Molecular transport in articular cartilage — what have we learned from the past 50 years?

The Effect of Antibody Size and Mechanical Loading on Solute Diffusion Through the Articular Surface of Cartilage

(2017) Chris D. DiDomenico et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis

(2017) Bruno R da Costa et al.   LANCET

Cartilage-targeting drug delivery: can electrostatic interactions help?

(2017) Ambika G. Bajpayee et al.   Nature Reviews Rheumatology

Sliding enhances fluid and solute transport into buried articular cartilage contacts

(2017) B.T. Graham et al.   OSTEOARTHRITIS AND CARTILAGE

Hyaluronic Acid Nanoporous Microparticles with Long In Vivo Joint Residence Time and Sustained Release

(2017) Graziana Palmieri et al.   PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION

Solute Transport of Negatively Charged Contrast Agents Across Articular Surface of Injured Cartilage

(2016) H. T. Kokkonen et al.   ANNALS OF BIOMEDICAL ENGINEERING

Cationic Contrast Agent Diffusion Differs Between Cartilage and Meniscus

(2016) Juuso T. J. Honkanen et al.   ANNALS OF BIOMEDICAL ENGINEERING

Cyclic Mechanical Loading Enhances Transport of Antibodies Into Articular Cartilage

(2016) Chris D. DiDomenico et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Nanodrugs to target articular cartilage: An emerging platform for osteoarthritis therapy

(2016) Massimo Bottini et al.   Nanomedicine-Nanotechnology Biology and Medicine

Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth

(2016) Sung Eun Kim et al.   Nature Nanotechnology

Charge based intra-cartilage delivery of single dose dexamethasone using Avidin nano-carriers suppresses cytokine-induced catabolism long term

(2016) A.G. Bajpayee et al.   OSTEOARTHRITIS AND CARTILAGE

The efficacy of intra-articular steroids in hip osteoarthritis: a systematic review

(2016) P.S. McCabe et al.   OSTEOARTHRITIS AND CARTILAGE

Drug delivery to chondrocytes

(2016) C.H. Evans   OSTEOARTHRITIS AND CARTILAGE

Intra-articular delivery of anti-Hif-2α siRNA by chondrocyte-homing nanoparticles to prevent cartilage degeneration in arthritic mice

(2015) Y Pi et al.   GENE THERAPY

Safety and efficacy of intra-articular anti-tumor necrosis factor α agents compared to corticosteroids in a treat-to-target strategy in patients with inflammatory arthritis and monoarthritis flare

(2015) Francesco Carubbi et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Transport of Neutral Solute Across Articular Cartilage: The Role of Zonal Diffusivities

(2015) V. Arbabi et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

A rabbit model demonstrates the influence of cartilage thickness on intra-articular drug delivery and retention within cartilage

(2015) Ambika G. Bajpayee et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Polyethylene-Glycol-Modified Single-Walled Carbon Nanotubes for Intra-Articular Delivery to Chondrocytes

(2014) Cristiano Sacchetti et al.   ACS Nano

Diffusion of MRI and CT Contrast Agents in Articular Cartilage under Static Compression

(2014) Yousef Shafieyan et al.   BIOPHYSICAL JOURNAL

Intra-articular and soft tissue injections, a systematic review of relative efficacy of various corticosteroids

(2014) Neha Garg et al.   CLINICAL RHEUMATOLOGY

Effect of mechanical convection on the partitioning of an anionic iodinated contrast agent in intact patellar cartilage

(2014) Vahid Entezari et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

OARSI guidelines for the non-surgical management of knee osteoarthritis

(2014) T.E. McAlindon et al.   OSTEOARTHRITIS AND CARTILAGE

Targeting of viral interleukin-10 with an antibody fragment specific to damaged arthritic cartilage improves its therapeutic potency

(2014) Chris Hughes et al.   ARTHRITIS RESEARCH & THERAPY

Solute transport across the articular surface of injured cartilage

(2013) Hooi Chuan Chin et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Decreased solute adsorption onto cracked surfaces of mechanically injured articular cartilage: Towards the design of cartilage-specific functional contrast agents

(2013) Mohammad Moeini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Avidin as a model for charge driven transport into cartilage and drug delivery for treating early stage post-traumatic osteoarthritis

(2013) Ambika G. Bajpayee et al.   BIOMATERIALS

High-Bandwidth AFM-Based Rheology Reveals that Cartilage is Most Sensitive to High Loading Rates at Early Stages of Impairment

