Integrating new findings and examining clinical applications of pattern separation

Acute moderate exercise improves mnemonic discrimination in young adults

(2017) Kazuya Suwabe et al.   HIPPOCAMPUS

Disruption of amygdala-entorhinal-hippocampal network in late-life depression

(2017) Stephanie L. Leal et al.   HIPPOCAMPUS

Repetition reveals ups and downs of hippocampal, thalamic, and neocortical engagement during mnemonic decisions

(2017) Zachariah M. Reagh et al.   HIPPOCAMPUS

Tau and β-Amyloid Are Associated with Medial Temporal Lobe Structure, Function, and Memory Encoding in Normal Aging

(2017) Shawn M. Marks et al.   JOURNAL OF NEUROSCIENCE

Age-related individual variability in memory performance is associated with amygdala-hippocampal circuit function and emotional pattern separation

(2017) Stephanie L. Leal et al.   NEUROBIOLOGY OF AGING

Spatial Representations of Granule Cells and Mossy Cells of the Dentate Gyrus

(2017) Douglas GoodSmith et al.   NEURON

Adult-born neurons modify excitatory synaptic transmission to existing neurons

(2017) Elena W Adlaf et al.   eLife

Aerobic fitness associates with mnemonic discrimination as a mediator of physical activity effects: evidence for memory flexibility in young adults

(2017) Kazuya Suwabe et al.   Scientific Reports

The Human Dentate Gyrus Plays a Necessary Role in Discriminating New Memories

(2016) Stevenson Baker et al.   CURRENT BIOLOGY

Greater loss of object than spatial mnemonic discrimination in aged adults

(2016) Zachariah M. Reagh et al.   HIPPOCAMPUS

Dendrites of dentate gyrus granule cells contribute to pattern separation by controlling sparsity

(2016) Spyridon Chavlis et al.   HIPPOCAMPUS

Strong Evidence for Pattern Separation in Human Dentate Gyrus

(2016) D. Berron et al.   JOURNAL OF NEUROSCIENCE

The enigmatic mossy cell of the dentate gyrus

(2016) Helen E. Scharfman   NATURE REVIEWS NEUROSCIENCE

Tracking the flow of hippocampal computation: Pattern separation, pattern completion, and attractor dynamics

(2016) James J. Knierim et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

The representational–hierarchical view of pattern separation: Not just hippocampus, not just space, not just memory?

(2016) B.A. Kent et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Modulating Neuronal Competition Dynamics in the Dentate Gyrus to Rejuvenate Aging Memory Circuits

(2016) Kathleen M. McAvoy et al.   NEURON

Distinct Contribution of Adult-Born Hippocampal Granule Cells to Context Encoding

(2016) Nathan B. Danielson et al.   NEURON

Cortical pattern separation and item-specific memory encoding

(2016) Laura M. Pidgeon et al.   NEUROPSYCHOLOGIA

Synaptic Proteins in the Hippocampus Indicative of Increased Neuronal Activity in CA3 in Schizophrenia

(2015) Wei Li et al.   AMERICAN JOURNAL OF PSYCHIATRY

Stability of age-related deficits in the mnemonic similarity task across task variations.

(2015) Shauna M. Stark et al.   BEHAVIORAL NEUROSCIENCE

Hippocampal Subfields and Major Depressive Disorder

(2015) Benjamin Adam Samuels et al.   BIOLOGICAL PSYCHIATRY

Illness Progression, Recent Stress, and Morphometry of Hippocampal Subfields and Medial Prefrontal Cortex in Major Depression

(2015) Michael T. Treadway et al.   BIOLOGICAL PSYCHIATRY

Changes in pattern completion – A key mechanism to explain age-related recognition memory deficits?

