Article
Chemistry, Analytical
Hiroshi Yamashita, Takeshi Akinaga, Masako Sugihara-Seki
Summary: The study focused on the effect of Reynolds number on inertial focusing in rectangular duct flows. Numerical simulations were conducted to analyze the lift force on spherical particles in the duct, determining the lift-force distribution map over a wide range of Reynolds numbers. The study identified different particle-focusing patterns based on the duct cross-section shape and Reynolds number, including subcritical pitchfork and supercritical pitchfork bifurcations.
Article
Chemistry, Analytical
Haidong Feng, Alexander R. Jafek, Bonan Wang, Hayden Brady, Jules J. Magda, Bruce K. Gale
Summary: This paper studies particle focusing in viscoelastic flow and predicts the focusing position by analyzing the force balance. The research finds that particle separation resolution can be improved in viscoelastic flows.
Article
Multidisciplinary Sciences
Amir Shamloo, Amin Naghdloo, Mohsen Besanjideh
Summary: The study focused on isolating rare cancer cells using two centrifugal microfluidic devices. The passive design isolates cells through inertial effects and bifurcation law, while the hybrid design captures magnetically labeled cells using permanent magnets at the end of the microchannel. The hybrid design offers better separation efficiency and purity, while the passive one is simpler and cost-effective without the need for cell labeling.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Analytical
Uihwan Kim, Byeolnim Oh, Jiyeon Ahn, Sangwook Lee, Younghak Cho
Summary: In this study, an integrated microfluidic device was proposed for non-contact, label-free separation of particles and cells using a combination of inertial microfluidics and acoustophoresis. The device demonstrated excellent separation performance and high recovery ratio, making it a potential alternative to current cell separation methods.
Article
Chemistry, Analytical
Jianguo Feng, Yang Wang, Jun Liu, Yuanting Zhang, Mengjun Zhang, Gaobin Xu, Xichen Yuan, Pavel Neuzil
Summary: Inertial-focusing microfluidics has extensive applications in particle manipulation, single-cell analysis, and flow cytometry. This study investigated the inertial focusing mechanism of a combination of four channel types and found that combining an annular channel with obstacles along the inner wall improved the focusing efficiency. The findings provide insights for the design of combined channels to enhance cell focusing and separation.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Multidisciplinary
Rasool Dezhkam, Ali Shafiei Souderjani, Amir Shamloo, Mohammadmahdi Eskandarisani, Ali Mashhadian
Summary: Cell separation is important for diagnosing and improving diseases like cancer. Inertial methods offer a more affordable option for separating circulating tumor cells (CTCs) in blood samples. This study compares the effectiveness of different serpentine-shaped channels in separating CTCs, and also compares the lab-on-a-chip (LOC) and lab-on-a-disk (LOD) platforms. The results show that the simple serpentine channel has the highest separation percentage, and the LOD platform is more efficient for cell separation. Additionally, the Omega channel shows promise for particle focusing applications in both platforms. ©2023 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2023)
Article
Engineering, Mechanical
Jin-Yang Li, Si-Ying Jiang, Hai-Lei Zhou, Du-Chang Xu, Yuan-Qing Xu
Summary: This paper presents a 2D particle inertial focusing model using the immersed boundary-lattice Boltzmann method (IB-LBM) to investigate the impact of particle shapes on their focusing state. Circular particles were first studied as validation, obtaining consistent focus positions with previous reports. The focusing of circle, rectangle, ellipse, and capsule particles were then examined in detail, revealing significant influences of particle shapes on focusing positions, self-rotation, and running speed. This study provides valuable insights for screening or separating particles with different shapes in microfluidic devices.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART C-JOURNAL OF MECHANICAL ENGINEERING SCIENCE
(2023)
Article
Chemistry, Analytical
Lei Zhao, Mengqi Gao, Yanbing Niu, Jianchun Wang, Shaofei Shen
Summary: A novel microchannel structure was developed for flow-rate and particle-size insensitive inertial focusing; efficient focusing of particles and tumor cells at different flow rates was achieved through enhanced secondary flow; providing important reference for the development of portable inertial microfluidic devices.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Mechanics
I. Banerjee, M. E. Rosti, T. Kumar, L. Brandt, A. Russom
Summary: A unique tunable trend in particle focusing is reported in elasto-inertial flows, where particles can be tuned to different focusing bandwidths. Numerical simulations and experimental observations show that particle focusing is affected by minute amounts of elasticity and flow rates. The study provides a new understanding of particle focusing in weakly elastic and strongly inertial flows, with potential applications in microfluidics-based biological sorting.
Article
Physics, Multidisciplinary
Pei-Feng Lin, Xiao Hu, Jian-Zhong Lin
Summary: The lattice Boltzmann method is used to study the inertial focusing and rotating characteristics of two-dimensional elliptical particles and rectangular particles in channel flow. The results show that both types of particles form single-line and staggered particle trains, with axial spacing increasing with aspect ratio and Reynolds number. Perpendicular orientation angles are more pronounced in elliptical or rectangular particle pairs at larger aspect ratios and lower Reynolds numbers.