(2013) Hadi Tavakoli Nia et al.   BIOPHYSICAL JOURNAL

Adsorption and Distribution of Fluorescent Solutes near the Articular Surface of Mechanically Injured Cartilage

(2013) Sarah G.A. Decker et al.   BIOPHYSICAL JOURNAL

Chemokine and cytokine levels in osteoarthritis and rheumatoid arthritis synovial fluid

(2013) Ulrike Hampel et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Biologic agents in osteoarthritis: hopes and disappointments

(2013) Xavier Chevalier et al.   Nature Reviews Rheumatology

Progress in intra-articular therapy

(2013) Christopher H. Evans et al.   Nature Reviews Rheumatology

Detection of cartilage matrix degradation by autofluorescence lifetime

(2012) Hugh B. Manning et al.   MATRIX BIOLOGY

Bath Concentration of Anionic Contrast Agents Does Not Affect Their Diffusion and Distribution in Articular Cartilage In Vitro

(2012) Tuomo S. Silvast et al.   Cartilage

Targeted delivery of non-viral vectors to cartilage in vivo using a chondrocyte-homing peptide identified by phage display

(2011) Yanbin Pi et al.   BIOMATERIALS

Dynamic loading of immature epiphyseal cartilage pumps nutrients out of vascular canals

(2011) Michael B. Albro et al.   JOURNAL OF BIOMECHANICS

In vivo transport of Gd-DTPA2− in human knee cartilage assessed by depth-wise dGEMRIC analysis

(2011) Zana K. Hawezi et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Simultaneous Measurement of Anisotropic Solute Diffusivity and Binding Reaction Rates in Biological Tissues by FRAP

(2010) Francesco Travascio et al.   ANNALS OF BIOMEDICAL ENGINEERING

Transport and equilibrium uptake of a peptide inhibitor of PACE4 into articular cartilage is dominated by electrostatic interactions

(2010) Sangwon Byun et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Human single-chain variable fragment that specifically targets arthritic cartilage

(2010) Chris Hughes et al.   ARTHRITIS AND RHEUMATISM

Validation of theoretical framework explaining active solute uptake in dynamically loaded porous media

(2010) Michael B. Albro et al.   JOURNAL OF BIOMECHANICS

Diffusion coefficients of articular cartilage for different CT and MRI contrast agents

(2010) K.A.M. Kulmala et al.   MEDICAL ENGINEERING & PHYSICS

Intra-articular drug delivery: The challenge to extend drug residence time within the joint

(2010) Scott H.R. Edwards   VETERINARY JOURNAL

Anti-inflammatory and cartilage-protecting effects of an intra-articularly injected anti-TNF  single-chain Fv antibody (ESBA105) designed for local therapeutic use

(2009) D M Urech et al.   ANNALS OF THE RHEUMATIC DISEASES

Intraarticular injection of anakinra in osteoarthritis of the knee: A multicenter, randomized, double-blind, placebo-controlled study

(2009) X. Chevalier et al.   ARTHRITIS AND RHEUMATISM

In situ measurement of transport between subchondral bone and articular cartilage

(2009) Jun Pan et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Depth-wise progression of osteoarthritis in human articular cartilage: investigation of composition, structure and biomechanics

(2009) S. Saarakkala et al.   OSTEOARTHRITIS AND CARTILAGE

Evaluating Intra-Articular Drug Delivery for the Treatment of Osteoarthritis in a Rat Model

(2009) Kyle D. Allen et al.   TISSUE ENGINEERING PART B-REVIEWS

Microscale Diffusion Properties of the Cartilage Pericellular Matrix Measured Using 3D Scanning Microphotolysis

(2008) Holly A. Leddy   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Protein-nanoparticle interactions

(2008) Iseult Lynch et al.   Nano Today

Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage

(2008) Dominique A. Rothenfluh et al.   NATURE MATERIALS

Role of Particle Size in Phagocytosis of Polymeric Microspheres

(2008) Julie A. Champion et al.   PHARMACEUTICAL RESEARCH

Are there promising biologic therapies for osteoarthritis?

(2008) David J. Hunter   Current Rheumatology Reports

Solute transport in the deep and calcified zones of articular cartilage

(2007) K.P. Arkill et al.   OSTEOARTHRITIS AND CARTILAGE