Extracellular vesicle-mediated delivery of molecular compounds into gametes and embryos: learning from nature

Bioconjugated Gold Nanoparticles Penetrate Into Spermatozoa Depending on Plasma Membrane Status

(2015) Annette Barchanski et al.   Journal of Biomedical Nanotechnology

Functionalization of mesoporous silica nanoparticles with a cell-penetrating peptide to target mammalian spermin vitro

(2015) Natalia Barkalina et al.   Nanomedicine

108 CHARACTERIZATION OF BOVINE OVIDUCTAL EXOSOMES FROM IN VIVO AND IN VITRO ORIGIN

(2015) C. Almi�ana et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

266 BIOCOMPATIBILITY OF NANOCERIA IN RAM SPERM DURING 24 HOURS OF INCUBATION

(2015) L. Falchi et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Placenta-Derived Exosomes and Syncytiotrophoblast Microparticles and their Role in Human Reproduction: Immune Modulation for Pregnancy Success

(2014) Lucia Mincheva-Nilsson et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Cell-based Therapy for Acute Organ Injury

(2014) Antoine Monsel et al.   ANESTHESIOLOGY

Increased Conception Rates in Beef Cattle Inseminated with Nanopurified Bull Semen1

(2014) John F. Odhiambo et al.   BIOLOGY OF REPRODUCTION

Exosomes as divine messengers: are they the Hermes of modern molecular oncology?

(2014) C Braicu et al.   CELL DEATH AND DIFFERENTIATION

Embryonic Toxicity of Nanoparticles

(2014) Petra Celá et al.   CELLS TISSUES ORGANS

Improvement of Cloned Embryos Development by Co-Culturing with Parthenotes: A Possible Role of Exosomes/Microvesicles for Embryos Paracrine Communication

(2014) Islam M. Saadeldin et al.   Cellular Reprogramming

Progress in the delivery of nanoparticle constructs: towards clinical translation

(2014) Sinéad M Ryan et al.   CURRENT OPINION IN PHARMACOLOGY

Molecular characterization of exosomes and their microRNA cargo in human follicular fluid: bioinformatic analysis reveals that exosomal microRNAs control pathways involved in follicular maturation

(2014) Manuela Santonocito et al.   FERTILITY AND STERILITY

Clinically relevant enhancement of human sperm motility using compounds with reported phosphodiesterase inhibitor activity

(2014) Steve Tardif et al.   HUMAN REPRODUCTION

BMP-regulated exosomes fromDrosophilamale reproductive glands reprogram female behavior

(2014) Laura Corrigan et al.   JOURNAL OF CELL BIOLOGY

Cell-penetrating peptide delivery of biologically active oct4 protein into culturedTakifugu rubripesspermary cells

(2014) X. X. Yang et al.   JOURNAL OF FISH BIOLOGY

Microfluidic fabrication of cell-derived nanovesicles as endogenous RNA carriers

(2014) Wonju Jo et al.   LAB ON A CHIP

Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice

(2014) J. Mark Cooper et al.   MOVEMENT DISORDERS

Nanotechnology in reproductive medicine: Emerging applications of nanomaterials

(2014) Natalia Barkalina et al.   Nanomedicine-Nanotechnology Biology and Medicine

Large-scale generation of cell-derived nanovesicles

(2014) W. Jo et al.   Nanoscale

Nanoparticle Incorporation of Melittin Reduces Sperm and Vaginal Epithelium Cytotoxicity

(2014) Andrew P. Jallouk et al.   PLoS One

Regulation of ACVR1 and ID2 by cell-secreted exosomes during follicle maturation in the mare

(2014) Juliano C da Silveira et al.   Reproductive Biology and Endocrinology

Effect of crotamine, a cell-penetrating peptide, on blastocyst production and gene expression of in vitro fertilized bovine embryos

(2014) Iana S. Campelo et al.   ZYGOTE

Exosomes/miRNAs as mediating cell-based therapy of stroke

(2014) Hongqi Xin et al.   Frontiers in Cellular Neuroscience

Injection of ligand-free gold and silver nanoparticles into murine embryos does not impact pre-implantation development

(2014) Ulrike Taylor et al.   Beilstein Journal of Nanotechnology

Extravillous trophoblast cells-derived exosomes promote vascular smooth muscle cell migration

