Disruption of lipid-raft localized Gαs/tubulin complexes by antidepressants: a unique feature of HDAC6 inhibitors, SSRI and tricyclic compounds

Antidepressants Accumulate in Lipid Rafts Independent of Monoamine Transporters to Modulate Redistribution of the G Protein, Gαs

(2016) Samuel J. Erb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

cAMP signaling in brain is decreased in unmedicated depressed patients and increased by treatment with a selective serotonin reuptake inhibitor

(2016) M Fujita et al.   MOLECULAR PSYCHIATRY

Activation of Microtubule Dynamics Increases Neuronal Growth via the Nerve Growth Factor (NGF)- and Gαs-mediated Signaling Pathways

(2015) Tulika Sarma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spatial encoding of cyclic AMP signaling specificity by GPCR endocytosis

(2014) Nikoleta G Tsvetanova et al.   Nature Chemical Biology

Lateral Diffusion of Gαs in the Plasma Membrane Is Decreased after Chronic but not Acute Antidepressant Treatment: Role of Lipid Raft and Non-Raft Membrane Microdomains

(2014) Andrew H Czysz et al.   NEUROPSYCHOPHARMACOLOGY

From Pathophysiology to Novel Antidepressant Drugs: Glial Contributions to the Pathology and Treatment of Mood Disorders

(2013) Gerard Sanacora et al.   BIOLOGICAL PSYCHIATRY

Increased Gsα within blood cell membrane lipid microdomains in some depressive disorders: An exploratory study

(2013) John J. Mooney et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Antidepressant-Like Properties of Novel HDAC6-Selective Inhibitors with Improved Brain Bioavailability

(2013) Jeanine Jochems et al.   NEUROPSYCHOPHARMACOLOGY

Next generation antidepressants

(2013) S. J. Russo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Downregulation of Brain Phosphodiesterase Type IV Measured with 11C-(R)-Rolipram Positron Emission Tomography in Major Depressive Disorder

(2012) Masahiro Fujita et al.   BIOLOGICAL PSYCHIATRY

HDAC6 Regulates Glucocorticoid Receptor Signaling in Serotonin Pathways with Critical Impact on Stress Resilience

(2012) J. Espallergues et al.   JOURNAL OF NEUROSCIENCE

Imipramine Induces Brain-Derived Neurotrophic Factor mRNA Expression in Cultured Astrocytes

(2012) Katsura Takano et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Histone deacetylase 6 gates the synaptic action of acute stress in prefrontal cortex

(2012) Janine B. Lee et al.   JOURNAL OF PHYSIOLOGY-LONDON

Loss of Deacetylation Activity of Hdac6 Affects Emotional Behavior in Mice

(2012) Masahide Fukada et al.   PLoS One

3 -Methoxy-pregnenolone (MAP4343) as an innovative therapeutic approach for depressive disorders

(2012) M. Bianchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antidepressants elevate GDNF expression and release from C6 glioma cells in a β-arrestin1-dependent, CREB interactive pathway

(2011) Moran Golan et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Agomelatine (S20098) modulates the expression of cytoskeletal microtubular proteins, synaptic markers and BDNF in the rat hippocampus, amygdala and PFC

(2011) Nataly Ladurelle et al.   PSYCHOPHARMACOLOGY

A Molecular and Structural Mechanism for G Protein-mediated Microtubule Destabilization

(2010) Rahul H. Davé et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antidepressants act on glial cells: SSRIs and serotonin elicit astrocyte calcium signaling in the mouse prefrontal cortex

(2010) Carola G. Schipke et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Epigenetic GABAergic targets in schizophrenia and bipolar disorder

(2010) A. Guidotti et al.   NEUROPHARMACOLOGY

Elongator Controls the Migration and Differentiation of Cortical Neurons through Acetylation of α-Tubulin

(2009) Catherine Creppe et al.   CELL

Chronic fluoxetine differentially modulates the hippocampal microtubular and serotonergic system in grouped and isolation reared rats

(2009) Massimiliano Bianchi et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Cytosolic GαsActs as an Intracellular Messenger to Increase Microtubule Dynamics and Promote Neurite Outgrowth

(2009) Jiang-Zhou Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antidepressant Actions of Histone Deacetylase Inhibitors

(2009) H. E. Covington et al.   JOURNAL OF NEUROSCIENCE

Chronic Treatment with Escitalopram but Not R-Citalopram Translocates G s from Lipid Raft Domains and Potentiates Adenylyl Cyclase: A 5-Hydroxytryptamine Transporter-Independent Action of This Antidepressant Compound

(2009) L. Zhang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Altered gene expression of histone deacetylases in mood disorder patients

(2009) Teruyuki Hobara et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Caveolin-1 and Lipid Microdomains Regulate Gs Trafficking and Attenuate Gs/Adenylyl Cyclase Signaling

(2009) J. A. Allen et al.   MOLECULAR PHARMACOLOGY

Heterotrimeric G-Proteins Interact Directly with Cytoskeletal Components to Modify Microtubule-Dependent Cellular Processes

(2009) Rahul H. Dave et al.   NEUROSIGNALS

HDAC6 is a target for protection and regeneration following injury in the nervous system

(2009) M. A. Rivieccio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluoxetine administration modulates the cytoskeletal microtubular system in the rat hippocampus

(2009) Massimiliano Bianchi et al.   SYNAPSE

Structural model of a complex between the heterotrimeric G protein, Gsα, and tubulin

(2008) Brian T. Layden et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Postmortem Brain Tissue of Depressed Suicides Reveals Increased Gs  Localization in Lipid Raft Domains Where It Is Less Likely to Activate Adenylyl Cyclase

(2008) R. J. Donati et al.   JOURNAL OF NEUROSCIENCE

Mice Lacking Histone Deacetylase 6 Have Hyperacetylated Tubulin but Are Viable and Develop Normally

(2008) Y. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

HDAC6: a key regulator of cytoskeleton, cell migration and cell–cell interactions

(2008) Agustín Valenzuela-Fernández et al.   TRENDS IN CELL BIOLOGY

Antidepressants induce acute CREB phosphorylation and CRE-mediated gene expression in glial cells: a possible contribution to GDNF production

(2007) Kazue Hisaoka et al.   BRAIN RESEARCH