From obesity genetics to the future of personalized obesity therapy

Association of FTO gene variants with body composition in UK twins

(2012) Gregory Livshits et al.   ANNALS OF HUMAN GENETICS

Genetic determinants of common obesity and their value in prediction

(2012) Ruth J.F. Loos   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Novel association approach for variable number tandem repeats (VNTRs) identifies DOCK5 as a susceptibility gene for severe obesity

(2012) Julia S. El-Sayed Moustafa et al.   HUMAN MOLECULAR GENETICS

Melanocortin-4 Receptor Signaling Is Required for Weight Loss after Gastric Bypass Surgery

(2012) Ida J. Hatoum et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Human SH2B1 mutations are associated with maladaptive behaviors and obesity

(2012) Michael E. Doche et al.   JOURNAL OF CLINICAL INVESTIGATION

High prevalence of leptin and melanocortin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous families

(2012) Sadia Saeed et al.   MOLECULAR GENETICS AND METABOLISM

KCTD13 is a major driver of mirrored neuroanatomical phenotypes of the 16p11.2 copy number variant

(2012) Christelle Golzio et al.   NATURE

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

(2012) Atsuhiko Ichimura et al.   NATURE

Patterns and rates of exonic de novo mutations in autism spectrum disorders

(2012) Benjamin M. Neale et al.   NATURE

De novo mutations revealed by whole-exome sequencing are strongly associated with autism

(2012) Stephan J. Sanders et al.   NATURE

A genome-wide association meta-analysis identifies new childhood obesity loci

(2012)   NATURE GENETICS

Whole-Exome Sequencing and High Throughput Genotyping Identified KCNJ11 as the Thirteenth MODY Gene

(2012) Amélie Bonnefond et al.   PLoS One

Estimation of Newborn Risk for Child or Adolescent Obesity: Lessons from Longitudinal Birth Cohorts

(2012) Anita Morandi et al.   PLoS One

Melanocortin-4 Receptor Mutations and Polymorphisms Do Not Affect Weight Loss after Bariatric Surgery

(2012) Marion Valette et al.   PLoS One

Heterozygous Mutations Causing Partial Prohormone Convertase 1 Deficiency Contribute to Human Obesity

(2011) J. W. M. Creemers et al.   DIABETES

Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations

(2011) R Dorajoo et al.   INTERNATIONAL JOURNAL OF OBESITY

Age- and gender-dependent obesity in individuals with 16p11.2 deletion

(2011) Yongguo Yu et al.   Journal of Genetics and Genomics

Developments in Obesity Genetics in the Era of Genome-Wide Association Studies

(2011) Felix R. Day et al.   Journal of Nutrigenetics and Nutrigenomics

Genetic variants in FTO associated with metabolic syndrome: a meta- and gene-based analysis

(2011) Haina Wang et al.   MOLECULAR BIOLOGY REPORTS

Homozygosity for a novel missense mutation in the leptin receptor gene (P316T) in two Egyptian cousins with severe early onset obesity

(2011) I. Mazen et al.   MOLECULAR GENETICS AND METABOLISM

Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus

(2011) Sébastien Jacquemont et al.   NATURE

High Allelic Burden of Four Obesity SNPs Is Associated With Poorer Weight Loss Outcomes Following Gastric Bypass Surgery

(2011) Christopher D. Still et al.   Obesity

A Genome-Wide Association Study on Obesity and Obesity-Related Traits

(2011) Kai Wang et al.   PLoS One

Genome-Wide Population-Based Association Study of Extremely Overweight Young Adults – The GOYA Study

(2011) Lavinia Paternoster et al.   PLoS One

A Genome-wide Study Reveals Copy Number Variants Exclusive to Childhood Obesity Cases

(2010) Joseph T. Glessner et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Investigation of Mendelian forms of obesity holds out the prospect of personalized medicine

(2010) Alexandra I. F. Blakemore et al.   Annals of the New York Academy of Sciences

LocusZoom: regional visualization of genome-wide association scan results

(2010) R. J. Pruim et al.   BIOINFORMATICS

Large Copy-Number Variations Are Enriched in Cases With Moderate to Extreme Obesity

(2010) K. Wang et al.   DIABETES

Novel common copy number variation for early onset extreme obesity on chromosome 11q11 identified by a genome-wide analysis