(2014) Carlos Salomon et al.   Frontiers in Pharmacology

Bioinspired Exosome-Mimetic Nanovesicles for Targeted Delivery of Chemotherapeutics to Malignant Tumors

(2013) Su Chul Jang et al.   ACS Nano

Reprotoxicity of gold, silver, and gold–silver alloy nanoparticles on mammalian gametes

(2013) Daniela Tiedemann et al.   ANALYST

Exosomes as new vesicular lipid transporters involved in cell–cell communication and various pathophysiologies

(2013) Michel Record et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis1

(2013) Clémence Belleannée et al.   BIOLOGY OF REPRODUCTION

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

(2013) Yanhua Tian et al.   BIOMATERIALS

Vesicular transfer of membrane components to bovine epididymal spermatozoa

(2013) A. Schwarz et al.   CELL AND TISSUE RESEARCH

Effects of combined antioxidant supplementation on human sperm motility and morphology during sperm manipulation in vitro

(2013) Jung Im Yun et al.   FERTILITY AND STERILITY

Levels of the oocyte activation factor, phospholipase c zeta, in human sperm are reduced following incubation with polyvinylpyrrolidone (PVP)

(2013) S. Yelumalai et al.   FERTILITY AND STERILITY

Changes in DNA fragmentation during sperm preparation for intracytoplasmic sperm injection over time

(2013) Natalia Rougier et al.   FERTILITY AND STERILITY

The number of babies born globally after treatment with the assisted reproductive technologies (ART)

(2013) G.D. Adamson et al.   FERTILITY AND STERILITY

Intracellular translocation and differential accumulation of cell-penetrating peptides in bovine spermatozoa: evaluation of efficient delivery vectors that do not compromise human sperm motility

(2013) S. Jones et al.   HUMAN REPRODUCTION

Strategies to support human oocyte development in vitro

(2013) Evelyn E. Telfer et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Ultrastructural Interactions and Genotoxicity Assay of Cerium Dioxide Nanoparticles on Mouse Oocytes

(2013) Blandine Courbiere et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection

(2013) Yuki Takahashi et al.   JOURNAL OF BIOTECHNOLOGY

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Exosomes Secreted by Human Placenta Carry Functional Fas Ligand and TRAIL Molecules and Convey Apoptosis in Activated Immune Cells, Suggesting Exosome-Mediated Immune Privilege of the Fetus

(2013) A.-C. Stenqvist et al.   JOURNAL OF IMMUNOLOGY

Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies

(2013) Johnny C. Akers et al.   JOURNAL OF NEURO-ONCOLOGY

Morphological and cytogenetic assessment of cleavage and blastocyst stage embryos

(2013) E. Fragouli et al.   MOLECULAR HUMAN REPRODUCTION

Intelligent nanomaterials for medicine: Carrier platforms and targeting strategies in the context of clinical application

(2013) Roman Lehner et al.   Nanomedicine-Nanotechnology Biology and Medicine

Effects of mesoporous silica nanoparticles upon the function of mammalian sperm in vitro

(2013) Natalia Barkalina et al.   Nanomedicine-Nanotechnology Biology and Medicine

Gold nanoparticles interfere with sperm functionality by membrane adsorption without penetration

(2013) Ulrike Taylor et al.   Nanotoxicology

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

Endometrial Exosomes/Microvesicles in the Uterine Microenvironment: A New Paradigm for Embryo-Endometrial Cross Talk at Implantation

(2013) York Hunt Ng et al.   PLoS One

CD9-Positive Microvesicles Mediate the Transfer of Molecules to Bovine Spermatozoa during Epididymal Maturation

(2013) Julieta N. Caballero et al.   PLoS One

Exosomal Signaling during Hypoxia Mediates Microvascular Endothelial Cell Migration and Vasculogenesis

(2013) Carlos Salomon et al.   PLoS One

Exosomal and Non-Exosomal Transport of Extra-Cellular microRNAs in Follicular Fluid: Implications for Bovine Oocyte Developmental Competence

