Article
Medicine, Research & Experimental
Liang He, Zhuoran Wang, Rui Zhou, Wei Xiong, Yuqiao Yang, Ning Song, Jinqiao Qian
Summary: Myocardial ischemia/reperfusion (I/R) injury is a common cause of mortality. Cardiac miR-146a is emerging as a potent regulator of myocardial function. Dexmedetomidine preconditioning provides cardioprotective effects, of which mechanisms related to miR-146a-3p targeting IRAK1 and TRAF6 through inhibition of NF-kappa B signaling pathway and ROS emission.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell Biology
Zhongfei Zhang, Xiaoxiong Zou, Run Zhang, Yu Xie, Zhiming Feng, Feng Li, Jianbang Han, Haitao Sun, Qian Ouyang, Shiting Hua, Bingke Lv, Tian Hua, Zhizheng Liu, Yingqian Cai, Yuxi Zou, Yanping Tang, Xiaodan Jiang
Summary: The study showed that hUMSC-Exos can attenuate microglia-mediated neuroinflammation and improve neural deficits following ischemic stroke. MiR-146a-5p plays a crucial role in this process.
Article
Multidisciplinary Sciences
Ruifang Han, Juan Gao, Liming Wang, Peng Hao, Xi Chen, Yuchuan Wang, Zhixin Jiang, Li Jiang, Ting Wang, Lin Zhu, Xuan Li
Summary: MiR-146a plays a role in regulating corneal inflammation in dry eye disease and negatively regulates inflammation in human corneal epithelial cells through the IRAK1/TRAF6/NF-κB pathway. This study provides a potential therapeutic approach for the treatment of dry eye disease.
SCIENTIFIC REPORTS
(2023)
Article
Environmental Sciences
Zhi Chen, QinYue Lu, Xiang Cao, Kun Wang, YuHao Wang, Yanni Wu, Zhangping Yang
Summary: Lead exposure was found to promote apoptosis and inflammation in mouse and cow mammary tissue. The up-regulation of IRAK1 and its specific target miR-146a were identified in the high-throughput sequencing profile of mammary gland tissue. Additionally, circRNA-05280 was found to regulate apoptosis and inflammation in the mammary gland by binding miR-146a and releasing its expression on target gene IRAK1.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Oncology
Yalun Li, Weilong Li, Jun Lin, Chunjing Lv, Guangdong Qiao
Summary: The effect of miR-146a on the sensitivity of breast cancer cells to paclitaxel was investigated. It was found that miR-146a can enhance the sensitivity of breast cancer cells to paclitaxel, which may be related to the downregulation of IRAK1.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2022)
Article
Immunology
Meng Zhou, Yuzhen Liu, Haoxiang Xu, Xu Chen, Nana Zheng, Zhimin Duan, Yiping Ge, Dongqing Li, Tong Lin, Rong Zeng, Qing Chen, Min Li
Summary: This study revealed the role of hsa-circ_0102678 in regulating inflammation induced by C. acnes biofilm in acne. The findings showed that hsa-circ_0102678 could bind to miR-146a and promote the expression of IRAK1 and TRAF6, thus promoting keratinocyte inflammation.
JOURNAL OF INNATE IMMUNITY
(2023)
Article
Medicine, Research & Experimental
Yanli Li, Shilian Tan, Yuanying Shen, Le Guo
Summary: The primary pathophysiological alteration caused by inflammatory bowel disease (IBD) is prolonged, excessive inflammatory response to stimulation factors, which leads to intestinal mucosal lesions. This study found that miR-146a-5p negatively regulated the expression of inflammatory factors through targeted downregulation of IRAK1/TRAF6, thus negatively regulating the IL-1 beta-stimulated inflammatory response in human intestinal epithelial cells. Therefore, miR-146a-5p may act as an important diagnostic biomarker and treatment target of IBD.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Rheumatology
R. Kong, J. Gao, L. Ji, Y. Peng, J. Zhang, D. Zhao
Summary: This study demonstrates that iguratimod can ameliorate the progression of rheumatoid arthritis by regulating miR-146a-mediated IRAK1 expression and TRAF6/JNK1 pathway. The experimental results indicate that iguratimod can reduce cell proliferation, migration, invasion, and inflammatory cytokine expression in RA-FLS, while enhancing apoptosis.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Huoying Cai, Lin Huang, Mingshan Wang, Ruiming Liu, Jiacong Qiu, Yuansen Qin, Xi Yao, Shenming Wang, Chen Yao, Zuojun Hu, Yu Zhou
Summary: Pterostilbene (PTE) has a protective effect on abdominal aortic aneurysm (AAA) by inhibiting inflammatory responses and macrophage pyroptosis. The beneficial effect of PTE on macrophage pyroptosis and AAA formation is mediated by the miR-146a-5p/TRAF6 axis.
