Article
Biochemistry & Molecular Biology
Fanny Jumeau, Nathalie Rives, Pauline Lechevallier, Coline Boniou, Maria Letailleur, Audrey Real-Lhommet, Aurelie Feraille
Summary: Sperm chromatin condensation is found to have an impact on the kinetics of early embryo development. However, it does not affect live birth rates or the occurrence of miscarriages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Obstetrics & Gynecology
Kiri H. Beilby, Ezra Kneebone, Tessa J. Roseboom, Indah M. van Marrewijk, Jeremy G. Thompson, Robert J. Norman, Rebecca L. Robker, Ben Willem J. Mol, Rui Wang
Summary: Since the first IVF baby was born in 1978, over 10 million children have been conceived via ART. The long-term safety of these technologies was not comprehensively assessed before their introduction into clinical practice. This systematic review and meta-analysis examined the evidence from animal studies on the physiological outcomes of offspring conceived through IVF, IVM, or ICSI compared to natural conception, providing insights into the long-term safety of reproductive technologies.
HUMAN REPRODUCTION UPDATE
(2023)
Article
Obstetrics & Gynecology
Robert B. Gilchrist, Johan Smitz
Summary: Oocyte in vitro maturation (IVM) is a minimally invasive technique involving the collection and culture of immature oocytes to maturity outside the body. It is now classified as nonexperimental and is primarily indicated for patients with a high antral follicle count and for fertility preservation in cancer patients. Significant advances in IVM culture methods have been made based on animal studies and a simplified patient treatment protocol, leading to its routine practice in specialized centers worldwide.
FERTILITY AND STERILITY
(2023)
Review
Reproductive Biology
Gabriela Ramos Leal, Clara Ana Santos Monteiro, Luciano de Rezende Carvalheira, Joanna M. G. Souza-Fabjan
Summary: Simulated Physiological Oocyte Maturation (SPOM) is an in vitro method that mimics the physiological events of oocyte maturation using cAMP modulators. This study systematically analyzes the literature on the use of SPOM and compares the outcomes to the original study. The results indicate difficulties in reproducing the SPOM system worldwide and suggest that meiosis arrest alone is not sufficient for successful SPOM application. The different supplements used in the IVM medium and their interaction with modulators may impact experimental success.
Article
Medicine, General & Internal
Huahua Jiang, Yaxin Guo, Lixue Chen, Huifeng Shi, Ning Huang, Hongbin Chi, Rui Yang, Xiaoyu Long, Jie Qiao
Summary: Polycystic ovary syndrome (PCOS) can lead to fertility and metabolism disorders, increasing the risk of glucose metabolism disorders and health hazards for women and their offspring. This study aimed to assess the impact of maternal preconception glucose metabolism on neonatal birthweight in PCOS women undergoing IVF/ICSI cycles. The results indicated that maternal preconception glucose metabolism indicators had associations with singleton and twin birthweight in PCOS women, with potential interaction effects observed in relation to maternal preconception BMI and delivery mode. These findings highlight the importance of preconception glucose and insulin management for PCOS women.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Chloe De Roo, Kelly Tilleman
Summary: In vitro maturation of ovarian tissue oocytes is an effective assisted reproductive treatment, but further validation and research are needed for its effectiveness. The introduction of biphasic IVM (CAPA-IVM) has shown significant improvement in the maturation protocol for oocytes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Wei Guo, Yalan Xu, Tian Tian, Shuo Yang, Rong Li, Jie Qiao, Xiaoying Zheng
Summary: This study compared the impact of in vitro maturation (IVM) treatment on subsequent in vitro fertilization (IVF) cycles in women with polycystic ovary syndrome (PCOS). The results showed that even if the first IVM attempt failed, comparable cumulative live birth rates were observed in the subsequent IVF cycle. IVM treatment does not adversely affect the subsequent IVF cycle.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Robert B. Gilchrist, Tuong M. Ho, Michel De Vos, Flor Sanchez, Sergio Romero, William L. Ledger, Ellen Anckaert, Lan N. Vuong, Johan Smitz
Summary: Recent advances in understanding oocyte biology and ovulation from animal studies have led to the development of biphasic IVM approaches, which involve pre-culturing immature oocytes before routine in vitro maturation. This novel procedure has the potential to significantly impact human ART practices. This review examines the scientific advances in ovarian biology, biphasic IVM procedures, and reports on outcomes from animal and clinical human data.