(2013) Md. Mahmodul Hasan Sohel et al.   PLoS One

Expression and Secretion of Plasma Membrane Ca2+-ATPase 4a (PMCA4a) during Murine Estrus: Association with Oviductal Exosomes and Uptake in Sperm

(2013) Amal A. Al-Dossary et al.   PLoS One

Distinct lipid compositions of two types of human prostasomes

(2013) Jos F. Brouwers et al.   PROTEOMICS

Contribution of proteomics to understanding the role of tumor-derived exosomes in cancer progression: State of the art and new perspectives

(2013) Fontana Simona et al.   PROTEOMICS

Epididymosomes, prostasomes, and liposomes: their roles in mammalian male reproductive physiology

(2013) Robert Sullivan et al.   REPRODUCTION

Application of a novel cell-permeable peptide-driven protein delivery in mouse blastocysts

(2013) Sojung Kwon et al.   REPRODUCTION

Boar seminal plasma exosomes: Effect on sperm function and protein identification by sequencing

(2013) Lidia L. Piehl et al.   THERIOGENOLOGY

Systematic review: the applications of nanotechnology in gastroenterology

(2012) G. Brakmane et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems

(2012) Alexandre Albanese et al.   Annual Review of Biomedical Engineering

Epididymosomes Transfer Epididymal Sperm Binding Protein 1 (ELSPBP1) to Dead Spermatozoa During Epididymal Transit in Bovine1

(2012) Olivier D'Amours et al.   BIOLOGY OF REPRODUCTION

Abstract 5235: Surgical stress promotes the development of cancer metastases by coagulation dependent inhibition of natural-killer cell mediated tumor cell clearance

(2012) Rashmi Seth et al.   CANCER RESEARCH

cSrc is necessary for epididymal development and is incorporated into sperm during epididymal transit

(2012) Dario Krapf et al.   DEVELOPMENTAL BIOLOGY

Embryo incubation and selection in a time-lapse monitoring system improves pregnancy outcome compared with a standard incubator: a retrospective cohort study

(2012) Marcos Meseguer et al.   FERTILITY AND STERILITY

Paternal DNA Damage Resulting From Various Sperm Treatments Persists After Fertilization and Is Similar Before and After DNA Replication

(2012) Y. Yamauchi et al.   JOURNAL OF ANDROLOGY

Bovine sperm raft membrane associated Glioma Pathogenesis-Related 1-like protein 1 (GliPr1L1) is modified during the epididymal transit and is potentially involved in sperm binding to the zona pellucida

(2012) Julieta Caballero et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cell entry of cell penetrating peptides: tales of tails wagging dogs

(2012) Arwyn T. Jones et al.   JOURNAL OF CONTROLLED RELEASE

The next big things are tiny

(2012) David Holmes   LANCET NEUROLOGY

Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth

(2012) Arda Mizrak et al.   MOLECULAR THERAPY

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

(2012) Shin-ichiro Ohno et al.   MOLECULAR THERAPY

Nanomedicine for the prevention, treatment and imaging of atherosclerosis

(2012) Costas Psarros et al.   Nanomedicine-Nanotechnology Biology and Medicine

Exosome-mediated delivery of siRNA in vitro and in vivo

(2012) Samir El-Andaloussi et al.   Nature Protocols

Review: Does size matter? Placental debris and the pathophysiology of pre-eclampsia

(2012) C.W.G. Redman et al.   PLACENTA

Promotion of Human Early Embryonic Development and Blastocyst Outgrowth In Vitro Using Autocrine/Paracrine Growth Factors

(2012) Kazuhiro Kawamura et al.   PLoS One

The Membrane of the Mammalian Spermatozoa: Much More Than an Inert Envelope

(2012) JA Tapia et al.   REPRODUCTION IN DOMESTIC ANIMALS

Mesenchymal Stem Cells for Cardiac Therapy: Practical Challenges and Potential Mechanisms

(2012) Timothy J. Cashman et al.   Stem Cell Reviews and Reports

Application of quantum dot nanoparticles for potential non-invasive bio-imaging of mammalian spermatozoa

(2012) Jean M Feugang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Theranostic Nanomedicine

