Epigenetically regulated PAX6 drives cancer cells toward a stem-like state via GLI-SOX2 signaling axis in lung adenocarcinoma

Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma

(2017) A Po et al.   ONCOGENE

Cancer stem cells in drug resistant lung cancer: Targeting cell surface markers and signaling pathways

(2016) Gemma Leon et al.   PHARMACOLOGY & THERAPEUTICS

Molecular Pathways: Novel Approaches for Improved Therapeutic Targeting of Hedgehog Signaling in Cancer Stem Cells

(2015) Verline Justilien et al.   CLINICAL CANCER RESEARCH

Targeting Notch, Hedgehog and Wnt pathways in cancer stem cells: clinical update

(2015) Naoko Takebe et al.   Nature Reviews Clinical Oncology

Targeting GLI factors to inhibit the Hedgehog pathway

(2015) Paola Infante et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Gli1-Mediated Regulation of Sox2 Facilitates Self-Renewal of Stem-Like Cells and Confers Resistance to EGFR Inhibitors in Non–Small Cell Lung Cancer

(2015) Namrata Bora-Singhal et al.   NEOPLASIA

Comprehensive molecular profiling of lung adenocarcinoma

(2014) Eric A. Collisson et al.   NATURE

SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma

(2014) Soufiane Boumahdi et al.   NATURE

SOX2 regulates self-renewal and tumorigenicity of human melanoma-initiating cells

(2014) R Santini et al.   ONCOGENE

Hopping between Differentiation States in Lung Adenocarcinoma

(2013) Hideo Watanabe et al.   CANCER CELL

Control of Alveolar Differentiation by the Lineage Transcription Factors GATA6 and HOPX Inhibits Lung Adenocarcinoma Metastasis

(2013) William K.C. Cheung et al.   CANCER CELL

Selection Criteria for Lung-Cancer Screening

(2013) Martin C. Tammemägi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cisplatin Selects for Multidrug-Resistant CD133+ Cells in Lung Adenocarcinoma by Activating Notch Signaling

(2012) Y.-P. Liu et al.   CANCER RESEARCH

Targeted silencing of the oncogenic transcription factor SOX2 in breast cancer

(2012) Sabine Stolzenburg et al.   NUCLEIC ACIDS RESEARCH

Correction: Heat Loss May Explain Bill Size Differences between Birds Occupying Different Habitats

(2012) Russell Greenberg et al.   PLoS One

An Epigenetic Marker Panel for Detection of Lung Cancer Using Cell-Free Serum DNA

(2011) S. Begum et al.   CLINICAL CANCER RESEARCH

The role of Pax6 in regulating the orientation and mode of cell division of progenitors in the mouse cerebral cortex

(2011) M. Asami et al.   DEVELOPMENT

Discovery and assessment of conserved Pax6 target genes and enhancers

(2011) Pedro Coutinho et al.   GENOME RESEARCH

Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

DNA methylation biomarkers for lung cancer

(2011) Tibor A. Rauch et al.   TUMOR BIOLOGY

Lung cancer stem cells: tools and targets to fight lung cancer

(2010) A Eramo et al.   ONCOGENE

Potential utility of HOP homeobox gene promoter methylation as a marker of tumor aggressiveness in gastric cancer

(2010) A Ooki et al.   ONCOGENE

PAX6 Is Expressed in Pancreatic Cancer and Actively Participates in Cancer Progression through Activation of the MET Tyrosine Kinase Receptor Gene

(2009) Joseph B. Mascarenhas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Level of the Transcription Factor Pax6 Is Essential for Controlling the Balance between Neural Stem Cell Self-Renewal and Neurogenesis

(2009) Stephen N. Sansom et al.   PLoS Genetics

Concise Review: Pax6 Transcription Factor Contributes to both Embryonic and Adult Neurogenesis as a Multifunctional Regulator

(2008) Noriko Osumi et al.   STEM CELLS

PAX6 is expressed in pancreatic adenocarcinoma and is downregulated during induction of terminal differentiation

(2007) Deborah Lang et al.   MOLECULAR CARCINOGENESIS