HUMAN REPRODUCTION UPDATE
(2023)
Article
Andrology
Arief Boediono, Nining Handayani, Henny Natalya Sari, Nuraeni Yusup, Wahyu Indrasari, Arie A. Polim, Ivan Sini
Summary: The study found that IMSI and ICSI resulted in embryos with similar morphokinetics, but IMSI had a lower incidence of multinucleation compared to ICSI. However, neither method showed an improvement in the proportion of chromosomally euploid embryos.
Article
Biochemistry & Molecular Biology
Huixia Yang, Thomas Kolben, Sarah Meister, Corinna Paul, Julia van Dorp, Sibel Eren, Christina Kuhn, Martina Rahmeh, Sven Mahner, Udo Jeschke, Viktoria von Schoenfeldt
Summary: In vitro maturation of oocytes is considered a simple and safe assisted reproductive technology, mainly used for patients with impaired oocyte maturation and women at risk of losing fertility. However, its underperformance limits its widespread clinical use. Factors such as the IVM system, culture medium, and supplementation significantly affect the outcomes of oocyte IVM, but further research is needed to fully clarify their roles.
Article
Endocrinology & Metabolism
Zhuoyao Mai, Manlin Liu, Ping Pan, Lin Li, Jia Huang, Xiaoli Chen, Dongzi Yang
Summary: This study found that women with PCOS aged 35 years and older had a higher cumulative live birth rate over two years of IVF/ICSI cycles compared with age- and BMI-matched controls. Factors such as the number of transferable embryos and antral follicle counts were significant predictors of cumulative live birth.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Neelke De Munck, Asina Bayram, Ibrahim Elkhatib, Andrea Abdala, Ahmed El-Damen, Ana Arnanz, Laura Melado, Barbara Lawrenz, Human Mousavi Fatemi
Summary: Minor morphokinetic differences are observed between conventional IVF and ICSI. Distinct cleavage patterns are observed between embryos that will undergo biopsy and those that will not, early in the development.
Article
Endocrinology & Metabolism
Yiqing Yang, Bowen Liu, Gengxiang Wu, Jing Yang
Summary: In PCOS patients, progesterone level is correlated with clinical pregnancy rate while P/E2 ratio is not. In subgroup analysis using three different COS protocols, a significant association between progesterone level and clinical pregnancy rate can be observed in the long GnRH agonist protocol and ultralong GnRH agonist protocol. Progesterone level is significantly better than the P/E2 ratio in predicting the pregnancy outcome of PCOS patients, especially in ultralong GnRH agonist cycles.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sofia Persson, Kumari A. Ubhayasekera, Jonas Bergquist, Sahruh Turkmen, Inger Sundstroem Poromaa, Evangelia Elenis
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women, and hyperandrogenism can cause psychological morbidity and impaired quality of life. This study aimed to investigate whether hyperandrogenism persists into midlife and its impact on quality of life.
Article
Medicine, General & Internal
Enrico Carmina
Summary: The diagnosis of PCOS is based on the Rotterdam guidelines, but the current classification does not include obesity and metabolic changes. This makes it challenging to establish clear strategies for follow-up and treatment of high-risk patients and may hide genetic or environmental differences between PCOS patients. A new classification is suggested which divides each Rotterdam phenotype into obese or lean sub-phenotypes, aiming to improve our understanding and treatment of PCOS.