(2011) Twan Lammers et al.   ACCOUNTS OF CHEMICAL RESEARCH

Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle1

(2011) Juliano C. da Silveira et al.   BIOLOGY OF REPRODUCTION

Identification of Distinct Populations of Prostasomes That Differentially Express Prostate Stem Cell Antigen, Annexin A1, and GLIPR2 in Humans1

(2011) Marian Aalberts et al.   BIOLOGY OF REPRODUCTION

Prostasomal DNA characterization and transfer into human sperm

(2011) Göran K. Ronquist et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

(2011) Xiaoying Zhuang et al.   MOLECULAR THERAPY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Effects of cryopreservation and density-gradient washing on phospholipase C zeta concentrations in human spermatozoa

(2011) Junaid Kashir et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Ca2+ Signaling Tools Acquired from Prostasomes Are Required for Progesterone-Induced Sperm Motility

(2011) K.-H. Park et al.   Science Signaling

NanoSMGT: transfection of exogenous DNA on sex-sorted bovine sperm using nanopolymer

(2011) V.F. Campos et al.   THERIOGENOLOGY

NanoSMGT: Transgene transmission into bovine embryos using halloysite clay nanotubes or nanopolymer to improve transfection efficiency

(2011) Vinicius Farias Campos et al.   THERIOGENOLOGY

Preparation and incubation conditions affect the DNA integrity of ejaculated human spermatozoa

(2010) Rieko Matsuura et al.   ASIAN JOURNAL OF ANDROLOGY

Toxicology of engineered nanomaterials: Focus on biocompatibility, biodistribution and biodegradation

(2010) Andrea Kunzmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Prostasomes: inhibitors of capacitation and modulators of cellular signalling in human sperm

(2010) H. Pons-Rejraji et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

(2010) Dongmei Sun et al.   MOLECULAR THERAPY

Microvesicle-mediated RNA Molecule Delivery System Using Monocytes/Macrophages

(2010) Yukihiro Akao et al.   MOLECULAR THERAPY

Strategies in the design of nanoparticles for therapeutic applications

(2010) Robby A. Petros et al.   NATURE REVIEWS DRUG DISCOVERY

Contribution of culture media to oxidative stress and its effect on human oocytes

(2010) Francisco Javier Martín-Romero et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Nanomedicine-Challenge and Perspectives

(2009) Kristina Riehemann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Compartmentalization of Proteins in Epididymosomes Coordinates the Association of Epididymal Proteins with the Different Functional Structures of Bovine Spermatozoa1

(2009) Julie Girouard et al.   BIOLOGY OF REPRODUCTION

Processing of semen can result in increased sperm DNA fragmentation

(2009) Estefanía Toro et al.   FERTILITY AND STERILITY

Targeted drug-delivery approaches by nanoparticulate carriers in the therapy of inflammatory diseases

(2009) W. Ulbrich et al.   Journal of the Royal Society Interface

The solubilisation of boar sperm membranes by different detergents - a microscopic, MALDI-TOF MS, 31P NMR and PAGE study on membrane lysis, extraction efficiency, lipid and protein composition

(2009) Ulrike Jakop et al.   Lipids in Health and Disease

ADAM7 is associated with epididymosomes and integrated into sperm plasma membrane

(2009) Jeong Su Oh et al.   MOLECULES AND CELLS

Effect of sperm treatment on efficiency of EGFP-expressing porcine embryos produced by ICSI-SMGT

(2009) F.A. García-Vázquez et al.   THERIOGENOLOGY

Damage of embryo development caused by peroxidized mineral oil and its association with albumin in culture

(2008) Junko Otsuki et al.   FERTILITY AND STERILITY

Structural heterogeneity and protein composition of exosome-like vesicles (prostasomes) in human semen

(2008) Anton Poliakov et al.   PROSTATE

Effect of N-acetyl-L-cysteine Supplementation in Semen Extenders on Semen Quality and Reactive Oxygen Species of Chilled Canine Spermatozoa

(2008) AJ Michael et al.   REPRODUCTION IN DOMESTIC ANIMALS

Prostasome-like vesicles stimulate acrosome reaction of pig spermatozoa

(2008) Laura Siciliano et al.   Reproductive Biology and Endocrinology

Modified PVA-Fe3O4Nanoparticles as Protein Carriers into Sperm Cells

(2008) Shirly Ben-David Makhluf et al.   Small