Review
Biochemistry & Molecular Biology
Yasuyuki Tanahashi, Seiichi Komori, Hayato Matsuyama, Takio Kitazawa, Toshihiro Unno
Summary: The article reviews the mechanism of mAChRs in regulating gastrointestinal smooth muscle function and highlights the major signaling events induced by mAChRs. Challenges in studying individual mAChR subtypes and the need for novel strategies such as genetic manipulation are emphasized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Etienne de Coulon, Christian Dellenbach, Stephan Rohr
Summary: The LSSE system allows for comprehensive intracellular electrical recordings on cells undergoing strain events, providing stable conditions for studying mechanically activated ion currents. This system offers advanced insights into mechanosensitive ion channel function and allows for quantitative comparisons among different types of channels and cells.
Article
Multidisciplinary Sciences
Li-Hua Zhao, Jingyu Lin, Su-Yu Ji, X. Edward Zhou, Chunyou Mao, Dan-Dan Shen, Xinheng He, Peng Xiao, Jinpeng Sun, Karsten Melcher, Yan Zhang, Xiao Yu, H. Eric Xu
Summary: This study presents the structures of CRF2R bound to UCN1 and coupled to G proteins G(11) and G(o), and compares them with the structure of CRF2R bound to G(s), uncovering the structural differences that determine the selective coupling of G protein subtypes by CRF2R.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Nicholas C. Vierra, Samantha C. O'Dwyer, Collin Matsumoto, L. Fernando Santana, James S. Trimmer
Summary: In mammalian brain neurons, membrane depolarization triggers Ca2+ influx through voltage-gated Ca2+ channels, leading to diverse cellular responses, including gene expression. The L-type Ca2+ channels in neuronal soma and dendrites play a key role in this process. The organization of signaling complexes by Kv2.1 at endoplasmic reticulum-plasma membrane junctions enhances the clustering and activity of Cav1.2 channels, impacting somatic Ca2+ signals and excitation-transcription coupling.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Raziye Karapinar, Jan Claudius Schwitalla, Dennis Eickelbeck, Johanna Pakusch, Brix Mucher, Michelle Grommke, Tatjana Surdin, Thomas Knopfel, Melanie D. Mark, Ida Siveke, Stefan Herlitze
Summary: Opn7b is a non-visual G protein-coupled receptor expressed in zebrafish that can be controlled by light to modulate neuronal activity and neural circuit properties.
NATURE COMMUNICATIONS
(2021)
Review
Neurosciences
Huan Ma, Houda G. Khaled, Xiaohan Wang, Nataniel J. Mandelberg, Samuel M. Cohen, Xingzhi He, Richard W. Tsien
Summary: Excitation-transcription coupling (E-TC) plays a crucial role in linking synaptic and cellular activity to nuclear gene transcription, contributing to learning and memory. E-TC is mediated by long-range signaling from the synapse to the nucleus and local interactions within dendritic spines. Understanding the molecular mechanisms of E-TC can provide insights into its mesoscale functions and its regulation of neuronal network activity and behavior in physiological and pathological conditions.
NATURE REVIEWS NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Alexandra M. Carbone, Jordana Borges, Malka S. Suster, Anastasiya Sizova, Natalie Cora, Victoria L. Desimine, Anastasios Lymperopoulos
Summary: This study demonstrates the essential role of RGS4 in regulating propionate/FFAR3 signaling and its protective effects against inflammation and adverse remodeling in cardiomyocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Simonas Griesius, Cian O'Donnell, Sophie Waldron, Kerrie L. Thomas, Dominic M. Dwyer, Lawrence S. Wilkinson, Jeremy Hall, Emma S. J. Robinson, Jack R. Mellor
Summary: Loss of function in the DLG2 gene is associated with increased risk of schizophrenia, autism spectrum disorder, and intellectual disability. In a rat model, DLG2 haploinsufficiency led to impaired synaptic integration and associative long-term potentiation due to increased potassium channel function. This impairment was rescued by activation of muscarinic M1 receptors, suggesting a potential therapeutic target.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Yuan-yuan Ma, Ye Xu, Tian Zhang, Zhi-bin Chen, Tan Wang
Summary: This study found that GRK2 suppresses the electrophysiological activity of SH-SY5Y cells by blocking the Na channel, which may have implications for the occurrence of neurological diseases.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Review
Biochemistry & Molecular Biology
Alexandra M. Carbone, Giselle Del Calvo, Deepika Nagliya, Karina Sharma, Anastasios Lymperopoulos
Summary: Epicardial adipose tissue (EAT) interacts with the cardiac sympathetic and parasympathetic nervous systems, playing important biological roles in the heart. Abnormal secretion of EAT is implicated in the development of pathological conditions such as coronary atherosclerosis, atrial fibrillation, and heart failure. Studies have focused on understanding the autonomic regulation of EAT and its impact on heart disease progression.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kevin Paul, Robert Patejdl, Thomas K. Noack
Summary: Variant angina, also known as Prinzmetal angina or vasospastic angina, is characterized by transient or persistent contraction of coronary arteries, resulting in reduced blood flow. Symptoms of Prinzmetal angina include chest pain episodes that occur during rest at night. The mechanisms and optimal medications for treatment are difficult to determine.
TRACE ELEMENTS AND ELECTROLYTES
(2023)
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.