Editorial Material
Clinical Neurology
Yi Dong, Xin Cheng, Qiang Dong
Summary: A 47-year-old man presented with progressive right-hand bradykinesia and shuffling gait, diagnosed with Parkinsonism and hereditary diffuse leukoencephalopathy. MRI findings confirmed the diagnosis, but treatment with levodopa and selegiline showed minimal response.
Editorial Material
Clinical Neurology
Jasvir Virdee, Ahoane Qureshi, Susan P. Mollan
Summary: A 71-year-old man with blurred optic discs was referred to the emergency department and was diagnosed with optic disc drusen after further examination.
Editorial Material
Clinical Neurology
Jennifer Ling, Jonathan A. Micieli
Summary: A 37-year-old female presented with painful vision loss in both eyes due to optic neuritis, which was followed by central serous chorioretinopathy after corticosteroid treatment. The CSCR resolved after oral prednisone taper. CSCR can be misdiagnosed as optic neuritis or develop in patients with optic neuritis after corticosteroid treatment, and should be considered in cases of worsening vision after corticosteroid therapy.
Review
Clinical Neurology
Monica E. Maher, William Kingston
Summary: This review summarizes the literature and case reports on retinal migraine over the past 15 years, finding it to be a rare and predominantly female migraine variant possibly related to retinal vessel constriction. Diagnosis of retinal migraine should be exclusionary, and patients with this condition seem to respond well to typical migraine treatments.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2021)
Review
Pharmacology & Pharmacy
Farzin Zobdeh, Aziza Ben Kraiem, Misty M. Attwood, Vladimir N. Chubarev, Vadim V. Tarasov, Helgi B. Schioth, Jessica Mwinyi
Summary: Migraine is a prevalent disease globally and limited therapy response requires individually adjusted treatment. The pharmaceutical development for acute and chronic migraine has significantly intensified in recent years, with an expansion of drug targets and increased number of clinical trials.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Clinical Neurology
Katherine Podraza, Nitin Bangera, Akira Feliz, Andrew Charles
Summary: This study investigates the changes in retinal vasculature during and between migraine attacks using OCTA. It finds that there is reduced perfusion in the parafoveal retina during migraine attacks, and interictally, the foveal retina in migraine with aura has reduced perfusion compared to migraine without aura.
Review
Clinical Neurology
XiaoGuang Lin, ZhongQuan Yi, XueLing Zhang, QinQin Liu, Hui Zhang, RuYuan Cai, ChaoChun Chen, HongJie Zhang, PanWen Zhao, PingLei Pan
Summary: Migraine is a common disabling disease that can lead to abnormalities in the brain and retina. A meta-analysis showed that RNFL thickness reduction in migraine patients was significant, especially in those with aura, suggesting a potential role for RNFL thickness measurement in differentiating migraine patients from healthy controls.
NEUROLOGICAL SCIENCES
(2021)
Editorial Material
Clinical Neurology
Victor Hugo Pantoja Leao, Marcelo de Melo Aragao, Ricardo Silva Pinho, Marcelo Rodrigues Masruha
Summary: A 24-year-old woman with severe intellectual disability presented with refractory epilepsy since birth, along with global developmental delay and abnormalities in both primary and secondary teeth. Whole exome sequencing revealed compound heterozygous mutations in SLC13A5.
Correction
Clinical Neurology
S. A. A. Johnson, J. J. Chen, W. O. Tobin
Summary: This article describes a case of optic nerve sheath meningioma presenting as gaze-evoked amaurosis and points out an error in the first author's name, which has been corrected. The publisher regrets the error.
Review
Clinical Neurology
Juergen Borlak, Hans-Christoph Diener, Johanna Kleeberg-Hartmann, Karl Messlinger, Stephen Silberstein
Summary: Butterbur, a medicinal plant, contains petasins which have therapeutic benefits in treating migraine and tension headaches. Research shows that butterbur can reduce inflammation, decrease pain sensitivity, and prevent migraine attacks by regulating ion channels.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, General & Internal
Isidoro Raga-Martinez, Francisco J. Povedano-Montero, Jesus Hernandez-Gallego, Francisco Lopez-Munoz
Summary: The purpose of this study is to investigate the changes in retinal thickness in chronic migraine patients using optical coherence tomography (OCT). The study found that the thickness of the retinal nerve fibre layer and ganglion cell layer, as well as macular thickness, were significantly thinner in chronic migraine patients compared to healthy controls. These findings suggest that OCT can be used as a diagnostic tool for detecting retinal thinning in chronic migraines.
Article
Pharmacology & Pharmacy
Aqfan Jamaluddin, Chia-Lin Chuang, Elyse T. Williams, Andrew Siow, Sung Hyun Yang, Paul W. R. Harris, Jakeb S. S. M. Petersen, Rebekah L. Bower, Shanan Chand, Margaret A. Brimble, Christopher S. Walker, Debbie L. Hay, Kerry M. Loomes
Summary: This study explores the feasibility of developing lipidated CGRP peptide antagonists and demonstrates that selected lipidated peptide antagonists can retain potent antagonist activity at the CGRP receptor and inhibit endogenous CGRP action in vivo.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ming Jin, Xiao-Yu Zhang, Qian Ying, Hai-Jian Hu, Xin-Ting Feng, Zhen Peng, Yu-Lian Pang, Feng Yan, Xu Zhang
Summary: Low-color-temperature LEDs (1900K) have been found to be safe for retinal cells and can protect the ocular surface. In this study, we investigated the protective effects of 1900K LEDs on the retinal pigment epithelium (RPE) using ARPE-19 cell line and zebrafish. Our results showed that these LEDs increased cell vitality of ARPE-19 cells and protected RPE from damage caused by hydrogen peroxide. Furthermore, we demonstrated that irradiation with 1900K LEDs did not cause retinal damage in zebrafish. These findings lay the foundation for future light therapy using 1900K LEDs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Plant Sciences
Ruifang Yuan, Dingkun Zhang, Jinhui Yang, Zhenfeng Wu, Chuanhong Luo, Li Han, Fangli Yang, Junzhi Lin, Ming Yang
Summary: This study reviewed the pathogenesis of migraines, the application of plant essential oils in migraine treatment, and further explored the material basis and mechanism of action of plant essential oils against migraines. Results suggest that 10 types of plant essential oils could relieve migraine symptoms, with 16 monomers potentially playing a role in migraine treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Clinical Neurology
Yulian Pang, Ting Cao, Qinglin Zhang, Haijian Hu, Zhiruo Wang, Jiahe Nie, Ming Jin, Guiping Chen, Xu Zhang
Summary: This study used OCTA to study the retinal vascular density and foveal avascular zone in migraine patients. The results showed that migraine patients have decreased blood vessel density and increased avascular area in the fovea. This provides a theoretical basis for the rapid and non-invasive diagnosis of migraine using OCTA.
FRONTIERS IN NEUROLOGY
(2023)