A Multiscale Physiologically-Based Pharmacokinetic Model for Doxorubicin to Explore its Mechanisms of Cytotoxicity and Cardiotoxicity in Human Physiological Contexts

A Model-Based Approach To Assessing the Importance of Intracellular Binding Sites in Doxorubicin Disposition

(2017) Ilse R. Dubbelboer et al.   MOLECULAR PHARMACEUTICS

Pathways of cardiac toxicity: comparison between chemotherapeutic drugs doxorubicin and mitoxantrone

(2016) Roberto Marques Damiani et al.   ARCHIVES OF TOXICOLOGY

Intracellular PK/PD Relationships of Free and Liposomal Doxorubicin: Quantitative Analyses and PK/PD Modeling

(2016) Suvi K. Soininen et al.   MOLECULAR PHARMACEUTICS

A Whole-Body Physiologically Based Pharmacokinetic Model of Gefitinib in Mice and Scale-Up to Humans

(2015) Youwei Bi et al.   AAPS Journal

Physiologically based pharmacokinetic model of lapatinib developed in mice and scaled to humans

(2013) Susan F. Hudachek et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

A Physiologically Based Pharmacokinetic Model of Mitoxantrone in Mice and Scale-up to Humans: a Semi-Mechanistic Model Incorporating DNA and Protein Binding

(2012) Guohua An et al.   AAPS Journal

Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems

(2012) Oktay Tacar et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Pharmacogenetics of genes across the doxorubicin pathway

(2011) David Jamieson et al.   Expert Opinion on Drug Metabolism & Toxicology

Cardiovascular effects of systemic cancer treatment

(2010) Elżbieta Senkus et al.   CANCER TREATMENT REVIEWS

Pharmacokinetic Modeling of Doxorubicin Pharmacokinetics in Dogs Deficient in ABCB1 Drug Transporters

(2010) D.L. Gustafson et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Cardiomyocyte death in doxorubicin-induced cardiotoxicity

(2009) Yi-Wei Zhang et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

To scale or not to scale: the principles of dose extrapolation

(2009) Vijay Sharma et al.   BRITISH JOURNAL OF PHARMACOLOGY

Doxorubicin: The Good, the Bad and the Ugly Effect

(2009) Cristina Carvalho et al.   CURRENT MEDICINAL CHEMISTRY

Influence of ABCB1 and ABCG2 polymorphisms on doxorubicin disposition in Asian breast cancer patients

(2008) Suman Lal et al.   CANCER SCIENCE