Article
Environmental Sciences
Gasem M. Abu-Taweel, Mohsen G. Al-Mutary
Summary: Pomegranate juice showed significant improvements in neurobehavioral and biochemical disorders induced by aluminum chloride, including effects on body weight, memory and learning, neurotransmitters, and oxidative biomarkers in female mice.
ENVIRONMENTAL RESEARCH
(2021)
Article
Environmental Sciences
Azza Attia, Heba Ramadan, Reda ElMazoudy, Asmaa Abdelnaser
Summary: This study revealed that 26.9 nm citrate-coated AgNPs can access the brain of mice, causing damage to brain conductivity and relative permittivity along with high cellular toxicity. The findings raise concerns about the neurotoxic effects of citrate-coated AgNPs on the brain and suggest further investigation into axonal relevant signal transduction levels in future studies.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Neurosciences
Jing Lu, Yan Zhu, Helena C. Parkington, Maytham Hussein, Jinxin Zhao, Phillip Bergen, David Rudd, Mary A. Deane, Sara Oberrauch, Linda Cornthwaite-Duncan, Rafah Allobawi, Rajnikant Sharma, Gauri Rao, Jian Li, Tony Velkov
Summary: This study investigated the underlying mechanisms of polymyxin-induced neurotoxicity through transcriptomic and imaging analyses. Gene expression changes were observed in the brain but not the spinal cord following intracerebroventricular administration of polymyxin B. The study identified key signaling pathways associated with hormones and neurotransmitters, and demonstrated the distribution pattern of polymyxin B in the brain. Electrophysiological measurements further confirmed the detrimental effects of polymyxin B on neurons. These findings provide important insights for the development of safe and effective treatment regimens for CNS infections caused by multidrug-resistant Gram-negative pathogens.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Pawel Grochecki, Irena Smaga, Karolina Wydra, Marta Marszalek-Grabska, Tymoteusz Slowik, Ewa Kedzierska, Joanna Listos, Ewa Gibula-Tarlowska, Malgorzata Filip, Jolanta H. H. Kotlinska
Summary: This study examined the complex issue of treating Post-Traumatic Stress Disorder (PTSD) when it coexists with drug use disorder. The results showed that conditioned fear, a model for PTSD, can alter the rewarding effect of mephedrone, and repeated injections of mephedrone can impact trauma-related behaviors such as fear sensitization, extinction, and recall. The study also found changes in the expression of metalloproteinase-9 (MMP-9) and GluN2A and GluN2B subunits of the N-methyl-D-aspartate (NMDA) glutamate receptor in the hippocampus and basolateral amygdala, suggesting the involvement of these brain structures in fear memory impairment and drug seeking behavior.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Dongyin Lian, Tengfei Chen, Lihua Yan, Hongping Hou, Shuangrong Gao, Qin Hu, Guangping Zhang, Han Li, Ling Song, Yunhang Gao, Yunxi Pu, Ying Chen, Bo Peng
Summary: The compatible herbs in Jin-Gu-Lian formula alleviate the neurotoxicity induced by A. chinense by improving oxidative damage, preventing abnormality of neurotransmitters, and modulating pharmacokinetics. These findings provide a theoretical basis for the clinical application of A. chinense.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Lu Wang, Min Zhang, Jing Wen, Yalan Xiang, Xiaoyu Duan, Changwei Yu, Miao Yan, Bikui Zhang, Pingfei Fang
Summary: Acute neurotoxicity of Semen Strychni can lead to hippocampal neuronal degeneration, while isoliquiritigenin may alleviate this effect by restoring neurotransmitter metabolic pathways, potentially through the activation of NMDA receptors.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Lulu Guo, Jian Mao, Qidong Zhang, Wu Fan, Dingzhong Wang, Zhonghao Li, Jiaqiang Huang, Jianping Xie
Summary: The metabolism and disposition of nicotine in the brain play a crucial role in determining its exposure. A new method was developed to analyze the dynamic profiles of nicotine metabolites and neurotransmitters. Inhibiting nicotine metabolism can enhance the residence of nicotine in the brain and its local neurotransmitter effects.