Article
Clinical Neurology
Megan Galbally, Stuart J. Watson, Jeffrey A. Keelan, Olav Spigset, Andrew Lewis
Summary: This study examined the relationship between antidepressant use during the perinatal period and oxytocin levels. While concurrent oxytocin blood concentrations were not associated with antidepressant use, women taking antidepressants during pregnancy showed larger increases in oxytocin over the perinatal period compared to control women. Future research could investigate specific antidepressant agents and their impact on parenting.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Review
Obstetrics & Gynecology
Laura A. Wijs, Melinda R. Fusco, Dorota A. Doherty, Jeffrey A. Keelan, Roger J. Hart
Summary: The study revealed a trend towards a significantly increased risk of asthma in offspring conceived after ART, but not allergies.
HUMAN REPRODUCTION UPDATE
(2022)
Article
Pediatrics
Jacob Twiss, Alistair Stewart, Catherine A. Gilchrist, Jeffrey A. Keelan, Russell Metcalfe, Catherine A. Byrnes
Summary: This study investigates the efficacy of nebulised gentamicin in improving respiratory function in children with bronchiectasis. The results show that gentamicin reduces sputum bacterial density and inflammation, but does not lead to major improvements in clinical outcomes. Adherence to treatment was also a challenge.
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2022)
Article
Obstetrics & Gynecology
L. A. Wijs, D. A. Doherty, J. A. Keelan, V Panicker, P. Burton, J. L. Yovich, R. J. Hart
Summary: This study found no clinically relevant differences in thyroid function between adolescents and young adults conceived with and without ART.
HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
L. A. Wijs, D. A. Doherty, J. A. Keelan, P. Burton, J. L. Yovich, L. Beilin, T. A. Mori, R. C. Huang, L. A. Adams, J. K. Olynyk, O. T. Ayonrinde, B. Penova-Veselinovic, R. J. Hart
Summary: A study comparing cardiometabolic health parameters between adolescents conceived through ART and those conceived without ART found that the majority of health indicators were similar or more favorable in the ART group.
HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
Laura A. Wijs, Dorota A. Doherty, Jeffrey A. Keelan, Blagica Penova-Veselinovic, Peter Burton, John L. Yovich, Graham L. Hall, Peter D. Sly, Patrick G. Holt, Roger J. Hart
Summary: Adolescents conceived with assisted reproductive technologies (ART) show no difference in asthma prevalence compared to those conceived without, but have slightly altered lung function, increased rates of allergic rhinoconjunctivitis, food allergies, and positive skin prick testing.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Nutrition & Dietetics
Debra J. Palmer, Jeffrey Keelan, Johan Garssen, Karen Simmer, Maria C. Jenmalm, Ravisha Srinivasjois, Desiree Silva, Susan L. Prescott
Summary: Infant allergy is an early sign of increased inflammation and immune dysregulation in modern environments, often caused by refined low-fibre diets. This study focuses on the potential benefits of prebiotic dietary fibres in changing gut microbiota and reducing the risk of allergic disease in infants. A randomized controlled trial is being conducted to investigate the effects of maternal prebiotic supplementation on child allergic disease outcomes.
Article
Obstetrics & Gynecology
L. A. Wijs, D. A. Doherty, J. A. Keelan, P. Burton, J. L. Yovich, M. Robinson, R. J. Hart
Summary: The study found differences in behavior and mental health outcomes between adolescents conceived with and without ART, showing less externalizing behavior but more internalizing behavior and clinical depression in the ART group. These differences were observed at age 14 but not at age 17.
HUMAN REPRODUCTION
(2022)
Article
Respiratory System
Rachel E. Foong, Peter Franklin, Francesca Sanna, Graham L. Hall, Peter D. Sly, Eric B. Thorstensen, Dorota A. Doherty, Jeffrey A. Keelan, Roger J. Hart
Summary: This study investigated the effects of prenatal exposure to phthalates and bisphenol A (BPA) on asthma, allergy, and lung function outcomes from childhood to adulthood. The results showed that prenatal BPA exposure was associated with an increased likelihood of persistent asthma in males, while prenatal phthalate exposure was associated with an increased likelihood of adult asthma in males. However, lung function was not adversely affected by prenatal exposure to these chemicals.
