Article
Cell Biology
Inmaculada M. Gonzalez-Gonzalez, John A. Gray, Joana Ferreira, Maria Jose Conde-Dusman, Delphine Bouchet, Isabel Perez-Otano, Laurent Groc
Summary: Signaling via NMDARs is regulated by the expression of GluN2A and GluN3A subunits, with GluN3A controlling the surface diffusion of GluN2A-NMDARs during early development.
Article
Multidisciplinary Sciences
Anjali Gour, Kevin M. Boergens, Natalie Heike, Yunfeng Hua, Philip Laserstein, Kun Song, Moritz Helmstaedter
Summary: The study quantifies the circuit patterns of synaptogenesis for inhibitory interneurons in the developing mouse somatosensory cortex, revealing different developmental profiles and time courses for synaptic innervation of cell bodies, apical dendrites, and axon initial segments. Apical dendrites are innervated early and specifically, while axons innervating cell bodies gradually acquire specificity over time.
Article
Neurosciences
Kristen M. Harris, Dusten D. Hubbard, Masaaki Kuwajima, Wickliffe C. Abraham, Jennifer N. Bourne, Jared B. Bowden, Andrea Haessly, John M. Mendenhall, Patrick H. Parker, Bitao Shi, Josef Spacek
Summary: Microtubules play a crucial role in the delivery of resources to and from synapses. Three-dimensional reconstructions in rat hippocampus reveal a sampling bias in terms of spine density, which needs to be accounted for when considering dendrite size and microtubule number for resource delivery. The relationship between microtubules and dendritic arbors varies across different regions. These findings provide valuable insights into the regulation of resource delivery by microtubules.
Article
Chemistry, Multidisciplinary
Ender Ercan, Yan-Cheng Lin, Wei-Chen Yang, Wen-Chang Chen
Summary: This study investigates the influence of solution processing and treatments on perovskite quantum dot/polymer composite films, leading to improved photonic synaptic performance. The resulting synaptic devices demonstrate superior energy efficiency and operation without a gate, attributed to homogeneous QD distribution and formation of polymer nanofibrils and co-aggregates. These findings offer new insights for the fabrication of artificial synapses mimicking human-like memory and neuromorphic computing.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Multidisciplinary Sciences
Jaclyn McCoy, Marc Nahmani
Summary: This article presents a methodological pipeline for the rapid 3D analysis of subcellular structures, focusing on identifying and tracing structures within thin neuronal processes. It also includes a list of freely available software programs for data analysis and offers tips for improving 3D reconstructions.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Multidisciplinary Sciences
Kai Yang, Tong Liu, Ze Wang, Jing Liu, Yuxinyao Shen, Xinyi Pan, Ruyi Wen, Haotian Xie, Zhaoxuan Ruan, Zixiao Tan, Yingying Chen, Aike Guo, He Liu, Hua Han, Zengru Di, Ke Zhang
Summary: In Drosophila melanogaster, olfactory projection neurons show diverse structural morphology in their boutons, with complex boutons having the highest capability of releasing neurotransmitters and neuromodulators. The distribution of dense-core vesicles within different bouton subtypes are preferentially linked to specific molecular markers, indicating a potential functional specialization of these distinct bouton types in transmitting odor information.
Article
Endocrinology & Metabolism
Ana Fuentes, Cristina Garcia-Ajofrin, Ruth Romero, Juan Carlos Castillo, Jose A. A. Ortiz, Monica Hortal, Jaime Guerrero, Andrea Bernabeu, Rafael Bernabeu
Summary: This study aimed to investigate the impact of the start time of luteal phase stimulation on ovarian response in DuoStim cycles. The results showed that the start time did not affect the number of oocytes collected, but early stimulation led to lower quality of fertilized oocytes and blastocysts.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biology
Filippo Ghezzi, Andre Marques-Smith, Paul G. Anastasiades, Daniel Lyngholm, Cristiana Vagnoni, Alexandra Rowett, Gokul Parameswaran, Anna Hoerder-Suabedissen, Yasushi Nakagawa, Zoltan Molnar, Simon J. B. Butt
Summary: Subplate neurons are heterogeneous in morphology and synaptic connectivity, with fusiform and pyramidal subtypes playing different roles in processing sensory information in the neocortex.
Article
Cell Biology
Lorenzo Gesuita, Anna Cavaccini, Ali Ozgur Argunsah, Emilia Favuzzi, Leena Ali Ibrahim, Tevye Jason Stachniak, Martina De Gennaro, Sebastian Utz, Melanie Greter, Theofanis Karayannis
Summary: Microglia play a crucial role in the development of inhibitory networks, especially in the proper development of SST+ cell synapses. The molecules CX3CL1 and CXCL12 have opposing effects on the elaboration of SST+ cell axons. In terms of cortical activity development, microglia are essential for the activation of SST+ cells.
Article
Clinical Neurology
Goncalo Cotovio, Albino J. Oliveira-Maia, Carter Paul, Francisco Faro Viana, Daniel Rodrigues da Silva, Carolina Seybert, Adam P. Stern, Alvaro Pascual-Leone, Daniel Z. Press
Summary: The study evaluated the daily variability of motor threshold in the treatment of depression using repetitive transcranial magnetic stimulation and found that this variability has a significant impact on treatment intensity. Regular assessments of motor threshold, either daily or weekly, are recommended to improve the effectiveness and safety of therapeutic rTMS practice.
