Review
Immunology
Yingying Lin, Ting Qiu, Guifeng Wei, Yueyue Que, Wenxin Wang, Yichao Kong, Tian Xie, Xiabin Chen
Summary: Inflammation is a defensive reaction to external stimuli in the human body and is associated with various diseases. Histone modifications play a significant role in the regulation of inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Faith M. Joseph, Nicolas L. Young
Summary: Post-translational modifications (PTMs) of histones play a key role in DNA-based processes and contribute to cell differentiation and gene function by adding an extra layer of regulation. Variations in histone sequences within each family of histones expand the chromatin repertoire and provide further mechanisms for regulation and signaling. However, much remains unknown about variant-specific PTMs and their role in regulating chromatin due to limited technologies and appropriate reagents.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Review
Microbiology
Yiman Li, Zhihui Song, Ente Wang, Liming Dong, Jie Bai, Dong Wang, Jinyan Zhu, Chao Zhang
Summary: Invasive aspergillosis is a significant cause of death in patients with hematological malignancies and transplant recipients. Antifungal drug resistance has become a concern in managing infections, and understanding histone posttranslational modifications may provide insights for developing new antifungal drugs.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemical Research Methods
Sony Shrestha, Amuza Byaruhanga Lucky, Awtum Marie Brashear, Xiaolian Li, Liwang Cui, Jun Miao
Summary: This study profiled the histone post-translational modifications (PTMs) in the development of Plasmodium falciparum gametocytes, revealing novel PTM sites and distinct patterns from asexual stages. The results suggest that these PTMs play critical roles in gametocyte development and provide insights into the epigenetic regulation in the life cycle of the malaria parasite.
JOURNAL OF PROTEOME RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Ivana Samarzija
Summary: The specific functional form of a protein is mostly achieved through dynamic interactions of many enzymes in post-translational modifications, which cells widely use to respond to stimuli, regulate transcription, and maintain proteostasis. Post-translational modifications play important roles in driving prostate cancer, particularly in regulating protein activity at the level of post-translational modifications.
Review
Oncology
Chiara Mazziotta, Carmen Lanzillotti, Roberta Gafa, Antoine Touze, Marie-Alice Durand, Fernanda Martini, John Charles Rotondo
Summary: This article reviews the recent progress in understanding the etiology and treatment of Merkel Cell Carcinoma (MCC), focusing on the role of histone post-translational modifications (PTMs) and their potential as diagnostic and therapeutic markers.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
You-Wei Wang, Jia-Chen Zuo, Chong Chen, Xiao-Hong Li
Summary: Post-translational modifications (PTMs) covalently attach functional groups to proteins, leading to structural and functional changes. PTMs play a significant role in regulating liver cancer development and the immune response against cancer. Immunotherapies that harness the immune system's potential have shown promise in improving cancer patient prognosis and survival. This review provides a comprehensive summary of key PTMs and their potential targets to enhance immunotherapies against liver cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yunhua Peng, Huadong Liu, Jiankang Liu, Jiangang Long
Summary: Mitochondria play a crucial role in the initiation and development of tumor cells, with metabolic proteins serving as key mediators in tumorigenesis. Understanding mitochondria-related post-translational modifications is important for the future of cancer treatment.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Biotechnology & Applied Microbiology
Hanna Dotter, Melanie Boll, Matthias Eder, Ann-Christin Eder
Summary: Innovative biotechnological methods facilitate the identification of new drug candidates, with phage, ribosome, and mRNA display enabling high throughput screenings for targeted drug discovery. Chemical modifications, such as introducing unnatural amino acids or cyclization, play a crucial role in enhancing peptides stability and affinity, particularly when using selected display approaches.
BIOTECHNOLOGY ADVANCES
(2021)
Review
Food Science & Technology
Aurelie Etier, Fabien Dumetz, Sylvain Chereau, Nadia Ponts
Summary: Studies have shown that histone post-translational modifications play a crucial role in biological processes of fungi, particularly in regulating primary and secondary metabolisms of filamentous fungi.
