Inferring parsimonious migration histories for metastatic cancers

Single-cell DNA sequencing reveals a late-dissemination model in metastatic colorectal cancer

(2017) Marco L. Leung et al.   GENOME RESEARCH

Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer

(2017) Alvin P Makohon-Moore et al.   NATURE GENETICS

Origins of lymphatic and distant metastases in human colorectal cancer

(2017) Kamila Naxerova et al.   SCIENCE

Local recurrences at the anastomotic area are clonally related to the primary tumor in sporadic colorectal carcinoma

(2017) Efsevia Vakiani et al.   Oncotarget

Genomic Alteration During Metastasis of Lung Adenocarcinoma

(2016) Qiang Tan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

How Subclonal Modeling Is Changing the Metastatic Paradigm

(2016) Geoff Macintyre et al.   CLINICAL CANCER RESEARCH

Variable Intra-Tumor Genomic Heterogeneity of Multiple Lesions in Patients With Hepatocellular Carcinoma

(2016) Ruidong Xue et al.   GASTROENTEROLOGY

Intraindividual genomic heterogeneity of high-grade serous carcinoma of the ovary and clinical utility of ascitic cancer cells for mutation profiling

(2016) Youn Jin Choi et al.   JOURNAL OF PATHOLOGY

Spatial and temporal clonal evolution during development of metastatic urothelial carcinoma

(2016) Mathilde B.H. Thomsen et al.   Molecular Oncology

Early dissemination seeds metastasis in breast cancer

(2016) Hedayatollah Hosseini et al.   NATURE

Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer

(2016) Andrew McPherson et al.   NATURE GENETICS

The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis

(2016) William J Gibson et al.   NATURE GENETICS

Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer

(2016) Himisha Beltran et al.   NATURE MEDICINE

Early and multiple origins of metastatic lineages within primary tumors

(2016) Zi-Ming Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters

(2016) Kevin J. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A collective route to metastasis: Seeding by tumor cell clusters

(2016) K. J. Cheung et al.   SCIENCE

Metastasis as an evolutionary process

(2016) S. Turajlic et al.   SCIENCE

Tumor Evolution in Two Patients with Basal-like Breast Cancer: A Retrospective Genomics Study of Multiple Metastases

(2016) Katherine A. Hoadley et al.   PLOS MEDICINE

Inferring the Mutational History of a Tumor Using Multi-state Perfect Phylogeny Mixtures

(2016) Mohammed El-Kebir et al.   Cell Systems

Reconstruction of clonal trees and tumor composition from multi-sample sequencing data

(2015) Mohammed El-Kebir et al.   BIOINFORMATICS

Clonality inference in multiple tumor samples using phylogeny

(2015) Salem Malikic et al.   BIOINFORMATICS

Inferring the Origin of Metastases from Cancer Phylogenies

(2015) W. S. Hong et al.   CANCER RESEARCH

Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity

(2015) T.-M. Kim et al.   CLINICAL CANCER RESEARCH

The evolutionary history of lethal metastatic prostate cancer

(2015) Gunes Gundem et al.   NATURE

A Big Bang model of human colorectal tumor growth

(2015) Andrea Sottoriva et al.   NATURE GENETICS

Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancers

(2015) Melissa Q McCreery et al.   NATURE MEDICINE

Using tumour phylogenetics to identify the roots of metastasis in humans

(2015) Kamila Naxerova et al.   Nature Reviews Clinical Oncology

Phylogenetic analyses of melanoma reveal complex patterns of metastatic dissemination

(2015) J. Zachary Sanborn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pancreatic Cancer Metastases Harbor Evidence of Polyclonality

(2015) R. Maddipati et al.   Cancer Discovery

Spatial and Temporal Heterogeneity in High-Grade Serous Ovarian Cancer: A Phylogenetic Analysis

(2015) Roland F. Schwarz et al.   PLOS MEDICINE

BitPhylogeny: a probabilistic framework for reconstructing intra-tumor phylogenies

(2015) Ke Yuan et al.   GENOME BIOLOGY

Fast and scalable inference of multi-sample cancer lineages

(2015) Victoria Popic et al.   GENOME BIOLOGY

PhyloWGS: Reconstructing subclonal composition and evolution from whole-genome sequencing of tumors

(2015) Amit G Deshwar et al.   GENOME BIOLOGY

Inferring clonal evolution of tumors from single nucleotide somatic mutations

(2014) Wei Jiao et al.   BMC BIOINFORMATICS

Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis

(2014) Nicola Aceto et al.   CELL

Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing

(2014) Marco Gerlinger et al.   NATURE GENETICS

PyClone: statistical inference of clonal population structure in cancer

(2014) Andrew Roth et al.   NATURE METHODS

Inferring Clonal Composition from Multiple Sections of a Breast Cancer

(2014) Habil Zare et al.   PLoS Computational Biology

Late Recurrence in Melanoma: Clinical Implications of Lost Dormancy

(2013) Mark B. Faries et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Establishing the origin of metastatic deposits in the setting of multiple primary malignancies: The role of massively parallel sequencing

(2013) Leticia De Mattos-Arruda et al.   Molecular Oncology

The causes and consequences of genetic heterogeneity in cancer evolution

(2013) Rebecca A. Burrell et al.   NATURE

TrAp: a tree approach for fingerprinting subclonal tumor composition

(2013) Francesco Strino et al.   NUCLEIC ACIDS RESEARCH

Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

(2013) M. Yu et al.   SCIENCE

The Life History of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fluid biopsy in patients with metastatic prostate, pancreatic and breast cancers

(2012) Dena Marrinucci et al.   PHYSICAL BIOLOGY

Inference of Population Splits and Mixtures from Genome-Wide Allele Frequency Data

(2012) Joseph K. Pickrell et al.   PLoS Genetics

Clinical implications of cancer self-seeding

(2011) Elizabeth Comen et al.   Nature Reviews Clinical Oncology

The patterns and dynamics of genomic instability in metastatic pancreatic cancer

(2010) Peter J. Campbell et al.   NATURE