Article
Anatomy & Morphology
Irina Mikheeva, Natalya Zhujkova, Gulnara Mikhailova, Rashid Shtanchaev, Lyubov Pavlik, Vladimir Arkhipov
Summary: The cellular mechanisms of neuroplastic changes in the structure of motoneurons and neuropils of the oculomotor (III) nuclei in mice after a 30-day space flight and 7 days after landing were studied. Microgravity caused degenerative phenomena in neurons, including a decrease in dendritic branches, axodendritic synapses, and the number of mitochondria. These changes were not fully restored after readaptation. Conversely, in the trochlear nucleus, dendrites and synaptic contacts were restored, and mitogenesis was significantly enhanced after readaptation.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Behavioral Sciences
Laura E. Hawley, Faith Prochaska, Megan Stringer, Charles R. Goodlett, Randall J. Roper
Summary: The neurotypical spatiotemporal patterns of gene expression are disrupted in Down syndrome due to trisomy of human chromosome 21. In the Ts65Dn DS mouse model, the DYRK1A gene is overexpressed in the brain, and treatment with a DYRK1A inhibitor fails to normalize behavior in trisomic animals. The study highlights the importance of understanding the developmental timing of dysregulated DYRK1A expression in Down syndrome for therapeutic interventions.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Article
Materials Science, Multidisciplinary
Y. B. Liu, D. Cai, T. C. Zhao, M. Shen, X. Zhou, Z. H. Zhang, X. W. Meng, D. E. Gu
Summary: This study demonstrates a high-performance monolayer MoS2 Ion based synaptic device (ISD) using Na+ ions doped in the MoS2 lattice as ion sources. The device exhibits various synaptic plasticity and biological features, with low synaptic event response voltage and energy consumption. The resistance switching mechanism and the recognition accuracy of the MNIST handwritten digits are also investigated.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Review
Physiology
Masoumeh Kourosh-Arami, Nasrin Hosseini, Alireza Komaki
Summary: Neuroplasticity refers to the brain's ability to change its structure or functions due to previous stimuli, which is a key mechanism in maintaining a dynamic brain. This study reviews research on homosynaptic and heterosynaptic neuroplasticity and aims to understand different mechanisms related to synaptic plasticity in brain development.
JOURNAL OF PHYSIOLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Jiaqi Liu, Jiangdong Gong, Huanhuan Wei, Yameng Li, Haixia Wu, Chengpeng Jiang, Yuelong Li, Wentao Xu
Summary: This study presents a flexible artificial synapse utilizing a rapidly crystallized perovskite layer at room temperature. The device achieves low energy consumption and fast response frequency, and is successfully applied in a multi-stimulus accumulative artificial neuromuscular system.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Biochemistry & Molecular Biology
Linnaea Ostroff, Hongkui Zeng
Article
Cell Biology
Craig H. Bailey, Eric R. Kandel, Kristen M. Harris
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
(2015)
Article
Biology
Thomas M. Bartol, Cailey Bromer, Justin Kinney, Michael A. Chirillo, Jennifer N. Bourne, Kristen M. Harris, Terrence J. Sejnowski
Article
Multidisciplinary Sciences
Kristen M. Harris, Josef Spacek, Maria Elizabeth Bell, Patrick H. Parker, Laurence F. Lindsey, Alexander D. Baden, Joshua T. Vogelstein, Randal Burns
Article
Biology
Heather L. Smith, Jennifer N. Bourne, Guan Cao, Michael A. Chirillo, Linnaea E. Ostroff, Deborah J. Watson, Kristen M. Harris
Article
Neurosciences
Linnaea E. Ostroff, Benjamin Botsford, Sofya Gindina, Kiriana K. Cowansage, Joseph E. LeDoux, Eric Klann, Charles Hoeffer
JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
Maria Elizabeth Bell, Jennifer N. Bourne, Michael A. Chirillo, John M. Mendenhall, Masaaki Kuwajima, Kristen M. Harris
JOURNAL OF COMPARATIVE NEUROLOGY
(2014)
Article
Biology
Yelena D. Kulik, Deborah J. Watson, Guan Cao, Masaaki Kuwajima, Kristen M. Harris
Article
Neurosciences
Elizabeth Litvina, Amy Adams, Alison Barth, Marcel Bruchez, James Carson, Jason E. Chung, Kristin B. Dupre, Loren M. Frank, Kathleen M. Gates, Kristen M. Harris, Hannah Joo, Jeff William Lichtman, Khara M. Ramos, Terrence Sejnowski, James S. Trimmer, Samantha White, Walter Koroshetz
JOURNAL OF NEUROSCIENCE
(2019)
Editorial Material
Neurosciences
Kristen M. Harris
JOURNAL OF NEUROSCIENCE
(2020)
Article
Neurosciences
Olga I. Ostrovskaya, Guan Cao, Cagla Eroglu, Kristen M. Harris
Article
Multidisciplinary Sciences
Jae Hoon Jung, Lyndsey M. Kirk, Jennifer N. Bourne, Kristen M. Harris
Summary: Long-term potentiation is a cellular mechanism of learning and memory characterized by changes in vesicle density and structure of vesicle tethering filaments, resulting in an increase in release probability following LTP.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)