Review
Cardiac & Cardiovascular Systems
Sebastian Guttzeit, Johannes Backs
Summary: This article discusses the importance of epigenetic regulators in cardiovascular disease, particularly the role of class IIa histone deacetylases in cellular homeostasis and response to external stimuli. The review summarizes the reversible post-translational modifications of class IIa HDACs and their impact on transcriptional changes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Review
Oncology
Hashnu Dutta, Nishant Jain
Summary: Post-translational modifications are crucial regulatory mechanisms that alter the properties and functions of proteins, expanding the diversity of the proteome. They play a key role in physiological processes and have clinical relevance in diseases. These modifications involve covalently attaching modified chemical groups to amino acid residues, causing changes in protein activity, structure, location, and function.
FRONTIERS IN ONCOLOGY
(2023)
Review
Immunology
Yanqing Li, Runfang Zhang, Hu Hei
Summary: Protein post-translational modification (PTM) is a regulatory mechanism that involves adding or removing specific chemical groups on amino acid residues to modulate protein activity, localization, expression, and interactions. It plays a vital role in important biological processes and the occurrence and development of diseases, as well as in tumor immunotherapy. This review comprehensively summarizes the role of several types of PTMs in tumor immunotherapy and provides new insights and future research directions.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Dongha Kim, Hye Jin Nam, Sung Hee Baek
Summary: Lysine-specific demethylase 1 (LSD1) plays a crucial role in regulating gene expression through its catalytic activity and interactions with various protein partners. The function of LSD1 is tightly regulated by diverse post-translational modifications (PTMs). This review provides a comprehensive understanding of the regulation and function of LSD1 following various PTMs and discusses the therapeutic implications of targeting these modifications for human diseases.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2023)
Review
Genetics & Heredity
Vincenzo Cavalieri
Summary: The emergence of a nucleosome-based chromatin structure during the evolutionary transition from prokaryotes to eukaryotes plays a crucial role in adaptive responses to environmental influence through epigenetic mechanisms involving histones. The overwhelming number of post-translational modifications at multiple residues of histones and their implications in nucleosome dynamics and chromatin processes are discussed in this review.
Article
Biotechnology & Applied Microbiology
Stefano Amatori, Giuseppe Persico, Francesco Cantatore, Martina Rusin, Mauro Formica, Luca Giorgi, Eleonora Macedi, Francesca Casciaro, Alfredo Errico Provenzano, Stefano Gambardella, Roberta Noberini, Tiziana Bonaldi, Vieri Fusi, Marco Giorgio, Mirco Fanelli
Summary: This study characterizes the epigenomic effects of maltonis, a novel maltol-derived molecule, in acute promyelocytic leukemia (APL) cells. The results show that maltonis treatment can remodel histone code, alter gene expression, induce an antiviral-like response, and regulate c-MYC-related pathways.
CANCER GENE THERAPY
(2023)
Article
Biotechnology & Applied Microbiology
Elena Di Nisio, Valerio Licursi, Cecilia Mannironi, Valentina Buglioni, Alessandro Paiardini, Giulia Robusti, Roberta Noberini, Tiziana Bonaldi, Rodolfo Negri
Summary: KDM5B histone demethylase is overexpressed in many cancers and has a dual role in oncogenesis depending on the specific context. One particular isoform of KDM5B, called KDM5B-NTT, is found to be more stable in breast cancer cell lines compared to the canonical PLU-1 isoform. Overexpression of KDM5B-NTT leads to increased H3K4 methylation and the derepression of genes involved in tumor suppression and interferon response.
CANCER GENE THERAPY
(2023)
Article
Oncology
Aram Ko, Mohammad Hasanain, Young Taek Oh, Fulvio D'Angelo, Danika Sommer, Brulinda Frangaj, Suzanne Tran, Franck Bielle, Bianca Pollo, Rosina Paterra, Karima Mokhtari, Rajesh Kumar Soni, Matthieu Peyre, Marica Eoli, Laura Papi, Michel Kalamarides, Marc Sanson, Antonio Iavarone, Anna Lasorella
Summary: LZTR1 is a substrate-specific adaptor of a CUL3-dependent ubiquitin ligase frequently mutated in cancer. The study identified EGFR and AXL as LZTR1 substrates targeted for degradation, and found that LZTR1 mutations result in the accumulation and deregulated signaling of EGFR and AXL. The study also revealed vulnerabilities of LZTR1-mutant tumors to inhibition of EGFR and AXL, providing precision targeting for patients with LZTR1-mutant cancer.
