Article
Polymer Science
Ogun Bozkaya, Esra Arat, Zehra Gun Gok, Mustafa Yigitoglu, Ibrahim Vargel
Summary: The aim of this study was to develop a therapeutic and antimicrobial nanofiber wound dressing material with suitable physical properties. This was achieved by synthesizing Centella asiatica coated silver nanoparticles and electrospinning them with poly caprolactone and polyethylene oxide to produce hybrid nanofibers. The surface and physico-chemical properties were characterized, and the degradation and antimicrobial properties were investigated. The results demonstrated the potential of this material for wound healing applications.
EUROPEAN POLYMER JOURNAL
(2022)
Review
Materials Science, Multidisciplinary
Shokoh Parham, Anousheh Zargar Kharazi, Hamid Reza Bakhsheshi-Rad, Mahshid Kharaziha, Ahmad Fauzi Ismail, Safian Sharif, Mahmood Razzaghi, Seeram RamaKrishna, Filippo Berto
Summary: Wound dressings have evolved from using natural materials to customizable electrospun polymers that contain active compounds for wound healing and infection prevention. Electrospun polymeric nanofibers are considered promising for enhancing skin regeneration and controlling wound infection.
ADVANCED ENGINEERING MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Claudia Mouro, Ana P. Gomes, Merja Ahonen, Raul Fangueiro, Isabel C. Gouveia
Summary: This study successfully incorporated Chelidonium majus extract into nanofibrous meshes using a needleless emulsion electrospinning technique, demonstrating promising healing support properties for wound infections.
Article
Engineering, Biomedical
Tien Ngoc-Thuy Nguyen, Thien Bui-Thuan Do, Minh Hieu Ho, Nam Minh-Phuong Tran, Nhi Ngoc-Thao Dang, Thai Minh Do, Hoai Thi-Thu Nguyen, Thang Bach Phan, Quyen Ngoc Tran, Toi Van Vo, Hiep Thi Nguyen
Summary: The study revealed that an increase in coated layers affects the absorptive capacity and degradation rate of the membrane, making it stiffer in dry state and reducing tensile strength, elongation, and cell viability in wet state. PCLGelAg3 was identified as the optimal choice for wound healing due to its sufficient buffer uptake, elasticity, cell viability, as well as inducing abnormalities in bacterial morphology and preventing biofilm formation.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Chemistry, Physical
Fereshte Nazemi Harandi, Alireza Chackoshian Khorasani, Seyed Abbas Shojaosadati, Sameereh Hashemi-Najafabadi
Summary: Demand for the development of advanced antimicrobial and antibiofilm agents is increasing due to the prevalence of antibiotic-resistant microbial infections. This study developed a new antimicrobial surface coating material and demonstrated its excellent antimicrobial efficacy and biocompatibility for wound dressing applications.