Article
Environmental Sciences
Ye'elah E. Berman, Dorota A. Doherty, Trevor A. Mori, Lawrence J. Beilin, Oyekoya T. Ayonrinde, Leon A. Adams, Rae-Chi Huang, John K. Olynyk, Jeffrey A. Keelan, John P. Newnham, Roger J. Hart
Summary: This study found that prenatal exposure to phthalate metabolites is associated with adverse metabolic profiles. Prenatal exposure to mono-carboxy-iso-octyl phthalate (MCiOP) is positively correlated with systolic blood pressure, while prenatal exposure to mono-n-butyl phthalate (MnBP) is associated with a higher incidence of non-alcoholic fatty liver disease (NAFLD). Prenatal exposure to Mono-3-carboxypropyl phthalate (MCPP) is linked to lower serum HDL-C levels, and higher prenatal exposure to mono-iso-butyl phthalate (MiBP) is associated with higher LDL-C levels. Additionally, mid-level prenatal exposure to mono-2-ethylhexyl phthalate (MEHP) metabolites is connected to higher insulin levels in adulthood, and higher prenatal exposure to Di-(2-ethyl-hexyl) phthalate (DEHP) and Di-iso-nonyl phthalate (DiNP) metabolites is linked to higher fasting serum glucose levels in adulthood.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Microbiology
Lisa F. Stinson, Yey Berman, Shaofu Li, Jeffrey A. Keelan, Jan E. Dickinson, Dorota A. Doherty, John P. Newnham, Matthew S. Payne
Summary: There is a strong association between intrauterine bacteria and preterm birth. This study investigated the bacterial and cytokine profiles in mid-gestation amniotic fluid samples from Australian preterm and term births. The results showed low diversity and richness in bacterial DNA profiles, with no significant differences between term and preterm samples. Certain cytokine levels were elevated in the presence of specific bacteria, but the biological relevance of this remains unknown.
Article
Obstetrics & Gynecology
Yuki Takahashi, Tsukasa Takahashi, Haruo Usuda, Sean Carter, Erin L. Fee, Lucy Furfaro, Sylvain Chemtob, David M. Olson, Jeffrey A. Keelan, Suhas Kallapur, Matthew W. Kemp
Summary: The study demonstrates that intraamniotic administration of rytvela and anakinra can significantly inhibit inflammation induced by intraamniotic lipopolysaccharide in preterm fetal sheep, protecting the fetal brain.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Meeting Abstract
Obstetrics & Gynecology
L. Wijs, D. A. Doherty, J. A. Keelan, B. Penova-Veselinovic, P. Burton, J. L. Yovich, G. L. Hall, P. D. Sly, P. G. Holt, R. J. Hart
HUMAN REPRODUCTION
(2022)
Meeting Abstract
Obstetrics & Gynecology
L. Wijs, D. Doherty, J. Keelan, P. Burton, J. Yovich, L. Beilin, T. Mori, R. C. Huang, L. Adams, J. Olynyk, O. Ayonrinde, R. Hart
HUMAN REPRODUCTION
(2021)
Article
Microbiology
Alishum Ali, Claus T. Christophersen, Jeffrey A. Keelan
Summary: Preterm birth is a significant global health issue, leading to high mortality and morbidity rates among neonates. Understanding the role of vaginal bacteria in triggering biomolecular causes of PTB is crucial, but practical applications of this knowledge remain challenging. New techniques in high-throughput sequencing have improved our understanding of the vaginal microbiome, offering potential cost-effective alternatives for analysis.
MICROBIOLOGY AUSTRALIA
(2021)