Article
Oncology
Jing Jin, Zhengyu Yang, Haichao Liu, Mingling Guo, Borui Chen, Haoming Zhu, Yu Wang, Jianping Lin, Shizhong Wang, Shaoqing Chen
Summary: Background: Sarcopenia during aging is closely linked to chronic inflammation, and existing treatments are not exact. Acupuncture, as an effective anti-inflammatory therapy, may have the potential to treat sarcopenia. This study found that acupuncture can alleviate skeletal muscle atrophy and suppress inflammation in aging rats.
ANNALS OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Neda K. Dezfuli, Shamila D. Alipoor, Neda Dalil Roofchayee, Sharareh Seyfi, Babak Salimi, Ian M. Adcock, Esmaeil Mortaz
Summary: The study found that miR-146a expression was significantly downregulated in NSCLC patients, while IL-6 and TGF-beta levels were elevated. The frequencies of immune cells CD3+ CTLA-4+ and Treg cells were also higher in patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medical Laboratory Technology
Chuanming Zheng, Zhong Ji, Zhipeng Xu, Zhaohui Du, Zhenjie Wang
Summary: The study investigated the expression and role of miR-146a-5p in acute pancreatitis, demonstrating that miR-146a-5p can ameliorate inflammation and autophagy in TLCs-treated AR42J cells by inhibiting the IRAK1/TRAF6/NF-kappa B pathway.
ANNALS OF CLINICAL AND LABORATORY SCIENCE
(2022)
Article
Cell & Tissue Engineering
Yuyan Xiong, Ruijie Tang, Junyan Xu, Wenyang Jiang, Zhaoting Gong, Lili Zhang, Yu Ning, Peisen Huang, Jun Xu, Guihao Chen, Xiaosong Li, Mengjin Hu, Jing Xu, Chunxiao Wu, Chen Jin, Xiangdong Li, Haiyan Qian, Yuejin Yang
Summary: This study found that pretreatment of mesenchymal stem cells (MSCs) with the Chinese medicine Tongxinluo (TXL) can enhance cardiac repair in acute myocardial infarction (AMI) by transferring miR-146a-5p through exosomes to target the IRAK1/NF-kappa B p65 pathway. This has significant potential for clinical translation.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Tong Hua, Mei Yang, Honghao Song, Erliang Kong, Mengqiu Deng, Yongchang Li, Jian Li, Zhixiao Liu, Hailong Fu, Yue Wang, Hongbin Yuan
Summary: This study demonstrates that huc-MSCs-derived exosomes attenuated chronic inflammatory pain, possibly through the regulation of autophagy and pyroptosis by miR-146a-5p/TRAF6.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Jinli Ding, Yan Zhang, Xiaopeng Cai, Yi Zhang, Sisi Yan, Jiayu Wang, Sainan Zhang, Tailang Yin, Chaogang Yang, Jing Yang
Summary: The study revealed that M1 macrophages suppressed trophoblast EMT and reduced their migration and invasion abilities by secreting extracellular vesicles (EVs). miR-146a-5p and miR-146b-5p were identified as the most upregulated miRNAs in trophoblasts treated with M1-EVs, playing a role in inhibiting trophoblast EMT by directly suppressing TNF receptor-associated factor 6 (TRAF6) expression. Aberrant expression of miR-146a-5p, miR-146b-5p, and TRAF6 was found in placental villous tissues from patients with RSA, with negative correlations between miR-146a-5p/miR-146b-5p and TRAF6 expression levels.