zhiqiang Liu, Shilong Sun, Kehu Yang, Jinhui Tian, Xiaohu Wang
Summary: The purpose of this study was to evaluate the biological effects of cancer stem cells (CSCs) irradiated by charged particle, including proliferation, invasion, migration, and changes in the molecular level. The results showed that CSCs have obvious radio-resistance compared with non-CSCs, and charged particle irradiation or in combination with drugs could overcome this resistance, specifically manifested in inhibiting CSCs' proliferation, invasion, migration, and causing more and harder to repair DNA double-stranded breaks (DSB) of CSCs.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Health Care Sciences & Services
Yan Wang, Nan Chen, Kangle Guo, Yanfei Li, Fenfen E, Chaoqun Yang, Xue Shang, Xiuxia Li, Kehu Yang
Summary: This study evaluated and mapped the reporting and methodological quality of network meta-analysis (NMA) on acupuncture. The reporting quality of NMAs was found to be moderate, but the methodological quality was very low, especially for Chinese studies. Future NMAs, especially those from China, need to improve their reporting and methodological quality further.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Article
Physics, Multidisciplinary
Xingxing Yang, Yang Li, Xin Guo, Meiling Ding, Jingxuan Yang
Summary: This paper proposes a strategy to reduce energy consumption by storing and transmitting regenerative energy of trains through multi-agent simulation. By optimizing the train operation time and dwell time, the traction energy consumption is reduced, and the accuracy of the simulation model is validated in a practical case study.
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
(2023)
Review
Nutrition & Dietetics
Bei Pan, Honghao Lai, Ning Ma, Dan Li, Xiyuan Deng, Xiaoman Wang, Qian Zhang, Qiuyu Yang, Qi Wang, Hongfei Zhu, Mengting Li, Xiao Cao, Jinhui Tian, Long Ge, Kehu Yang
Summary: Through a systematic review and meta-analysis of 37 cohort studies, it was found that an increased consumption of sugar-sweetened beverages (SSBs) per 250 mL/day was associated with a higher risk of breast, colorectal, biliary tract, and prostate cancer. Increased consumption of artificially sweetened beverages (ASBs) per 250 mL/day was associated with a higher risk of leukemia. Increased consumption of 100% fruit juice per 250 mL/day was associated with a higher risk of overall cancer, melanoma, squamous cell carcinoma, and thyroid cancer. There were linear dose-response associations between SSBs consumption and breast and kidney cancer, and between ASBs and fruit juices consumption and pancreatic cancer.
INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
(2023)
Review
Clinical Neurology
Ying Che, Tingting Lu, Tianming Wang, Hairong Zhao, Xulin Song, Qing Zhan, Chengzu Zhang, Haibang Pan, Kehu Yang, Bo Wang
Summary: This study evaluated the effects of head-of-bed elevation on patients with acquired brain injury (ABI). The results showed that elevating the head of the bed by 30 degrees can significantly reduce intracranial pressure (ICP), but did not have statistical differences on cerebral perfusion pressure (CPP) and disability at 90 days. Therefore, head-of-bed elevation of 30 degrees may be an effective noninvasive nursing practice for the prognosis and rehabilitation of ABI patients.
JOURNAL OF NEUROSCIENCE NURSING
(2023)
Review
Sport Sciences
Meng Xu, Chen Tian, Yong Wang, Shanshan Liang, Yiyun Wang, Xiuxia Li, Kehu Yang
Summary: This study conducted an umbrella review to summarize the evidence of associations between Pilates and multiple health outcomes, and evaluated the strength and validity of these associations. It found that Pilates can reduce body mass index and body fat percentage, relieve pain and disability, and improve sleep quality and balance. However, the certainty of the evidence was mostly low, and further high quality randomized controlled trials are needed to support these promising findings.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2023)
Article
Chemistry, Physical
Ye Ji, Xi-Lian Guo, Jia-Yu Yang, Hai-Han Zhang, Xu-Hui Liu, Ming-Xing Song, Zheng-Kun Qin, Jia Wang, Fu-Quan Bai
Summary: In this article, six novel heterocyclic Ir(III) complexes were designed and calculated using DFT and TD-DFT. The bands of the lowest-lying absorptions and lowest energy emissions, as well as the spectral properties, frontier molecular orbitals, and spin-orbital coupling values, were studied. These complexes exhibit low efficiency roll-off properties, which is significant for the development of OLEDs.