FRONTIERS IN CHEMISTRY
(2023)
Article
Environmental Sciences
Jingjing Tian, Jia Hu, Di Liu, Jian Yin, Mingli Chen, Lianqun Zhou, Huancai Yin
Summary: Cadmium is a significant environmental pollutant that can harm the ecological environment and organismal health, affecting behavior, neurotransmitter levels, and neuronal development in offspring. Exposure to cadmium chloride in sexually-mature zebrafish led to reduced swimming speed and distance in F1 offspring, disruption of neurotransmitter levels, and altered gene expression related to neuro-development and neurotransmitter metabolism, causing developmental neurotoxicity. These findings highlight the harm that cadmium chloride poses to aquatic ecosystems.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Mohaddeseh Sadat Alavi, Hamid Reza Sadeghnia, Niloufar Nikpasand, Sajad Sahab Negah, Roghayeh Rashidi, Gholamreza Naseri, Ahmad Ghorbani
Summary: This study found that mephedrone exposure negatively affects the proliferation, differentiation, and apoptosis of rat embryonic neural stem/progenitor cells (NS/PC). Mephedrone at concentrations of 20-640 μM significantly reduced NS/PC proliferation, induced cell cycle arrest, and increased apoptosis and necrosis. Additionally, mephedrone decreased the expressions of DCX and NeuN neuronal markers. These findings suggest that mephedrone exposure during fetal or neonatal life may impair neurogenesis and subsequent brain development.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Adham Salah, Mokhtar Yousef, Maher Kamel, Ahmed Hussein
Summary: LPS is an important tool for inducing neuroinflammatory models and demonstrating the consequences of endotoxemia. Curcumin, in its native form, protects dopaminergic neurons against LPS-induced neurotoxicity but has poor bioavailability. This study explores the molecular mechanism of LPS-induced neurotoxicity and the protective effects of orally supplemented nanocurcumin. Nanocurcumin exhibits antioxidant and neuroprotective effects against LPS endotoxin.
Article
Pharmacology & Pharmacy
Mohaddeseh Sadat Alavi, Hamid Reza Sadeghnia, Niloufar Nikpasand, Sajad Sahab Negah, Roghayeh Rashidi, Gholamreza Naseri, Ahmad Ghorbani
Summary: This study investigated the effects of mephedrone exposure on the proliferation, differentiation, and apoptosis of rat embryonic NS/PC. The results showed that mephedrone significantly decreased the proliferation of NS/PC, induced cell cycle arrest, and increased the percentage of apoptotic and necrotic cells.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2023)
Article
Chemistry, Analytical
Ming Zhao, Yan Cao, I-wen Huang, Harold G. Monbouquette
Summary: Highly sensitive and selective choline microbiosensors were created by using microcontact printing and a crosslinked, polyamine-functionalized zwitterionic polymer matrix. The sensors exhibited higher enzyme loading and spatial resolution, and also showed selectivity against potential interfering compounds.
Article
Environmental Sciences
Anri Hirai, Ryo Yamazaki, Atsushi Kobayashi, Takashi Kimura, Kei Nomiyama, Shuichi Shimma, Shouta M. M. Nakayama, Mayumi Ishizuka, Yoshinori Ikenaka
Summary: Monoamine neurotransmitters play a crucial role in regulating brain functions, and exposure to neonicotinoids may lead to neurological symptoms associated with altered levels of monoamine neurotransmitters.