(2010) Ivonne Jarick et al.   HUMAN MOLECULAR GENETICS

Bariatric surgery in a patient with complete MC4R deficiency

(2010) I R Aslan et al.   INTERNATIONAL JOURNAL OF OBESITY

Associations of markers in 11 obesity candidate genes with maximal weight loss and weight regain in the SOS bariatric surgery cases

(2010) M A Sarzynski et al.   INTERNATIONAL JOURNAL OF OBESITY

A new highly penetrant form of obesity due to deletions on chromosome 16p11.2

(2010) R. G. Walters et al.   NATURE

De novo mutations of SETBP1 cause Schinzel-Giedion syndrome

(2010) Alexander Hoischen et al.   NATURE GENETICS

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

(2010) Elizabeth K Speliotes et al.   NATURE GENETICS

Weight Loss after Roux-en-Y Gastric Bypass in Obese Patients Heterozygous for MC4R Mutations

(2010) Ivy R. Aslan et al.   OBESITY SURGERY

Molecular Diagnosis of Neonatal Diabetes Mellitus Using Next-Generation Sequencing of the Whole Exome

(2010) Amélie Bonnefond et al.   PLoS One

A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly

(2010) A. J. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Association Study of Height and Body Mass Index in Australian Twin Families

(2010) Jimmy Z. Liu et al.   Twin Research and Human Genetics

Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups

(2010) André Scherag et al.   PLoS Genetics

Modification effects of physical activity and protein intake on heritability of body size and composition

(2009) Karri Silventoinen et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Leptin: a pivotal regulator of human energy homeostasis

(2009) I Sadaf Farooqi et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Recent progress in the genetics of common obesity

(2009) Ruth J. F. Loos   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Two British women studies replicated the association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) and BMI

(2009) Yin Yao Shugart et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Common body mass index-associated variants confer risk of extreme obesity

(2009) Chris Cotsapas et al.   HUMAN MOLECULAR GENETICS

Genome-wide association study suggested copy number variation may be associated with body mass index in the Chinese population

(2009) Bao-Yong Sha et al.   JOURNAL OF HUMAN GENETICS

Human genetics illuminates the paths to metabolic disease

(2009) Stephen O’Rahilly   NATURE

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Large, rare chromosomal deletions associated with severe early-onset obesity

(2009) Elena G. Bochukova et al.   NATURE

Origins and functional impact of copy number variation in the human genome

(2009) Donald F. Conrad et al.   NATURE

Microduplications of 16p11.2 are associated with schizophrenia

(2009) Shane E McCarthy et al.   NATURE GENETICS

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

(2009) David Meyre et al.   NATURE GENETICS

The genetic contribution to non-syndromic human obesity

(2009) Andrew J. Walley et al.   NATURE REVIEWS GENETICS

NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium

(2009) Nancy L. Heard-Costa et al.   PLoS Genetics

Prevalence of Melanocortin-4 Receptor Deficiency in Europeans and Their Age-Dependent Penetrance in Multigenerational Pedigrees

(2008) F. Stutzmann et al.   DIABETES

FTO Variants Are Associated With Obesity in the Chinese and Malay Populations in Singapore

(2008) J. T. Tan et al.   DIABETES

The ADRB3 Trp64Arg variant and BMI: a meta-analysis of 44 833 individuals

(2008) N Kurokawa et al.   INTERNATIONAL JOURNAL OF OBESITY

Is Obesity Our Genetic Legacy?

(2008) Alexandra I. F. Blakemore et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Common nonsynonymous variants in PCSK1 confer risk of obesity

(2008) Michael Benzinou et al.   NATURE GENETICS

Common variants near MC4R are associated with fat mass, weight and risk of obesity

(2008) Ruth J F Loos et al.   NATURE GENETICS

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

(2008) Gudmar Thorleifsson et al.   NATURE GENETICS

Common genetic variation near MC4R is associated with waist circumference and insulin resistance

(2008) John C Chambers et al.   NATURE GENETICS

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

(2008) Cristen J Willer et al.   NATURE GENETICS

Association between Microdeletion and Microduplication at 16p11.2 and Autism

(2008) Lauren A. Weiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

Leptin Replacement Improves Cognitive Development

(2008) Gilberto J. Paz-Filho et al.   PLoS One