Review
Integrative & Complementary Medicine
Meng Xu, Chaoqun Yang, Tao Nian, Chen Tian, Liying Zhou, Yanan Wu, Yanfei Li, Xinxin Deng, Xiuxia Li, Kehu Yang
Summary: This study examines the adverse effects of acupuncture and finds that there are various types of adverse reactions, but the symptoms are mild. However, most of the included studies have low quality, indicating a need for further randomized controlled trials and systematic reviews to comprehensively analyze acupuncture-related adverse events.
Review
Emergency Medicine
Qi Zhou, Wenbo Meng, Yanhan Ren, Qinyuan Li, Marja A. Boermeester, Peter Muli Nthumba, Jennifer Rickard, Bobo Zheng, Hui Liu, Qianling Shi, Siya Zhao, Zijun Wang, Xiao Liu, Zhengxiu Luo, Kehu Yang, Yaolong Chen, Robert G. Sawyer
Summary: This study reviewed the effectiveness of intraoperative peritoneal lavage (IOPL) with saline in patients with intra-abdominal infections (IAIs). The findings suggest that IOPL with saline does not significantly reduce the risk of mortality, intra-abdominal abscess, incisional surgical site infection, postoperative complication, reoperation, and readmission when compared to non-IOPL. Therefore, routine use of IOPL with saline in patients with IAIs is not supported.
WORLD JOURNAL OF EMERGENCY SURGERY
(2023)
Article
Health Care Sciences & Services
Xuping Song, Yan Ma, Jing Tang, Jiali Peng, Yue Hu, Yunze Han, Xinyu Fu, Xufei Luo, Xiuxia Li, Long Ge, Kehu Yang, Yaolong Chen
Summary: This study analyzed the trends and gaps in evidence of health effects on pollutants and extreme temperatures through evidence mapping, and conducted a cross-sectional survey on the use of GRADE in systematic reviews or meta-analyses. The results showed that GRADE is not widely used in these evaluations, and the certainty of evidence is generally low.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Article
Plant Sciences
Sreelekha Duruvasula, Ulaganathan Kandasamy, Sujatha Mulpuri
Summary: The study identified the MLO gene family in the sunflower genome using computational methods, analyzed their chromosomal distribution, gene structure, and phylogenetic relationship, providing a reference for future functional studies. Additionally, the analysis revealed 12 differentially expressed genes between powdery mildew resistant and susceptible sunflower varieties, further contributing to understanding genetic resistance mechanisms in sunflower.
PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY
(2024)
Article
Plant Sciences
Zainul A. Khan, Damini Diksha, Pooja Thapa, Yazing S. Mailem, Susheel K. Sharma, Nitika Gupta, Gopi Kishan, Santosh Watpade, Virendra K. Baranwal
Summary: This study reported the presence of several viruses, including apple rubbery wood virus 1, apple necrotic mosaic virus, citrus virus A, apple stem grooving virus, apple stem pitting virus, apple chlorotic leaf spot virus, in pear trees in India for the first time. The genomes of these viruses were sequenced and analyzed, revealing the expansion of their host range in pear trees. These findings are of great importance for the biological study of pear viruses and virus indexing programs.
PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY
(2024)
Article
Plant Sciences
Xueren Cao, Qiaohui Han, Jonathan S. West
Summary: Spraying double-stranded RNAs (dsRNA) targeting the genes of E. quercicola can effectively control rubber tree powdery mildew and reduce the expression of pathogen genes as well as the severity of the disease.
PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY
(2024)
