Protected 5-(hydroxymethyl)uracil nucleotides bearing visible-light photocleavable groups as building blocks for polymerase synthesis of photocaged DNA

Reversible modification of DNA by methyltransferase-catalyzed transfer and light-triggered removal of photo-caging groups

(2018) Lea Anhäuser et al.   CHEMICAL COMMUNICATIONS

Structural Insights into the Processing of Nucleobase-Modified Nucleotides by DNA Polymerases

(2016) Audrey Hottin et al.   ACCOUNTS OF CHEMICAL RESEARCH

Three-Dimensional Control of DNA Hybridization by Orthogonal Two-Color Two-Photon Uncaging

(2016) Manuela A. H. Fichte et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Replacement of Thymidine by a Modified Base in the Escherichia coli Genome

(2016) Angad P. Mehta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enigmatic 5-hydroxymethyluracil: Oxidatively modified base, epigenetic mark or both?

(2016) Ryszard Olinski et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Influence of major-groove chemical modifications of DNA on transcription by bacterial RNA polymerases

(2016) Veronika Raindlová et al.   NUCLEIC ACIDS RESEARCH

DNA hydroxymethylation controls cardiomyocyte gene expression in development and hypertrophy

(2016) Carolina M. Greco et al.   Nature Communications

Searching for Improved Photoreleasing Abilities of Organic Molecules

(2015) Tomáš Šolomek et al.   ACCOUNTS OF CHEMICAL RESEARCH

Age-Dependent Levels of 5-Methyl-, 5-Hydroxymethyl-, and 5-Formylcytosine in Human and Mouse Brain Tissues

(2015) Mirko Wagner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Polymerase Synthesis and Restriction Enzyme Cleavage of DNA Containing 7-Substituted 7-Deazaguanine Nucleobases

(2015) Michaela Mačková et al.   CHEMBIOCHEM

TET Family Proteins: Oxidation Activity, Interacting Molecules, and Functions in Diseases

(2015) Xingyu Lu et al.   CHEMICAL REVIEWS

Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex

(2015) Lanfeng Wang et al.   NATURE

TET3 Is Recruited by REST for Context-Specific Hydroxymethylation and Induction of Gene Expression

(2015) Arshan Perera et al.   Cell Reports

Polymerase Synthesis of Photocaged DNA Resistant against Cleavage by Restriction Endonucleases

(2014) Zuzana Vaníková et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Comparison of the Absolute Level of Epigenetic Marks 5-Methylcytosine, 5-Hydroxymethylcytosine, and 5-Hydroxymethyluracil Between Human Leukocytes and Sperm1

(2014) Jolanta Guz et al.   BIOLOGY OF REPRODUCTION

Synthesis of Base-Modified 2′-Deoxyribonucleoside Triphosphates and Their Use in Enzymatic Synthesis of Modified DNA for Applications in Bioanalysis and Chemical Biology

(2014) Michal Hocek   JOURNAL OF ORGANIC CHEMISTRY

Site-Specific Promoter Caging Enables Optochemical Gene Activation in Cells and Animals

(2014) James Hemphill et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA

(2014) Toni Pfaffeneder et al.   Nature Chemical Biology

Effects of Tet-mediated Oxidation Products of 5-Methylcytosine on DNA Transcription in vitro and in Mammalian Cells

(2014) Changjun You et al.   Scientific Reports

Optochemical Control of Deoxyoligonucleotide Function via a Nucleobase-Caging Approach

(2013) Qingyang Liu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Synthesis and enzymatic incorporation of photolabile dUTP analogues into DNA and their applications for DNA labeling

(2013) Junzhou Wu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Preparation and affinity-based purification of caged linear DNA for light-controlled gene expression in mammalian cells

(2013) Aoi Teraoka et al.   CHEMICAL COMMUNICATIONS

Relative and absolute determination of fluorescence quantum yields of transparent samples

(2013) Christian Würth et al.   Nature Protocols

Caged nucleotides/nucleosides and their photochemical biology

(2013) Xinjing Tang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Four Levels of Wavelength-Selective Uncaging for Oligonucleotides

