Protonation/reduction dynamics at the [4Fe–4S] cluster of the hydrogen-forming cofactor in [FeFe]-hydrogenases

Protein dynamics observed by tunable mid-IR quantum cascade lasers across the time range from 10 ns to 1 s

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Bridging Hydride at Reduced H-Cluster Species in [FeFe]-Hydrogenases Revealed by Infrared Spectroscopy, Isotope Editing, and Quantum Chemistry

(2017) Stefan Mebs et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Proton Coupled Electronic Rearrangement within the H-Cluster as an Essential Step in the Catalytic Cycle of [FeFe] Hydrogenases

(2017) Constanze Sommer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Observation of an Iron-Bound Terminal Hydride in [FeFe]-Hydrogenase by Nuclear Resonance Vibrational Spectroscopy

(2017) Edward J. Reijerse et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In situ click chemistry generation of cyclooxygenase-2 inhibitors

(2017) Atul Bhardwaj et al.   Nature Communications

Pre-Steady-State Kinetics of Catalytic Intermediates of an [FeFe]-Hydrogenase

(2017) Brandon L. Greene et al.   ACS Catalysis

Guiding Principles of Hydrogenase Catalysis Instigated and Clarified by Protein Film Electrochemistry

(2016) Fraser A. Armstrong et al.   ACCOUNTS OF CHEMICAL RESEARCH

Why Nature Chose Selenium

(2016) Hans J. Reich et al.   ACS Chemical Biology

[FeFe]-Hydrogenase with Chalcogenide Substitutions at the H-Cluster Maintains Full H2 Evolution Activity

(2016) Jens Noth et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Proton Inventory and Dynamics in the Nia-S to Nia-C Transition of a [NiFe] Hydrogenase

(2016) Brandon L. Greene et al.   BIOCHEMISTRY

Single-Amino Acid Modifications Reveal Additional Controls on the Proton Pathway of [FeFe]-Hydrogenase

(2016) Adam J. Cornish et al.   BIOCHEMISTRY

Following [FeFe] Hydrogenase Active Site Intermediates by Time-Resolved Mid-IR Spectroscopy

(2016) Mohammad Mirmohades et al.   Journal of Physical Chemistry Letters

Identification of a Catalytic Iron-Hydride at the H-Cluster of [FeFe]-Hydrogenase

(2016) David W. Mulder et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stepwise isotope editing of [FeFe]-hydrogenases exposes cofactor dynamics

(2016) Moritz Senger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vibrational spectroscopy reveals the initial steps of biological hydrogen evolution

(2016) S. Katz et al.   Chemical Science

A structural view of synthetic cofactor integration into [FeFe]-hydrogenases

(2016) J. Esselborn et al.   Chemical Science

Hybrid [FeFe]-Hydrogenases with Modified Active Sites Show Remarkable Residual Enzymatic Activity

(2015) Judith F. Siebel et al.   BIOCHEMISTRY

Protonation and Proton-Coupled Electron Transfer at S-Ligated [4Fe-4S] Clusters

(2015) Caroline T. Saouma et al.   CHEMISTRY-A EUROPEAN JOURNAL

DFT Dissection of the Reduction Step in H2 Catalytic Production by [FeFe]-Hydrogenase-Inspired Models: Can the Bridging Hydride Become More Reactive Than the Terminal Isomer?

(2015) Giulia Filippi et al.   INORGANIC CHEMISTRY

Proton-Coupled Electron Transfer: Moving Together and Charging Forward

(2015) Sharon Hammes-Schiffer   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Unexpected explanation for the enigmatic acid-catalysed reactivity of [Fe4S4X4]2− clusters

(2014) Ahmed Alwaaly et al.   CHEMICAL COMMUNICATIONS

Hydrogenases

(2014) Wolfgang Lubitz et al.   CHEMICAL REVIEWS

Mimicking hydrogenases: From biomimetics to artificial enzymes

(2014) Trevor R. Simmons et al.   COORDINATION CHEMISTRY REVIEWS

Combining experimental and theoretical methods to learn about the reactivity of gas-processing metalloenzymes

(2014) Claudio Greco et al.   Energy & Environmental Science

Hydride Binding to the Active Site of [FeFe]-Hydrogenase

(2014) Petko Chernev et al.   INORGANIC CHEMISTRY

Changes in the hydrogen-bonding strength of internal water molecules and cysteine residues in the conductive state of channelrhodopsin-1

(2014) Víctor A. Lórenz-Fonfría et al.   JOURNAL OF CHEMICAL PHYSICS

New Redox States Observed in [FeFe] Hydrogenases Reveal Redox Coupling Within the H-Cluster

(2014) Agnieszka Adamska-Venkatesh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Investigations on the Role of Proton-Coupled Electron Transfer in Hydrogen Activation by [FeFe]-Hydrogenase

(2014) David W. Mulder et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The oxidative inactivation of FeFe hydrogenase reveals the flexibility of the H-cluster

(2014) Vincent Fourmond et al.   Nature Chemistry

Resonance Raman Spectroscopy as a Tool to Monitor the Active Site of Hydrogenases

(2013) Elisabeth Siebert et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular basis of [FeFe]-hydrogenase function

(2013) Martin Winkler et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Molecular dynamics study of the proposed proton transport pathways in [FeFe]-hydrogenase

(2013) Bojana Ginovska-Pangovska et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

[FeFe] hydrogenase active site modeling: a key intermediate bearing a thiolate proton and Fe hydride

(2013) Yu-Chiao Liu et al.   CHEMICAL COMMUNICATIONS

Crystallographic Characterization of a Fully Rotated, Basic Diiron Dithiolate: Model for the HredState?

