Article
Clinical Neurology
Jiejie Li, Yuesong Pan, Jie Xu, Shiyu Li, Mengxing Wang, Kehua Quan, Xia Meng, Hao Li, Jinxi Lin, Yilong Wang, Xingquan Zhao, Liping Liu, Yongjun Wang
Summary: Residual inflammatory risk only may predict recurrent stroke and poor functional outcome in patients with acute ischemic stroke or transient ischemic attack, especially in those with large-artery atherosclerosis.
Article
Neurosciences
Yueqi Zhang, Guangjian Zhang, Xuecong Chen
Summary: The aim of this study is to investigate the correlation between serum calcium levels and clinical severity or functional outcome at discharge in Chinese patients with acute ischemic stroke. The analysis of 339 patients revealed a positive correlation between serum calcium levels and stroke severity, as well as infarct size. Multivariate analysis showed that higher serum calcium levels were associated with a higher risk of unfavorable outcome. This study suggests that calcium may serve as a prognostic biomarker for stroke in Chinese patients.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Immunology
Yulong Tan, Xiaoqian Liu, Xueting Yu, Tingting Shen, Zeze Wang, Zhen Luo, Xue Luo, Xuesen Yang
Summary: The study found that T lymphocytes play an important role in the pathophysiology of heat stroke, and the lack of T lymphocytes may exacerbate the severity of heat stroke by enhancing inflammatory response. Early circulating T lymphocytes levels may be negatively associated with the severity of heat stroke.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Eleftheria Ztriva, Adonis Protopapas, Pavlos Mentizis, Anastasios Papadopoulos, Christiana Gogou, Maria Kiosi, Maria Kyziroglou, Ioanna Minopoulou, Anastasia Gkounta, Erofili Papathanasiou, Evangelos Cholongitas, Christos Savopoulos, Konstantinos Tziomalos
Summary: This study aimed to evaluate the relationship between hepatic fibrosis and the severity and outcome of acute ischemic stroke. The study found that hepatic fibrosis, assessed by the FIB-4 index, is associated with more severe ischemic stroke and may also be an independent risk factor for in-hospital mortality in patients admitted with acute ischemic stroke.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Mengmeng Gu, Nihong Chen, Huanhuan Sun, Zhongyuan Li, Xiangliang Chen, Junshan Zhou, Yingdong Zhang
Summary: Stroke leads to gut microbiota disorder, with differences in composition based on stroke severity. Enrichment of Roseburia genus may play a protective role in stroke evolution and outcome, highlighting potential for targeted therapy in acute ischemic stroke.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Vijay Kumar, Sonia Kiran, Haidar A. Shamran, Udai P. Singh
Summary: Interstitial cystitis (IC)/bladder pain syndrome (BPS) primarily affects women and currently lacks effective treatment. Utilizing an experimental autoimmune cystitis (EAC) model, differential expression of specific miRs in iliac lymph nodes (ILNs) and urinary bladders (UB) of IC mice was observed, potentially highlighting mechanisms of IC pathogenesis and providing new therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Liyun Wang, Xiaoxing Xiong, Luyuan Zhang, Jian Shen
Summary: Ischemic stroke, resulting from sudden blockage of brain blood vessels, has a significant impact on health. Recent studies have highlighted the influence of the neurovascular unit on stroke outcomes, providing new strategies for treatment. The pathophysiology and neurovascular repair processes of IS are closely linked to the homeostatic state of the NVU, suggesting potential expansions in treatment options.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Clinical Neurology
Junhong Li, Jingjing Huang, Tingting Pang, Zikun Chen, Jing Li, Lin Wu, Yuqiang Hu, Wei Chen
Summary: A clinical-lab nomogram was developed and validated for predicting infectious and inflammatory disorders in patients with acute ischemic stroke (AIS). Age, comatose state, diabetes, and congestive heart failure were identified as risk factors for IAID. Neutrophil, monocyte, hemoglobin, and high-sensitivity C-reactive protein were also independently associated with IAID. The clinical-lab model showed better performance in differentiating IAID from AIS patients compared to lab or clinical models.
FRONTIERS IN NEUROLOGY
(2021)
Review
Clinical Neurology
Yingzhi Xu, Yue Hu, Shixin Xu, Fengzhi Liu, Ying Gao
Summary: Ischemic stroke (IS) is a leading cause of disability and death worldwide with high morbidity and mortality rates. Exosomes play a critical role in the pathogenesis, diagnosis, and treatment of cerebral infarctions resulting from IS, especially through the transfer of functional mRNAs/miRNAs and proteins to target cells, making them potential non-invasive biomarkers and drug carriers for the early diagnosis and treatment of IS.
FRONTIERS IN NEUROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Salman M. Toor, Eman K. Aldous, Aijaz Parray, Naveed Akhtar, Yasser Al-Sarraj, Essam M. Abdelalim, Abdelilah Arredouani, Omar El-Agnaf, Paul J. Thornalley, Sajitha V. Pananchikkal, Ghulam Jeelani Pir, Raheem Ayadathil Thazhhe Kuni, Ashfaq Shuaib, Nehad M. Alajez, Omar M. E. Albagha
Summary: This study conducted comprehensive circulating miRNA profiling in ischemic stroke patients with and without type 2 diabetes mellitus, identifying 5 differentially regulated miRNAs between the two groups. The findings offer insights into potential pathways associated with stroke and diabetes comorbidity.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Yalan Li, Jun Lu, Jie Wang, Peizhi Deng, Changjiang Meng, Haibo Tang
Summary: This study assessed the causal effects of inflammatory cytokines on the risk of ischemic stroke using Mendelian randomization analysis. The results showed that genetically increased IL-4 levels have a protective effect on the risk of ischemic stroke.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hongliang Zhao, Chengxiang Li, Zhenxiao Jin, Weixun Duan, Lei Shang, Yingjuan Chang, Jingji Xu, Jialiang Ren, Shushen Lin, Yan Wang, Li Zhu, Gang Wang, Xin Chen, Chao He, Minwen Zheng
Summary: A nomogram, based on simple imaging and clinical variables collected on admission, showed good discrimination and calibration abilities in predicting preoperative AIS for ATAAD patients.
EUROPEAN RADIOLOGY
(2023)
Review
Neurosciences
Meiling Bai, Ruize Sun, Bin Cao, Juan Feng, Jue Wang
Summary: Ischemic stroke is a leading cause of death worldwide and the most common cause of disability in Western countries. Inflammation plays a vital role in the development and progression of ischemic stroke, and peripheral blood immune cells, particularly monocytes, are involved in the immune cascade after stroke.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Immunology
Nicholas Henry, Jacqueline Frank, Christopher McLouth, Amanda L. Trout, Andrew Morris, Jianzhong Chen, Ann M. Stowe, Justin F. Fraser, Keith Pennypacker
Summary: This study found that plasma SCFA concentrations at the time of stroke are not associated with stroke severity. However, higher levels of SCFAs at the time of stroke are associated with increased markers of inflammation, less recovery from admission to discharge, and worse symptom burden at discharge.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Qingqing Wang, Bin Han, Xu Man, Huali Gu, Jinping Sun
Summary: This study revealed that CZTL alleviates neuroinflammation and brain damage in mice with acute ischemic stroke by modulating microglia polarization.
BRAIN RESEARCH BULLETIN
(2022)