Andrographolide Ameliorates Liver Fibrosis in Mice: Involvement of TLR4/NF-κB and TGF-β1/Smad2 Signaling Pathways

Transforming Growth Factor-β (TGF-β) Directly Activates the JAK1-STAT3 Axis to Induce Hepatic Fibrosis in Coordination with the SMAD Pathway

(2017) Liu-Ya Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoplasmic Reticulum Stress in Hepatic Stellate Cells Promotes Liver Fibrosis via PERK-Mediated Degradation of HNRNPA1 and Up-regulation of SMAD2

(2016) Ja Hyun Koo et al.   GASTROENTEROLOGY

The secretin/secretin receptor axis modulates liver fibrosis through changes in transforming growth factor-β1 biliary secretion in mice

(2016) Nan Wu et al.   HEPATOLOGY

Runt-related Transcription Factor 1 (RUNX1) Binds to p50 in Macrophages and Enhances TLR4-triggered Inflammation and Septic Shock

(2016) Mao-Cai Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Andrographolide ameliorates diabetic nephropathy by attenuating hyperglycemia-mediated renal oxidative stress and inflammation via Akt/NF-κB pathway

(2016) Xiaoqian Ji et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Insights into the Role and Interdependence of Oxidative Stress and Inflammation in Liver Diseases

(2016) Sha Li et al.   Oxidative Medicine and Cellular Longevity

Andrographolide derivative AL-1 ameliorates TNBS-induced colitis in mice: involvement of NF-кB and PPAR-γ signaling pathways

(2016) Yali Yang et al.   Scientific Reports

Activation of Slit2-Robo1 signaling promotes liver fibrosis

(2015) Jianlan Chang et al.   JOURNAL OF HEPATOLOGY

Hepatic fibrosis: Concept to treatment

(2015) Christian Trautwein et al.   JOURNAL OF HEPATOLOGY

Modulation of thioacetamide-induced hepatic inflammations, angiogenesis and fibrosis by andrographolide in mice

(2014) Tzung-Yan Lee et al.   JOURNAL OF ETHNOPHARMACOLOGY

Inflammation and portal hypertension – The undiscovered country

(2014) Gautam Mehta et al.   JOURNAL OF HEPATOLOGY

Thymoquinone attenuates liver fibrosis via PI3K and TLR4 signaling pathways in activated hepatic stellate cells

(2013) Ting Bai et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Andrographolide Protects against LPS-Induced Acute Lung Injury by Inactivation of NF-κB

(2013) Tao Zhu et al.   PLoS One

Resveratrol improves intrahepatic endothelial dysfunction and reduces hepatic fibrosis and portal pressure in cirrhotic rats

(2012) Marco Di Pascoli et al.   JOURNAL OF HEPATOLOGY

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

(2012) P. Ramachandran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-fibrogenic strategies and the regression of fibrosis

(2011) Tatiana Kisseleva et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Intestinal decontamination inhibits TLR4 dependent fibronectin-mediated cross-talk between stellate cells and endothelial cells in liver fibrosis in mice

(2011) Qiang Zhu et al.   JOURNAL OF HEPATOLOGY

Modulation of the cannabinoid receptors by andrographolide attenuates hepatic apoptosis following bile duct ligation in rats with fibrosis

(2010) Tzung-Yan Lee et al.   APOPTOSIS

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

Functional linkage of cirrhosis-predictive single nucleotide polymorphisms of toll-like receptor 4 to hepatic stellate cell responses

(2008) Jinsheng Guo et al.   HEPATOLOGY

NF-κB Transcription Factor p50 Critically Regulates Tissue Factor in Deep Vein Thrombosis

(2008) Yi-Dan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liver cirrhosis

(2008) Detlef Schuppan et al.   LANCET