(2013) Wenguang Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Metal–Metal Bond in the Light-Induced State of [NiFe] Hydrogenases with Relevance to Hydrogen Evolution

(2013) Mario Kampa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

EPR and FTIR Analysis of the Mechanism of H2 Activation by [FeFe]-Hydrogenase HydA1 from Chlamydomonas reinhardtii

(2013) David W. Mulder et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biomimetic assembly and activation of [FeFe]-hydrogenases

(2013) G. Berggren et al.   NATURE

Spontaneous activation of [FeFe]-hydrogenases by an inorganic [2Fe] active site mimic

(2013) Julian Esselborn et al.   Nature Chemical Biology

Electronic and molecular structures of the active-site H-cluster in [FeFe]-hydrogenase determined by site-selective X-ray spectroscopy and quantum chemical calculations

(2013) Camilla Lambertz et al.   Chemical Science

Identification and Characterization of the “Super-Reduced” State of the H-Cluster in [FeFe] Hydrogenase: A New Building Block for the Catalytic Cycle?

(2012) Agnieszka Adamska et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Terminal vs Bridging Hydrides of Diiron Dithiolates: Protonation of Fe2(dithiolate)(CO)2(PMe3)4

(2012) Riccardo Zaffaroni et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Site Saturation Mutagenesis Demonstrates a Central Role for Cysteine 298 as Proton Donor to the Catalytic Site in CaHydA [FeFe]-Hydrogenase

(2012) Simone Morra et al.   PLoS One

Targeting Intermediates of [FeFe]-Hydrogenase by CO and CN Vibrational Signatures

(2011) Lian Yu et al.   INORGANIC CHEMISTRY

Importance of the Protein Framework for Catalytic Activity of [FeFe]-Hydrogenases

(2011) Philipp Knörzer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of Proton Transfer in [FeFe]-Hydrogenase fromClostridium pasteurianum

(2011) Adam J. Cornish et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proton-Coupled Electron Flow in Protein Redox Machines

(2010) Jillian L. Dempsey et al.   CHEMICAL REVIEWS

Models for the Active Site in [FeFe] Hydrogenase with Iron-Bound Ligands Derived from Bis-, Tris-, and Tetrakis(mercaptomethyl)silanes

(2010) Ulf-Peter Apfel et al.   INORGANIC CHEMISTRY

Stepwise [FeFe]-hydrogenase H-cluster assembly revealed in the structure of HydAΔEFG

(2010) David W. Mulder et al.   NATURE

Proton-Coupled Electron Transfer in Biology: Results from Synergistic Studies in Natural and Model Systems

(2009) Steven Y. Reece et al.   Annual Review of Biochemistry

Structural and Functional Analogues of the Active Sites of the [Fe]-, [NiFe]-, and [FeFe]-Hydrogenases†

(2009) Cédric Tard et al.   CHEMICAL REVIEWS

How algae produce hydrogen—news from the photosynthetic hydrogenase

(2009) Sven T. Stripp et al.   DALTON TRANSACTIONS

Electrochemical Kinetic Investigations of the Reactions of [FeFe]-Hydrogenases with Carbon Monoxide and Oxygen: Comparing the Importance of Gas Tunnels and Active-Site Electronic/Redox Effects

(2009) Gabrielle Goldet et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure–function relationships of anaerobic gas-processing metalloenzymes

(2009) Juan C. Fontecilla-Camps et al.   NATURE

14N HYSCORE investigation of the H-cluster of [FeFe] hydrogenase: evidence for a nitrogen in the dithiol bridge

(2009) Alexey Silakov et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Isolation and first EPR characterization of the [FeFe]-hydrogenases from green algae

(2008) Christina Kamp et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Small molecule mimics of hydrogenases: hydrides and redox

(2008) Frédéric Gloaguen et al.   CHEMICAL SOCIETY REVIEWS

Optimized over-expression of [FeFe] hydrogenases with high specific activity in Clostridium acetobutylicum

(2008) G VONABENDROTH et al.   INTERNATIONAL JOURNAL OF HYDROGEN ENERGY

Aza- and Oxadithiolates Are Probable Proton Relays in Functional Models for the [FeFe]-Hydrogenases

(2008) Bryan E. Barton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dithiomethylether as a Ligand in the Hydrogenase H-Cluster

(2008) Arti S. Pandey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY