Article
Multidisciplinary Sciences
Sarah Sternbach, Nicole West, Naveen K. Singhal, Robert Clements, Soumitra Basu, Ajai Tripathi, Ranjan Dutta, Ernest J. Freeman, Jennifer McDonough
Summary: The presence of BHMT enzyme in oligodendrocytes was confirmed, and betaine was shown to modulate histone and DNA methyltransferase activity through BHMT in these cells. The availability of methyl donors can impact epigenetic changes and maturation in oligodendrocytes. This study highlights the importance of the BHMT-betaine methylation pathway in regulating epigenetic mechanisms in neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Hannah Demond, Courtney W. Hanna, Juan Castillo-Fernandez, Fatima Santos, Evangelia K. Papachristou, Anne Segonds-Pichon, Kamal Kishore, Simon Andrews, Clive S. D'Santos, Gavin Kelsey
Summary: EHMT1 and EHMT2 play important roles in oogenesis, and loss of EHMT1 results in a significant impairment in oocyte maturation and developmental competence. EHMT1 contributes to local transcriptional repression in the oocyte, partially independent of EHMT2, and is critical for oogenesis and oocyte developmental competence.
Article
Medicine, Research & Experimental
Dongmei Gou, Rui Liu, Xiaoqun Shan, Haijun Deng, Chang Chen, Jin Xiang, Yi Liu, Qingzhu Gao, Zhi Li, Ailong Huang, Kai Wang, Ni Tang
Summary: The study found that the gluconeogenic enzyme PCK1 promoted the generation of S-adenosylmethionine (SAM) through the serine synthesis pathway. SAM served as a methyl donor to support H3K9me3 modification, inhibiting the oncogene S100A11. This study reveals the potential therapeutic strategy of targeting the metabolic enzyme PCK1 and H3K9 trimethylation for hepatocellular carcinoma (HCC) treatment.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Environmental Sciences
Yawen Xu, Li Wang, Jun Zhu, Ping Jiang, Zhan Zhang, Lei Li, Qian Wu
Summary: The study found that both Cr (III) and Cr (VI) can interfere with one carbon metabolism, affecting DNA methylation and histone methylation to regulate the expression of neuro-related genes, leading to neurotoxicity.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Health Care Sciences & Services
Gerardo Alfonso Perez, Javier Caballero Villarraso
Summary: This article presents a technique based on Shannon Entropy to select CpGs as inputs for non-linear classification algorithms, effectively reducing the difficulty of diagnosing multiple sclerosis and improving accuracy.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Genetics & Heredity
Jacqueline E. Mermoud
Summary: The RNA methylation of adenosine at the N6-position (m(6)A) plays a crucial role in RNA biology and gene expression. METTL3 and METTL14 are the main methyltransferases responsible for m(6)A deposition, while METTL16 regulates the cellular levels of the major methyl donor S-adenosylmethionine (SAM). This review summarizes recent progress in understanding the function of METTL16 in sensing and relaying metabolic information and discusses its similarities and differences with the better-known METTL3/14 complex, as well as its target specificity and potential roles.
Article
Plant Sciences
Yue Lu, Qing Bu, Mingli Chuan, Xiaoyun Cui, Yu Zhao, Dao-Xiu Zhou
Summary: Chromatin modifications play a crucial role in shaping the epigenome and regulating gene expression during plant development and adaptation to environmental changes. The activities of chromatin modification enzymes are influenced by cellular metabolites, such as S-adenosyl-methionine, acetyl-CoA, alpha-ketoglutarate, and NAD(+). On the other hand, changes in the plant epigenome and activity of epigenetic regulators can impact cellular metabolism through regulation of metabolic enzymes. This review highlights recent advances in understanding the metabolic control of plant chromatin regulators and epigenomes, which contribute to plant adaptation to environmental stresses.
Article
Biochemistry & Molecular Biology
Alison C. Brewer
Summary: The epigenetic landscape plays a crucial role in gene transcription and cellular phenotype determination, with chromatin remodelling during cellular differentiation being a key factor. Redox-dependent molecular mechanisms, including NADPH oxidases generating ROS, are important in regulating epigenetic changes. The role of NADPH oxidases in redox-dependent chromatin remodelling and the impact of epigenetic changes on ROS-producing enzymes are discussed in relation to cellular differentiation and homeostasis, particularly focusing on Nox4.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biotechnology & Applied Microbiology
Nasrullah, Abrar Hussain, Sagheer Ahmed, Mahmood Rasool, Abdul Jabbar Shah
Summary: DNA methylation is a process of adding methyl groups to the DNA molecule, which can alter the function of DNA. The importance and role of DNA methylation vary across different organisms, with mammals showing a strong relationship between DNA methylation and diseases such as cancer and placental development.
Article
Toxicology
SunilGowda Sunnaghatta Nagaraja, Umadevi Subramanian, Devipriya Nagarajan
Summary: This study investigated the role of histone methyltransferase G9a in radiation-induced EMT signaling, finding that G9a inhibitor can inhibit radiation-induced EMT and ROS generation, as well as affect the expression of the E-cadherin promoter.
TOXICOLOGY IN VITRO
(2021)
Article
Biochemistry & Molecular Biology
Jie Chang, Lude Wang, Xi Zhou, Jianlie Yuan, Wenxia Xu
Summary: This study found that methionine restriction can increase CXCL8 expression in glioma cells by mediating the degradation of LSD1 via CBL. Additionally, CXCL8 expression is significantly higher in glioma than in normal brain tissue and is associated with poor prognosis.
Review
Genetics & Heredity
Zahra Sahafnejad, Shahin Ramazi, Abdollah Allahverdi
Summary: Epigenetics is a significant field in biology that investigates changes in gene expression patterns not attributed to DNA sequence changes. Epigenetic marks, such as histone modifications, non-coding RNAs, and DNA methylation, play crucial roles in gene regulation. Aberrant epigenetic marks have been found to be associated with various diseases.
Article
Plant Sciences
Sofia Alves, Angelo Braga, Denise Parreira, Ana Teresa Alhinho, Helena Silva, Miguel Jesus Nunes Ramos, Maria Manuela Ribeiro Costa, Leonor Morais-Cecilio
Summary: This study investigates the epigenetic regulators in the Fagaceae family, an important family of trees and shrubs in the northern hemisphere ecosystems. The researchers identified orthologs of DNA methyltransferases, demethylases, and histone modifiers involved in acetylation, deacetylation, methylation, and demethylation. They also analyzed the evolutionary history of these genes within Fagaceae and found duplication events and the involvement of transposable elements in gene duplication. This work provides valuable knowledge for future studies on epigenetic regulation in the economically important Fagaceae family.
PHYSIOLOGIA PLANTARUM
(2022)
Article
Endocrinology & Metabolism
Amanda L. Morin, Phyo W. Win, Angela Z. Lin, Christina A. Castellani
Summary: Bidirectional crosstalk between the nuclear and mitochondrial genomes is crucial for cell functioning. Mitochondrial DNA copy number and heteroplasmy can influence mitochondrial function, nuclear genome, and contribute to overall health and disease. Mitochondria act as environmental biosensors, conveying essential information about cell state to the nuclear genome. Cellular communication between mitochondrial variation and nuclear epigenome can occur through modifications of metabolites and intermediates, affecting epigenetic modifications.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Allergy
Liuhui Fu, Jie Zhao, Jiaoyan Huang, Na Li, Xin Dong, Yao He, Wenyan Wang, Yu Wang, Ju Qiu, Xiaohuan Guo
Summary: This study reveals that the mitochondrial STAT3-methionine metabolism pathway is a key regulator of ILC2 effector function through epigenetic regulation. By promoting epigenetic reprogramming, this pathway further enhances ILC2-driven allergic lung inflammation. These findings suggest that the related proteins or metabolites could represent potential therapeutic targets for allergic lung inflammation.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Naveen Kumar Singhal, Swati Agarwal, Priyanka Bhatnagar, Manindra Nath Tiwari, Shashi Kant Tiwari, Garima Srivastava, Pradeep Kumar, Brashket Seth, Devendra Kumar Patel, Rajnish Kumar Chaturvedi, Mahendra Pratap Singh, Kailash Chand Gupta
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2015)
Article
Neurosciences
Naveen Kumar Singhal, Shuo Li, Erland Arning, Kholoud Alkhayer, Robert Clements, Zachary Sarcyk, Rohan S. Dassanayake, Nicola E. Brasch, Ernest J. Freeman, Teodoro Bottiglieri, Jennifer McDonough
JOURNAL OF NEUROSCIENCE
(2015)
Article
Biochemistry & Molecular Biology
Nolan Brown, Kholoud Alkhayer, Robert Clements, Naveen Singhal, Roger Gregory, Sausan Azzam, Shuo Li, Ernest Freeman, Jennifer McDonough
JOURNAL OF MOLECULAR NEUROSCIENCE
(2016)
Article
Neurosciences
N. K. Singhal, H. Huang, S. Li, R. Clements, J. Gadd, A. Daniels, E. E. Kooijman, P. Bannerman, T. Burns, F. Guo, D. Pleasure, E. Freeman, L. Shriver, J. McDonough
EXPERIMENTAL BRAIN RESEARCH
(2017)
Article
Neurosciences
Jiho Sohn, Peter Bannerman, Fuzheng Guo, Travis Burns, Laird Miers, Christopher Croteau, Naveen K. Singhal, Jennifer A. McDonough, David Pleasure
JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
N. K. Singhal, K. Alkhayer, J. Shelestak, R. Clements, E. Freeman, J. McDonough
MOLECULAR NEUROBIOLOGY
(2018)
Article
Biotechnology & Applied Microbiology
Peter Bannerman, Fuzheng Guo, Olga Chechneva, Travis Burns, Xiaoqing Zhu, Yan Wang, Bokyung Kim, Naveen K. Singhal, Jennifer A. McDonough, David Pleasure
Article
Multidisciplinary Sciences
Daniela C. Popescu, He Huang, Naveen K. Singhal, Leah Shriver, Jennifer McDonough, Robert J. Clements, Ernest J. Freeman
Article
Psychiatry
Andrew H. Czysz, Charles South, Bharathi S. Gadad, Erland Arning, Abigail Soyombo, Teodoro Bottiglieri, Madhukar H. Trivedi
TRANSLATIONAL PSYCHIATRY
(2019)
Article
Biochemistry & Molecular Biology
Naveen K. Singhal, Sarah Sternbach, Sheila Fleming, Kholoud Alkhayer, John Shelestak, Daniela Popescu, Alyx Weaver, Robert Clements, Brandi Wasek, Teodoro Bottiglieri, Ernest J. Freeman, Jennifer McDonough
Article
Clinical Neurology
Dana C. Walters, Erwin E. W. Jansen, Gajja S. Salomons, Erland Arning, Paula Ashcraft, Teodoro Bottiglieri, Jean-Baptiste Roullet, K. Michael Gibson
Summary: The study investigated the distribution of vigabatrin in different tissues of mice, with a focus on the preferential accumulation of the active isomer (S)-(+) VGB in the retina. This finding suggests the involvement of a stereospecific transporter in the partitioning of vigabatrin to the retina, which could potentially lead to new therapeutic approaches for mitigating its well-known retinal toxicity and expanding its clinical utility.
Article
Cell Biology
Silvia Ribo, David Sanchez-Infantes, Laura Martinez-Guino, Izaskun Garcia-Mantrana, Marta Ramon-Krauel, Mireia Tondo, Erland Arning, Miquel Nofrarias, Oscar Osorio-Conles, Antonio Fernandez-Perez, Pedro Gonzalez-Torres, Judith Cebria, Aleix Gavalda-Navarro, Empar Chenoll, Elvira Isganaitis, Francesc Villarroya, Mario Vallejo, Joaquim Segales, Josep C. Jimenez-Chillaron, Teodoro Bottiglieri, Ellen W. Demerath, David A. Fields, Maria Carmen Collado, Carles Lerin
Summary: The study found an inverse association between milk betaine content and infant growth, which was replicated in both humans and mice. Higher betaine intake during lactation led to lower adiposity and improved glucose homeostasis in mouse offspring. This effect was linked to increased Akkermansia abundance in the gut and higher intestinal goblet cell number.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Genetics & Heredity
Itay Tokatly Latzer, Jean-Baptiste Roullet, Samuele Cesaro, Melissa L. DiBacco, Erland Arning, Alexander Rotenberg, Henry H. C. Lee, Thomas Opladen, Kathrin Jeltsch, Angels Garcia-Cazorla, Natalia Julia-Palacios, K. Michael Gibson, Mariarita Bertoldi, Phillip L. Pearl
Summary: This study investigated the correlations between genotype, protein abnormalities, and clinical outcomes in succinic semialdehyde dehydrogenase deficiency (SSADHD). The results showed that the quantity and type of enzyme proteins, as well as their structural and functional impairments, contribute to the severity of the disease. These findings are valuable for disease prognosis, management, and understanding the relationships between genotype, protein, and phenotype in autosomal recessive disorders.
Article
Biochemistry & Molecular Biology
Hui-Ting Huang, Shun-Fen Tzeng
Summary: Our study demonstrates the role of interleukin-33 (IL-33) in a demyelinating mouse model induced by cuprizone (CPZ), showing that IL-33 can alleviate the reduction of APC+ OLs and the decline of IL-33 levels in the corpus callosum, and promote the expression of myelin basic protein (MBP).
NEUROCHEMISTRY INTERNATIONAL
(2024)