Article
Medicine, General & Internal
Jacopo Falco, Emanuele Rubiu, Morgan Broggi, Mariangela Farinotti, Ignazio G. Vetrano, Marco Schiariti, Elena Anghileri, Marica Eoli, Bianca Pollo, Marco Moscatelli, Francesco Restelli, Elio Mazzapicchi, Emanuele La Corte, Giulio Bonomo, Marco Gemma, Giovanni Broggi, Paolo Ferroli, Francesco Acerbi
Summary: Maximizing surgical resection using fluorescein-guided surgery has been shown to improve overall survival in patients with glioblastoma. In this retrospective analysis, we evaluated the role of fluorescein-guided surgery in tumor resection, survival, and complications. The study results demonstrated a high rate of complete resection without any adverse effects related to fluorescein. The survival and progression-free survival were significantly improved compared to previous studies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Paolo Ferroli, Francesco Restelli, Giacomo Bertolini, Emanuele Monti, Jacopo Falco, Giulio Bonomo, Irene Tramacere, Bianca Pollo, Chiara Calatozzolo, Monica Patane, Silvia Schiavolin, Morgan Broggi, Francesco Acerbi, Alessandra Erbetta, Silvia Esposito, Elio Mazzapicchi, Emanuele La Corte, Ignazio Gaspare Vetrano, Giovanni Broggi, Marco Schiariti
Summary: This retrospective study analyzed the associations between possible prognostic factors and survival rate. Surgical resection, tumor volume, histological grade, extent of resection, and 3-month postoperative performance status were identified as important prognostic factors. Surgery for thalamic gliomas improves overall survival, and patients with stable performance status after 3 months have better prognosis. Therefore, accurate evaluation of predictors of 3-month postoperative performance status is crucial in deciding between biopsy or surgical removal.
Correction
Oncology
F. Guffanti, M. F. Alvisi, A. Anastasia, F. Ricci, M. Chiappa, A. Llop-Guevara, V. Serra, R. Fruscio, A. Degasperi, S. Nik-Zainal, M. R. Bani, M. Lupia, R. Giavazzi, E. Rulli, G. Damia
BRITISH JOURNAL OF CANCER
(2023)
Article
Cell Biology
V. Nieddu, V. Melocchi, C. Battistini, G. Franciosa, M. Lupia, C. Stellato, G. Bertalot, J. V. Olsen, N. Colombo, F. Bianchi, U. Cavallaro
Summary: Ovarian cancer (OC) has the highest mortality rate among gynecological tumors, primarily due to early peritoneal dissemination, tumor relapse, and chemoresistance. These events are initiated and sustained by ovarian cancer stem cells (OCSC) with self-renewing and tumor-initiating properties. Interfering with OCSC function could offer novel therapeutic perspectives.
CELL DEATH & DISEASE
(2023)
Article
Genetics & Heredity
Tra My Tran Nguyen, Arno Munhoven, Anke Samel-Pommerencke, Rucha Kshirsagar, Alessandro Cuomo, Tiziana Bonaldi, Ann E. Ehrenhofer-Murray
Summary: This article reports the discovery of two modifications on the centromeric histone H3 variant CENP-A/Cse4 in Saccharomyces cerevisiae, namely methylation at arginine 143 (R143me) and lysine 131 (K131me), which affect centromere stability and kinetochore function.
Article
Oncology
Francesco Chu, Fausto Maffini, Daniela Lepanto, Davide Vacirca, Sergio Vincenzo Taormina, Rita De Berardinis, Sara Gandini, Silvano Vignati, Alberto Ranghiero, Alessandra Rappa, Susanna Chiocca, Massimo Barberis, Marta Tagliabue, Mohssen Ansarin
Summary: This study investigates the factors contributing to the progression from laryngeal dysplasia to invasive cancer, focusing on the alterations of the dysplastic micro-environment and immune system. Differentiating between progressing and non-progressing dysplasia is crucial for surveillance programs and cancer prevention.
Article
Biochemistry & Molecular Biology
Nadia Bertola, Stefano Regis, Silvia Bruno, Andrea Nicola Mazzarello, Martina Serra, Michela Lupia, Federica Sabatini, Fabio Corsolini, Silvia Ravera, Enrico Cappelli
Summary: Fanconi anemia (FA) is a rare genetic disease characterized by dysfunctional DNA repair and oxidative stress accumulation. Histone deacetylase inhibitors (HDACi) can correct the metabolic defect and improve oxidative stress levels and mitochondrial dynamics quality. Sodium valproate (VPA) shows promise as a potential treatment drug.
