Effects of Drying Process on an IgG1 Monoclonal Antibody Using Solid-State Hydrogen Deuterium Exchange with Mass Spectrometric Analysis (ssHDX-MS)
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Title
Effects of Drying Process on an IgG1 Monoclonal Antibody Using Solid-State Hydrogen Deuterium Exchange with Mass Spectrometric Analysis (ssHDX-MS)
Authors
Keywords
conformation, interactions, lyophilization, monoclonal antibodies, spray drying
Journal
PHARMACEUTICAL RESEARCH
Volume 35, Issue 1, Pages -
Publisher
Springer Nature
Online
2018-01-04
DOI
10.1007/s11095-017-2318-9
References
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Note: Only part of the references are listed.- Solid-State Hydrogen–Deuterium Exchange Mass Spectrometry: Correlation of Deuterium Uptake and Long-Term Stability of Lyophilized Monoclonal Antibody Formulations
- (2017) Balakrishnan S. Moorthy et al. MOLECULAR PHARMACEUTICS
- Characterization of Protein–Excipient Microheterogeneity in Biopharmaceutical Solid-State Formulations by Confocal Fluorescence Microscopy
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- Process and Formulation Effects on Protein Structure in Lyophilized Solids Using Mass Spectrometric Methods
- (2016) Lavanya K. Iyer et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Stabilization of proteins in solid form
- (2015) Marcus T. Cicerone et al. ADVANCED DRUG DELIVERY REVIEWS
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- Next Generation Drying Technologies for Pharmaceutical Applications
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- Predicting Protein Aggregation during Storage in Lyophilized Solids Using Solid State Amide Hydrogen/Deuterium Exchange with Mass Spectrometric Analysis (ssHDX-MS)
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- Controlled ice nucleation in the field of freeze-drying: Fundamentals and technology review
- (2013) R. Geidobler et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Localized Hydration in Lyophilized Myoglobin by Hydrogen–Deuterium Exchange Mass Spectrometry. 2. Exchange Kinetics
- (2012) Andreas M. Sophocleous et al. MOLECULAR PHARMACEUTICS
- Localized Hydration in Lyophilized Myoglobin by Hydrogen–Deuterium Exchange Mass Spectrometry. 1. Exchange Mapping
- (2012) Andreas M. Sophocleous et al. MOLECULAR PHARMACEUTICS
- Effect of pH and Excipients on Structure, Dynamics, and Long-Term Stability of a Model IgG1 Monoclonal Antibody upon Freeze-Drying
- (2012) Jihea Park et al. PHARMACEUTICAL RESEARCH
- Interactions of formulation excipients with proteins in solution and in the dried state
- (2011) Satoshi Ohtake et al. ADVANCED DRUG DELIVERY REVIEWS
- Determination of the Influence of Primary Drying Rates on the Microscale Structural Attributes and Physicochemical Properties of Protein Containing Lyophilized Products
- (2010) Andrew Parker et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Stability of Protein Pharmaceuticals: An Update
- (2010) Mark Cornell Manning et al. PHARMACEUTICAL RESEARCH
- Solid state fluorescence of lyophilized proteins
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