Journal
JOURNAL OF NEUROSCIENCE
Volume 37, Issue 7, Pages 1862-1872Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3301-16.2017
Keywords
cap-dependent translation; local translation; pavlovian conditioning; polyribosomes; serial electron microscopy; structural plasticity
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Funding
- National Institutes of Health Grants [MH083583, MH094965, NS034007, NS047384, NS086933, DA036673]
- Simons Foundation Grant [SFARI 27444]
- Brain and Behavior Research Foundation Grant [21069]
- Alzheimer's Association Grant
- [MNIRGDP-12-258900]
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Translation in dendrites is believed to support synaptic changes during memory consolidation. Although translational control mechanisms are fundamental mediators of memory, little is known about their role in local translation. We previously found that polyribosomes accumulate in dendritic spines of the adult rat lateral amygdala (LA) during consolidation of aversive pavlovian conditioning and that this memory requires cap-dependent initiation, a primary point of translational control in eukaryotic cells. Here we used serial electron microscopy reconstructions to quantify polyribosomes in LA dendrites when consolidation was blocked by the cap-dependent initiation inhibitor 4EGI-1. We found that 4EGI-1 depleted polyribosomes in dendritic shafts and selectively prevented their upregulation in spine heads, but not bases and necks, during consolidation. Cap-independent upregulation was specific to spines with small, astrocyte-associated synapses. Our results reveal that cap-dependent initiation is involved in local translation during learning and that local translational control varies with synapse type.
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