(2015) Paula Vieweg et al.   CORTEX

Complementary Roles of Human Hippocampal Subfields in Differentiation and Integration of Spatial Context

(2015) Jared Stokes et al.   JOURNAL OF COGNITIVE NEUROSCIENCE

Virtual Environmental Enrichment through Video Games Improves Hippocampal-Associated Memory

(2015) G. D. Clemenson et al.   JOURNAL OF NEUROSCIENCE

Adult Hippocampal Neurogenesis, Fear Generalization and Stress

(2015) Antoine Besnard et al.   NEUROPSYCHOPHARMACOLOGY

Clarifying the role of pattern separation in schizophrenia: The role of recognition and visual discrimination deficits

(2015) Cristina Martinelli et al.   SCHIZOPHRENIA RESEARCH

Neurocognitive Aging and the Hippocampus across Species

(2015) Stephanie L. Leal et al.   TRENDS IN NEUROSCIENCES

Analysis of Neural-BOLD Coupling Through Four Models of the Neural Metabolic Demand

(2015) Christopher W. Tyler et al.   Frontiers in Neuroscience

Response of the medial temporal lobe network in amnestic mild cognitive impairment to therapeutic intervention assessed by fMRI and memory task performance

(2015) Arnold Bakker et al.   NeuroImage-Clinical

Effects of aging on mnemonic discrimination of emotional information.

(2014) Stephanie L. Leal et al.   BEHAVIORAL NEUROSCIENCE

Temporal discrimination deficits as a function of lag interference in older adults

(2014) Jared M. Roberts et al.   HIPPOCAMPUS

Pattern separation of emotional information in hippocampal dentate and CA3

(2014) Stephanie L. Leal et al.   HIPPOCAMPUS

Social-cognitive, physiological, and neural mechanisms underlying emotion regulation impairments: understanding anxiety in autism spectrum disorder

(2014) Susan W. White et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Vascular hippocampal plasticity after aerobic exercise in older adults

(2014) A Maass et al.   MOLECULAR PSYCHIATRY

Post-study caffeine administration enhances memory consolidation in humans

(2014) Daniel Borota et al.   NATURE NEUROSCIENCE

Asymmetric effects of emotion on mnemonic interference

(2014) Stephanie L. Leal et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

CA3 Retrieves Coherent Representations from Degraded Input: Direct Evidence for CA3 Pattern Completion and Dentate Gyrus Pattern Separation

(2014) Joshua P. Neunuebel et al.   NEURON

Brain-state dependent uncoupling of BOLD and local field potentials in laminar olfactory bulb

(2014) Ling Gong et al.   NEUROSCIENCE LETTERS

Object and spatial mnemonic interference differentially engage lateral and medial entorhinal cortex in humans

(2014) Zachariah M. Reagh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of pattern separation performance in schizophrenia suggests dentate gyrus dysfunction

(2014) Tanusree Das et al.   SCHIZOPHRENIA RESEARCH

Performance on a pattern separation task by Alzheimer’s patients shows possible links between disrupted dentate gyrus activity and apolipoprotein E ∈4 status and cerebrospinal fluid amyloid-β42 levels

(2014) Keith A Wesnes et al.   Alzheimers Research & Therapy

A possible negative influence of depression on the ability to overcome memory interference

(2013) Don J. Shelton et al.   BEHAVIOURAL BRAIN RESEARCH

Dynamics of Hippocampal Neurogenesis in Adult Humans

(2013) Kirsty L. Spalding et al.   CELL

Spatial discrimination deficits as a function of mnemonic interference in aged adults with and without memory impairment

(2013) Zachariah M. Reagh et al.   HIPPOCAMPUS

Depressive mood modulates the anterior lateral CA1 and DG/CA3 during a pattern separation task in cognitively intact individuals: A functional MRI study

(2013) Takeshi Fujii et al.   HIPPOCAMPUS

Pattern separation and pattern completion in Alzheimer's disease: Evidence of rapid forgetting in amnestic mild cognitive impairment

(2013) Brandon A. Ally et al.   HIPPOCAMPUS

Hilar interneuron vulnerability distinguishes aged rats with memory impairment

(2013) Amy M. Spiegel et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Visual object pattern separation varies in older adults

(2013) H. M. Holden et al.   LEARNING & MEMORY

Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease

(2013) Usman A Khan et al.   NATURE NEUROSCIENCE

The touchscreen operant platform for testing working memory and pattern separation in rats and mice

(2013) Charlotte A Oomen et al.   Nature Protocols

A task to assess behavioral pattern separation (BPS) in humans: Data from healthy aging and mild cognitive impairment

(2013) Shauna M. Stark et al.   NEUROPSYCHOLOGIA

Functional correlates of the lateral and medial entorhinal cortex: objects, path integration and local-global reference frames