SURFACES AND INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Jean Lucas Tanaka, Caroline Barcelos Costa-Orlandi, Betina Sayeg Burd, Giovana Sant'Ana Pegorin, Thaina Venancio da Silva, Nayrim Brizuela Guerra, Maria Jose Soares Mendes-Giannini, Ana Marisa Fusco-Almeida, Rondinelli Donizetti Herculano, Natan Roberto de Barros
Summary: An inexpensive curative based on silver sulfadiazine (SS) and natural rubber latex (NRL) was developed to treat burn wounds, showing no interaction between drug and biopolymer in the infrared spectrum. The curative exhibited good mechanical properties, antifungal effects, and biocompatibility, representing a promising alternative for burn wound treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Multidisciplinary
Seyede Mahtab Hosseini, Majid Abdouss, Saeedeh Mazinani, Azim Soltanabadi, Mohammadreza Kalaee
Summary: This study prepared polyvinyl alcohol (PVA) nanofibers containing chitosan nanoparticles and drug-loaded graphene oxide-magnetite nanocomposites for smart wound dressing. The nanofiber membranes showed high water absorption, low degradability, controlled drug release, good antimicrobial properties against gram-positive and gram-negative bacteria, and high compatibility with cells.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Biotechnology & Applied Microbiology
Xi He, Meiling Zhou, Xuemei Chen, Jing Wang, Xiaoli Zhao, Yanxia Zhu, Tao Liu
Summary: This study developed a multifunctional wound dressing using electrospinning technology, which incorporated antimicrobial polypeptides (AMPs) and sphingosine-1-phosphate (S1P) to inhibit bacteria growth and induce angiogenesis. The results showed that the AMP/S1P@PLA/gelatin nanofibrous membranes exhibited excellent antibacterial properties and enhanced tube formation, promoting wound healing and skin regeneration.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Biochemistry & Molecular Biology
Priyadarshani Choudhary, Baskaran Ramalingam, Sujoy K. Das
Summary: Wound dressings with poor antibacterial properties, adhesion to the wound site, weak mechanical strength, and lack of porosity and flexibility lead to blood loss, delayed wound repair, and sometimes death. In this study, a multifunctional graphene-based nanobiocomposite wound dressing was developed, which demonstrated hydrophilic properties, good mechanical strength, antibacterial activity, non-toxicity to cells, and pro-angiogenic potential. In in-vivo studies using a rat model, the nanobiocomposite dressing significantly enhanced wound healing compared to commercially available dressings, achieving complete wound closure in 14 days. Overall, the CGAPL nanobiocomposite dressing offers a novel and efficient solution for faster wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Changchang Kong, Shijunyin Chen, Wenhao Ge, Yang Zhao, Xiaodong Xu, Shiming Wang, Jianfa Zhang
Summary: In this study, an antibacterial and anti-inflammatory wound dressing based on riclin and silver nanoparticles was developed. The results showed that the dressing had sustained release of silver nanoparticles, effectively suppressed pathogen growth, and had negligible toxicity to human cells. In addition, it promoted faster and smoother wound healing while reducing the expression of inflammatory mediators.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Physical
Nandini Sarviya, Urbashi Mahanta, Alexander Dart, Jyotsnendu Giri, Atul Suresh Deshpande, Mudrika Khandelwal, Mrinal Bhave, Peter Kingshott
Summary: A three-layer polymer nanofiber mesh with antibacterial properties has been developed using electrospinning. The mesh is capable of killing bacteria and has cytocompatibility, making it suitable for treating severe skin wounds. The second layer of the mesh contains silver nanoparticles for antibacterial activity, while the third layer acts as a hydrophilic, non-adhesive barrier to aid in wound healing. The study emphasizes the importance of optimizing the properties of antibacterial meshes to achieve a balance between high antibacterial activity and low toxicity.
APPLIED SURFACE SCIENCE
(2023)
Article
Biophysics
Miaomiao Zhang, Shixin Xu, Chen Du, Ruoying Wang, Cuicui Han, Yongan Che, Wei Feng, Chengwei Wang, Shan Gao, Wen Zhao
Summary: In this study, a novel bilayer wound dressing made of poly(L-lactate-caprolactone) copolymer (PLCL) nanofibrous and keratin hydrogel loaded with fibroblast growth factor (FGF-2) was prepared using the low-pressure filtration-assisted method. The bilayer dressing was found to mimic the dermis and epidermis. It exhibited good porosity, maximum water absorption, and tight bond at the interface. In vitro and in vivo studies demonstrated the biocompatibility, biodegradability, and ability to promote skin healing of the bilayer dressing, making it a promising biomedical wound dressing for skin tissue engineering applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Applied
Xiangyan Chen, Hongjin Li, Xiaoni Qiao, Tianze Jiang, Xue Fu, Yue He, Xia Zhao
Summary: Marine agarose oligosaccharides and silver nanoparticles combined with antimicrobial peptides form a novel composite nanomaterial, which shows significant promoting effects on wound healing with strong antimicrobial activities and good biocompatibility.
