Alpha-1 antitrypsin treatment of new-onset type 1 diabetes: An open-label, phase I clinical trial (RETAIN) to assess safety and pharmacokinetics

Alpha-1 antitrypsin therapy is safe and well tolerated in children and adolescents with recent onset type 1 diabetes mellitus

(2015) Marianna Rachmiel et al.   PEDIATRIC DIABETES

Immune-modulating effects of alpha-1 antitrypsin

(2014) Mario R. Ehlers   BIOLOGICAL CHEMISTRY

NOD1 receptor is up-regulated in diabetic human and murine myocardium

(2014) Patricia Prieto et al.   CLINICAL SCIENCE

α1-Antitrypsin Therapy Downregulates Toll-Like Receptor-Induced IL-1β Responses in Monocytes and Myeloid Dendritic Cells and May Improve Islet Function in Recently Diagnosed Patients With Type 1 Diabetes

(2014) Peter A. Gottlieb et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Targeted immune interventions for type 1 diabetes

(2014) Mark R. Rigby et al.   Current Opinion in Endocrinology Diabetes and Obesity

Therapeutic targeting of NOD1 receptors

(2013) L Moreno et al.   BRITISH JOURNAL OF PHARMACOLOGY

Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials

(2013) Antoinette Moran et al.   LANCET

Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial

(2013) Mark R Rigby et al.   Lancet Diabetes & Endocrinology

Fall in C-Peptide During First 2 Years From Diagnosis: Evidence of at Least Two Distinct Phases From Composite Type 1 Diabetes TrialNet Data

(2012) C. J. Greenbaum et al.   DIABETES

Effects of polymorphisms in nucleotide-binding oligomerization domains 1 and 2 on biomarkers of the metabolic syndrome and type II diabetes

(2012) Cristina Cuda et al.   Genes and Nutrition

The Role of TNF-α in Mice with Type 1- and 2- Diabetes

(2012) Maria Koulmanda et al.   PLoS One

Alpha 1-antitrypsin reduces inflammation and enhances mouse pancreatic islet transplant survival

(2012) M. Koulmanda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Making progress: preserving beta cells in type 1 diabetes

(2011) Mary Pat Gallagher et al.   Annals of the New York Academy of Sciences

NOD1 Activators Link Innate Immunity to Insulin Resistance

(2011) J. D. Schertzer et al.   DIABETES

Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial

(2011) Tihamer Orban et al.   LANCET

Etanercept Treatment in Children With New-Onset Type 1 Diabetes: Pilot randomized, placebo-controlled, double-blind study

(2009) L. Mastrandrea et al.   DIABETES CARE

α-1-Antitrypsin is an endogenous inhibitor of proinflammatory cytokine production in whole blood

(2009) Gregory B. Pott et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function

(2009) Mark D. Pescovitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Curative and   cell regenerative effects of  1-antitrypsin treatment in autoimmune diabetic NOD mice

(2008) M. Koulmanda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA