A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters

Temporally precise single-cell-resolution optogenetics

(2017) Or A. Shemesh et al.   NATURE NEUROSCIENCE

Droplet Microfluidic Flow Cytometer For Sorting On Transient Cellular Responses Of Genetically-Encoded Sensors

(2016) Brett L. Fiedler et al.   ANALYTICAL CHEMISTRY

Genetically encoded indicators of neuronal activity

(2016) Michael Z Lin et al.   NATURE NEUROSCIENCE

Feedback from Network States Generates Variability in a Probabilistic Olfactory Circuit

(2015) Andrew Gordus et al.   CELL

Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently

(2015) Andrew Currin et al.   CHEMICAL SOCIETY REVIEWS

Microfluidics-based selection of red-fluorescent proteins with decreased rates of photobleaching

(2015) Kevin M. Dean et al.   Integrative Biology

Optogenetics and the future of neuroscience

(2015) Edward S Boyden   NATURE NEUROSCIENCE

Swept confocally-aligned planar excitation (SCAPE) microscopy for high-speed volumetric imaging of behaving organisms

(2015) Matthew B. Bouchard et al.   Nature Photonics

Methods for the directed evolution of proteins

(2015) Michael S. Packer et al.   NATURE REVIEWS GENETICS

High-speed recording of neural spikes in awake mice and flies with a fluorescent voltage sensor

(2015) Y. Gong et al.   SCIENCE

Automated single cell sorting and deposition in submicroliter drops

(2014) Rita Salánki et al.   APPLIED PHYSICS LETTERS

Microfluidic cell sorter-aided directed evolution of a protein-based calcium ion indicator with an inverted fluorescent response

(2014) Yongxin Zhao et al.   Integrative Biology

Independent optical excitation of distinct neural populations

(2014) Nathan C Klapoetke et al.   NATURE METHODS

All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins

(2014) Daniel R Hochbaum et al.   NATURE METHODS

Visualizing samples with box plots

(2014) Martin Krzywinski et al.   NATURE METHODS

Simultaneous whole-animal 3D imaging of neuronal activity using light-field microscopy

(2014) Robert Prevedel et al.   NATURE METHODS

Noninvasive optical inhibition with a red-shifted microbial rhodopsin

(2014) Amy S Chuong et al.   NATURE NEUROSCIENCE

High-fidelity optical reporting of neuronal electrical activity with an ultrafast fluorescent voltage sensor

(2014) François St-Pierre et al.   NATURE NEUROSCIENCE

Engineering and characterizing monomeric fluorescent proteins for live-cell imaging applications

(2014) Hui-wang Ai et al.   Nature Protocols

Directed evolution of a far-red fluorescent rhodopsin

(2014) R. S. McIsaac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zebrafish models for translational neuroscience research: from tank to bedside

(2014) Adam Michael Stewart et al.   TRENDS IN NEUROSCIENCES

Archaerhodopsin variants with enhanced voltage-sensitive fluorescence in mammalian and Caenorhabditis elegans neurons

(2014) Nicholas C. Flytzanis et al.   Nature Communications

Adoption of the Q transcriptional regulatory system for zebrafish transgenesis

(2013) Abhignya Subedi et al.   METHODS

Ultrasensitive fluorescent proteins for imaging neuronal activity

(2013) Tsai-Wen Chen et al.   NATURE

Whole-brain functional imaging at cellular resolution using light-sheet microscopy

(2013) Misha B Ahrens et al.   NATURE METHODS

Far-red light photoactivatable near-infrared fluorescent proteins engineered from a bacterial phytochrome

(2013) Kiryl D. Piatkevich et al.   Nature Communications

Laser-based directed release of array elements for efficient collection into targeted microwells

(2012) Nicholas C. Dobes et al.   ANALYST

Brain-wide neuronal dynamics during motor adaptation in zebrafish

(2012) Misha B. Ahrens et al.   NATURE

Bright and stable near-infrared fluorescent protein for in vivo imaging

(2011) Grigory S Filonov et al.   NATURE BIOTECHNOLOGY

Optical recording of action potentials in mammalian neurons using a microbial rhodopsin

(2011) Joel M Kralj et al.   NATURE METHODS

Directed molecular evolution to design advanced red fluorescent proteins

(2011) Fedor V Subach et al.   NATURE METHODS

Two-photon absorption properties of fluorescent proteins

(2011) Mikhail Drobizhev et al.   NATURE METHODS

Studying cell behavior in whole zebrafish embryos by confocal live imaging: application to hematopoietic stem cells

(2011) Olivier Renaud et al.   Nature Protocols

A divide-and-conquer approach to determine the Pareto frontier for optimization of protein engineering experiments

(2011) Lu He et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Molecular and Cellular Approaches for Diversifying and Extending Optogenetics

(2010) Viviana Gradinaru et al.   CELL

Circuit Neuroscience in Zebrafish

(2010) Rainer W. Friedrich et al.   CURRENT BIOLOGY

Induced Transmembrane Voltage and Its Correlation with Electroporation-Mediated Molecular Transport

(2010) Tadej Kotnik et al.   JOURNAL OF MEMBRANE BIOLOGY

High-performance genetically targetable optical neural silencing by light-driven proton pumps

(2010) Brian Y. Chow et al.   NATURE

Design of protein-interaction specificity gives selective bZIP-binding peptides

(2009) Gevorg Grigoryan et al.   NATURE

Optogenetic dissection of a behavioural module in the vertebrate spinal cord

(2009) Claire Wyart et al.   NATURE

V2a and V2b neurons are generated by the final divisions of pair-producing progenitors in the zebrafish spinal cord

(2008) Y. Kimura et al.   DEVELOPMENT

Two-photon absorption standards in the 550-1600 nm excitation wavelength range

(2008) Nikolay S. Makarov et al.   OPTICS EXPRESS