Article
Engineering, Environmental
Shuang Liu, Jingcun Dong, Xiaolong Fang, Xueting Yan, He Zhang, Yu Hu, Qingqing Zhu, Ruibin Li, Qian Liu, Sijin Liu, Chunyang Liao, Guibin Jiang
Summary: This study examines the impact of nanoscale metal-organic frameworks (MOFs) on neurological behaviors and neurotransmitter metabolism. The results show that exposure to MOF-74-Zn nanoparticles leads to negative behaviors and neurotransmitter metabolism disorders. This underscores the importance of understanding and safely using nanoscale metal-based MOFs.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Walaa M. S. Ahmed, Nermeen A. Helmy, Marwa A. Ibrahim, Hossam M. Hassan, Amr R. Zaki
Summary: The study showed that Premna odorata extract has a potential protective effect against oxidative stress, DNA damage, and biochemical alterations induced by aluminum toxicity in the brain tissues of rats, and can also reduce the expression of pro-inflammatory genes.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Clinical Neurology
Karolina Noworyta, Rafal Rygula
Summary: This study investigates how individual trait sensitivity to reinforcement affects the reactivity of rats to acute antidepressant treatment, revealing that different types of reinforcement sensitivity may lead to different vulnerabilities to mood disorders.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Neurosciences
Adam Wojtas, Monika Herian, Mateusz Skawski, Malgorzata Sobocinska, Alejandro Gonzalez-Marin, Karolina Noworyta-Sokolowska, Krystyna Golembiowska
Summary: The study found that 25B-NBOMe increased the release of DA, 5-HT, ACh, and glutamate in rat brain regions, induced hallucinogenic activity, and reduced recognition index while decreasing locomotor activity. In anxiety and anti-anxiety tests, it showed dose-dependent effects. Compared to MDMA, 25B-NBOMe exhibited subtle genotoxic effects.
NEUROTOXICITY RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Agnieszka Wnuk, Malgorzata Kajta
Summary: Benzophenone-3 is commonly used as a sunscreen filter, but it can penetrate the skin and affect the nervous system when absorbed by the body. Recent research has shown that it can induce neurotoxicity and affect the development and function of neuronal cells.
ACTA BIOCHIMICA POLONICA
(2021)
Review
Pharmacology & Pharmacy
Karolina Noworyta, Agata Cieslik, Rafal Rygula
Summary: Alcohol use disorder is a common yet poorly treated psychiatric condition, with reinforcement-based cognitive biases playing a key role in its development and treatment. Recent preclinical research offers new opportunities to understand the role of reinforcement sensitivity and RBCBs in various aspects of AUD.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Joanna Rzemieniec, Laura Castiglioni, Paolo Gelosa, Majeda Muluhie, Benedetta Mercuriali, Luigi Sironi
Summary: Cardiovascular diseases lead to millions of deaths each year, with heart attacks and strokes being major causes. Current therapies have limitations, prompting the search for new molecular targets like nuclear receptors for protection against ischemia. Activation of ERs and PPARs, along with inhibition of AhR signaling, may offer promising strategies to protect the heart and brain from ischemic injuries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Monika Herian, Adam Wojtas, Marzena Mackowiak, Agnieszka Wawrzczak-Bargiela, Anna Solarz, Agnieszka Bysiek, Katarzyna Madej, Krystyna Golembiowska
Summary: This article studied the impact of 25I-NBOMe on rat brain tissue and found that it can easily cross the blood-brain barrier and accumulate in the brain tissue. Chronic treatment can cause DNA damage and glial cell death.
SCIENTIFIC REPORTS
(2022)
Review
Cell Biology
Karolina Noworyta, Agata Cieslik, Rafal Rygula
Summary: This review summarizes recent advances in understanding biased cognition in depressive disorder, focusing on pessimistic judgment bias and abnormal response to negative feedback. The discussion includes neurochemical mechanisms identified through genetic, molecular, and pharmacological studies, as well as experimental approaches to depression treatment based on improved understanding of cognitive substrates.