(2013) J. J. Knierim et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Neuronal plasticity and antidepressant actions

(2013) Eero Castrén et al.   TRENDS IN NEUROSCIENCES

Selection of distinct populations of dentate granule cells in response to inputs as a mechanism for pattern separation in mice

(2013) Wei Deng et al.   eLife

Adult hippocampal neurogenesis reduces memory interference in humans: opposing effects of aerobic exercise and depression

(2013) Nicolas Déry et al.   Frontiers in Neuroscience

Spatial pattern separation in cognitively normal young and older adults

(2012) Heather M. Holden et al.   HIPPOCAMPUS

The effect of interference on temporal order memory for random and fixed sequences in nondemented older adults

(2012) J. C. Tolentino et al.   LEARNING & MEMORY

Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders

(2012) Mazen A Kheirbek et al.   NATURE NEUROSCIENCE

Reduction of Hippocampal Hyperactivity Improves Cognition in Amnestic Mild Cognitive Impairment

(2012) Arnold Bakker et al.   NEURON

Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model

(2012) P. E. Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of adult neurogenesis impairs population coding of similar contexts in hippocampal CA3 region

(2012) Yosuke Niibori et al.   Nature Communications

Less efficient pattern separation may contribute to age-related spatial memory deficits

(2012) Heather M. Holden et al.   Frontiers in Aging Neuroscience

Evidence for area CA1 as a match/mismatch detector: A high-resolution fMRI study of the human hippocampus

(2011) Katherine Duncan et al.   HIPPOCAMPUS

Pattern Separation: A Common Function for New Neurons in Hippocampus and Olfactory Bulb

(2011) Amar Sahay et al.   NEURON

Towards a functional organization of episodic memory in the medial temporal lobe

(2011) Howard Eichenbaum et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Effects of environmental enrichment and voluntary exercise on neurogenesis, learning and memory, and pattern separation: BDNF as a critical variable?

(2011) Pedro Bekinschtein et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Pattern separation in the hippocampus

(2011) Michael A. Yassa et al.   TRENDS IN NEUROSCIENCES

The Hippocampal Formation in Schizophrenia

(2010) Carol A. Tamminga et al.   AMERICAN JOURNAL OF PSYCHIATRY

Emotion and episodic memory in neuropsychiatric disorders

(2010) Ekrem Dere et al.   BEHAVIOURAL BRAIN RESEARCH

Cognitive Decline Is Associated with Reduced Reelin Expression in the Entorhinal Cortex of Aged Rats

(2010) Alexis M. Stranahan et al.   CEREBRAL CORTEX

Distinct pattern separation related transfer functions in human CA3/dentate and CA1 revealed using high-resolution fMRI and variable mnemonic similarity

(2010) J. W. Lacy et al.   LEARNING & MEMORY

Individual differences in spatial pattern separation performance associated with healthy aging in humans

(2010) S. M. Stark et al.   LEARNING & MEMORY

High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic Mild Cognitive Impairment

(2010) Michael A. Yassa et al.   NEUROIMAGE

Ultrahigh-resolution microstructural diffusion tensor imaging reveals perforant path degradation in aged humans in vivo

(2010) Michael A. Yassa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Targeting of the CA1 Subfield of the Hippocampal Formation by Schizophrenia and Related Psychotic Disorders

(2009) Scott A. Schobel et al.   ARCHIVES OF GENERAL PSYCHIATRY

How and when the fMRI BOLD signal relates to underlying neural activity: The danger in dissociation

(2009) Arne Ekstrom   BRAIN RESEARCH REVIEWS

Visual object pattern separation deficits in nondemented older adults

(2009) C. K. Toner et al.   LEARNING & MEMORY

Treatment Strategies Targeting Excess Hippocampal Activity Benefit Aged Rats with Cognitive Impairment

(2009) Ming Teng Koh et al.   NEUROPSYCHOPHARMACOLOGY

A new touchscreen test of pattern separation: effect of hippocampal lesions

(2009) Stephanie M. McTighe et al.   NEUROREPORT

Novelty signals: a window into hippocampal information processing

(2009) Dharshan Kumaran et al.   TRENDS IN COGNITIVE SCIENCES

Pattern Separation in the Human Hippocampal CA3 and Dentate Gyrus

(2008) A. Bakker et al.   SCIENCE