CARBOHYDRATE POLYMERS
(2021)
Review
Polymer Science
Chang Huang, Xizi Xu, Junhao Fu, Deng-Guang Yu, Yanbo Liu
Summary: Bleeding control is crucial in healthcare, which has led to advancements in wound dressing research and development. Electrospun polyacrylonitrile nanofibers offer excellent properties for wound dressings, showing great potential in manufacturing.
Article
Chemistry, Analytical
Carlo Bergonzi, Annalisa Bianchera, Giulia Remaggi, Maria Cristina Ossiprandi, Ruggero Bettini, Lisa Elviri
Summary: The growing demand for personalized medicine requires innovative drug manufacturing using 3D printing technology to produce hydrogels for controlled drug delivery. This study explored the use of chitosan/alginate-based hydrogels loaded with silver sulfadiazine for wound healing. Different 3D chitosan/alginate architectures were designed to modulate drug release, and significant differences were observed in terms of elasticity, water content, and antimicrobial potency.
Article
Biophysics
Seyed Abdolmajid Yousefsani, Amir Shamloo, Farzam Farahmand
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2020)
Article
Energy & Fuels
Abbas Gholami, Amir Shamloo
CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION
(2020)
Article
Engineering, Chemical
Maryam Hajiabbas, Iran Alemzadeh, Manouchehr Vossoughi, Amir Shamloo
Summary: This study focused on in-situ crosslinking of gelatin to produce electrospun scaffold with improved fiber morphology and mechanical properties, showing that using EDC/NHS for crosslinking significantly enhances the stability and mechanical properties of G fibrous scaffolds, with no toxic effect on cell culture. Gelatin nanofibers with excellent properties may be considered as a candidate material in future biomedical applications.
CHEMICAL ENGINEERING COMMUNICATIONS
(2021)
Article
Biophysics
Ali Kamali, Amir Shamloo
JOURNAL OF BIOMECHANICS
(2020)
Article
Chemistry, Analytical
Rohollah Nasiri, Amir Shamloo, Javad Akbari, Peyton Tebon, Mehmet R. Dokmeci, Samad Ahadian
Article
Gastroenterology & Hepatology
Zahra Aghababaie, Niranchan Paskaranandavadivel, Satya Amirapu, Chih-Hsiang Alexander Chan, Peng Du, Samuel J. Asirvatham, Gianrico Farrugia, Arthur Beyder, Gregory O'Grady, Leo K. Cheng, Timothy R. Angeli-Gordon
Summary: This study demonstrates the potential of gastric ablation as a new method for modulating slow wave activation and propagation in vivo by creating localized electrical conduction blocks in the stomach. Results show the effective energy dose range for creating conduction blocks while maintaining tissue integrity, paving the way for future applications in disrupting dysrhythmic slow wave activation.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Amir Shamloo, Zahra Aghababaie, Homa Afjoul, Mehrzad Jami, Mina Razaghzadeh Bidgoli, Manouchehr Vossoughi, Ahmad Ramazani, Kambiz Kamyabhesari
Summary: Physically cross-linked hydrogels were developed by freezing-thawing method with different concentrations of honey for accelerated wound healing. The incorporation of honey increased the flexibility, antibacterial properties, and cell viability of hydrogels, while also accelerating wound healing.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Engineering, Biomedical
Saeed Alighaleh, Leo K. Cheng, Timothy R. Angeli-Gordon, Zahra Aghababaie, Gregory O'Grady, Niranchan Paskaranandavadivel
Summary: The study developed new flexible surface-contact pacing electrodes (SPE) for gastric pacing and simultaneous mapping of slow-wave activity. Results showed that SPE had a higher rate of entrainment and lower entrainment threshold compared to temporary cardiac pacing electrodes (CPE), but had lower tissue lead contact quality over time.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Article
Chemistry, Analytical
Rohollah Nasiri, Amir Shamloo, Javad Akbari
Summary: Isolating circulating tumor cells (CTCs) from blood samples is crucial for cancer diagnosis and treatment, and microfluidics shows great potential in this area. Combining inertial and magnetic methods on a single chip was found to be effective in separating CTCs, with high recovery rates and purity levels.