Article
Biochemistry & Molecular Biology
Adam Wojtas, Agnieszka Bysiek, Agnieszka Wawrzczak-Bargiela, Zuzanna Szych, Iwona Majcher-Maslanka, Monika Herian, Marzena Mackowiak, Krystyna Golembiowska
Summary: Clinical studies suggest that ketamine and psilocybin may have potential as fast-acting antidepressants. This study used microdialysis to investigate the effect of these drugs on neurotransmitter levels in rat brain regions. The findings showed that both ketamine and psilocybin affected neurotransmitter levels, but did not significantly alter animal behavior.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Karolina Przepiorska, Agnieszka Wnuk, Cordian Beyer, Malgorzata Kajta
Summary: Amorfrutin B is identified as a selective modulator of the PPAR gamma receptor with neuroprotective properties against hypoxic and ischemic damage in brain neurons. The delayed post-treatment with amorfrutin B prevents neuronal apoptosis by preserving mitochondrial function, inhibiting heterochromatin foci formation, and modulating the expression of specific genes and proteins. The protective mechanisms of amorfrutin B involve the inhibition of autophagy and the regulation of apoptosis-focused and autophagy-related miRNAs. Amorfrutin B shows promise as an anti-stroke therapeutic with a wide treatment window.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Agnieszka Wnuk, Karolina Przepiorska, Bernadeta Angelika Pietrzak, Malgorzata Kajta
Summary: Nuclear- and membrane-initiated estrogen signaling collaborate to regulate the diverse effects of estrogens. Classical estrogen receptors (ERs) control transcriptional activity and most hormonal effects, while membrane ERs (mERs) allow rapid modulation of estrogen signaling and exhibit strong neuroprotective capacity without nuclear ER-related side effects. The extensively studied mER, GPER1, has shown neuroprotection, cognitive improvement, metabolic homeostasis, and vascular protection, but controversy exists due to its involvement in tumorigenesis. Hence, non-GPER-dependent mERs, such as mER alpha and mER beta, have gained attention. These mERs have been found to offer protective effects against brain damage, synaptic plasticity impairment, memory and cognitive dysfunctions, metabolic imbalance, and vascular insufficiency. This suggests their potential as therapeutic targets for stroke and neurodegenerative diseases, as they can influence noncoding RNAs and regulate translational status in brain tissue by affecting histones.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Bernadeta A. Pietrzak, Agnieszka Wnuk, Karolina Przepiorska, Andrzej Lach, Malgorzata Kajta
Summary: Stroke and perinatal asphyxia cause neuronal cell damage and have high mortality rates worldwide each year. This study investigated the neuroprotective effects of ospemifene, a selective estrogen receptor modulator, in primary neocortical cell cultures subjected to hypoxia and/or ischemia. Ospemifene showed robust neuroprotective potential by reversing hypoxia- and ischemia-induced changes in LDH release, neurodegeneration, and metabolic activity, mainly mediated by ESR1 and GPER1.
NEUROTOXICITY RESEARCH
(2023)
Review
Biotechnology & Applied Microbiology
Andrzej Lach, Agnieszka Wnuk, Anna Katarzyna Wojtowicz
Summary: The purpose of this paper was to discuss the achievements of in vitro modeling of the blood-brain barrier (BBB) and provide a clear overview of this research area. The text is divided into three parts - the first part describes the structure and importance of the BBB, the second part discusses parameters for evaluating BBB models, and the third part explores different techniques for developing BBB in vitro models. The paper emphasizes the significance of this research area for neuroscience and the pharmaceutical industry.
BIOENGINEERING-BASEL
(2023)
Article
Biology
Luisa Moehle, Katja Stefan, Pablo Bascunana, Mirjam Brackhan, Thomas Bruening, Ivan Eiriz, Ahmed El Menuawy, Sylvie van Genderen, Irene Santos-Garcia, Anna Maria Gorska, Maria Villa, Jingyun Wu, Sven Marcel Stefan, Jens Pahnke
Summary: Reusing drugs may accelerate the development of effective dementia treatment. However, the drug dimethyl fumarate was found to be inefficient in reducing Alzheimer's disease-related changes in the brain due to the involvement of an essential brain transporter.
Article
Behavioral Sciences
Hiba Zaidan, Agnieszka Wnuk, Idan M. Aderka, Malgorzata Kajta, Inna Gaisler-Salomon
Summary: Stress during development affects both maternal behavior and offspring phenotypes, particularly in the context of adolescent stress that impacts brain development. Epigenetic processes such as DNA methylation play a role in the stress response and are influenced by maternal care quality. In this study, pre-reproductive stress (PRS) in female adolescent rats was found to impact maternal care behaviors and DNA methylation patterns in the brains of exposed dams and their adult F1 and F2 offspring. Furthermore, drug treatments reversed some of the offspring phenotypes but had no effect on maternal care. These findings suggest that adolescent stress has lasting effects and influences methylation levels across multiple generations, working in conjunction with social mechanisms to shape adult offspring phenotypes.
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2023)
