Neural Mechanisms of Inflammation-Induced Fever

Interferon-ɣ mediated signaling in the brain endothelium is critical for inflammation-induced aversion

(2018) Michael Fritz et al.   BRAIN BEHAVIOR AND IMMUNITY

Interleukin-1β signaling in fenestrated capillaries is sufficient to trigger sickness responses in mice

(2017) J. Gabriel Knoll et al.   Journal of Neuroinflammation

Immune-Induced Fever Is Dependent on Local But Not Generalized Prostaglandin E2Synthesis in the Brain

(2017) Anna Eskilsson et al.   JOURNAL OF NEUROSCIENCE

Cold-Induced Thermogenesis and Inflammation-Associated Cold-Seeking Behavior Are Represented by Different Dorsomedial Hypothalamic Sites: A Three-Dimensional Functional Topography Study in Conscious Rats

(2017) Samuel P. Wanner et al.   JOURNAL OF NEUROSCIENCE

Central neural control of thermoregulation and brown adipose tissue

(2016) Shaun F. Morrison   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Anorexia-cachexia syndrome in hepatoma tumour-bearing rats requires the area postrema but not vagal afferents and is paralleled by increased MIC-1/GDF15

(2016) Tito Borner et al.   Journal of Cachexia Sarcopenia and Muscle

Fever and sickness behavior: Friend or foe?

(2015) L.M. Harden et al.   BRAIN BEHAVIOR AND IMMUNITY

Immune challenge by intraperitoneal administration of lipopolysaccharide directs gene expression in distinct blood–brain barrier cells toward enhanced prostaglandin E2 signaling

(2015) Ana Maria Vasilache et al.   BRAIN BEHAVIOR AND IMMUNITY

Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice

(2015) Michael Fritz et al.   JOURNAL OF CLINICAL INVESTIGATION

In-depth conversation: Spectrum and kinetics of neuroimmune afferent pathways

(2014) Ning Quan   BRAIN BEHAVIOR AND IMMUNITY

Distribution of microsomal prostaglandin E synthase-1 in the mouse brain

(2014) Anna Eskilsson et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Deletion of Prostaglandin E2 Synthesizing Enzymes in Brain Endothelial Cells Attenuates Inflammatory Fever

(2014) D. B. Wilhelms et al.   JOURNAL OF NEUROSCIENCE

Immune-Induced Fever Is Mediated by IL-6 Receptors on Brain Endothelial Cells Coupled to STAT3-Dependent Induction of Brain Endothelial Prostaglandin Synthesis

(2014) A. Eskilsson et al.   JOURNAL OF NEUROSCIENCE

TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins

(2014) Victor Meseguer et al.   Nature Communications

TRP Channels and Pain

(2013) David Julius   Annual Review of Cell and Developmental Biology

Cancer-induced anorexia in tumor-bearing mice is dependent on cyclooxygenase-1

(2013) Johan Ruud et al.   BRAIN BEHAVIOR AND IMMUNITY

Minor Changes in Gene Expression in the Mouse Preoptic Hypothalamic Region by Inflammation-Induced Prostaglandin E2

(2013) A. M. Vasilache et al.   JOURNAL OF NEUROENDOCRINOLOGY

Behavioural fever is a synergic signal amplifying the innate immune response

(2013) S. Boltana et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Lipopolysaccharide-Induced Fever Depends on Prostaglandin E2 Production Specifically in Brain Endothelial Cells

(2012) Linda Engström et al.   ENDOCRINOLOGY

TAK1 in brain endothelial cells mediates fever and lethargy

(2011) Dirk A. Ridder et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Central efferent pathways for cold-defensive and febrile shivering

(2011) Kazuhiro Nakamura et al.   JOURNAL OF PHYSIOLOGY-LONDON

Sensory circumventricular organs in health and disease

(2010) Sílvia Sisó et al.   ACTA NEUROPATHOLOGICA

Food deprivation alters thermoregulatory responses to lipopolysaccharide by enhancing cryogenic inflammatory signaling via prostaglandin D2

(2010) Catherine M. Krall et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Acute starvation alters lipopolysaccharide-induced fever in leptin-dependent and -independent mechanisms in rats

(2010) Wataru Inoue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Dual Roles for Perivascular Macrophages in Immune-to-Brain Signaling

(2010) Jordi Serrats et al.   NEURON

Cyclooxygenase-1 or -2—which one mediates lipopolysaccharide-induced hypothermia?

(2009) Alexandre A. Steiner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Peripheral Lipopolysaccharide Administration Induces Cytokine mRNA Expression in the Viscera and Brain of Fever-Refractory Mice Lacking Microsomal Prostaglandin E Synthase-1

(2009) C. Nilsberth et al.   JOURNAL OF NEUROENDOCRINOLOGY

Parallel Preoptic Pathways for Thermoregulation

(2009) K. Yoshida et al.   JOURNAL OF NEUROSCIENCE

Endothelial microsomal prostaglandin E synthase-1 exacerbates neuronal loss induced by kainate

(2009) Takako Takemiya et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Different populations of prostaglandin EP3 receptor-expressing preoptic neurons project to two fever-mediating sympathoexcitatory brain regions

(2009) Y. Nakamura et al.   NEUROSCIENCE

Immune-to-brain signaling and central prostaglandin E2 synthesis in fasted rats with altered lipopolysaccharide-induced fever

(2008) Wataru Inoue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Central pathway for spontaneous and prostaglandin E2-evoked cutaneous vasoconstriction

(2008) Joseph A. Rathner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Fever response to intravenous prostaglandin E2 is mediated by the brain but does not require afferent vagal signaling

(2008) Youichirou Ootsuka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The Role of Interleukin-6 in Lipopolysaccharide-Induced Fever by Mechanisms Independent of Prostaglandin E2

(2008) Camilla Nilsberth et al.   ENDOCRINOLOGY

Dual modulation of synaptic transmission in the nucleus tractus solitarius by prostaglandin E2 synthesized downstream of IL-1

(2008) Vincent Marty et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Selective contribution of interleukin-6 and leptin to brain inflammatory signals induced by systemic LPS injection in mice

(2008) Christoph Rummel et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Nociceptors Are Interleukin-1  Sensors

(2008) A. M. Binshtok et al.   JOURNAL OF NEUROSCIENCE

Preoptic mechanism for cold-defensive responses to skin cooling

(2008) Kazuhiro Nakamura et al.   JOURNAL OF PHYSIOLOGY-LONDON

Localized inflammation in peripheral tissue signals the CNS for sickness response in the absence of interleukin-1 and cyclooxygenase-2 in the blood and brain

(2008) H. Zhang et al.   NEUROSCIENCE