(2013) Alexandre Rodrigues-Correia et al.   ORGANIC LETTERS

Regulation of Transcription through Light-Activation and Light-Deactivation of Triplex-Forming Oligonucleotides in Mammalian Cells

(2012) Jeane M. Govan et al.   ACS Chemical Biology

Stereochemistry of Benzylic Carbon Substitution Coupled with Ring Modification of 2-Nitrobenzyl Groups as Key Determinants for Fast-Cleaving Reversible Terminators

(2012) Brian P. Stupi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Light-Controlled Tools

(2012) Clara Brieke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photocaged DNA Provides New Levels of Transcription Control

(2012) Luke M. Ceo et al.   CHEMBIOCHEM

Photoremovable Protecting Groups in Chemistry and Biology: Reaction Mechanisms and Efficacy

(2012) Petr Klán et al.   CHEMICAL REVIEWS

N(3)-Protection of Thymidine with Boc for an Easy Synthetic Access to Sugar-Alkylated Nucleoside Analogs

(2012) Luca Simeone et al.   CHEMISTRY & BIODIVERSITY

The power of light: photosensitive tools for chemical biology

(2012) Ishtiaq Ahmed et al.   Molecular BioSystems

Nucleoside Triphosphates — Building Blocks for the Modification of Nucleic Acids

(2012) Marcel Hollenstein   MOLECULES

5-formylcytosine and 5-carboxylcytosine reduce the rate and substrate specificity of RNA polymerase II transcription

(2012) Matthew W Kellinger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Discovery of 5-Formylcytosine in Embryonic Stem Cell DNA

(2011) Toni Pfaffeneder et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transient and Switchable (Triethylsilyl)ethynyl Protection of DNA against Cleavage by Restriction Endonucleases

(2011) Pavel Kielkowski et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cleavage of Functionalized DNA Containing 5-Modified Pyrimidines by Type II Restriction Endonucleases

(2011) Hana Macíčková-Cahová et al.   CHEMBIOCHEM

Syntheses of Two 5-Hydroxymethyl-2′-deoxycytidine Phosphoramidites with TBDMS as the 5-Hydroxymethyl Protecting Group and Their Incorporation into DNA

(2011) Qing Dai et al.   JOURNAL OF ORGANIC CHEMISTRY

Improved nucleotide selectivity and termination of 3′-OH unblocked reversible terminators by molecular tuning of 2-nitrobenzyl alkylated HOMedU triphosphates

(2011) Vladislav A. Litosh et al.   NUCLEIC ACIDS RESEARCH

Quantification of the Sixth DNA Base Hydroxymethylcytosine in the Brain

(2010) Martin Münzel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Improved synthesis of 5-hydroxymethyl-2′-deoxycytidine phosphoramidite using a 2′-deoxyuridine to 2′-deoxycytidine conversion without temporary protecting groups

(2010) Anders S. Hansen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Photocaged Morpholino Oligomers for the Light-Regulation of Gene Function in Zebrafish andXenopusEmbryos

(2010) Alexander Deiters et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular Evolution of Functional Nucleic Acids with Chemical Modifications

(2010) Masayasu Kuwahara et al.   MOLECULES

Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates

(2010) Daniel Globisch et al.   PLoS One

Recent advances in the photochemical control of protein function

(2010) Chad W. Riggsbee et al.   TRENDS IN BIOTECHNOLOGY

Illuminating the Chemistry of Life: Design, Synthesis, and Applications of “Caged” and Related Photoresponsive Compounds

(2009) Hsien-Ming Lee et al.   ACS Chemical Biology

Light activation as a method of regulating and studying gene expression

(2009) Alexander Deiters   CURRENT OPINION IN CHEMICAL BIOLOGY

Cleavage of adenine-modified functionalized DNA by type II restriction endonucleases

(2009) Hana Macíčková-Cahová et al.   NUCLEIC ACIDS RESEARCH

A Practical and Efficient Approach to PNA Monomers Compatible with Fmoc-Mediated Solid-Phase Synthesis Protocols

(2008) Andrea Porcheddu et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY