期刊
NEUROCHEMISTRY INTERNATIONAL
卷 112, 期 -, 页码 1-4出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2017.10.011
关键词
Multiple sclerosis; Methionine metabolism; Histone methylation; DNA methyltransferases
资金
- College of Art and Science at Kent State University
We report a significant reduction in plasma methionine concentrations in relapse remitting multiple sclerosis (MS) patients compared to controls. In vivo studies demonstrate that changes in peripheral methionine levels in mice can regulate histone H3 methylation and expression of DNA methyltransfe rase 3A (DNMT3A) centrally, in the cerebral cortex. Therefore, we propose that decreases in circulating methionine represent one of the earliest manifestations of dysregulated methionine metabolism in MS with potential impacts on both histone H3 and DNA methylation in the central nervous system. (C) 2017 Elsevier Ltd. All rights reserved.
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