The mutant Moonwalker TRPC3 channel links calcium signaling to lipid metabolism in the developing cerebellum

The Moonwalker Mouse: New Insights into TRPC3 Function, Cerebellar Development, and Ataxia

(2014) Esther B. E. Becker   CEREBELLUM

Do mutations in the murine ataxia geneTRPC3cause cerebellar ataxia in humans?

(2014) Brent L. Fogel et al.   MOVEMENT DISORDERS

Sphingolipid lysosomal storage disorders

(2014) Frances M. Platt   NATURE

Insights From Cerebellar Transcriptomic Analysis Into the Pathogenesis of Ataxia

(2014) Conceição Bettencourt et al.   JAMA Neurology

Loss of Function of Glucocerebrosidase GBA2 Is Responsible for Motor Neuron Defects in Hereditary Spastic Paraplegia

(2013) Elodie Martin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutations in GBA2 Cause Autosomal-Recessive Cerebellar Ataxia with Spasticity

(2013) Monia B. Hammer et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Synapse elimination in the developing cerebellum

(2013) Kouichi Hashimoto et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Consensus Paper: Pathological Mechanisms Underlying Neurodegeneration in Spinocerebellar Ataxias

(2013) A. Matilla-Dueñas et al.   CEREBELLUM

Mature Purkinje Cells Require the Retinoic Acid-Related Orphan Receptor-  (ROR ) to Maintain Climbing Fiber Mono-Innervation and Other Adult Characteristics

(2013) X. R. Chen et al.   JOURNAL OF NEUROSCIENCE

Early Onset of Ataxia in Moonwalker Mice Is Accompanied by Complete Ablation of Type II Unipolar Brush Cells and Purkinje Cell Dysfunction

(2013) G. Sekerkova et al.   JOURNAL OF NEUROSCIENCE

Principles of branch dynamics governing shape characteristics of cerebellar Purkinje cell dendrites

(2012) K. Fujishima et al.   DEVELOPMENT

It’s a Lipid’s World: Bioactive Lipid Metabolism and Signaling in Neural Stem Cell Differentiation

(2012) Erhard Bieberich   NEUROCHEMICAL RESEARCH

Molecular and Cellular Control of Dendrite Maturation During Brain Development

(2012) F. Metzger   Current Molecular Pharmacology

Protein kinase A activates and phosphorylates RORα4 in vitro and takes part in RORα activation by CaMK-IV

(2011) Michael Ermisch et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

P/Q-type and T-type calcium channels, but not type 3 transient receptor potential cation channels, are involved in inhibition of dendritic growth after chronic metabotropic glutamate receptor type 1 and protein kinase C activation in cerebellar Purkinje c

(2011) Olivia S. Gugger et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Calcium Signaling in Synapse-to-Nucleus Communication

(2011) A. M. Hagenston et al.   Cold Spring Harbor Perspectives in Biology

A Deficiency of Ceramide Biosynthesis Causes Cerebellar Purkinje Cell Neurodegeneration and Lipofuscin Accumulation

(2011) Lihong Zhao et al.   PLoS Genetics

Branching out: mechanisms of dendritic arborization

(2010) Yuh-Nung Jan et al.   NATURE REVIEWS NEUROSCIENCE

SCA1-like Disease in Mice Expressing Wild-Type Ataxin-1 with a Serine to Aspartic Acid Replacement at Residue 776

(2010) Lisa Duvick et al.   NEURON

Human ataxias: a genetic dissection of inositol triphosphate receptor (ITPR1)-dependent signaling

(2010) Stephanie Schorge et al.   TRENDS IN NEUROSCIENCES

Emerging pathogenic pathways in the spinocerebellar ataxias

(2009) Kerri M Carlson et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Death and survival of heterozygous Lurcher Purkinje cellsIn vitro

(2009) Hadi S. Zanjani et al.   Developmental Neurobiology

Polyglutamine-expanded ataxin-7 causes cerebellar dysfunction by inducing transcriptional dysregulation

(2009) An-Hsun Chou et al.   NEUROCHEMISTRY INTERNATIONAL

Activity-dependent plasticity of developing climbing fiber–Purkinje cell synapses

(2009) L.W.J. Bosman et al.   NEUROSCIENCE

EuroPhenome: a repository for high-throughput mouse phenotyping data

(2009) Hugh Morgan et al.   NUCLEIC ACIDS RESEARCH

Genetic perturbation of postsynaptic activity regulates synapse elimination in developing cerebellum

(2009) E. Lorenzetto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker mice

(2009) E. B. E. Becker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enzymological Analysis of Mutant Protein Kinase Cγ Causing Spinocerebellar Ataxia Type 14 and Dysfunction in Ca2+Homeostasis

(2008) Naoko Adachi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Orphan Nuclear Receptor, RORα, Regulates Gene Expression That Controls Lipid Metabolism

(2008) Patrick Lau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutant γPKC found in spinocerebellar ataxia type 14 induces aggregate-independent maldevelopment of dendrites in primary cultured Purkinje cells

(2008) Takahiro Seki et al.   NEUROBIOLOGY OF DISEASE

Calmodulin-Kinases: Modulators of Neuronal Development and Plasticity

(2008) Gary A. Wayman et al.   NEURON

TRPC3 Channels Are Required for Synaptic Transmission and Motor Coordination

(2008) Jana Hartmann et al.   NEURON