Article
Gastroenterology & Hepatology
Chih-Hsiang Alexander Chan, Zahra Aghababaie, Niranchan Paskaranandavadivel, Recep Avci, Leo K. Cheng, Timothy R. Angeli-Gordon
Summary: This study identifies temporary dysrhythmic ectopic pacemakers in the distal stomach caused by localized gastric distension. These distension-induced dysrhythmias are interesting physiological phenomena that can inform the design of new interventional and electrophysiological protocols, and contribute to the understanding of stretch-sensitivity in the gut and postprandial physiology.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Zahra Aghababaie, Leo K. Cheng, Niranchan Paskaranandavadivel, Recep Avci, Chih-Hsiang Alexander Chan, Ashton Matthee, Satya Amirapu, Samuel J. Asirvatham, Gianrico Farrugia, Arthur Beyder, Gregory O'Grady, Timothy R. Angeli-Gordon
Summary: This study introduces gastric ablation as a new tool for modulating gastric bioelectrical activation, including eliminating both normal and abnormal pacemaker sites underlying gastric dysrhythmias. Targeted radiofrequency ablation successfully eliminated these pacemaker sites without disrupting the surrounding conduction capability or tissue structure. Gastric ablation presents a powerful new research tool for modulating gastric electrical activation and may hold therapeutic potential for disorders of gastric function.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Zahra Aghababaie, Gregory O'Grady, Linley A. Nisbet, Andre E. Modesto, Chih-Hsiang Alexander Chan, Ashton Matthee, Satya Amirapu, Arthur Beyder, Gianrico Farrugia, Samuel J. Asirvatham, Gregory B. Sands, Niranchan Paskaranandavadivel, Leo K. Cheng, Timothy R. Angeli-Gordon
Summary: This study evaluated the safety and feasibility of gastric ablation in modulating slow-wave conduction. The results showed that gastric ablation can safely and effectively induce sustained localized conduction block in the stomach, without disrupting the surrounding slow-wave conduction capability.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Chemistry, Analytical
Masoud Rezaeian, Moein Nouri, Mojtaba Hassani-Gangaraj, Amir Shamloo, Rohollah Nasiri
Summary: This study investigates the effect of magnetic field characteristics on the efficiency of mixing processes within droplets. It is found that increasing the magnetic field intensity enhances the mixing efficiency. The study also examines the effect of ferrofluid concentration on mixing efficiency and finds that increasing the concentration significantly improves mixing efficiency.
Article
Multidisciplinary Sciences
Zahra Aghababaie, Tim Hsu-Han Wang, Linley A. Nisbet, Ashton Matthee, Jarrah Dowrick, Gregory B. Sands, Niranchan Paskaranandavadivel, Leo K. Cheng, Gregory O'Grady, Timothy R. Angeli-Gordon
Summary: This study investigated the effects of two anesthetic drugs, intravenous propofol and volatile isoflurane, on gastric motility. The results showed that propofol had a positive effect on slow-wave activity, reducing dysrhythmias and increasing velocity and frequency. These findings suggest that propofol is a more suitable anesthetic for studying slow-wave patterns in vivo.
SCIENTIFIC REPORTS
(2023)
Proceedings Paper
Engineering, Biomedical
Matthew Savage, Recep Avci, Zahra Aghababaie, Ashton Matthee, Faraz Chamani, Punit Prakash, Leo K. Cheng, Timothy R. Angeli-Gordon
Summary: Gastric ablation is a promising therapy for gastrointestinal disorders, but is still in early development stage. A computational model of radio-frequency gastric ablation has been developed to accurately predict temperature changes and optimize ablation parameters. The model shows potential for further expansion to include irrigation and power-controlled settings.
2021 43RD ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE & BIOLOGY SOCIETY (EMBC)
(2021)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)