LACTB, a novel epigenetic silenced tumor suppressor, inhibits colorectal cancer progression by attenuating MDM2-mediated p53 ubiquitination and degradation

Dysfunction of the MDM2/p53 axis is linked to premature aging

(2017) Davor Lessel et al.   JOURNAL OF CLINICAL INVESTIGATION

FOXD3 Regulates CSC Marker, DCLK1-S, and Invasive Potential: Prognostic Implications in Colon Cancer

(2017) Shubhashish Sarkar et al.   MOLECULAR CANCER RESEARCH

LACTB is a tumour suppressor that modulates lipid metabolism and cell state

(2017) Zuzana Keckesova et al.   NATURE

Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity

(2017) Koji Nomura et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Core 3 mucin-type O-glycan restoration in colorectal cancer cells promotes MUC1/p53/miR-200c-dependent epithelial identity

(2017) J Ye et al.   ONCOGENE

Overexpression of LACTB, a Mitochondrial Protein, that Inhibits Proliferation and Invasion in Glioma Cells

(2017) Hai-Tao Li et al.   ONCOLOGY RESEARCH

Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity

(2017) Koji Nomura et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches

(2016) Andreas C. Joerger et al.   Annual Review of Biochemistry

MicroRNA-125b-5p attenuates lipopolysaccharide-induced monocyte chemoattractant protein-1 production by targeting inhibiting LACTB in THP-1 macrophages

(2016) Jing-Bo Lu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer

(2016) Dawid Walerych et al.   NATURE CELL BIOLOGY

MDM2 oligomers: antagonizers of the guardian of the genome

(2016) P L Leslie et al.   ONCOGENE

BRAFV600E mutation correlates with suppressive tumor immune microenvironment and reduced disease-free survival in Langerhans cell histiocytosis

(2016) Kaixuan Zeng et al.   OncoImmunology

Long non-coding RNA CCAL regulates colorectal cancer progression by activating Wnt/β-catenin signalling pathway via suppression of activator protein 2α

(2015) Yanlei Ma et al.   GUT

Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

(2014) Patricia A.J. Muller et al.   CANCER CELL

Tetramerization-defects of p53 result in aberrant ubiquitylation and transcriptional activity

(2014) Valérie Lang et al.   Molecular Oncology

Contribution of p53 to Metastasis

(2014) E. Powell et al.   Cancer Discovery

Hepatocyte Nuclear Factor 6 Suppresses the Migration and Invasive Growth of Lung Cancer Cells through p53 and the Inhibition of Epithelial-Mesenchymal Transition

(2013) Xin-Wang Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery and refinement of loci associated with lipid levels

(2013) Cristen J Willer et al.   NATURE GENETICS

Human rpL3 induces G₁/S arrest or apoptosis by modulating p21waf1/cip1levels in a p53-independent manner

(2012) Annapina Russo et al.   CELL CYCLE

p53 regulates epithelial–mesenchymal transition through microRNAs targeting ZEB1 and ZEB2

(2011) Taewan Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

p53 regulates epithelial–mesenchymal transition and stem cell properties through modulating miRNAs

(2011) Chun-Ju Chang et al.   NATURE CELL BIOLOGY

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE

Molecular Basis of Colorectal Cancer

(2009) Sanford D. Markowitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

LACTB is a filament-forming protein localized in mitochondria

(2009) Zydrune Polianskyte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of a family of metazoan active-site-serine enzymes from penicillin-binding proteins: a novel facet of the bacterial legacy

(2008) Nina Peitsaro et al.   BMC EVOLUTIONARY BIOLOGY