Article
Medicine, General & Internal
Matilde Taddei, Silvia Esposito, Gianluca Marucci, Alessandra Erbetta, Paolo Ferroli, Laura Grazia Valentini, Chiara Pantaleoni, Stefano D'Arrigo, Veronica Saletti, Bianca Pollo, Rosina Paterra, Daria Riva, Sara Bulgheroni
Summary: In this study, the cognitive and behavioral outcomes of children with low-grade CNS tumors treated with surgical intervention were analyzed retrospectively. The results showed that the sample had normal cognitive abilities and behavioral functioning, but weaknesses were observed in verbal working memory and processing speed. Factors such as younger age at symptoms' onset, glioneuronal histological type, cortical location with preoperative seizures, timing of surgery, and seizure control after surgery were found to be associated with cognitive and behavioral functioning. Timely treatment and regular assessment are important for the global outcome and daily functioning of these patients.
Article
Hematology
Elena Palmisani, Maurizio Miano, Alice Grossi, Marina Lanciotti, Michela Lupia, Paola Terranova, Isabella Ceccherini, Eugenia Montanari, Michaela Calvillo, Filomena Pierri, Concetta Micalizzi, Rosario Maggiore, Daniela Guardo, Sabrina Zanardi, Elena Facchini, Angela Maggio, Elena Mastrodicasa, Paola Corti, Giovanna Russo, Marta Pillon, Piero Farruggia, Simone Cesaro, Angelica Barone, Francesca Tosetti, Ugo Ramenghi, Nicoletta Crescenzio, Jack Bleesing, Carlo Dufour, Francesca Fioredda
Summary: This study compared the clinical and immunological features of ALPS-FAS/CASP10 and ALPS-U patients, and explored the genetic characteristics of the ALPS-U group. The results showed that ALPS-U patients had a more complex phenotype, involving multiple organs and higher positivity of autoimmune markers. In terms of treatment, ALPS-FAS/CASP10 patients were able to control symptoms with first- and second-line treatments, while ALPS-U patients required more treatment lines. ALPS-U appears to be a distinct entity from ALPS-FAS/CASP10, which is important for management and tailored treatments.
Review
Biochemical Research Methods
Roberta Noberini, Tiziana Bonaldi
Summary: The combined activity of epigenetic features, such as histone modifications, DNA methylation, and nucleosome positioning, independently regulates gene expression and is linked with various diseases, including cancer. Mass spectrometry-based proteomics has emerged as a versatile tool for epigenetic drug discovery, assisting in target validation, target deconvolution, and monitoring drug efficacy. This article provides an overview of the contributions of mass spectrometry-based proteomics to epigenetic drug discovery and highlights its role in the development and characterization of epigenetic drugs.
Article
Cell Biology
Alessandro Medda, Micaela Compagnoni, Giorgio Spini, Simona Citro, Ottavio Croci, Stefano Campaner, Marta Tagliabue, Mohssen Ansarin, Susanna Chiocca
Summary: Autophagy function is impaired in HPV-positive head and neck cancer cells, which can be restored by knocking down HPV E6/E7 oncoproteins. The upregulation of c-MYC contributes to the inhibition of autophagy, leading to decreased binding of MiT/TFE transcription factors to their autophagy targets. In addition, the upregulation of CIP2A by HPV oncoprotein E7 further stabilizes c-MYC, resulting in decreased autophagy gene expression. Inhibition of c-MYC expression increases autophagy and lysosomal gene expression, as well as resistance to cisplatin treatment.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Claudia Fierro, Veronica Gatti, Veronica La Banca, Sara De Domenico, Stefano Scalera, Giacomo Corleone, Maurizio Fanciulli, Francesca De Nicola, Alessandro Mauriello, Manuela Montanaro, George A. Calin, Gerry Melino, Angelo Peschiaroli
Summary: The transcription factor ΔNp63 is critical for maintaining the function and integrity of stratified epithelial tissues. In this study, the researchers discovered that it represses the expression of the lncRNA NEAT1 through the recruitment of the histone deacetylase HDAC1. Down-regulation of ΔNp63 during differentiation leads to increased NEAT1 levels and the formation of paraspeckles foci, which are important for epidermal morphogenesis. These findings highlight the role of NEAT1 as an additional player in the regulatory network controlled by ΔNp63.
NATURE COMMUNICATIONS
(2023)