Article
Engineering, Electrical & Electronic
Chih-Hsin Shih, Yuan -Ting Cheng, Ho-Chin Wu, Chia -Lin Chang, Yi-Xiang Zhao
Summary: This paper presents a sequential liquid release approach through decanting. By coordinating the Euler and centrifugal forces under rapid deceleration, liquid can be effectively poured from a reservoir into a reaction chamber on a centrifugal platform. No valves are used in this approach. The decanting mechanism is analyzed and the parameters that control the volume of decanted liquid are investigated. It is found that the onset of the decanting phenomenon is determined by the Bond number. An eight-step sequential flow control design is proposed to robustly deliver reagents to the reaction chamber and facilitate a multistep process.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Article
Engineering, Electrical & Electronic
Sina Ebrahimi, Mojgan Alishiri, Amir Shamloo, Esmail Pishbin, Parnian Hemmati, Saeed Seifi, Hossein Shaygani
Summary: Cell-based diagnosis and personalized drugs require effective cell isolation, and this study presents an optimized structure using the finite element method to achieve cell separation and focusing. Two serpentine micro-channel designs (fixed and variable slope) were presented, and their simulation results were verified with experimental findings. The optimized microchannels showed high separation efficiency and particle focusing efficiency, opening new possibilities for improved diagnosis.
SENSORS AND ACTUATORS A-PHYSICAL
(2023)
Article
Chemistry, Analytical
Mohammad Moein Naderi, Ludovica Barilla, Jian Zhou, Ian Papautsky, Zhangli Peng
Summary: The study on elasto-inertial focusing highlighted the interaction between elastic force and shear-gradient lift force leading to different particle focusing patterns. Both experimental and simulation studies were conducted to investigate the effects of flowrate, particle size, and shear-thinning extent on focusing patterns, emphasizing the importance of accurately estimating shear-thinning extent in modeling.
Review
Chemistry, Multidisciplinary
Bingyan Jiang, Tao Peng, Shuai Yuan, Mingyong Zhou
Summary: Particle focusing in microfluidic devices has become a rapidly growing research field, with active, passive, and sheath-assisted methods being the main focusing technologies. Passive focusing, utilizing fluid inertia and other characteristics, has proven to be a powerful tool due to its simplicity, label-free nature, biocompatibility, contact-free operation, low cost, and high throughput.
PROGRESS IN CHEMISTRY
(2021)
Article
Engineering, Electrical & Electronic
Javier Cruz, Karin Hjort, Klas Hjort
Summary: Fine manipulation of particles is crucial for analyzing complex samples like blood or environmental water. Inertial focusing is a promising technique for label-free manipulation of particles with sub-micron resolution at high flow rates. HARC microchannels provide a stable focus position near the center of the inner wall, independent of flow rate and particle size, showing potential for implementation in laboratories for analyzing complex fluids with biological particles.
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2021)
Article
Chemistry, Analytical
Masoud Madadelahi, Erfan Ghazimirsaeed, Amir Shamloo
ANALYTICA CHIMICA ACTA
(2019)
Article
Chemistry, Analytical
Ali Mashhadian, Amir Shamloo
ANALYTICA CHIMICA ACTA
(2019)
Article
Pharmacology & Pharmacy
Mina Mohseni, Amir Shamloo, Zahra Aghababaie, Homa Afjoul, Shabnam Abdi, Hamideh Moravvej, Manouchehr Vossoughi
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2019)
Article
Biochemistry & Molecular Biology
Mohsen Asadbegi, Amir Shamloo
ACS CHEMICAL NEUROSCIENCE
(2019)
Article
Engineering, Chemical
Miad Boodaghi, Amir Shamloo
Article
Biophysics
Seyed Abdolmajid Yousefsani, Amir Shamloo, Farzam Farahmand
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2020)
Article
Energy & Fuels
Abbas Gholami, Amir Shamloo
CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION
(2020)
Article
Engineering, Chemical
Maryam Hajiabbas, Iran Alemzadeh, Manouchehr Vossoughi, Amir Shamloo
Summary: This study focused on in-situ crosslinking of gelatin to produce electrospun scaffold with improved fiber morphology and mechanical properties, showing that using EDC/NHS for crosslinking significantly enhances the stability and mechanical properties of G fibrous scaffolds, with no toxic effect on cell culture. Gelatin nanofibers with excellent properties may be considered as a candidate material in future biomedical applications.
CHEMICAL ENGINEERING COMMUNICATIONS
(2021)
Article
Engineering, Biomedical
Amir Shamloo, Mohsen Besanjideh
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2020)
Article
Biophysics
Ali Kamali, Amir Shamloo
JOURNAL OF BIOMECHANICS
(2020)
Article
Chemistry, Analytical
Masoud Madadelahi, Marc J. Madou, Yeganeh Dorri Nokoorani, Amir Shamloo, Sergio O. Martinez-Chapa
SENSORS AND ACTUATORS B-CHEMICAL
(2020)
Article
Multidisciplinary Sciences
Amir Shamloo, Sina Ebrahimi, Ali Amani, Famida Fallah
SCIENTIFIC REPORTS
(2020)
Article
Chemistry, Analytical
Rohollah Nasiri, Amir Shamloo, Javad Akbari, Peyton Tebon, Mehmet R. Dokmeci, Samad Ahadian
Article
Chemistry, Analytical
Rohollah Nasiri, Amir Shamloo, Javad Akbari
Summary: Isolating circulating tumor cells (CTCs) from blood samples is crucial for cancer diagnosis and treatment, and microfluidics shows great potential in this area. Combining inertial and magnetic methods on a single chip was found to be effective in separating CTCs, with high recovery rates and purity levels.
Article
Chemistry, Analytical
Masoud Rezaeian, Moein Nouri, Mojtaba Hassani-Gangaraj, Amir Shamloo, Rohollah Nasiri
Summary: This study investigates the effect of magnetic field characteristics on the efficiency of mixing processes within droplets. It is found that increasing the magnetic field intensity enhances the mixing efficiency. The study also examines the effect of ferrofluid concentration on mixing efficiency and finds that increasing the concentration significantly improves mixing efficiency.